ライフサイエンスコーパス: L-glutamine

1 the complex of glutamine-binding protein and l-glutamine.

2 r hydroxyurea, crizanlizumab, voxelotor, and l-glutamine.

3 mutants with diminished ability to hydrolyze l-glutamine.

4 bon polyunsaturated fatty acids coupled with l-glutamine.

5 otein or GS activity and was auxotrophic for L-glutamine.

6 forms polar zippers similar to those of poly-L-glutamine.

7 ngest transport activities were specific for l-glutamine.

8 the C1A AS-B mutant is incubated with [14C]-L-glutamine.

9 n behavior with increasing concentrations of L-glutamine.

10 m underlying the base-generating response to L-glutamine.

11 of glutamine-binding protein and its ligand, l-glutamine.

12 perifused in leucine 0-10 mmol/l with 2 mmol/l glutamine 0-25 mmol/l, AA 0-10 mmol/l, or glucose 0-25

13 rval, were obtained after no treatment, oral L-glutamine (0.5 g/kg), or glutamine followed by NMDA (a

14 hicle (489 mL diet soda) or vehicle plus 2 g L-glutamine (28 mg/kg body wt) was ingested and the gain

15 (18)F-labeled (2S,4R)-4-fluoro-l-glutamine (4F-GLN) has demonstrated high uptake in tum

16 n-derived uremic solutes: alpha-phenylacetyl-l-glutamine, 5-hydroxyindole, indoxyl glucuronide, p-cre

17 Efficient diffusion of L-glutamine across the outer membrane suggests that the

18 L-Glutamine administration significantly increased ECF G

19 Conversely, L-glutamine, agmatine, and uridine 5-monophosphate are p

20 ses, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing g

21 The studies with the L-glutamine analogs showed that all except L-glutamic ac

22 10 mmol/L glutamine (EAS 44) or with 10 mmol/L glutamine and 20 mmol/L Pi(EAS 45), or in Adsol.

23 ic mechanism, with K(m) values of 280 mM for L-glutamine and 150 microM for acetyl-coenzyme A and wit

24 We show that cellular uptake of L-glutamine and its subsequent rapid efflux in the prese

25 However, l-glutamine and l-alanine model reactions showed the sam

26 ating aqueous d-glucose model reactions with l-glutamine and l-alanine yielded similar colored soluti

27 demonstrated by the isolation of protonated l-glutamine and l-lysine (Delta m/z = 0.0364) from a mix

28 of MOP tested, only N-1-(1-deoxy-D-lyxityl)-L-glutamine and N-1-(1-deoxy-D-mannityl)-L-asparagine se

29 pecific for imine conjugates of D-hexose and L-glutamine and was not inhibited by sugars or amino aci

30 The transported substrates L-alanine, L-glutamine, and alpha-(methylamino)isobutyrate inhibite

31 rescine, p-aminobenzoic acid, L-cysteine and L-glutamine, and horse serum.

32 dsorbed by the char, including l-asparagine, l-glutamine, and l-arginine.

33 of neutral amino acids, including l-alanine, l-glutamine, and l-histidine, across the plasma membrane

34 640 supplemented with 5% fetal bovine serum, L-glutamine, and nonessential amino acids.

35 only two therapies for SCD - hydroxyurea and L-glutamine - are approved by the US Food and Drug Admin

36 These results rule out a role for L-glutamine as a direct precursor of bicarbonate and ins

37 o NAD(+) Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadE(Gln)

38 nsporter failed to grow on medium containing l-glutamine as the sole nitrogen source.

39 L-Glutamine blocked the responses of L-citrulline but no

40 by SF188 cells is comparable to that of (3)H-L-glutamine but higher than that of (18)F-FDG.

41 at acts to hinder the correct positioning of l-glutamine but not l-asparagine.

42 The in vitro biosynthesis of N-linolenoyl-l-glutamine by membrane-associated enzyme(s) in M. sexta

43 the fatty acid amide elicitor, N-linolenoyl-l-glutamine, by microsomal fractions of several alimenta

44 icular, we reveal that the single amino acid L-glutamine, by undergoing a chemical transformation lea

45 ell lines with high basal cellular levels of L-glutamine bypass the need for L-glutamine uptake and a

46 L-Glutamine can reverse pilT downregulation of the ABC t

47 We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/

48 Increases in l-glutamine concentration in the pathophysiological rang

49 a substitution of the P(2)' l-glutamate by a l-glutamine corroborates the importance of a carboxylate

50 CD); however, only 4 therapies (hydroxyurea, l-glutamine, crizanlizumab, and voxeletor) are currently

51 e hydroxyurea is first-line therapy for SCD, L-glutamine, crizanlizumab, and voxelotor have been appr

52 l of the disease-modifying treatments (DMTs) l-glutamine, crizanlizumab, and voxelotor underscores th

53 Three additional therapies, L-glutamine, crizanlizumab, and voxelotor, have been app

54 Other substrates of asparaginases include L-glutamine, D-asparagine, and succinic acid monoamide.

55 e is an amino acid analog of l-glutamate and l-glutamine derived from various plant sources, includin

56 noviral properties relative to corresponding L-glutamine-derived molecules.

57 L-Arginine, L-glutamine, DL-histidine, malate, and DL-ornithine prom

58 els increased significantly 2.5 h after oral L-glutamine (e.g., from 1.76 +/- 0.04 micromol/g in vehi

59 sodium chloride, and mannitol, with 10 mmol/L glutamine (EAS 44) or with 10 mmol/L glutamine and 20

60 Our structure of poly-L-glutamine fibers may explain why, in all but one of th

61 and hitherto enigmatic x-ray diagram of poly-L-glutamine fits a cylindrical sheet of 31 A diameter ma

62 Thus, L-glutamine flux regulates mTOR, translation and autopha

63 ich catalyzes the ATP-dependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitou

64 li asparagine synthetase B (AS-B) with [14C]-L-glutamine gives a covalent adduct that can be isolated

65 1, GlnA3 and GlnA4 catalyse the synthesis of L-glutamine, GlnA2 catalyses the synthesis of D-glutamin

66 tudying the response to the substrate glycyl-L-glutamine (Gly-Gln) of the proton-coupled peptide tran

67 Glycyl-L-glutamine (Gly-Gln; beta-endorphin 30-31) is an endoge

68 In glutamine-starved cells, 10 mmol/L glutamine in the absence of serum stimulated [(3)H]thy

69 n SLC1A5 and its complex with the substrate, L-glutamine in an outward-facing conformation.

70 sue-independent biosynthesis of N-linolenoyl-l-glutamine in M. sexta.

71 presence of low millimolar concentrations of l-glutamine in the extracellular solution.

72 n the developing nervous system and N-acetyl-L-glutamine in the heart.

73 L-glutamine, the effective concentration of L-glutamine in the M. tuberculosis phagosome of THP-1 ce

74 Using [U-(13)C(5)]-l-glutamine in vitro and in vivo in a mouse model of B c

75 Use of l-glutamine increased briefly but gradually decreased th

76 In contrast, L-glutamine increased plasma bicarbonate concentration (

77 Furthermore, L-glutamine increased the speed of recovery of IAS tone

78 a)s of Me(10)Tu[3](2+) and an interaction of L-glutamine indicate a potential for binding anionic mol

79 also lactonized N-l-(1,2-dideoxy-D-mannityl)-L-glutamine, indicating that a hydroxyl group at carbon

80 N-linolenoyl-l-glutamine is a structural analog of several other elic

81 ation in which the alpha amino group of mono-l-glutamine is covalently linked to the side chain of gl

82 When GlnT is transfected into CV-1 cells, L-glutamine is the preferred substrate.

83 ine, an amino acid analog of l-glutamate and l-glutamine, is capable of preventing long-term THC side

84 hat are significantly enhanced compared with L-glutamine itself.

85 t that this newly discovered enzyme be named l-glutamine kinase.

86 IM862 is a synthetic dipeptide (L-glutamine L-tryptophan) with in vitro and in vivo anti

87 The low pH may inhibit the SNAT2 l-Glutamine (L-Gln) transporter, which controls protein

88 , we studied the effects of eight analogs of L-glutamine (L-glutamic acid gamma-methyl ester, L-gluta

89 , L-phenylalanine, 6-diazo-5-oxo-norleucine, L-glutamine, L-cysteine and L-glutamate were poor inhibi

90 p of amino acids that includes l-asparagine, l-glutamine, l-threonine, l-arginine, l-glycine, l-proli

91 is selected following prolonged culturing in L-glutamine-limited chemostats in a manner analogous to

92 L-acetylcarnitine, creatinine, L-asparagine, L-glutamine, linoleic acid, pyruvic acid, palmitoleic ac

93 kers of neurodegenerative diseases including L-glutamine, lysophosphatidylcholine (17:0), taurochenod

94 of plant volatiles, N-(17-hydroxylinolenoyl)-L-glutamine, named volicitin and isolated from beet army

95 te and requires the exogenous acquisition of L-glutamine or L-glutamate for function.

96 er that regulates the simultaneous efflux of L-glutamine out of cells and transport of L-leucine/EAA

97 nt in Relenza) via a flexible linker to poly-l-glutamine (PGN) enhances the anti-influenza virus acti

98 The l-glutamine-phosphate product was characterized using (3

99 c-resolution structural information for poly(l-glutamine) (polyQ) in aqueous solution experimentally,

100 such as volicitin [N-(17-hydroxylinolenoyl)-L-glutamine], present in caterpillar oral secretions.

101 insulin secretion in the presence of 2 mmol/l glutamine (Q2) in cultured mouse islets pretreated for

102 In clinical trials, L-glutamine reduced hospitalization rates by 33% and mea

103 incorporate P1 lactam moieties in lieu of an L-glutamine residue are described.

104 ternative substrates in place of ammonia and L-glutamine, respectively, has been investigated.

105 nked as the first of all submissions for the L-glutamine riboswitch and as the second for the ZMP rib

106 The molecular basis for L-glutamine sensitivity is due to SLC7A5/SLC3A2, a bidir

107 culture were found to produce L-Alanine and L-Glutamine, spheroids showed slight consumption in both

108 d, citric acid, and choline), 6 (creatinine, L-glutamine, succinic acid, pyruvic acid, L-lactic acid,

109 transport of changes in pH and extracellular l-glutamine, such as occur in cerebral ischemia and hepa

110 (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins.

111 in the presence of various concentrations of L-glutamine, the effective concentration of L-glutamine

112 This activity allowed the diffusion of L-glutamine, the monosaccharides arabinose and glucose,

113 The activity allows the diffusion of L-glutamine, the monosaccharides arabinose and glucose,

114 od transfusions or changes in hydroxyurea or l-glutamine therapy.

115 chment states, finding [5-13C,4,4-2H2,5-15N]-L-glutamine to be optimal for hyperpolarized measurement

116 cat)/K(M)) of nitrogen transfer from LGH and L-glutamine to beta-aspartyl-AMP are almost identical fo

117 Due to a fast occurring cyclization of l-glutamine to pyroglutamic acid, the typical amino-carb

118 sugars by transferring the amino group from l-glutamine to the acceptor substrate, fructose 6-phosph

119 ar levels of L-glutamine bypass the need for L-glutamine uptake and are primed for mTOR activation.

120 ystem-N transport plays an important role in l-glutamine uptake into isolated rat choroid plexus but

121 L-glutamine uptake is regulated by SLC1A5 and loss of SL

122 Krebs-Ringer bicarbonate buffer with 2 mmol/l glutamine using 10 mmol/l 2-aminobicyclo[2,2,1]-heptan

123 rmation of L-asparagine from L-aspartate and L-glutamine, via a beta-aspartyl-AMP intermediate.

124 that catalyzed biosynthesis of N-linolenoyl-l-glutamine was localized within the integral membrane p

125 ,3,4 - tetrahydro-3-isoquinolinyl]-carbonyl]-L-glutamine, was evaluated in vivo along with (S*,R*)-N-

126 or L-arginine were examined before and after L-glutamine, which is a putative blocker of L-citrulline

127 of this helix provides the binding site for L-glutamine, which is extensively hydrogen bonded to the

128 No.1 had high levels of L-glutamic acid and l-glutamine, while Longjing 43 showed elevated levels of

129 culocytes in McCoy's 5A medium modified with L-glutamine with 25 mM Hepes buffer supplemented with 20

130 ect phosphorylation of the amide nitrogen of l-glutamine with ATP by the catalytic activity of Cj1418