ライフサイエンスコーパス: L cell

1 ls producing the viral receptor ICAM-1 (ICAM-L cells).

2 n (D-cells) and peptide YY-expressing cells (L-cells).

3 as diminished to the level of vector control L cells.

4 le to establish persistent infection in HeLa-L cells.

5 ily established persistent infection in HeLa-L cells.

6 N-acetylneuraminic acid, and entered murine L cells.

7 ible p150 proteins were found in IFN-treated L cells.

8 l/GTP-stabilized cytosol prepared from GR(-) L cells.

9 age of rhinovirus 16 between HeLa and ICAM-1 L cells.

10 erified 22:4,n6 did not accumulate in HEK293-L cells.

11 cose-stimulated GLP-1 release in human ileal L cells.

12 expressed at the cell surface of transfected L cells.

13 xin-1a (syn1a) was expressed by murine ileal L cells.

14 had no effect on LXRalpha activity in HEK293-L cells.

15 h levels of apoptosis in both HeLa cells and L cells.

16 induced detectable Pkr mRNA accumulation in L cells.

17 in reticulocyte lysate remained unstable in L cells.

18 in assays using extracts prepared from mouse L cells.

19 ocrine tissue hormone produced by intestinal L cells.

20 umbers of other subtypes of EE cells such as L cells.

21 ncreased free fatty acids reaching the ileal L cells.

22 erived peptide secreted from enteroendocrine L cells.

23 cterial cell-free supernatants with NCI H716 L-cells.

24 utics aimed at targeting the GLP-1 producing L-cells.

25 o two HSPG-deficient cell lines derived from L-cells.

26 and cis-parinaric acids was undetectable in L-cells.

27 26 A between the two fluorescent sterols in L-cells.

28 nd control cells and was enriched in colonic L-cells.

29 als of prandial GLP-1 secreted by intestinal L-cells.

30 the development of the first rapid injection LD cell.

31 nmol/L), RKO (30 nmol/L), and SW620 (30 nmol/L) cells.

32 ramidal neurons provide excitatory inputs to LS cells.

33 ediated, feedforward mechanism that inhibits LS cells.

34 hibit Ca2+ influx into carrot (Daucus carota L.) cells.

35 of cells within layer 1 called late-spiking (LS) cells.

36 ower, estimated in the intact cell (85 mmol (l cell)(-1) (pH unit)(-1) at resting pH(i)), was somewha

37 ous estimates from cell lysates (50-70 mmol (l cell)(-1) (pH unit)(-1)).

38 centration factors were calculated (>10(3) L L(cell)(-1)).

39 concentrations between 10(-5) and 10(-3) mol L(cell)(-1).

40 HT-29 cells (58%), and SCP-2 overexpressing L-cells (37%).

41 is using human breast carcinoma MDA-MB-435-F-L cells, a highly metastatic variant of human breast can

42 In transiently transfected mouse L cells, a promoter fragment in which the NF-I site was

43 epG2, a human hepatic derived cell line, and L cells, a subline of NCTC clone 929 mouse fibroblasts.

44 e as well as in null versus AQP4-transfected L-cells, a cell type lacking endogenous adhesion molecul

45 in increasing endogenous GLP-1 secretion and L-cell abundance.

46 GLUT2 and CasR regulate K- and L-cell activity in response to nutrient and non-nutrient

47 ceptor agonist, are cosecreted by intestinal L-cells after each meal.

48 We here measure the surface tensions of L cell aggregates transfected to express N-, P- or E-cad

49 Mouse intestinal L cells also express alpha-gustducin.

50 oduction of glucagon-like peptide (GLP)-1 by L cells and alpha cells, leading to secretion of insulin

51 uction assays and inhibited T1L adherence to L cells and Caco-2(BBe) intestinal epithelial cells in v

52 Whether FXR is expressed in L cells and controls GLP-1 production is unknown.

53 ed buds of the trans-Golgi networks of mouse L cells and human HeLa cells.

54 glucagon-like peptides (GLP)-1 and -2 in the L cells and neurons.

55 s a pronounced antimitogenic effect in mouse L cells and NIH 3T3 cells.

56 eptide hormone secreted from enteroendocrine L cells and potentiates glucose-dependent insulin secret

57 specific hormones produced by the endocrine L cells and serotonin-producing cells.

58 itated from pervanadate-treated MC38/CEACAM1-L cells and the associated proteins were analyzed by two

59 Calcium imaging of primary L cells and the model cell line GLUTag revealed response

60 Examining translation in RNase L(-/-) cells and mice confirmed that RNase L activity re

61 DISC of both MCF7-Fas-Vec and MCF7-Fas-Bcl-x(L) cells and that the early steps of CD95 signaling such

62 types, specifically in intestinal endocrine L-cells and brown adipose tissue, has made it a promisin

63 ptor 1B, which is highly enriched in colonic L-cells and linked to the elevation of L-cell calcium an

64 veolin-1 primarily at the plasma membrane of L-cells and more so within intracellular punctuate struc

65 racterise the electrical activity of primary L-cells and the importance of voltage gated sodium and c

66 Cell fractionation of SCP-2 overexpressing L-cells and Western blotting detected SCP-2 in purified

67 in suspension cultured carrot (Daucas carota L.) cells and tobacco (Nicotiana tabacum L.) leaf tissue

68 g (83%), whereas electrical coupling between LS cells and non-LS cells was infrequent (2%).

69 e peptide-1- and peptide-2-expressing cells (L-cells), and have reduced numbers of somatostatin (D-ce

70 (grp43) and ffar3 (gpr41) in GLP-1-secreting L cells, and consistent with the reported coupling of GP

71 in three assays, with Xenopus oocytes, mouse L cells, and human embryonic stem cells, that secreted X

72 ressed in pancreatic alpha cells, intestinal L cells, and some hypothalamic and brainstem neurons.

73 a potent mutagen in human-hamster hybrid (A(L)) cells, and that it induces predominantly multilocus

74 dation, attention is now turning towards the L-cell, and addressing whether it would be both possible

75 urface of Vero, A431, HeLa, and BSC-1 cells, L-cells, and a mouse melanoma cell line expressing the g

76 peptide 1 (GLP-1) is secreted by intestinal L-cells, and augments glucose-induced insulin secretion,

77 Our findings indicate that L cells are a target of GVHD and that GLP-2-based treatm

78 Interestingly, DeltaPsi(m)L cells are highly efficient at in vitro mesodermal diff

79 JT/Bcl-2 and JT/Bcl-X(L) cells are susceptible to NO-mediated apoptosis, but B

80 Our data suggest L-cells are active players in the hypothalamic control o

81 and application of the micro-volume Couette LD cell are illustrated by the collection of data for DN

82 n yeast which can each be abrogated by BCL-X(L): cell arrest, which does not require aspects of mitoc

83 measurements indicated that Bcl-2 and Bcl-x(L) cells arrested more effectively in G(0) than controls

84 elevated calcium and cAMP concentrations in L-cells as measured in cultures from GLU-Cre/ROSA26-GCaM

85 ells formed GABAergic connections with other LS cells as well as with non-LS cells in layer 1 and wit

86 to different secretagogues in murine GLUTag L cells, as well as in the mRNA levels of several canoni

87 ut still detectable relative to the parental L-cells, as previously reported.

88 roductive HRV39 infection is blocked in ICAM-L cells at a step posttranslation and prior to the forma

89 In conclusion, we propose that AVP activates L-cell AVPR1B, causing GLP-1 and PYY secretion.

90 fied as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-li

91 Here, we review the current knowledge of LD cell biology and its translation to physiology.

92 le to establish persistent infection in HeLa-L cells but that recombinant viruses with combined subst

93 h Cad11-mediated cell-cell adhesion of mouse L cells, but significantly reduced Cad11-mediated cell m

94 these AD-related endocytic changes in murine L cells by overexpressing Rab5, a positive regulator of

95 stablishment of persistent infection in HeLa-L cells by the HeLa-H-EAVP80 virus.

96 lonic L-cells and linked to the elevation of L-cell calcium and cAMP concentrations.

97 s; thus, biological effects on neighboring A(L) cells can be attributed to the bystander response.

98 f fibroblast-like synoviocytes, we generated L cell clones expressing wild-type cadherin 11, mutant c

99 We conclude that L-cells co-secrete ATP together with GLP-1 and PYY, and

100 invasive capacity of cadherin 11-transfected L cells compared with L cells transfected with E-cadheri

101 ander mutation incidence among neighboring A(L) cells compared with controls.

102 s were produced by susceptible C57BL/6 RNase L-/- cells compared to RNase L+/+ cells that were either

103 Transfection of Xbves into nonadherent mouse L cells confers cell/cell adhesion.

104 ly inactive PTP1B with the Y152F mutation in L-cells constitutively expressing N-cadherin has no effe

105 ceptor protein-tyrosine phosphatase PTP1B in L-cells constitutively expressing N-cadherin results in

106 The K289M protein was expressed in mouse L cells containing the lambda cII mutational target.

107 eased expression of exogenous genes in RNase L(-/-) cells correlated with elevated levels of mRNA and

108 a novel sensory mechanism in enteroendocrine L cells, coupled to the facilitation of GLP-1 release, w

109 The purified enzyme is abundant (55 mg/L cell culture), highly active (approximately 4.7 x 10(3

110 Non-lignifying maize (Zea mays L.) cell cultures were incubated with l-[1-(3)H]arabinos

111 GR.hsp90 heterocomplexes immunoadsorbed from L cell cytosol contain dynein and that GR.hsp90 heteroco

112 Here, we show that FXR activation in L cells decreases proglucagon expression by interfering

113 GPBAR1 agonist, L3740, selectively increased L-cell density in mouse and human intestinal organoids a

114 P) stimulates the release of enteroendocrine L-cell derived hormones glucagon-like peptide-1 (GLP-1)

115 B82 mouse L cells devoid of EGFR were used to further investigate

116 In addition to Bcl-X(L), cells devoid of mitochondrial DNA (rho degrees cells

117 ndogenous GLP-1 production include promoting L-cell differentiation and increasing L-cell number.

118 ther powerful GLP-1 secretagogues facilitate L-cell differentiation through a paracrine GLP-1-depende

119 BAR1) as a selective regulator of intestinal L-cell differentiation.

120 that an independent peripheral clock in the L cell drives a circadian rhythm in GLP-1 secretory resp

121 lectively enhanced in hippocampus-associated LS cells during navigation behavior that requires workin

122 tive PCR analysis, we identified trpa1 as an L cell-enriched transcript in the small intestine.

123 R when the YAC is first transferred into the L-cell environment raises the possibility that normal ac

124 Duodenal L cells express sweet taste receptors, the taste G prote

125 We show that human duodenal L cells express sweet taste receptors, the taste G prote

126 erent, as compared with approximately 10% on L cells expressing E-selectin or ICAM-1 alone.

127 When transfected L cells expressing I-A(d) (AalphaAbeta(d)), I-E(d) (Ealp

128 In various combinations of L cells expressing NCAM, E-, P-, N-, R-, or B-cadherin,

129 ted to transfected Chinese hamster ovary and L cells expressing the GP Ib-IX-V complex.

130 re confirmed for endogenous mouse Abeta40 in L cells expressing these CD-MPR constructs but not overe

131 nd C/EBPgamma to activate a reporter gene in L cell fibroblasts but did not inhibit a chimeric C/EBPb

132 from purified plasma membranes isolated from L-cell fibroblasts and MDCK cells by detergent-free affi

133 laser scanning microscopy (MPLSM) of living L-cell fibroblasts cultured with dehydroergosterol for t

134 on in this role was addressed in transfected L-cell fibroblasts overexpressing L-FABP using a series

135 rst time, expression of SCP-2 in transfected L-cell fibroblasts reduced the plasma membrane levels of

136 Overall, HDL-mediated sterol efflux from L-cell fibroblasts reflected that of the cytoplasmic rat

137 scent sterol, was incorporated into cultured L-cell fibroblasts.

138 ized with PPARalpha in nuclei of transfected L-cell fibroblasts.

139 nlipid raft domains from plasma membranes of L-cell fibroblasts.

140 sterol uptake and intracellular targeting in L-cell fibroblasts.

141 eptide-1 (GLP-1) is released from intestinal L-cells following food ingestion.

142 r 12 hours and subsequently incubated with A(L) cells for 24 hours at 11 degrees C.

143 relin plays a role in priming the intestinal L-cell for nutrient-induced GLP-1 release.

144 Using paired recording, we showed that LS cells formed GABAergic connections with other LS cell

145 te of fall of specific activities of labeled L-cell fractions have been observed.

146 L cells from intestinal-epithelial syn1a-deficient mice

147 vel in vitro platform to generate functional L cells from three-dimensional cultures of mouse and hum

148 peptide 1 (GLP-1), secreted from intestinal L cells, glucose dependently stimulates insulin secretio

149 GLP-1 secretion is metabolically coupled in L cells (GLUTag) and in vivo in mice using the insulin-s

150 s and (b) mice inoculated i.m. with the RH30-L cells had more rhabdomyosarcoma cells in the bone marr

151 was fully functional in stable, transfected L-cells harboring a single copy of this transgene, inclu

152 GLP-1 is a gastrointestinal L-cell hormone that enhances glucose-stimulated insulin

153 Moreover, in Chinese hamster ovary and L-cells, HPV E7 and the adenovirus E1A protein repressed

154 cose infusion activated half of all duodenal L cells in humans.

155 Low numbers of L cells in intestinal biopsies and high serum levels of

156 ibitor dibenzazepine increased the number of L cells in intestinal organoid-based mouse and human cul

157 us to study and modulate the development of L cells in mouse and human crypts as a potential basis f

158 ing pathways, SCFAs raised cytosolic Ca2+ in L cells in primary culture.

159 ptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insu

160 intestinal epithelium, and reduced number of L cells in the distal ileum.

161 e membrane and of cell particulate matter of L cells in tissue culture in logarithmic and plateau pha

162 CHO cells were mixed with A(L) cells in a 1:5 ratio and briefly centrifuged to produ

163 V) into xenografts derived from DU-145-Bcl-x(L) cells in athymic nude mice completely eradicated not

164 gs describe, for the first time, the role of L-cells in AVP regulated intestinal fluid secretion, pot

165 eptide-1 (GLP-1) is released from intestinal L-cells in response to a range of nutrients, hormones, a

166 eptide-1 (GLP-1) is released from intestinal L-cells in response to nutrient ingestion.

167 ucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important

168 ions with other LS cells as well as with non-LS cells in layer 1 and with pyramidal cells in layer 2/

169 nd virions used similar routes of entry into L cells, including processing by lysosomal cysteine prot

170 terfering RNA inhibition of hERG in beta and L cells increased insulin and GLP-1 secretion up to 50%.

171 heterotrophic sycamore (Acer pseudoplatanus L.) cells incubated in various nutrient media contain lo

172 uanosine (8-OHdG) in human-hamster hybrid (A(L)) cells induced by crocidolite fibers in an attempt to

173 Nutrient stimulation of enteroendocrine L cells induces the release of the incretin and satiatin

174 gon-like peptide 1 (GLP-1) by the intestinal L cell is essential for the incretin effect after nutrie

175 the mechanisms underlying GLP-1 release from L-cells is key to this type of approach, and the use of

176 GLP-1 release from primary L-cells is linked to electrical activity and activation

177 The stimulus-secretion pathway in L-cells is still incompletely understood and a topic of

178 gon in pancreatic alpha-cells and intestinal L cells leads to production of distinct hormonal product

179 At the single L-cell level, first-phase forskolin-induced exocytosis w

180 2, we analyzed splicing responses on the MSD-L cell line and found that the missense mutation of prol

181 The human L cell line NCI-H716 expresses alpha-gustducin, taste re

182 e compared after expression in a mouse RNase L(-/-) cell line.

183 This revealed that every heteroplasmic L-cell line harbored a mtDNA that had been generated by

184 and alpha7-nAChR transcription in human SCC-L cell lines and SCC-L tumors.

185 loss of gene expression; (2) treatment of L/L cell lines with a demethylating agent resulted in re-e

186 While analyzing the mtDNAs of several mouse L cell lines, we discovered that every cell line harbore

187 ) increased alpha7-nAChR levels in human SCC-L cell lines.

188 downregulation of phosphorylated STAT3 in L/L cell lines; (3) all 55 control specimens and the lymph

189 -2(-)/Bcl-x(L)(+)) and Daudi (Bcl-2(+)/Bcl-x(L)(+)) cell lines.

190 relin directly stimulated GLP-1 release from L-cell lines (murine GLUTag, human NCI-H716) through an

191 We found previously that in gut endocrine L-cell lines, TCF7L2 controls transcription of the progl

192 s were then targeted to the lox sites of the LES cell lines.

193 e peptide-1 (GLP-1), an incretin secreted by L-cells lining the gastrointestinal epithelium, has impo

194 d that both fluorescent sterols localized to L-cell lipid droplets, the surface of which contained ad

195 ) Priming: After H2O2 exposure (100 micromol/L), cells maintain a constant DeltaPsi(m) for the cell-t

196 glutamine and related analogs by GDH in the L cell may explain why GLP-1 secretion, but not that of

197 ectrical activity and GLP-1 release from the L-cell model line GLUTag.

198 plate flow chamber having as a substrate an L cell monolayer coexpressing E-selectin and ICAM-1 (E/I

199 e of neutrophils rolling on HUVECs and on an L-cell monolayer coexpressing E-selectin and ICAM-1.

200 phosphorylation was not diminished in Y325F L-cell mutants suggesting Tyr-325 was not required for t

201 In HEK293-L cells, non-esterified 20:4,n6 also increased (5-fold)

202 rs Ngn3 and NeuroD1 L3740 also increased the L-cell number and GLP-1 levels and improved glucose tole

203 moting L-cell differentiation and increasing L-cell number.

204 etes, dibenzazepine administration increased L cell numbers in the intestine, improved the early insu

205 g of the signalling mechanisms that underlie L-cell nutrient responsiveness.

206 We conclude that L cells of the gut "taste" glucose through the same mech

207 naturally occurring peptide secreted by the L cells of the small intestine.

208 When control and Bcl-x(L) cells of equivalent size and pyronin Y fluorescence w

209 Peptide-YY (PYY) is secreted from endocrine L-cells of the gastrointestinal tract in response to cal

210 (SS), fast-adapting (FA), and late-spiking (LS) cells, of which RS and IB cells were common to LII a

211 ecombinant insulin secretion from intestinal L-cells on both a per-cell and per-graft basis.

212 When expressed in thymidine kinase-deficient L cells or 3T3 cells, C/EBPalpha is detected in a protei

213 th aggregation experiments using transfected L cells or primary chick brain cells.

214 ipped steroid receptors isolated from either L cells or WCL2 cells.

215 , and gammaFULL LENGTH (FL)) co-expressed in L-cells or CHO cells with wild-type (WT) IL-4Ralpha.

216 Transfection of l-cells or McAR7777 hepatoma cells with cDNA encoding pr

217 diated suppression of the ES, but not of the LS cell output synapse.

218 The receptor is found on gut enteroendocrine L-cells, pancreatic beta-cells, and sympathetic neurons,

219 low-passage-number human cervix cells (HeLa-L cells; passages 95 to 115) or in several other cell li

220 )-1 and GLP-2, the two major enteroendocrine L-cell peptides.

221 be facilitated by a better understanding of L-cell physiology.

222 IgA and IgG MAbs neutralized reovirus T1L in L cell plaque reduction assays and inhibited T1L adheren

223 r in Vero monkey kidney cells than in murine L cells, plaquing efficiency of individual isolates did

224 peptide YY (PYY) is released from intestinal L-cells post-prandially in proportion to calorie intake,

225 Upon a nutrient challenge, L cells produce glucagon-like peptide 1 (GLP-1), a power

226 ential (TRP) ion channels in enteroendocrine L cells producing GLP-1.

227 We hypothesized that enteroendocrine L-cells producing glucagon-like peptide 1 (GLP-1) and pe

228 human lung microvascular endothelial (HMVEC-L) cells promoted their apoptosis.

229 The concept of an electrically excitable L-cell provides a basis for understanding how GLP-1 rele

230 L-cells purified by flow cytometry were used to measure

231 adhesion molecule, transfection of Bves into L-cells readily confers adhesive behavior to these cells

232 e peptide 1 (GLP-1) released from intestinal L cells regulate insulin secretion.

233 ptor Y1 receptor antagonist, suggesting that L-cell-released PYY acts locally on the epithelium to mo

234 ination revealed that the effect of L3740 on L cells required intact GLP-1 receptor and serotonin 5-h

235 essed in duodenal enterochromaffin cells and L cells, respectively.

236 o and overexpression of SCP-2 in transfected L-cells resulted in the following: (i) redistribution of

237 tty acids selectively increase the number of L cells, resulting in an elevation of GLP-1 release.

238 In SCP-2 overexpressing L-cells, SCP-2 was detected in close proximity to caveol

239 oinhibitory feedback mechanism that controls L cell secretion; the effect on insulin and glucagon con

240 We found that (a) RH30-L cells seed better to the bone marrow, liver, and lymph

241 Mouse L cells stably expressing CD-MPRs with mutations that en

242 The invasive behavior of L cells stably transfected with a cadherin 11 construct

243 ake and metabolism play an important role in L cell stimulus-secretion coupling.

244 incretin hormone produced by the intestinal L cell that acts as a link between the gut and pancreati

245 irus type 16 was found to replicate in mouse L cells that express the viral receptor, human intercell

246 tor 2 (FFA2) is expressed on enteroendocrine L cells that release glucagon-like peptide 1 (GLP-1) and

247 The use of A(L) cells that are dominant negative for connexin 43 and

248 e C57BL/6 RNase L-/- cells compared to RNase L+/+ cells that were either left untreated or pretreated

249 ly, we identify an overlapping population of LS cells that change firing to cue and reward during con

250 on that innervates the longitudinal muscles (L-cells) that contributes to a defensive withdrawal refl

251 revealed that, within the nucleus of control L-cells, the nonhydrolyzable fluorescent LCFA-CoA (BODIP

252 mulated the release of GLP-1 from intestinal L-cells, thereby providing a plausible mechanism for VSL

253 Exposure of JT/Bcl-2 and JT/Bcl-X(L) cells to the NO donor, S-nitroso-N-acetylpenacillamin

254 may underlie the physiological responses of L-cells to food ingestion.

255 cent model of electrical activity in primary L-cells to include spatiotemporal glucose and Ca(2+) dyn

256 Paradoxically, this anabolic program led cells to apoptosis during chronic ER stress in a man

257 ptogenetic activation of the projection from LS cells to the VMHvl terminated ongoing attacks immedia

258 Analysis of the primary L-cell transcriptome, as well as of the intestinal micro

259 The invasive capacity of L cell transfectants and cultured fibroblast-like synovi

260 We developed L cell transfectants expressing cadherin-11, cadherin-11

261 L cell transfectants expressing SE-positive DR molecules

262 CD16 Fcgamma receptor and studied in stable L cell transfectants.

263 adherin 11-transfected L cells compared with L cells transfected with E-cadherin or control vector.

264 Using L cells transfected with genes for MHC class II, invaria

265 the JAK-STAT pathway in these models and in L cells transfected with STPB-C.

266 In contrast, l-cells transfected with cDNA encoding SCP-2 exhibited 3

267 F-I proteins, NF-IA, -B, -C, or -X, in mouse L cells transiently transfected with an ldhc promoter-re

268 r 1C, expression was increased in fibroblast L cells treated with IFN, and a consensus ISRE element w

269 In murine L cells, treatment with calpeptin or calpain inhibitor I

270 we demonstrate that evoked ATP release from L-cells triggers electrical responses in neighbouring en

271 tide 1 (GLP-1) is secreted by the intestinal L cell upon nutrient ingestion.

272 and Kv9.3 alpha subunits expressed in mouse L cells using the whole-cell patch-clamp technique.

273 Likewise, L-cells very poorly esterified these fluorescent fatty a

274 content (79.4+/-5.7 to 115.2+/-6.6 micromol/L cell volume [mean+/-SEM; P:<0.001]), and, after a wave

275 that mengovirus plaque formation in HeLa or L cells was inhibited nearly 100% by the presence of 80

276 RGS4 that was transiently expressed in mouse L cells was short-lived in these cells.

277 tabilization of p27 in G(0) in BCL2 or BCL-x(L) cells was due to phosphorylation of p27 at Ser(10) by

278 Electrical activity in L-cells was due to large voltage gated sodium currents,

279 electrical coupling between LS cells and non-LS cells was infrequent (2%).

280 e between the human transfectant and a mouse L cell, was used as donor of the Ecogpt-carrying human c

281 Using the human-hamster hybrid A(L) cells, we show here that arsenic alters mitochondrial

282 peptide-1 (GLP-1) secreting enteroendocrine L-cells, we have designed TGR5 agonists with low intesti

283 We investigate whether enteroendocrine L-cells, well known for their production of the incretin

284 When 10(4) AW/tmFlt3-L cells were injected i.v. into mice, only 35.7% (5 of 1

285 Nonlabeled bystander A(L) cells were isolated from among labeled CHO cells by u

286 Primary murine L-cells were identified and purified using transgenic mi

287 Fluorescent L-cells were identified within primary colonic cultures

288 The dendrites and axons of layer 1 LS cells were confined primarily to layer 1.

289 greement with that hypothesis, we found that LS cells were interconnected by electrical coupling (83%

290 RS and IB cells were common to LII and LIII, LS cells were specific to LIII, and the remaining types

291 driven synaptically by LOT stimulation (type L cells) were concentrated in the superficial half of th

292 lucagon-like peptide-1 (GLP-1) production by L cells which potentiates beta-cell glucose-induced insu

293 sis that increasing the number of intestinal L cells, which produce GLP-1, is an alternative strategy

294 an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of en

295 roximately 86%) of neurons are late-spiking (LS) cells, which can delay the onset of their spike trai

296 ed peptide GLP-2, cosecreted from intestinal L cells with GLP-1, has recently been demonstrated to en

297 stably transfected APP-overexpressing murine L cells with human CD-MPR.

298 at irradiation of 20% of randomly selected A(L) cells with 20 alpha particles each results in a mutan

299 rotein sulfhydryls (mainly glutathione) in A(L) cells with buthionine S-R-sulfoximine increases the m

300 Transduction of insulin-expressing GLUTag L-cells with lentivirus carrying an additional human ins