ライフサイエンスコーパス: Jagged-1

1 e S17 and on S17 cells engineered to express Jagged 1.

2 pression of which was dependent on epidermal jagged 1.

3 ic processes were affected, one of which was jagged-1.

4 for a soluble form of a Notch ligand, human Jagged-1.

5 echanisms and prevented the glycosylation of Jagged-1.

6 ed the Notch-1 receptor and the Notch ligand Jagged-1.

7 ulate Notch3 while endothelial cells express Jagged-1.

8 DLL1 and DLL4, but not with the Notch ligand Jagged-1.

9 g and the CSC phenotype by secreting soluble Jagged-1.

10 as suggested by the increased expression in Jagged-1.

11 athway involving inactivation of Notch-1 and Jagged-1.

12 und Notch receptors (Notch 1-4) and ligands (Jagged 1-2 and Delta-like 1, 3, 4), resulting in cell-co

13 ssion of Notch 1-4 receptors, their ligands (Jagged 1-2, DLL1,3,4), gamma-secretase complex proteins

14 angiogenesis factors including Notch ligands Jagged 1/2 and DLL-4 and VEGF were significantly reduced

15 ts ligands (DLL (Delta-like protein)-1/3/4), Jagged 1/2) and Notch-induced transcription factor Hes1

16 t during biliary regeneration, expression of Jagged 1 (a Notch ligand) by myofibroblasts promoted Not

17 EC tip cell phenotype and the expression of jagged-1, a ligand for the notch pathway.

18 Computational analyses identified two genes, Jagged-1, a Notch-receptor ligand, and embryonic-lethal

19 Mechanistically, JAGGED-1, a transmembrane ligand for the NOTCH receptor,

20 Significantly, exogenously added Wnt-1 and Jagged-1 also stalled MDDC differentiation, suggesting t

21 Reducing the expression of Jagged 1 and 2 in the Mgp(-/-) mice by crossing them wit

22 Expression of Notch 2, Jagged 1 and 2, Delta 1 and 4, Hes 1 and 5, and Deltex w

23 inase 1 enhances expression of Notch ligands Jagged 1 and 2, which increases Notch activity and alter

24 g major histocompatibility complex class II, Jagged 1 and interferon-response molecules and upregulat

25 ings, in vitro-differentiated and HDM-pulsed Jagged 1 and Jagged 2 double-deficient DCs lacked the ca

26 sthma mouse model to compare the capacity of Jagged 1 and Jagged 2 single- and double-deficient DCs t

27 of the C-terminal extracellular portions of Jagged 1 and Jagged 2.

28 The down-regulation of Notch 1 and Jagged 1 and loss of their osteoprotective function migh

29 lated organ defects occur in mice that carry jagged 1 and notch 2 mutations.

30 mber produce high levels of the Notch ligand jagged 1 and support an increase in the number of haemat

31 Jagged-1 and Delta-1 equally activated CBF-1/RBPJkappa t

32 Furthermore, ethanol induced both Jagged-1 and ELAVL2 mRNA.

33 eased significantly, along with increases in Jagged-1 and Hes-1 coinciding with the progression and r

34 This study documents the regulation of the Jagged-1 and Notch-3 genes in VSMCs by growth factor sti

35 The downregulation of Jagged-1 and Notch-3 was associated with a decrease in C

36 , we demonstrated a cooperative influence of Jagged-1 and TGFbeta1 on cholangiocytic differentiation.

37 f the arterial and venous markers (EphB4 and Jagged-1), and showed evidence of arteriovenous shunting

38 iption 3-dependent up-regulation of Notch-3, Jagged-1, and carbonic anhydrase IX.

39 sis with concomitant attenuation of Notch-1, Jagged-1, and its downstream genes such as Hes-1 in vitr

40 uments that the Notch-3 receptor, the ligand Jagged-1, and the downstream transcription factor, HESR-

41 i-NOTCH2 negative regulatory region and anti-jagged 1 antibodies.

42 ent study shows that Notch-2 and its ligand, Jagged-1, are highly up-regulated in GR cells, which is

43 at Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines an

44 These results obtained in vitro table Jagged 1 as a candidate regulator of stem cell fate in t

45 In this report, we identify Jagged-1 as the highest expressed Notch ligand in ovaria

46 ts of the Notch pathway, Notch1, Notch2, and Jagged 1, as direct targets of miR-34a.

47 these results unveil a novel stromal PTEN-to-JAGGED-1 axis in maintaining the MaSC niche, and subsequ

48 at removing one copy of Rumi in a Jag1(+/-) (jagged 1) background results in severe bile duct morphog

49 dendritic cells that upregulate Notch ligand Jagged-1 but not Delta-4.

50 HDM exposure promoted expression of Jagged 1, but not Jagged 2, on DCs.

51 Hence, transgenic expression of Jagged-1 by antigen-presenting cells can induce antigen-

52 Upregulation of OX40L and Jagged-1 by mDC resulted in mDC-driven Th2 responses.

53 Down-regulation of Notch-1, Delta-like-1, or Jagged-1 by RNA interference induces apoptosis and inhib

54 In addition, we demonstrated that exogenous Jagged-1, Delta-like 1, and Delta-like 4 within the cell

55 Normal and CML LTHSCs cultured with Jagged-1 demonstrated reduced cell cycling, consistent w

56 Stimulation of CD45RA+ naive T cells by Jagged-1 EBV-LCL reduces production of interferon-gamma,

57 ing cells and overexpressed the Notch ligand Jagged-1 (EBV-LCL J1) by adenoviral transduction.

58 Notch3-expressing ovarian cancer cells with Jagged-1-expressing feeder cells activated the promoter

59 KL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control gr

60 neage differentiation requires Smad3-induced Jagged-1 expression and Notch activation, MEK/Smad3-regu

61 Immunohistochemical analyses demonstrated jagged-1 expression in distal tubules of kidneys from no

62 On the basis of the array analysis, jagged-1 expression was further evaluated in cultured ce

63 Jagged-1 expression was significantly increased in the k

64 Reintroduction of JAGGED-1 expression within the PTEN-null fibroblasts was

65 nscription factor NF-kB and its induction of Jagged-1 expression, which promoted Notch signaling and

66 f differentiated chondrocytes and failure of Jagged-1 expression.

67 fied extracellular domain of human Jagged-1 (Jagged-1(ext)).

68 1-induced Notch signaling (using immobilized Jagged-1 fusion protein) during stimulation of purified

69 We found that main Notch ligands Delta-1 and Jagged-1 had the opposite effect on DC differentiation.

70 To investigate if the stromal expression of Jagged 1 has functional effects on hematopoietic progeni

71 Causative dominant mutations in human Jagged 1 have been identified in most AGS patients.

72 of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-alpha, IL-17, RANKL, and OPG

73 Notch activation resulted in upregulation of jagged 1 in both epidermis and dermis.

74 in stimulates expression of the Notch ligand jagged 1 in osteoblasts.

75 stern blotting, we demonstrate expression of Jagged 1 in primary stromal cultures.

76 Down-regulation of Jagged-1 in BMS substantially increased DC differentiati

77 dherin, thrombospondin, and the notch ligand jagged-1 in cultured human proximal tubular epithelial (

78 e effects were blocked by immunodepletion of Jagged-1 in EC-conditioned medium or blockade of ADAM17

79 quired for TNF induction of the notch ligand jagged-1 in EC.

80 Here we demonstrate that TNF induction of jagged-1 in human EC is rapid and dependent upon signali

81 activity implying a direct role for stromal JAGGED-1 in regulation of MaSC properties.

82 Enrichment of jagged-1 in tip cells was confirmed by immunofluorescent

83 , Notch-1 and Notch-2, and one Notch ligand, Jagged-1, in hematopoietic cells.

84 We overexpressed a Notch ligand, Jagged-1, in these cells by adenoviral vector transducti

85 The presence of Jagged 1 increased the number of colonies formed in subs

86 re of DCs with cells expressing Notch ligand Jagged-1 induced up-regulation of maturation markers, IL

87 In the present report we demonstrate that Jagged-1-induced Notch signaling (using immobilized Jagg

88 We conclude that jagged 1 is a key mediator of non-cell autonomous Notch

89 Jagged 1 is expressed throughout the developing embryo,

90 These results suggest that jagged-1 is expressed in normal kidneys and that this ex

91 Taken together, our results show that Jagged-1 is the primary Notch3 ligand in ovarian carcino

92 Expression of Notch-1 and its ligand, Jagged-1, is associated with the poorest survival, inclu

93 erized by overexpression of the NOTCH ligand JAGGED-1 (JAG-1) in small pulmonary artery smooth muscle

94 Activation of Notch signaling by Jagged-1 (Jag-1) in vascular smooth muscle cells (VSMC)

95 In human primary VSMCs, Jagged-1 (Jag-1) significantly reduced proliferation thr

96 nalysis of expression data, the Notch ligand Jagged-1 (Jag-1) was identified as a downstream target o

97 tic disease primarily caused by mutations in jagged 1 ( JAG1) , BD paucity often results in severe ch

98 Expression of the Notch ligand Jagged 1 (JAG1) and Notch activation promote poor-progno

99 K) signaling, which induces the Notch ligand Jagged 1 (Jag1) and promotes cell differentiation.

100 DPT), and increased expression of IGFBP5 and jagged 1 (JAG1) are seen only in fibroblasts cultured fr

101 gille syndrome is caused by mutations in the Jagged 1 (JAG1) gene, which encodes a ligand for Notch f

102 uring cochlear development, the Notch ligand JAGGED 1 (JAG1) plays an important role in the specifica

103 Conversely, misexpression of human jagged 1 (JAG1) represses ventral gene expression and do

104 Mutations in the human Notch ligand jagged 1 (JAG1) result in a multi-system disorder called

105 Deletion of jagged 1 (Jag1) results in inhibition of the hair growth

106 Mutations of Jagged 1 (JAG1), a ligand in the Notch signaling pathway

107 idual genes, multidrug resistant 1a (Mdr1a), jagged 1 (Jag1), and notch homolog 3 (Notch3), were targ

108 omponents of the Notch pathway, most notably Jagged 1 (Jag1), as targets of PM induction in human mon

109 we show that conditional inactivation of the Jagged 1 (Jag1)-Notch2 signaling pathway in the developi

110 gh levels of the Notch ligand family member, Jagged 1 (Jag1).

111 hed the membrane-anchored signaling molecule Jagged 1 (Jag1).Wealso mapped the cleavage sites of Jag1

112 e differentially regulated by Notch ligands: Jagged-1 (Jag1) and Delta-like ligand 1 (Dll1).

113 a vascular niche that produces Notch ligands jagged-1 (JAG1) and delta-like ligand-4 (DLL4) drives de

114 through their expression of the NOTCH ligand JAGGED-1 (JAG1) at stage VIII of the seminiferous epithe

115 onic enhancer region within the Notch ligand Jagged-1 (JAG1) gene, an event requiring DeltaNp63.

116 Cotreatment with soluble OX40L and Jagged-1 (JAG1) proteins increased Tregs, TFR cells, and

117 teractions, such as angiopoietin-2 (ANGPT2), jagged-1 (JAG1), and notch-4 (NOTCH4), as well as genes

118 IL1B), cysteine-rich protein 61 (CYR61), and jagged-1 (JAG1), that act downstream of p63 as key effec

119 he JAG1-3'UTR and inhibits the expression of Jagged-1 (JAG1).

120 regeneration via the Notch signaling ligand Jagged-1 (Jag1).

121 h the purified extracellular domain of human Jagged-1 (Jagged-1(ext)).

122 ch was activated in the absence of epidermal jagged 1, jagged 1 was not upregulated in the dermis, an

123 Notch ligands, Delta-like 1 (Dll1) and Jagged 1 (Jg1), are expressed by follicular dendritic ce

124 arian cancer cells that were cocultured with Jagged-1 knockdown mesothelial and tumor feeder cells.

125 miR-21 and miR-34a, or addition of Wnt-1 and Jagged-1, led to a decrease in endocytic capacity, a key

126 nds, including increased Delta-4 and reduced Jagged-1 levels, reflecting decreased T(H)2 polarization

127 cell-cell contact for reciprocal binding of Jagged-1 ligands and Notch-1 receptors between adjacent

128 ics of Notch signaling involving Delta-4 and Jagged-1 ligands determines tip cell selection and vesse

129 may result from the inhibition of endogenous Jagged 1-mediated Notch signaling since it was not possi

130 nt and requires the repression of endogenous Jagged 1-mediated Notch signaling, which is tolerant to

131 osis was required for selectively activating Jagged-1-mediated Notch3 signaling.

132 its effects on CD4+ T cell differentiation, Jagged-1-mediated signaling inhibits T cell cytokine sec

133 ted OX40 ligand (OX40L) and the Notch ligand Jagged-1 mRNA and expression on mDC.

134 The expression of jagged-1 mRNA and protein was observed to be significant

135 Recombinant human TGF-beta1 increased jagged-1 mRNA levels at concentrations between 10(-11) a

136 R-335, -21, and -153 significantly increased Jagged-1 mRNA.

137 nephron remodeling process and induction of jagged 1/NOTCH signaling, which expands the cortical con

138 Ang-1 also upregulated Jagged-1, Notch3 and apelin expression followed by incre

139 imary Notch3 ligand in ovarian carcinoma and Jagged-1/Notch3 interaction constitutes a juxtacrine loo

140 Upregulation of OX40L as well as Jagged-1 on mDC required HBEC and did not occur in the p

141 further test this possibility, the effect of Jagged-1 on murine marrow precursor cells was assessed b

142 2 in the Mgp(-/-) mice by crossing them with Jagged 1 or 2 deficient mice reduces Notch activity, nor

143 M-driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required.

144 tization and challenge with HDM, DC-specific Jagged 1 or Jagged 2 single- or double-deficient mice ha

145 ) with a 3T3 cell layer that expressed human Jagged-1 or by incubating sorted precursors with beads c

146 creased vascular branching as treatment with Jagged-1 peptide reduced the size of the arterial networ

147 Our data suggest that activation of Notch by Jagged-1 plays an important role in maturation of human

148 We found that Jagged-1, presented both on the cell surface and on bead

149 Notch signaling in human T cells induced by Jagged-1 promotes a novel form of T cell hyporesponsiven

150 served in vivo, resulted in deceased Notch 1/Jagged 1 protein expression however, DHA supplementation

151 trate significant attenuation of Notch 1 and Jagged 1 protein levels in response to DHA supplementati

152 The interplay between Notch receptors and Jagged 1 protein, as expressed by many cells of the live

153 Jagged-1 protein expression was increased in tubules not

154 There was a commensurate increase in jagged-1 protein levels, as assessed by Western blotting

155 in the gene encoding the human Notch ligand jagged 1 result in a multisystem autosomal dominant diso

156 ceptor by exposing cells to the Notch ligand Jagged-1 resulted in upregulation of PDGF-B expression.

157 cellular domain significantly suppressed the Jagged-1 shRNA-mediated growth inhibitory effect.

158 consistent with a possible role for loss of Jagged-1 signals in altered HSC and LSC function after O

159 he transmembrane ligand for Notch receptors, Jagged 1 (sJ1), in NIH 3T3 cells results in the formatio

160 eration of fully differentiated DCs, whereas Jagged-1 stimulated accumulation of DC precursors but pr

161 In Notch3-expressing ovarian cancer cells, Jagged-1-stimulating peptides enhanced cellular prolifer

162 ephros region of day 11 mouse embryos on the Jagged 1(-) stromal cell line S17 and on S17 cells engin

163 our and a half LIM domains protein 2), JAG1 (jagged 1), SULF2 (extracellular sulfatase Sulf-2), and T

164 our and a half LIM domains protein 2), JAG1 (jagged 1), SULF2 (extracellular sulfatase Sulf-2), and T

165 MS expressed a substantially higher level of Jagged-1 than Delta-1.

166 Because MAGP-2 interacts with Jagged-1 that controls cell-matrix interaction and cell

167 or (PDGF) markedly downregulated Notch-3 and Jagged-1 through ERK-dependent signaling mechanisms and

168 find that TNF also induces the notch ligand jagged-1, through an NFkappaB-dependent mechanism.

169 Furthermore, OX40L and Jagged-1 upregulation was inhibited when HBEC expression

170 An EC-derived, soluble form of Jagged-1, via ADAM17 proteolytic activity, led to Notch

171 ivated in the absence of epidermal jagged 1, jagged 1 was not upregulated in the dermis, and epiderma

172 The notch ligand Jagged-1 was overexpressed on CML OBs.

173 However, Jagged-1 was seen in cultured primary murine fetal liver

174 The Notch ligand, Jagged-1, was not detected in whole marrow or in precurs

175 beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever musc

176 on DC differentiation was similar to that of Jagged-1, whereas the effect of SS was similar to the ef