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1 glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.
2 rcially available methyl (R)-(+)-lactate and l-glutamic acid.
3 with a commercially available derivative of L-glutamic acid.
4 F) from glucose, guanine, and p-aminobenzoyl-l-glutamic acid.
5 39 0.08) for 17 metabolites, and highest for L-glutamic acid (0.41 0.09) and hypoxanthine (0.42 0.08)
6 inofuro[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid (1) with respect to dihydrofolate reduct
7 and kinetics of (S)-4-(3-[18F]fluoropropyl)-l-glutamic acid ((18)F FSPG) in healthy volunteers and t
8 acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new P
9 T radiotracer, (S)-4-(3-[(18)F]fluoropropyl)-L-glutamic acid ([(18)F]FSPG), decreases in proportion t
10 2-chloroethyl)(2-mesyloxyethyl)amino]benzoyl-l-glutamic acid, 1a, which has been in clinical trials.
11 rothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl} -L-glutamic acid 2 and 13 nonclassical analogues 2a-2m we
12 (pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid (2) and N-[2-amino-4-ethyl-6-methyl[(pyr
14 -pyrrolo[2,3-d]pyrimidin-6-yl)th io]benzoyl}-L-glutamic acid 3 and N-{4-[(2-amino-4-oxo-5-methyl-4,7-
15 opyrido[3,4-g]pteridin-7-yl)me thyl]benzoyl]-L-glutamic acid 3 was detrimental to DHFR inhibitory act
16 ibited by the gamma-boronic acid analogue of L-glutamic acid, 3-amino-3-carboxypropaneboronic acid (g
17 in-5-yl)ethyl]benzoyl inverted question mark-L-glutamic acid (3a) was designed and synthesized as a p
18 rrolo[3,2- d]pyrimidin-5-yl)methyl]benzoyl}- l-glutamic acid 4 and 11 nonclassical analogues 5- 15 as
19 -pyrrolo[2,3-d]pyrimidin-6-yl) thio]benzoyl}-L-glutamic acid 4 were designed, synthesized, and evalua
20 (pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l -glutamic acid (4), were designed and synthesized as p
21 ,3-d]pyrimidin-5-yl) thio]-2'-fluorobenzoyl]-l-glutamic acid (4) and N-[4-[(2-amino-6-methyl-3,4-dihy
22 ieno[2,3- d]pyrimidin-5-yl)sulfanyl]benzoyl}-L-glutamic acid (4) and nine nonclassical analogues 5-13
23 -pyrrolo[2,3-d]pyrimidin-5-yl)t hio]benzoyl]-L-glutamic acid (4) and thirteen nonclassical analogues
24 no acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methyl ester, is a convenient and sens
25 inofuro[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid (5) and its C8-C9 conformationally restr
26 ,3-d]pyrimidin-5-yl) thio]-2'-chlorobenzoyl]-l-glutamic acid (5), as TS inhibitors and antitumor agen
27 ibitor N-(p-methoxybenzenethiocarbonyl)amino-L-glutamic acid 6d, chosen for preliminary investigation
28 erial constructed from renewable feedstocks, L-glutamic acid (an amino acid) and riboflavin (vitamin
29 yme biosynthetic pathway to kainic acid from l-glutamic acid and dimethylallyl pyrophosphate in red m
30 bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamic acid and its iodoethylamino analogue were eff
32 We used a customized stoichiometric ratio of l-glutamic acid and l-lysine within an amphiphilic polym
33 es and antifolates as exemplified by pteroyl-l-glutamic acid and methotrexate (MTX), respectively.
37 ste of F-III was due to the presence of free l-glutamic acid at 6 times, while FII and FIV were due t
38 ock copolymers, poly(ethylene glycol)-b-poly(L-glutamic acid)-b-poly(L-phenylalanine), which effectiv
40 ry neurotransmitter GABA is synthesized from L-glutamic acid by the enzyme glutamic acid decarboxylas
42 e coupling of N(6)-hydroxylated l-lysine and l-glutamic acid catalyzed by the hydrazine synthetase Py
44 lysine within an amphiphilic polymer of poly(l-glutamic acid-co-l-lysine), or P(Glu-co-Lys), to effec
45 rrolo[2,3-d]-pyrimidin-6-yl)propyl]benzoy l}-L-glutamic acid (compound 2) and N-{4-[4-2-amino-4-oxo-4
46 rrolo[2,3-d]-pyrimidin-6-yl)butyl]benzoyl} *-L-glutamic acid (compound 3), respectively) were inhibit
47 ssion modelling identified that increases in L-glutamic acid concentration and drum speed were the ke
49 lays an important role in regulating soluble l-glutamic acid decarboxylase (GAD) and membrane-associa
51 in the inner plexiform layer (IPL) of single L-glutamic acid decarboxylase-immunoreactive (GAD-IR) an
52 ribed starting from a commercially available L-glutamic acid derivative, (4S)-5-(tert-butoxy)-4-[(ter
53 the ring-opening polymerization (ROP) of an l-glutamic acid-derived N-carboxyanhydride (NCA) monomer
55 n appropriate N-substituted (4-aminobenzoyl)-L-glutamic acid dialkyl ester or N-(5-amino-2-thenoyl)-L
57 ntifolate 7 utilized 4-(chloromethyl)benzoyl-l-glutamic acid diethyl ester (17) instead of the benzyl
59 e L-glutamine analogs showed that all except L-glutamic acid dimethyl ester inhibited ANR activity in
60 roxamate, L-glutamic acid gamma-ethyl ester, L-glutamic acid dimethyl ester, L-asparagine, L-aspartic
61 urtain impacted the fluidisation of cohesive L-glutamic acid fine particles, while total energy input
63 ydrazide, L-glutamic acid gamma-hydroxamate, L-glutamic acid gamma-ethyl ester, L-glutamic acid dimet
64 utamine (L-glutamic acid gamma-methyl ester, L-glutamic acid gamma-hydrazide, L-glutamic acid gamma-h
65 as due to formation of the glutamine analogs L-glutamic acid gamma-hydroxamate and L-glutamic acid ga
66 thyl ester, L-glutamic acid gamma-hydrazide, L-glutamic acid gamma-hydroxamate, L-glutamic acid gamma
67 rved between the strong inhibitory effect of L-glutamic acid gamma-methyl ester on ANR activity and t
68 the effects of eight analogs of L-glutamine (L-glutamic acid gamma-methyl ester, L-glutamic acid gamm
70 y of this enzyme to employ hydroxylamine and L-glutamic acid gamma-monohydroxamate (LGH) as alternati
71 -4-[bis(2-chloroethyl)amino]phenyl]carbamoyl-l-glutamic acid gave a differential of >227 in MDA MB361
72 oxidase (GmOx) microelectrode for measuring l-glutamic acid (GluA) in oxygen-depleted conditions, wh
74 um or the amino acids L-alanine, L-arginine, L-glutamic acid, glycine, and DL-serine as sole nitrogen
75 ein we report self-assembly behavior of poly(l-glutamic acid)-grafted gold NPs in solution and descri
76 ally pure 2-pyrrolidinones (4) derived from (L)-glutamic acid has been investigated as a method for t
78 , infusion of the glutamate receptor agonist L-glutamic acid into the LS mimicked the V1aR antagonist
80 solution, we identified three equivalents of l-glutamic acid (l-Glu) bound to each subunit interface.
81 ns that also can serve as substrates, namely L-glutamic acid (L-Glu), D-aspartic acid (D-Asp), and su
82 ynthetic amino acid copolymer of L-tyrosine, L-glutamic acid, L-alanine, and L-lysine that is effecti
83 synthetic amino acid copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine, effective bot
84 icles were prepared by self-assembly of poly(L-glutamic acid-L-tyrosine) co-polymer with hematoporphy
85 pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben zoyl]-L-glutamic acid (LY231514) and 1, whereas 4 was inactive
86 yrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyri
87 rbon sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezitose, D-Sorbito
90 g plant-based biodegradable chelating agent, L-glutamic acid, N,N-diacetic acid (GLDA) to remediate h
91 ed glutamate, N-(o-nitromandelyl)oxycarbonyl-L-glutamic acid (Nmoc-Glu), that liberates free glutamat
92 end on both the grafting density of the poly(l-glutamic acid) on the NPs and the size of the NPs.
95 threonine, D-threonine, L-leucine, L-lysine, L-glutamic acid, or diglycine with L-serine as a major c
96 ificantly higher in tumors treated with poly(L-glutamic acid)-paclitaxel (10.76 +/- 1.38 %ID/g; P = 0
97 .38 %ID/g; P = 0.001) and with combined poly(L-glutamic acid)-paclitaxel and C225 (9.84 +/- 2.51 %ID/
98 onal antibody C225, or a combination of poly(L-glutamic acid)-paclitaxel and C225, followed by intrav
100 g MDA-MB-468 breast tumors treated with poly(L-glutamic acid)-paclitaxel and cetuximab (IMC-C225) ant
102 respectively, 4 d after treatment with poly(L-glutamic acid)-paclitaxel or combined poly(L-glutamic
103 A-PEG-ovalbumin was also observed after poly(L-glutamic acid)-paclitaxel treatment (55.6%), although
105 zolinyl)methyl]-N-prop- 2-ynylamino]benzoyl]-L-glutamic acid (PDDF, 1) and N-[5-[N-[(3,4-dihydro-2-me
107 ultilayers ~700nm thick fabricated from poly-l-glutamic acid (PGA) and poly-l-lysine (PLL) can be loa
108 conformation of poly-l-lysine (PLL) and poly-l-glutamic acid (PGA) in their non-alpha-helical states.
109 nd Ida were covalently linked to poly(alpha)-L-glutamic acid (PGA) via reducible disulfide and acid-s
110 acterized a pH-responsive biodegradable poly-L-glutamic acid (PGA)-fluocinolone acetonide (FLUO) conj
112 significant effect, negatively charged poly-L-glutamic acid, PLG, stabilized both heterodimers and h
113 g sequences for the expression of poly(alpha,L-glutamic acid) (PLGA) as fusion proteins with dihydrof
114 iants in complex with L-aspartic acid versus L-glutamic acid provide insights into their differential
115 -glutamine) and three known umami compounds (l-glutamic acid, pyroglutamic acid, and 5'-adenosine mon
116 olin-6-ylmethyl)-N-methyl-amino]-2-theno yl)-l-glutamic acid (raltitrexed, Tomudex; ZD1694), or N(alp
117 s were prepared using amphiphilic PEG-b-poly(L-glutamic acid)/SN38 conjugates and subsequently loaded
118 arged segments of poly(l-lysine HBr) or poly(l-glutamic acid sodium salt), and helical, hydrophobic s
120 8545 (Lithium Carbonate LSVEC), NIST RM8573 (L-Glutamic Acid USGS40), NIST RM8542 (IAEA-CH6 Sucrose)
121 T RM8542 (IAEA-CH6 Sucrose) and NIST RM8574 (L-Glutamic Acid USGS41) differed from reference values b
122 In this study, vancomycin was coated with L-glutamic acid using an isothermal dry particle coater
123 tter-tasting caffeine, and the umami-tasting l-glutamic acid were the main contributors to the taste
124 nfluence of polyions, poly-L-lysine and poly-L-glutamic acid, were investigated to determine the effe
125 ein metabolisms, glutathione, guanosine, and L-glutamic acid, which are implicated in protection agai
126 ost and guest particles, here vancomycin and L-glutamic acid, yielding uniform surface coverage that