ライフサイエンスコーパス: K-Cl cotransporter

1 to the human colonic T84 epithelial cell Na-K-Cl cotransporter.

2 that it would be distantly related to the Na-K-Cl cotransporter.

3 nd increased gene expression of NKCC1--a Na+-K+-Cl- cotransporter.

4 o examine the effect on O2 dependency of the K+-Cl- cotransporter.

5 rter, and NKCC, the chloride accumulator Na+-K+-Cl- cotransporter.

6 ial homology to KCC2, the mammalian neuronal K(+)-Cl(-) cotransporter.

7 of spinal CSF-cNs (18.3%) express the Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) allowing intracellula

8 been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in gl

9 The Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) is particularly relev

10 Alternatively, inhibition of the Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1), a Cl(-) importer exp

11 exhibited sustained expression of the Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1), whereas inhibitory n

12 is accompanied by down-regulation of the Na-K-Cl cotransporter 1 (Nkcc1) and the Ca(2+)-activated an

13 T(1A) receptor (encoded by Agtr1a) and Na(+)-K(+)-Cl(-) cotransporter-1 (NKCC1, encoded by Slc12a2) i

14 t colonic basolateral membrane suggests that K-Cl cotransporter: 1) is involved in transepithelial po

15 The K(+)-Cl(-) cotransporter 2 (KCC2) plays an important rol

16 However, we did not find expression of the K(+)-Cl(-) cotransporter 2 (KCC2) responsible for Cl(-)

17 The VP neurons lacked expression of the K(+)-Cl(-) cotransporter 2 (KCC2), the predominant Cl(-)

18 he Na(+)-K(+)-2Cl(-) cotransporter 1 and the K(+)-Cl(-) cotransporter 2 (KCC2).

19 TAL, cisplatin-treated rats had higher Na(+)-K(+)-Cl(-) cotransporter 2 (NKCC2) abundance but lower p

20 pagliflozin reversed cisplatin-induced Na(+)-K(+)-Cl(-) cotransporter 2 inhibition and claudin-16 dow

21 (sodium-chloride symporter) and NKCC2 (Na(+)-K(+)-Cl(-) cotransporter 2) activation at residues Thr53

22 K(+)/Cl(-) cotransporter 2 (KCC2) is selectively express

23 bundance and function of the neuron-specific K(+)/Cl(-) cotransporter 2 (KCC2), which maintains chlor

24 It is emerging that impaired K+/Cl- cotransporter 2 (KCC2) activity leads to deficits

25 Expression of the K+Cl- cotransporter 2 (KCC2) also increased across these

26 evidence indicates that the neuron-specific K-Cl cotransporter 2 (KCC2) is the major chloride extrus

27 and GABA(A) receptor alpha1 subunit, but not K-Cl cotransporter 2, are colocalized at the presumed po

28 K(+)-Cl(-) cotransporter-2 (KCC2) critically controls ne

29 a(+)-K(+)-2Cl(-) cotransporter-1 (NKCC1) and K(+)-Cl(-) cotransporter-2 (KCC2), critically influence

30 n the absence of water transport through the K(+)-Cl(-) cotransporter, a large osmotic gradient build

31 d with a monoclonal antibody to mammalian Na-K-Cl cotransporter and a fluorescent secondary antibody

32 mportant new insights into the regulation of K-Cl cotransporters and provides in vivo evidence that i

33 +)/Pi co-transporter 2, phosphorylated Na(+)/K(+)/Cl(-) cotransporter, and phosphorylated Na(+)/Cl(-)

34 sion patterns of KCC2, the chloride extruder K+-Cl- cotransporter, and NKCC, the chloride accumulator

35 P (sickle), Ca 2+ -sensitive K channel, and K:Cl cotransporter, and of therapies targeted at these t

36 in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurolog

37 Electroneutral Na-(K)-Cl cotransporters are present in most cell types, whe

38 The Na-K-Cl cotransporters are a class of ion transport protein

39 n chloride cotransporters, e.g. Na-K-2Cl and K-Cl cotransporters, are activated to maintain fluid/ion

40 Regulation of the K+-Cl- cotransporter by O2 is very similar in equine, sh

41 Expression of NKCC1, an Na-K-Cl cotransporter characteristic for ductal epithelia,

42 the expected functional characteristics of a K+Cl- cotransporter: Cl--dependent uptake of 86Rb+ which

43 Here we review what is known about the Na-(K)-Cl cotransporters cloned to date and what can be dedu

44 ced monoclonal antibody (T4) specific for Na-K-Cl cotransporter displays the same localization.

45 ing the chloride gradient by blocking the Na-K-Cl cotransporter eliminated responses to light moving

46 Two Na-K-Cl cotransporters encoded by different genes have been

47 KCC2 is a neuron-specific K(+)-Cl(-) cotransporter essential for establishing the

48 Na-K-Cl cotransporter fluorescence patterns showed more var

49 ve no effect on total KCC2 protein level and K-Cl cotransporter function.

50 Na(+)-K(+)-Cl(-) cotransporters functions as an anion importer

51 The other members of this K(+)-Cl(-) cotransporter gene family are exclusively swe

52 KCC2 is the neuron-specific member of the of K(+)-Cl(-) cotransporter gene family.

53 Na(+)-K(+)-Cl(-) cotransporter has been proposed to play an im

54 mutations that reduce the level of the sole K+/Cl- cotransporter in the fruitfly Drosophila melanoga

55 m tight junctions supports a role for the Na-K-Cl cotransporter in ciliary epithelium as a chloride e

56 dertaken to determine the location of the Na-K-Cl cotransporter in fixed sections of bovine eye.

57 assing a total of seven Na-Cl, Na-K-2Cl, and K-Cl cotransporters, in addition to two related transpor

58 The pharmacology of the K-Cl cotransporter is dominated by loop diuretics such a

59 t the behavior of the endogenous HEK cell Na-K-Cl cotransporter is unlike either of the two forms whi

60 that pharmacological inhibition of the Na(+)-K(+)-Cl(-) cotransporter isoform 1 (NKCC1) during ischem

61 , which inhibit Cl- influx through the Na(+)-K(+)-Cl- cotransporter isoform-1 (NKCC-1) and efflux thr

62 er isoform-1 (NKCC-1) and efflux through the K(+)-Cl- cotransporter isoform-2, were unable to inhibit

63 2 is 67% identical to the widely distributed K-Cl cotransporter isoform (KCC1) identified in rat brai

64 ary screening, we have identified a putative K-Cl cotransporter isoform (KCC2) in rat brain that is s

65 at cation-dependent Cl- transport protein Na-K-Cl cotransporter isoform 1 (NKCC1) plays a role in the

66 Na-K-Cl cotransporter isoform 1 (NKCC1) plays an important

67 However, Na-K-Cl cotransporter isoform 1 (NKCC1) was significantly u

68 suggest that a novel mechanism involving Na-K-Cl cotransporter isoform 1 mediates the observed long-

69 To date, two Na-K-Cl cotransporter isoforms have been identified: NKCC1,

70 o includes Na-Cl cotransporters and multiple K-Cl cotransporter isoforms.

71 While animals lacking ABTS-1 or the K(+)-Cl(-) cotransporter KCC-2 display only mild behavio

72 ed K(+) channel (the Gardos channel) and the K(+)-Cl(-) cotransporter (KCC) - it would have a synergi

73 ent the structure of a CCC, the Mus musculus K(+)-Cl(-) cotransporter (KCC) KCC4, in lipid nanodiscs

74 a cryoelectron microscopy structure of human K(+)-Cl(-) cotransporter (KCC)1 bound with the VU0463271

75 The K(+):Cl(-) cotransporter (KCC) activity is modulated by

76 ects of CDNB (1 mM) on the activities of the K+-Cl- cotransporter (KCC; measured as Cl--dependent K+

77 s among the polypeptide products of the four K-Cl cotransporter (KCC) genes are little understood.

78 The K-Cl cotransporter (KCC) regulates red blood cell (RBC)

79 cells (VSMCs) express at least two mRNAs for K-Cl cotransporters (KCC): KCC1 and KCC3.

80 Na(+)/K(+)/Cl(-) cotransporter NKCC1 and the K(+)/Cl(-) cotransporters KCC1, KCC2, KCC3 and KCC4 have

81 2Cl cotransporter NKCC1 and Cl(-) efflux via K-Cl cotransporters, KCC1 or KCC2.

82 The neuron-specific K(+)-Cl(-) cotransporter KCC2 plays a crucial role in de

83 The K(+)-Cl(-) cotransporter KCC2, encoded by the Slc12a5 ge

84 al disease, the regulatory mechanisms of the K(+)/Cl(-) cotransporter KCC2 (encoded by SLC12A5) durin

85 The K(+)/Cl(-) cotransporter KCC2 (SLC12A5) allows mature ne

86 Diminished levels of the K(+)/Cl(-) cotransporter KCC2 and a depolarizing GABAA r

87 The K(+)/Cl(-) cotransporter KCC2 is the main mechanism by w

88 d postsynaptic activity acts on the neuronal K+/Cl- cotransporter KCC2 to shift the reversal potentia

89 larger in mature neurons, which express the K-Cl cotransporter KCC2 at high levels, and inhibition o

90 The K-Cl cotransporter KCC2 establishes the low intraneurona

91 Targeted deletion of the neuronal-specific K-Cl cotransporter KCC2 generates mice with a profound s

92 pmental fall in [Cl(-)]i and the role of the K-Cl cotransporter KCC2 in this process.

93 The neuronal K-Cl cotransporter KCC2 maintains the low intracellular

94 The K-Cl cotransporter KCC2 plays a crucial role in neuronal

95 se gradients are primarily maintained by the K/Cl cotransporter KCC2.

96 /K(+) /2Cl(-) cotransporter type 1 (NKCC1), K(+) /Cl(-) cotransporter (KCC2), the water channel aqua

97 in Cl(-) homeostasis is the neuron-specific K(+)-Cl(-) cotransporter (KCC2).

98 The K(+)/Cl(-) cotransporter (KCC2) allows adult neurons to

99 n caused a progressive downregulation of the K+-Cl- cotransporter (KCC2), which may have contributed

100 The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as

101 o test this, we immunostained retina for the K-Cl cotransporter (KCC2) that normally extrudes chlorid

102 ess-induced functional downregulation of the K(+), Cl(-) cotransporter, KCC2.

103 ted E(GABA), expression of the Cl- extruding K+/Cl- cotransporter, KCC2 was decreased.

104 ted that the protein product of Slc12a6, the K(+)-Cl(-) cotransporter Kcc3, was not detectable in gax

105 dates for Mendelian human disorders, and the K-Cl cotransporter KCC3, in particular, may be involved

106 EAAT1(P>R) mutation, the chloride-extruding K(+)-Cl(-) cotransporter KccB also caused astroglial mal

107 K(+)-Cl(-) cotransporters (KCCs) play a fundamental role

108 K(+)-Cl(-) cotransporters (KCCs) play important roles in

109 ires a Cl(-) gradient established in part by K(+)-Cl(-) cotransporters (KCCs).

110 The K+-Cl- cotransporters (KCCs) belong to the gene family o

111 Cl(-) exit via K-Cl cotransporters (KCCs) is a major determinant of [Cl

112 -sensitive K channel, and the electroneutral K:Cl cotransporter-leading to sickle cell dehydration.

113 s, particularly R(+)-butylindazone-sensitive K-Cl cotransporters, may have a synapse- and/or cell typ

114 In contrast, the Na(+)-K(+)-Cl(-) cotransporter Ncc69, which normally allows ch

115 tes this variation, presumably via an Na(+), K(+), Cl(-) cotransporter (NKCC) and the Shaw K(+) chann

116 mbrane conductance regulator (CFTR) or Na(+)-K(+)-Cl(-) cotransporters (NKCC) blocked alveolar fluid

117 tanide and furosemide, two blockers of Na(+)/K(+)/Cl(-) cotransporters (NKCC), inhibited all capacita

118 25% identity) to the bumetanide-sensitive Na-K-Cl cotransporter (NKCC or BSC) and the thiazide-sensit

119 The Na-K-Cl cotransporter (NKCC) mediates the coupled movement

120 The Na-K-Cl cotransporter (NKCC) plays a key role in electrolyt

121 The Na-K-Cl cotransporter (NKCC) plays central roles in cellula

122 at normally extrudes chloride and for the Na-K-Cl cotransporter (NKCC) that normally accumulates chlo

123 The human and shark Na-K-Cl cotransporters (NKCC), although 74% identical in am

124 ovided by these new structures for the Na(+)/K(+)/Cl(-) cotransporter NKCC1 and the K(+)/Cl(-) cotran

125 The Na-K-Cl cotransporter NKCC1 is activated by phosphorylation

126 The secretory Na-K-Cl cotransporter NKCC1 is activated by secretagogues t

127 cryo-electron microscopy structure of the Na-K-Cl cotransporter NKCC1, an extensively studied member

128 um preparation, AqF026 did not affect the Na-K-Cl cotransporter NKCC1.

129 osphorylation-dependent activation of the Na-K-Cl cotransporter (NKCC1) has been previously well docu

130 In particular, activation of the Na-K-Cl cotransporter (NKCC1) has been shown to be involved

131 Although the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide has prom

132 The Na-K-Cl cotransporter (NKCC1) is expressed in most vertebra

133 re we report that a substrate of PP1, the Na-K-Cl cotransporter (NKCC1), bears this motif in its N te

134 at kidney, the "secretory" isoform of the Na-K-Cl cotransporter, NKCC1 (BSC-2), localizes to the baso

135 we show a key role for the bidirectional Na-K-Cl cotransporter, NKCC1, in the choroid plexus (ChP) t

136 examine the structure and function of the Na-K-Cl cotransporter, NKCC1, we tagged the transporter wit

137 Three splice variants of the renal Na-K-Cl cotransporter (NKCC2 F, A, and B) are spatially dis

138 ternatively spliced variants of the renal Na-K-Cl cotransporter (NKCC2) are found in distinct regions

139 The renal Na-K-Cl cotransporter (NKCC2) is selectively expressed in t

140 Na-K-Cl cotransporter (NKCC2)-mediated sodium chloride reab

141 esence of furosemide, an inhibitor of the Na,K,Cl-cotransporter, NMDA-induced edema were reduced by 6

142 ID cell formation, as did inhibitors of the K:Cl cotransporter, okadaic acid, and [(dihydroindenyl)

143 KCC2, a neuronal-specific K-Cl cotransporter, plays a major role in maintaining in

144 er BSC2, one of the two major isoforms of Na-K-Cl cotransporters present in mammalian cells, can be d

145 hat a time-dependent expression of the Na(+)-K(+)-Cl(-) cotransporter protein occurs not only in cort

146 vealed that an intense staining of the Na(+)-K(+)-Cl(-) cotransporter protein was observed in dendrit

147 Na-K-Cl cotransporter protein was detected on immunoblots o

148 dient by ion substitution or by blocking the K-Cl cotransporter resulted in the starburst cells respo

149 use line expressing an activated form of the K-Cl cotransporter Slc12a4 (Kcc1), which results in a se

150 The neuron-specific K(+)-Cl(-) cotransporter SLC12A5, also known as KCC2, he

151 turally similar shark and human secretory Na-K-Cl cotransporters (sNKCC1 and hNKCC1).

152 al membrane transport systems, including the K+-Cl- cotransporter (termed KCC), cause HbS-containing

153 KCC2 is a neuron-specific K(+)-Cl(-) cotransporter that is essential for Cl(-) hom

154 KCC2 is a vital neuronal K(+)/Cl(-) cotransporter that is implicated in the etiol

155 ch is mediated primarily by KCC2, a neuronal K+/Cl- cotransporter that determines the intracellular c

156 ility and the activities of the Na-K-2Cl and K-Cl cotransporters, the Na/H exchanger, and the Gardos

157 Localization of the Na-K-Cl cotransporter to the plasma membrane on the blood s

158 The structure of the Na-K-Cl cotransporter transport protein is not known, but f

159 However, during Na-K-Cl cotransporter type 1 (NKCC1) blockade, the electric

160 ty in unmyelinated C-fibres is coupled to Na-K-Cl cotransporter type 1 (NKCC1) loading of axonal chlo

161 double staining demonstrates that the Na(+)-K(+)-Cl(-) cotransporter was expressed in astrocytes wit

162 lyculin A, consistent with mediation via the K+-Cl- cotransporter, was revealed by depleting deoxygen

163 erogeneous; some cells that expressed the Na-K-Cl cotransporter were weakly stained with the anti-ROM

164 We report here that kcc functions as a K(+)-Cl(-) cotransporter when expressed heterologously i

165 ctivity modulated the mRNA levels of KCC2, a K(+)-Cl(-) cotransporter whose expression correlates wit

166 de the primary link coupling activity of the K+-Cl- cotransporter with O2 tension.

167 hat the KCC1 cDNAs encode a widely expressed K-Cl cotransporter with the characteristics of the K-Cl