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1                                              Krabbe disease (KD) and metachromatic leukodystrophy (ML
2                                              Krabbe disease (KD) is a lysosomal storage disease (LSD)
3                                              Krabbe disease (KD) is a neurodegenerative lysosomal dis
4                                              Krabbe disease (KD) is caused by a deficiency of galacto
5                                              Krabbe disease is a devastating neurodegenerative diseas
6                                              Krabbe disease is a devastating pediatric leukodystrophy
7                                              Krabbe disease is a rare neurodegenerative disorder caus
8                                              Krabbe disease is an infantile neurodegenerative disorde
9                                              Krabbe disease is caused by a deficiency of the lysosoma
10                                              Krabbe disease is characterized by GALC deficiency and S
11                                              Krabbe disease or globoid cell leukodystrophy (GLD) is a
12                                              Krabbe disease, also named globoid cell (GC) leukodystro
13                                              Krabbe disease, an inherited leukodystrophy, is a sphing
14                                              Krabbe's disease is an infantile neurodegenerative disea
15                                              Krabbe's disease or globoid cell leukodystrophy is a rar
16 ases psychosine accumulation in cells from a Krabbe patient and prolongs the life span of the twitche
17  and GM2 gangliosidosis; Fabry, Gaucher, and Krabbe diseases; and metachromatic leukodystrophy).
18 somal storage diseases (LSDs), Gaucher's and Krabbe's diseases.
19 oid cell leukodystrophy (GLD), also known as Krabbe disease, is a devastating, degenerative neurologi
20 globoid cell leukodystrophy, better known as Krabbe disease.
21                    Differences in RA between Krabbe disease patients and control subjects were signif
22                      Mutations in GALC cause Krabbe disease (KD), a fatal neurological lysosomal diso
23 nzyme beta-galactocerebrosidase (GALC) cause Krabbe disease, a devastating genetic disorder character
24 te-onset GLD and in 1 patient with classical Krabbe disease.
25  novel target to complement in therapies for Krabbe disease.
26  data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study
27 e value of AAV-based combination therapy for Krabbe disease.
28 the disease is the classical infantile form (Krabbe disease), later-onset forms also have been descri
29  infantile globoid cell leukodystrophy (GLD [Krabbe disease]).
30           Globoid cell leukodystrophy (GLD) (Krabbe disease) is an autosomal recessive, degenerative,
31 rlier with globoid cell leukodystrophy (GLD, Krabbe disease) by his severe deficiency of galactocereb
32  Infantile globoid cell leukodystrophy (GLD, Krabbe disease) is a demyelinating disease caused by the
33  Infantile globoid cell leukodystrophy (GLD, Krabbe disease) is a fatal demyelinating disorder caused
34            Globoid cell leukodystrophy (GLD, Krabbe disease) is a lysosomal storage disease (LSD) cau
35            Globoid cell leukodystrophy (GLD, Krabbe disease) is diagnosed by measuring galactosylcera
36            Globoid cell leukodystrophy (GLD, Krabbe disease) is due to autosomal recessive mutations
37            Globoid cell leukodystrophy (GLD; Krabbe disease) is a progressive, incurable neurodegener
38 thogenic mutations on GALC function in human Krabbe variants and a compelling explanation for the sev
39 ic nerve and in samples from brains of human Krabbe patients.
40                                           In Krabbe disease, the brunt of demyelination and neurodege
41 ychosine, the neurotoxin that accumulates in Krabbe disease.
42 structurally and functionally compromised in Krabbe disease, even before demyelination, suggesting a
43 se (GALC), the lysosomal enzyme deficient in Krabbe disease.
44  changes conducive to muscle degeneration in Krabbe disease using the murine (twitcher mouse) and can
45  work indicates that muscular dysfunction in Krabbe disease is compounded by a pathogenic mechanism i
46 itcher, has a nonsense mutation not found in Krabbe patients, although it is similar to the human 30
47 ent inflammatory response here identified in Krabbe disease and the other neurodegenerative disorders
48 osyl ceramidase, i.e., the enzyme lacking in Krabbe disease, upon psychosine treatment suggest that p
49 t an important role for neuroinflammation in Krabbe disease progression.
50  aspect for the mechanism of pathogenesis in Krabbe disease.
51 erability of various neuronal populations in Krabbe disease.
52 ve capabilities play no instrumental role in Krabbe disease; however, putative kinase-independent fun
53 aracterize the peripheral neuropathy seen in Krabbe disease.
54 get for substrate reduction therapy (SRT) in Krabbe patients.
55      To determine whether alpha-synuclein in Krabbe disease brain displayed disease-associated pathog
56        To explore whether alpha-synuclein in Krabbe disease has pathological similarities to that in
57                                    Infantile Krabbe disease is a rapidly progressive and fatal disord
58                                    Infantile Krabbe's disease produces progressive neurologic deterio
59  literature that reclassifies late-infantile Krabbe disease to be symptom onset at 12 to 36 months of
60 missense mutation in patients with infantile Krabbe disease.
61  unrelated donors in newborns with infantile Krabbe's disease favorably altered the natural history o
62  (age range, 142 to 352 days) with infantile Krabbe's disease underwent transplantation of umbilical-
63                 Globoid cell leukodystrophy (Krabbe disease) is characterized by the accumulation of
64 le globoid cell leukodystrophy (GLD) in man (Krabbe disease) and in several other mammalian species,
65        The typical infantile disease in man (Krabbe disease) is caused by deficiency of lysosomal gal
66  the nervous system causing the neurological Krabbe disease.
67                         Approximately 85% of Krabbe disease cases are the infantile subtypes, among w
68          Our study describes a new aspect of Krabbe disease, placing patients at risk of immune-relat
69 sease, confirming the prion-like capacity of Krabbe disease-derived alpha-synuclein.
70 evidence of the expression of iNOS in CNS of Krabbe patient and show that the iNOS-expressing cells i
71  therapeutic efficacy in the murine model of Krabbe disease (Twitcher).
72                 In twitcher mice (a model of Krabbe disease [KD]), a central nervous system (CNS)-pen
73 xpression of Ripk1 in the authentic model of Krabbe disease strongly resemble those reported in Alzhe
74 ways in twitcher mice, an authentic model of Krabbe disease.
75 found in nerve samples from a mouse model of Krabbe disease.
76 ion of neuroinflammation in a mouse model of Krabbe disease.
77 rapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) sign
78 ngolimod in twitcher mice, a murine model of Krabbe's disease.
79 ify the role of Ripk1 in the pathogenesis of Krabbe disease, we first explored the contribution of it
80 and ONOO- may play a role in pathogenesis of Krabbe disease.
81 y directly contribute to the pathogenesis of Krabbe disease.
82 okines may contribute to the pathogenesis of Krabbe's disease.
83  Cst7 and Ch25h, correlated with severity of Krabbe disease genetically modelled in the twitcher mous
84 formed an observational post-mortem study of Krabbe disease brain tissue (n = 4) compared to infant c
85 P receptors as drug targets for treatment of Krabbe's disease.SIGNIFICANCE STATEMENT This study demon
86 red as protective in our previous studies on Krabbe disease, which is caused by mutations in both GAL
87                    Patients with early-onset Krabbe disease (four girls and three boys) underwent dif
88     We report the presentation of late-onset Krabbe's disease in 2 siblings, a 17-year-old boy and hi
89         Globoid cell leukodystrophy (GLD) or Krabbe disease is a devastating, degenerative neurologic
90         Globoid cell leukodystrophy (GLD) or Krabbe disease is a neurodegenerative disorder caused by
91         Globoid cell leukodystrophy (GLD) or Krabbe's disease is a fatal genetic demyelinating diseas
92 ants of human globoid cell leukodystrophy or Krabbe disease, were investigated.
93              Globoid cell leukodystrophy, or Krabbe disease, is a severe, autosomal recessive disorde
94              Globoid cell leukodystrophy, or Krabbe's disease, is a severe disorder of the central an
95 ation in each glial cell type contributes to Krabbe pathogenesis, we used conditional Galc-floxed mic
96  The inflammasome signature is not unique to Krabbe disease; to varying degrees, this signature is al
97  and effective inhibitors of ACDase to treat Krabbe disease.
98 es observed in rhesus macaques affected with Krabbe's disease.
99                       In eight patients with Krabbe disease and eight age-matched control subjects, a
100 atrophy of skeletal muscles in patients with Krabbe disease is a major debilitating manifestation tha
101 re of abnormal white matter in patients with Krabbe disease, (b) are more sensitive than T2-weighted
102 al abilities of late-infantile patients with Krabbe disease, particularly those who underwent transpl
103 of decreased hyperintensity in patients with Krabbe disease.

 
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