ライフサイエンスコーパス: KO mouse

1 e fibrosis similar to that seen in the Bmal1 KO mouse.

2 underlies the hyperconnectivity in the Fmr1 KO mouse.

3 age-related pathologies in the Gsk3a global KO mouse.

4 underlie the behavioral deficit in the fmr1 KO mouse.

5 ed pathologies in the striated muscle of the KO mouse.

6 IFN-gamma production by T cells in the IL-2-KO mouse.

7 ects of innate immune challenge in the PC1/3 KO mouse.

8 subtypes retained homologous coupling in the KO mouse.

9 red in the embryonic heart of the global CAR-KO mouse.

10 on by generating and characterizing a PSD-95 KO mouse.

11 analysis or immunohistochemistry in the Rs1h-KO mouse.

12 stigate these roles by phenotyping of a Muc4 KO mouse.

13 k for neurobiological phenotypes in the Rgs2 KO mouse.

14 s synaptic correlates in the fmr1 knock-out (KO) mouse.

15 (FXS), the Fmr1 (tm1Cgr) or Fmr1 "knockout" (KO) mouse.

16 ient phenotype similar to the IRF8 knockout (KO) mouse.

17 e in the FXS mouse model-the Fmr1 knock-out (KO) mouse.

18 rmation parameters using the IGF-I knockout (KO) mouse.

19 y Kv3.2 or Kv3.4 in the respective knockout (KO) mouse.

20 transport of B12 in a TCblR/CD320-knockout (KO) mouse.

21 The Fmr1 KO mouse, a model of FXS, exhibits elevated translation

22 In the Norrin KO (Ndp (KO) ) mouse, a model of familial exudative vitreoretinop

23 cific Na(+) /Ca(2+) exchange (NCX) knockout (KO) mouse, a model of cellular Ca(2+) overload.

24 The Fmr1 knockout (Fmr1-KO) mouse, a mouse model for FXS, has been shown to repl

25 The multidrug resistance 2 (Mdr2)-knockout (KO) mouse (adenosine triphosphate-binding cassette b4(-/

26 This COX10 KO mouse allowed us to correlate the muscle function wit

27 Moreover, given that this conditional Fktn-KO mouse allows the generation of tissue- and timing-spe

28 f Kiss1r in GFAP-positive cells in the G-KiR-KO mouse altered gene expression of key factors in PGE2

29 Previous studies using the Fmr1 knockout (KO) mouse, an FXS mouse model, have attributed behaviora

30 ameliorates ER stress and fibrosis in Grp78 KO mouse and IPF lung slice cultures.Conclusions: These

31 ed this conundrum using a Ca(v)1.4 knockout (KO) mouse and a knock-in (G369i KI) mouse expressing a n

32 opoietic lineage commitment using knock out (KO) mouse and cell line models.

33 ss this issue, we used the miR-155 knockout (KO) mouse and diffuse large B-cell lymphoma (DLBCL) cell

34 stemically inactivated in adult mouse (alpha-KO mouse), and the role of PDGFRalpha was examined in th

35 m potentiation (LTP) is impaired in the fmr1 KO mouse, and motor skill training does not occlude LTP

36 increased in these regions in WT but not in KO mouse aorta in response to Ang II.

37 eostasis and establish the liver-specific GS KO mouse as a model with which to study effects of chron

38 We used DAT-KO mouse as model for DTDS to explore the potential util

39 The ERG of the Rs1h-KO mouse at early ages reflects disruption of photorecep

40 Furthermore, PancMet KO mouse beta-cells were more sensitive to dexamethasone

41 inhibitory neurotransmission deficits in the KO mouse BLA.

42 We transplanted SMS2 KO mouse bone marrow into low-density lipoprotein (LDL)

43 dependent increase in LPC levels in the PPT1-KO mouse brain positively correlates with elevated expre

44 e phagocytic cells are recruited in the PPT1-KO mouse brain remains poorly understood.

45 nduced by ROS, in human INCL as well as PPT1-KO mouse brain tissues are markedly elevated.

46 sion of GluA2 and GluA3 is increased in STEP-KO mouse brain, and STEP knockdown in hippocampal slices

47 lic phospholipase A(2) (cPLA(2)) in the PPT1-KO mouse brain, is a 'lipid signal' for phagocyte recrui

48 xpression remained unaltered in adult WT and KO mouse brain, SC, and kidneys.

49 -KO mice, as well as in transgenic alpha-Syn-KO mouse brains in vivo.

50 ptide precursor VGF was also affected in PC1 KO mouse brains with a decrease in the level of an endog

51 cessing of proenkephalin was impaired in PC1 KO mouse brains with a decrease in the level of Met-Enke

52 des in the lipid-associated fraction of HEXB KO mouse brains, and intraneuronal accumulation of gangl

53 g of proSAAS into PEN was not altered in PC1 KO mouse brains.

54 is study, we generated a TSHR knockout (TSHR-KO) mouse by homologous recombination for use as a model

55 We generated a Chga knock-out (KO) mouse by the targeted deletion of the Chga gene in n

56 The PEDF-knockout (KO) mouse captures crucial elements of the human disease

57 rom ALR (flox/flox)/Alb-Cre [ALR-L-knockout (KO)] mouse causes robust steatosis and apoptosis of hepa

58 ogenesis machinery, in mitochondria from TAZ-KO mouse cells and in CL-deleted yeast crd1Delta cells,

59 Our technique revealed that Top1mt KO mouse cells process the mitochondrial transcripts nor

60 ponse was more pronounced in Neil2 knockout (KO) mouse cells than in WT cells, suggesting that NEIL2

61 In the Fmr1 KO mouse, chronic treatment with mGluR5-negative alloste

62 P1 with occludin and E-cadherin genes in DRA-KO mouse colon, suggesting that posttranscriptional mech

63 AO A/B double knock-out (KO) mice in a MAO B KO mouse colony.

64 tic transmission in a TARP gamma-4 knockout (KO) mouse corroborates our expression data and demonstra

65 vers, or spleens of MyD88 KO mice, the first KO mouse described with this phenotype to our knowledge.

66 The connexin43 knockout (Cx43alpha1 KO) mouse dies at birth from outflow obstruction associa

67 The Fmr1 KO mouse displays phenotypes similar to symptoms in the

68 Compared to wild type mice, the LIF KO mouse displays reduced astrocyte and microglial activ

69 ablation of the cav1 gene (ad-cav1 knockout [KO] mouse) does not result in elimination of the protein

70 r glutamatergic neurons-in an otherwise Fmr1 KO mouse-eliminates AGSs.

71 Consistent with this, FIP200 KO mouse embryo fibroblasts and liver cells showed incre

72 Reconstitution of KO mouse embryo fibroblasts showed that both the pleckst

73 cadian rhythm in a Cry1(-/-)Cry2(-/-) double KO mouse embryonic fibroblast cell line.

74 Using SV40- and K-Ras-transformed caspase-2 KO mouse embryonic fibroblast cells reconstituted with e

75 In response to adipogenic stimuli, PP5-KO mouse embryonic fibroblast cells showed almost no lip

76 d insulin signaling were restored in ATG16L1 KO mouse embryonic fibroblasts (MEF) upon proteasome inh

77 bryonic fibroblasts lacking Atg16l1 (ATG16L1 KO mouse embryonic fibroblasts (MEFs)), an essential aut

78 eased cell migration was observed from Arl15 KO mouse embryonic fibroblasts (MEFs).

79 r disease (FAD) PS1 mutants expressed in PS1-KO mouse embryonic fibroblasts inhibited both the EphB2-

80 in tRNA were significantly decreased in Tet2 KO mouse embryonic stem cells (mESCs) in comparison with

81 d MIP-1alpha was reduced in IL-18 knock-out (ko) mouse embryonic fibroblast (MEF)-like cells.

82 Wild-type and PP5-deficient (KO) mouse embryonic fibroblast cells were used to show b

83 wild-type (WT) and Bcl-xL knock-out (Bcl-xL-KO) mouse embryonic fibroblast cells.

84 We show that lysates from Nedd4-1 knockout (KO) mouse embryonic fibroblasts (MEFs) have significantl

85 e (WT) and p21-activated kinase 1-null (PAK1-KO) mouse embryonic fibroblasts (MEFs), we found TF and

86 n in both wild-type (WT) and RSK2 knock-out (KO) mouse embryonic fibroblasts (MEFs).

87 We found that in PAI-1 knock-out (KO) mouse embryonic fibroblasts), alphavbeta3 endocytosi

88 ockdown or Parp1 heterozygosity of Brca2(cko/ko) mouse embryonic stem cells (mESCs), carrying a null

89 Analysis of miR-34/449 knockout (KO) mouse embryos demonstrates significant spindle misor

90 We postulated that inclusions in Myo5b KO mouse enterocytes form through invagination of the ap

91 f2 were significantly downregulated in Hdac3 KO mouse epicardial cells.

92 In Oga KO mouse ES cells, we observed pronounced changes in exp

93 Conditional KO mouse experiments indicate that the effect of KLF2 on

94 A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would advance

95 The size and weight of IRBP KO mouse eyes were greater than those of the WT mouse, e

96 Micro-computed tomography of A(2A)KO mouse femurs showed a significantly decreased bone vo

97 By using a knockout (KO) mouse for MKK3, a key regulator of the p38MAPK pathw

98 ted gene expression was dysregulated in TrkC-KO mouse glomeruli.

99 The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO

100 ll homing to the gut and as a result the VDR KO mouse has reduced numbers of CD8alphaalpha IEL with l

101 The Mtm1 knockout (KO) mouse has a severe phenotype and its short lifespan

102 A fragile X knockout (fmr1 KO) mouse has been described that has some of the charac

103 eneration of the connexin-36 knock-out (Cx36 KO) mouse has offered a unique opportunity to examine th

104 odel of ApoE deficiency, the ApoE knock-out (KO) mouse, has reduced synapses and cognitive impairment

105 Banded End.LepR-KO mouse hearts exhibited less apoptosis ( P=0.0218), in

106 pregulation of apoptosis were observed in CM-KO mouse hearts.

107 we have now employed a genetic HRI-knockout (KO) mouse hepatocyte model.

108 analysis revealed that the ischemic GFAP-ARO-KO mouse hippocampus failed to upregulate the "A2" panel

109 c cardiac contractile performance of the PLN-KO mouse in the long term.

110 We generated an AKAP7 KO mouse in which all isoforms were deleted and tested w

111 tion in vivo, we generated a conditional RB1-KO mouse in which pRb expression is efficiently extingui

112 g a pan-brain-specific conditional knockout (KO) mouse incapable of FAO due to the loss of carnitine

113 Studies in the insulin receptor FOXO1 KO mouse indicate that insulin is a key signaling molecu

114 intestinal cell lines, human MVID, and Myo5b KO mouse intestine revealed changes in the subcellular r

115 w that the rate of cone cell loss in the GC1 KO mouse is comparable to that previously described in t

116 The Rs1h-KO mouse is consistent with human clinical X-linked juve

117 that the faster Vus of smooth muscle of the KO mouse is consistent with, but does not prove without

118 dy provides the first evidence that the Fmrl KO mouse is impaired in inhibitory control, attention, a

119 The Ndufs4 knockout (Ndufs4 KO) mouse is a mitochondrial complex 1-deficient model t

120 The dopamine transporter knockout (DAT KO) mouse is a model of chronic hyperdopaminergia used t

121 The Fmr1 knock-out (KO) mouse is a useful model for studying FXS.

122 DAT-Knockout (DAT-KO) mouse is currently the best animal model for this sy

123 While a CPEB knockout (KO) mouse is sterile but overtly normal, embryo fibrobla

124 PancMet KO mouse islets failed to upregulate GLUT2 and pancreati

125 Perifusion of neurexin-1alpha KO mouse islets revealed a significant increase in secon

126 ntly, glucose cycling was abolished in G6pc2 KO mouse islets, confirming that G6pc2 opposes the actio

127 od photoreceptor neuron-specific conditional KO mouse lacking MSI1 and MSI2.

128 oss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a c

129 nd cardiac function in CaMKIIdelta knockout (KO) mouse left ventricle (LV).

130 Using a GluN2D KO mouse line (GluN2D(-/-)), we assessed behavioral phen

131 Here we develop a novel Cnksr2 KO mouse line and show that male mice exhibit increased

132 The GAL3-KO mouse line exhibited normal breeding and physical dev

133 ariants found in the large patient cohort, a KO mouse line lacking Gpr37l1 was generated.

134 Thus, we use a conditional GluN2B KO mouse line to assess both basal and ethanol-dependent

135 lementary mouse models, an alpha4 knock-out (KO) mouse line and a knock-in line (Leu9'Ala) expressing

136 Both Kv1.6 KO mouse lines exhibited an unexpected reduction in sens

137 We then compared RasGRF1 and RasGRF2 KO mouse lines, demonstrating that cocaine SA in RasGRF2

138 used conditional and conventional knock-out (KO) mouse lines, with viral expression of Cre-recombinas

139 X in ZGA, we generated Dux cluster knockout (KO) mouse lines.

140 that compared with wild type littermates, UG-KO mouse lungs express markedly elevated levels of SCCA-

141 notably, the metastasized B16F10 cells in UG-KO mouse lungs express MMP-2, MMP-9, and MMP-14 as well

142 Remarkably, UG-KO mouse lungs overexpress two calcium-binding proteins,

143 f neutrophil elastase and myeloperoxidase in KO mouse lungs.

144 The increased chemotaxis of Fpr2-KO mouse macrophages in response to LLC Sup was due to t

145 increase in TRPC1 protein abundance in I-mfa KO mouse mesangial cells.

146 The RS-KO mouse mimics structural features of human X-linked ju

147 vel skeletal muscle-specific GRK2 knock-out (KO) mouse (MLC-Cre:GRK2(fl/fl)) to gain a better underst

148 ole of Abi1, we generated a conditional Abi1-KO mouse model and MEFs lacking Abi1 expression.

149 We propose that the MARC2 KO mouse model could be a powerful tool for predicting M

150 row-derived macrophages from an IRAK3 CRISPR KO mouse model demonstrated a proinflammatory phenotype

151 Here we present the first report of a Tcap KO mouse model for LGMD2G and the results of an investig

152 use of our Pdx1-Cre-driven conditional PAK4 KO mouse model for testing in vivo potential functions o

153 In this study, we characterized an existing KO mouse model lacking the functional MARC2 gene and fed

154 Obliteration of CHGA expression in a KO mouse model led to decreased size and number of chrom

155 nd more severe cardiac injury, making the MT-KO mouse model of alcohol-induced cardiac fibrosis a use

156 Thus, in the Ndufs4 KO mouse model of mitochondrial optic neuropathy, papave

157 We are the first to establish a viable KO mouse model of Tcap deficiency and our model mice dem

158 Using a conditional KO mouse model where Atg7, a critical gene for macroauto

159 Importantly, in a Deptor-KO mouse model, Deptor knockout accelerated prostate tum

160 Based on an LRRC52 KO mouse model, LRRC52 regulation of large conductance K

161 When using an AMPK-beta1 KO mouse model, the protective effects of metformin stil

162 Using the Aire KO mouse model, we demonstrated an essential role for CC

163 By using an Hsd17b4 KO mouse model, we demonstrated that peroxisomes contrib

164 inflammatory lung microenvironment of Gprc5a-ko mouse model.

165 atory T(h)1 pathway is dominant in the PC1/3 KO mouse model.

166 g a Th17 response in the hyperlipidemic apoE KO mouse model.

167 ucose and insulin tolerance tests in a Ramp3 KO mouse model.

168 ons and in combination with the alpha1,3GalT-KO mouse model.

169 ne 2,3-dioxygenase, and was confirmed in IDO-KO mouse model.

170 s study were 1) to develop a novel knockout (KO) mouse model (Mct6(-/-)) using CRISPR/Cas9 technology

171 mparing tumor formation in an Mdr2-knockout (KO) mouse model (n = 15) and tumor growth in a remote BN

172 story of a retinoschisin gene knockout (Rs1h-KO) mouse model and evaluated the long-term effects of r

173 using the conditional nebulin knockout (cNeb KO) mouse model and subsequently performing global prote

174 A knockout (KO) mouse model exhibits behavioral and adult neurogenes

175 The PC1/3 knock-out (KO) mouse model has allowed us to elucidate its physiolo

176 ow that IFITM3 deficiency in a new knockout (KO) mouse model increases weight loss and mortality foll

177 d connectivity maps of the Cntnap2 knockout (KO) mouse model of ASD.

178 to OCD, we used the Sapap3 knock-out (Sapap3-KO) mouse model of compulsive behaviors, which also exhi

179 dence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe poten

180 ala synaptic function in the Fmr1 knock-out (KO) mouse model of FXS, however, remain largely unexplor

181 hippocampal synapses in the Fmr1-knock-out (KO) mouse model of FXS.

182 ry bulb in the commonly-used Fmr1 knock-out (KO) mouse model of FXS.

183 s of gastric tissues from the TFF1 knockout (KO) mouse model of gastric neoplasia, demonstrated phosp

184 thyl-CpG-binding protein 2 (Mecp2) knockout (KO) mouse model of Rett syndrome, we show that naive exc

185 An ssTnT-knockout (KO) mouse model recapitulates key features of ANM such a

186 An LRRC26 knockout (KO) mouse model recently revealed that LRRC26 is also hi

187 The knockout (KO) mouse model showed the absence of endosialin/TEM1 ex

188 erate a hepatocyte-specific CHIP knockout (H-KO) mouse model that develops NAFLD more rapidly in resp

189 romoter-driven aromatase knock-out (GFAP-ARO-KO) mouse model to deplete astrocyte-derived E2 in the b

190 ebrain neuron-specific aromatase KO (FBN-ARO-KO) mouse model to deplete neuron-derived E2 in the fore

191 We used a knockout (KO) mouse model to determine CTRP2 function and found th

192 in Ras activation, using a RasGRP1 knockout (KO) mouse model to examine the response of keratinocytes

193 A conditional betaENaC MG knockout (KO) mouse model was generated to elucidate the pathogene

194 A sucrase-isomaltase knockout (Sis-KO) mouse model was used to further elucidate the findin

195 he underlying mechanism by using a knockout (KO) mouse model with a genetic ablation of Splunc1.

196 r 3 (IGSF3) by generating an Igsf3 knockout (KO) mouse model with CRISPR/Cas9-mediated genome enginee

197 Here we compare a liver-specific knockout (KO) mouse model with total KO mice.

198 f nNOS was provided by an nNOS knockout (NOS-KO) mouse model, B6-129S4-Nos1(tm1Plh)/J.

199 Here we report the first NIS knockout (KO) mouse model, obtained by targeting exons 6 and 7 of

200 In a vimentin knockout (Vim KO) mouse model, we note that Vim KO mice challenged wit

201 Here, using an eIF2A-knockout (KO) mouse model, we present evidence implicating eIF2A i

202 loid cell-specific SIRT1 knockout (Mac-SIRT1 KO) mouse model, we show that ablation of SIRT1 in macro

203 Using the Jak3 knock-out (KO) mouse model, we show that Jak3 is expressed in colon

204 Using a knockout (KO) mouse model, we show that loss of FAM19A1 results in

205 rrier, we used a Grhl2 conditional knockout (KO) mouse model, which allows for epithelial tissue-spec

206 fiber bundles from a nebulin knock-out (NEB KO) mouse model.

207 characterization of the first Far1 knockout (KO) mouse model.

208 n using a tamoxifen-inducible Lkb1 knockout (KO) mouse model: Rosa26-Cre(ER): Lkb1(flox/flox) (abbrev

209 novel B6.Cg-Pla2g6(DeltaEx2-VB) (PLA2g6 ex2(KO)) mouse model.

210 ted global as well as cardiac-specific HSPB7 KO mouse models and found that loss of HSPB7 globally or

211 -containing BK channels remains rudimentary, KO mouse models may help define other organs in which LR

212 vention studies using DBA2/J and Nos3 (eNos) KO mouse models of diabetes, TEPP-46 treatment reversed

213 Here we used real-time 3D imaging and KO mouse models to clarify how particles (human red bloo

214 sis, as demonstrated using single and double KO mouse models.

215 types reported in pituitary-specific ERalpha KO mouse models.

216 ypes have not been delineated in conditional KO mouse models.

217 By comparing relevant previous knockout (KO) mouse models (3'RR KO and hs3b-4 KO) to a novel muta

218 f deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) raised some

219 Conditional knockout (KO) mouse models are invaluable for elucidating the phys

220 Herein, conditional knockout (KO) mouse models that ablate Intu specifically from kidn

221 aches of COX-2 transgenic (Tg) and knockout (KO) mouse models to evaluate the mechanism of COX-2 in F

222 1-, STIM2-, and double STIM1/STIM2-knockout (KO) mouse models, which reveal the essential role of STI

223 To date, four separate alsin knockout (Alsin(KO)) mouse models have been generated, and despite hopes

224 n quantifiable or qualitative changes in DAT KO mouse MSNs relative to wild-type (WT) littermates.

225 g corresponding double- and triple-knockout (KO) mouse mutants.

226 ineralization of vibrissae, whereas grafting KO mouse muzzle skin onto WT mice did not.

227 verity to that in WT mice, but the iPLA2beta-KO mouse myocardium contained more parasite pseudocysts.

228 bound stimulation of ICa in both WT and NOS3-KO mouse myocytes.

229 naline (Iso) was studied in both WT and NOS3-KO mouse myocytes.

230 in permeabilized phospholamban knockout (PLN-KO) mouse myocytes phosphorylates ryanodine receptors (R

231 tants of SynIII in primary SynIII knock-out (KO) mouse neurons at early stages of in vitro developmen

232 We generated a conditional KO mouse of the Bit1 gene by using the Cre-LoxP recombin

233 sing a megakaryocyte-specific Mkl2 knockout (KO) mouse on the conventional Mkl1 KO background to prod

234 s a sarcomeric protein that when absent (NEB KO mouse) or present at low levels (nemaline myopathy (N

235 in A and B dramatically decreased in the PC1 KO mouse pituitaries, while the levels of peptides deriv

236 inhibitor indomethacin, we found that PTPN7 KO mouse platelets aggregated and secreted to the same e

237 PTPN7 KO mouse platelets exhibited increased platelet function

238 o1e constructs were delivered into the Myo1e-KO mouse podocyte-derived cells via adenoviral infection

239 stimulation was significantly higher in CSE-KO mouse preparations compared to the amplitude of S-IJP

240 inine (l-NNA, 200 mum) and in nNOS-knockout (KO) mouse preparations, PAG shifted the transwall gradie

241 We generated a germline CETN2 knock-out (KO) mouse presenting with syndromic ciliopathy including

242 ulation of Abcg2 in some tissues of the Mrp4 KO mouse prompted us to evaluate the possibility that Ab

243 s was tested in a prostate-specific PTEN-/- (KO) mouse prostatic adenocarcinoma model through DNA met

244 ing heart-brain stem preparation of the Cx36-KO mouse, respiratory-coupled sympathetic nerve discharg

245 enting normal Rs1h protein in the adult Rs1h-KO mouse restored the normal ERG configuration.

246 ious electrophysiological studies of the GC1 KO mouse retina, provide evidence that GC1-GCAP1 interac

247 n early age, the retinoschisin knockout (Rs1-KO) mouse retina has progressive photoreceptor degenerat

248 unaltered in the connexin36 (Cx36) knockout (KO) mouse retina, indicating that it is not dependent on

249 P levels and polymerized F-actin in the Rpgr(ko) mouse retina.

250 In the Rs1-KO mouse, retinal layer formation and synaptic protein e

251 tigated Sphingosine kinase 2 knockout (Sphk2 KO) mouse retinas, tested their sensitivity to light, an

252 ubtypes in wild-type (WT) and Cx36 knockout (KO) mouse retinas.

253 Initial studies of a Hyal2 knock-out (KO) mouse revealed a mild phenotype with high serum HA,

254 -C(-/-) sera; however, MBL-null or MASP-1/-3 KO mouse sera demonstrated significantly decreased S2238

255 Furthermore, neuropathology of jam2 KO mouse showed prominent vacuolation in the cerebral co

256 ubsequent studies in a prosaposin knock-out (KO) (-/-) mouse showed intact but slightly reduced heari

257 volunteers and examined the aged 11beta-HSD1 KO mouse skin phenotype.

258 A comparison of IL-17C+ and IL-17C+KO mouse skin transcriptomes with that of human psoriasi

259 f skin of patients with psoriasis and IL-17C+KO mouse skin, and confirmed an exacerbation of the infl

260 Histological staining of Panx1 knockout (KO) mouse skin revealed a reduction in epidermal and der

261 After dorsal column SCI, miR-155 KO mouse spinal cord has reduced neuroinflammation and i

262 VLP-immunized than in SHIV VLP-immunized CD4 KO mouse splenocytes.

263 The low homeostatic impact of Hcrt(ko/ko) mouse spontaneous waking correlates with decreased c

264 the decrease in AMPAR function in the PSD-95 KO mouse stems from an increase in the proportion of "si

265 A genetic knockout (KO) mouse strain lacking K(Na) channels (KCNT1 and KCNT2

266 was crossed to a conditional Dicer knockout (KO) mouse strain to analyze the role of microRNAs (miRNA

267 tional B cell-specific Kidins220 knockout (B-KO) mouse strain, we show that Kidins220 couples the BCR

268 vestigated by newly created subcongenic znt7-KO mouse strains carrying different lengths of genomic s

269 had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play impor

270 after transverse aortic constriction (TAC), KO mouse survival was only 60% of WT, and surviving KO m

271 maffin cells isolated from a PICK1 knockout (KO) mouse the amount of exocytosis was reduced, while re

272 We generated two new strains from the Mdr2-KO mouse, the Mdr2:CCR5 and the Mdr2:CCR1 double knockou

273 eatine kinase conditional frataxin knockout (KO) mouse; this mouse develops a severe cardiac phenotyp

274 used a tamoxifen-inducible EphA4 conditional KO mouse to achieve strong reduction of EphA4 levels in

275 romoter-driven aromatase knock-out (GFAP-ARO-KO) mouse to deplete astrocyte-derived E2 and elucidate

276 ted a cardiomyocyte-specific Mgat1 knockout (KO) mouse to establish a model useful in exploring the r

277 We used a 5-HTT knock-out (KO) mouse to examine the effects of genetically driven l

278 the present study, we used an NR2A knockout (KO) mouse to examine the role of this subunit in the exp

279 16 results in a primary excretion of acid in KO mouse urine, leading to mild metabolic alkalosis ("re

280 d a uterine-specific GR knockout (uterine GR KO) mouse using the PR(cre) mouse model.

281 ld type (WT) and phospholamban knockout (PLB-KO) mouse ventricular myocytes to test whether exogenous

282 expression was about the same in both WT and KO mouse visceral yolk sac, brain, and spinal column.

283 This reduction in amyloid plaques in the KO mouse was accompanied by a reduction in Abeta42 level

284 Seizure activity in the KO mouse was only moderately diminished by intraperitone

285 ity in the high-fat diet-fed (HFD-fed) Gpr21 KO mouse was traced to a marked reduction in tissue infl

286 an estrogen receptor beta (ERbeta) knockout (KO) mouse was created by interrupting the gene at the DN

287 ecently, a transglutaminase 3 knockout (TGM3/KO) mouse was generated that showed impaired hair develo

288 In the near term KO mouse, we also observed a profusion of large coronary

289 Hence, by using the TSHR-KO mouse, we provided in vivo evidence, demonstrating th

290 Using a conditional VGLUT3 KO mouse, we show that deletion of the transporter from

291 Using a CD34 knockout (KO) mouse, we tested the hypothesis that CD34 may partic

292 onditioned by osteoblasts derived from IGF-I KO mouse were below those detectable by RIA.

293 Unexpectedly, the silent synapses in the KO mouse were located onto morphologically mature spines

294 APN wild type (WT) and knockout (KO) mouse were employed in the study.

295 ing the 2 exons deleted in the global Pam(KO/KO) mouse, were indistinguishable from wild-type mice.

296 X syndrome mouse model, the Fmr1 knock-out (KO) mouse, where pharmacological and genetic reduction o

297 blasts (MEFs) derived from Fam20a knock-out (KO) mouse, while it was detected in the media from WT ME

298 This feature rendered the IL-10 knockout (KO) mouse, whose infiltrating cells are incapable of IL-

299 Cells lacking Abi1 and the conditional Abi1-KO mouse will serve as critical models for defining Abi1

300 ons of the wild-type mouse, but not the Kal7(KO) mouse, with an Abl inhibitor caused an increase in l