ライフサイエンスコーパス: L-histidine

1 the natural dipeptide carnosine (beta-alanyl-L-histidine).

2 throcytes incubated in the presence of 40 mM L-histidine.

3 LHT1 can also transport l-hydroxyproline and l-histidine.

4 occupancy of the allosteric sites by TIH and L-histidine.

5 the penultimate step in the biosynthesis of L-histidine.

6 ity, a K(ii) value of 4 muM was obtained for l-histidine.

7 r in solution, in the presence or absence of l-histidine.

8 f apoptosis, by the singlet oxygen scavenger L-histidine.

9 d an affordable linker prepared from natural l-histidine.

10 L-Histidine (1 mM) at pH 8.5, at which histidine is unch

11 and Na+-dependent with a 14-fold increase in L-histidine- (1 mM) evoked current (I(His) = -14.7 +/- 1

12 and low conductivity species such as: d- and l-histidine; 1- and 3-methylhistidines; carnosine; imida

13 L-histidine (1000 mg/kg) and thioperamide (5 mg/kg) were

14 ionic micelle from a block copolymer of poly(L-histidine) (3.7kDa) and short branched polyethyleneimi

15 Anserine (beta-alanyl-N(Pi)-methyl-L-histidine), a methylated derivative of carnosine (beta

16 acids, including l-alanine, l-glutamine, and l-histidine, across the plasma membrane and are involved

17 L-histidine, an inhibitor of mitochondrial glutamine tra

18 res of EgtD-inhibitor complexes confirm that L-Histidine analogs bind solely to the L-Histidine bindi

19 s TGX-221, and S-Glycyl-H-1152 span both the L-Histidine and AdoMet binding sites.

20 We complexed (64)Cu to l-histidine and analyzed clearance from blood, uptake in

21 regulate metabolic partitioning between the l-histidine and coformycin pathways.

22 luble receptor of this permease, HisJ, binds L-histidine and L-arginine (tightly) and L-lysine and L-

23 free media) only a partial inhibitor whereas L-histidine and L-cysteine are fully effective.

24 rgoing sizable reductions, including loss of L-histidine and L-tryptophan biosynthesis.

25 Peptides rich in L-histidine and L-tryptophan residues are selectively re

26 no acid transporters including Na+-dependent L-histidine and Na+-independent L-arginine and L-phenyla

27 In this study we tested administration of L-histidine and thioperamide in surgical brain injury in

28 We conclude that combined treatment with l-histidine and thioperamide leads to increased BBB brea

29 in rodents have shown that administration of L-histidine and thioperamide reduces ischemic tissue los

30 33), and surgical brain injury with combined l-histidine and thioperamide treatment (SBI+H) (n=29).

31 Carnosine (beta-alanyl-l-histidine) and anserine (beta-alanyl-3-methyl-l-histid

32 -aminothiazole, 2amino-4,5-dimethylthiazole, L-histidine, and 7-nitroindazole resulted in high spin h

33 were conducted with amino acids (l-arginine, l-histidine, and glycine) that are representative of tho

34 Competition studies with free glycine, l-histidine, and nitrilotriacetic acid (NTA) indicate an

35 The cell permeability was unaffected by l-histidine, and the sensor response remained unchanged.

36 istidine) and anserine (beta-alanyl-3-methyl-l-histidine) are abundant peptides in the nervous system

37 l ligand derived from the natural amino acid l-histidine, are replaced by CH3NH3(+).

38 to use the dipeptide carnosine (beta-alanyl-L-histidine) as a sole carbon or nitrogen source was iso

39 acid transporter, with unique selectivity to L-histidine at neutral pH (K(0.5)(L-His) = 0.34 +/- 0.07

40 endogenous dipeptide carnosine (beta-alanyl-L-histidine), at 0.1-10 mM, provokes sustained contractu

41 abolic deficiencies-were co-cultured with an L-histidine auxotroph and optimized via adaptive laborat

42 cid groups and an unusual threo-beta-hydroxy-l-histidine available for Fe(III) chelation.

43 ion (K(ii)), on the contrary, indicates that l-histidine better inhibits MtATP-phosphoribosytransfera

44 that L-Histidine analogs bind solely to the L-Histidine binding site while drug-like inhibitors, suc

45 y nuclear magnetic resonance, indicates that l-histidine binds better as the neutral alpha-amino grou

46 se catalyzes the first and committed step in l-histidine biosynthesis in Mycobacterium tuberculosis a

47 rlaps significantly with the early stages of l-histidine biosynthesis.

48 NCIB 3610 cells revealed that genes from the L-histidine biosynthetic pathway, the purine, pyrimidine

49 f the enzyme closely resembles the inhibited L-histidine-bound closed conformation, revealing the unc

50 on behavior of Deionized (DI) water and 10mM L-Histidine buffer solution which were subjected to drop

51 ccurrence of cavitation between DI water and L-Histidine buffer solution.

52 L-histidine, but not D-histidine, stimulated 65Zn uptake

53 olymer, methoxy poly(ethylene glycol)-b-poly(l-histidine-co-l-phenylalanine) (PEGbPHF).

54 Theoretical models suggest that Cu(II) and l-histidine complexation around the analyte chiral cente

55 , although the enzymes also methylated other l-histidine-containing di- and tripeptides.

56 tes, including glycine, L-proline, L-serine, L-histidine, D-alanine, Gly-Gly, and Gly-Gly-Gly, to ach

57 Wild-type (WT) and l-histidine decarboxylase (Hdc(-/-)) mice were fed a con

58 lood FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and ser

59 rocessing of the histamine-producing enzyme, L-histidine decarboxylase (HDC), leads to the formation

60 strin receptor and regulates the activity of L-histidine decarboxylase (HDC), the enzyme that produce

61 rter B family member 2 knockout mice lacking l-histidine decarboxylase were injected with vehicle or

62 functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in h

63 are genetic form of Tourette syndrome due to L-histidine-decarboxylase mutation, with similar feature

64 Target compound 5, the N tau-(carboxymethyl)-L-histidine derivative of 4, was also prepared.

65 tidine uptake was inhibited significantly by L-histidine followed by 2-endoamino-bicycloheptane-2-car

66 ldol reaction catalyzed by readily available l-histidine followed by biotransformation of the aldol a

67 The presence of threo-beta-hydroxy-l-histidine gives rise to a unique mode of Fe(III) coord

68 ation at the C-5 position of fully protected L-histidine has been achieved via a palladium-catalyzed

69 the transport of another System-N substrate, l-histidine, has yet to be determined.

70 e a, were incorporated into the bis(3-methyl-l-histidine) heme binding sites in [Delta7-H3m](2).

71 -helix bundle that contains two bis(3-methyl-l-histidine) heme binding sites with known absolute ferr

72 tes, bacteria, and archaebacteria synthesise L-histidine (His) in a similar, multistep pathway that i

73 , we engineered the hLNC surface with either L-histidine (hLNC-Hist) or short-chain polyethylene glyc

74 ino)isobutyric acid, implying that uptake of L-histidine in H2.35 cells is primarily mediated by syst

75 ate and methotrexate analogues 6 and 4, with L-histidine in place of L-glutamate, were designed and s

76 acid transporter (NBAT)-induced transport of L-histidine in Xenopus laevis oocytes.

77 rsor of the dipeptide carnosine (beta-alanyl-l-histidine) in muscle.

78 e-limiting for the overall reaction and that l-histidine inhibition is caused by trapping the enzyme

79 teady-state kinetic studies demonstrate that l-histidine inhibition is uncompetitive versus ATP and n

80 udies showing that, relative to D-histidine, L-histidine is able to more strongly bind to RNA.

81 hylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate s

82 at catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine leve

83 ropyl methacrylate (HPMA-Cl) and followed by L-Histidine (L-His) modification.

84 Proline, L-arginine, L-histidine, L-isoleucine, and tryptophan were accumulat

85 ated for separation, and four l-amino acids (l-histidine, l-tryptophan, l-proline, and l-tyrosine) we

86 MF), methyl salicylate, caffeine, l-leucine, l-histidine, loratadine, ibuprofen, acetaminophen, acety

87 e acetal monomers (3-dimethoxymethylbenzoyl)-L-histidine methyl ester 1 and (3-dimethoxymethylbenzoyl

88 1 and (3-dimethoxymethylbenzoyl)-tau-benzyl-L-histidine methyl ester 2 were prepared from a histidin

89 The probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galac

90 id based recognition element, N-methacryloyl-L-histidine methylester (MAH), 2-Hydroxyethyl methacryla

91 of this unique feature, we have incorporated L-histidine (N,N-di-n-hexadecylamine) ethylamide (L(H))

92 d deoxyribozyme from this selection requires L-histidine or a closely related analog to catalyze RNA

93 sed by families of ligands such as imidazole/L-histidine or thiazole/2-aminothiazole confirms the con

94 Transport of L-histidine (pH 7.5) was electrogenic and Na+-dependent

95 f the catalytic pocket, while the pai-methyl-l-histidine (Pmh) moiety transfers the electrophile.

96 This biosensor can be used to isolate L-histidine-producing strains by FACS, showing that TR e

97 The present study examined whether L-histidine similarly abolishes OS, the mPT, and brain e

98 By comparing Ir1 binding to BNT-II versus L-histidine, steric and quenching effects were noted in

99 These changes were completely abolished by L-histidine, supporting a key role of mitochondrial glut

100 t catalytic turnover is ~10,000x faster with L-histidine than with L,L-lanthionine.

101 to one of the aromatic nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic bond.

102 se (AdoMet), catalyzes the trimethylation of L-Histidine to initiate EGT biosynthesis and this reacti

103 he action of HutH, HutU, and HutI to convert L-histidine to N-formimino-L-glutamate.

104 ments were performed for a similar molecule, l-histidine, to test for selectivity.

105 The induction of Na+-dependent L-histidine transport in NBAT-expressing oocytes provide

106 ike L-phenylalanine or L-arginine transport, L-histidine transport is Na+-dependent and stereoselecti

107 y, the possible effects on System-N mediated l-histidine transport of changes in pH and extracellular

108 L-Histidine transport, at pH 7.5, is stimulated by NBAT

109 It accounted for 30% of l-histidine uptake in the presence of physiological conc

110 tion in the pathophysiological range reduced l-histidine uptake via both System-L and -N.

111 The L-histidine uptake was inhibited significantly by L-hist

112 d to synthesize a series of protected 5-aryl-L-histidines using aryl iodides as coupling partners, in

113 e MProP-silicas exhibit high affinity toward L-histidine via metal-nitrogen axial ligation interactio

114 Consistently, the transport of the substrate l-histidine was increased with short, but not long, trea

115 tial production of NH2Cl from l-arginine and l-histidine was observed at Cl/P = 1.0 and 2.0 when post

116 At pH 7.5, L-histidine weakly inhibited the Na+-independent L-argin

117 m UV254-irradiated samples of l-arginine and l-histidine when Cl/P = 2.0 and 3.0, as well as from gly

118 AtmBAC1 recognized l-histidine whereas both yeast Ort1p and the mammalian o

119 ific for the side chain and binds protonated L-histidine with 10(2)-10(3)-fold stereoselectivity and

120 is residues, the reactions of Nalpha-benzoyl-L-histidine with autoxidizing linoleic acid and with the

121 he biosynthetic oxidation of L-histidinol to L-histidine with sequential reduction of two molecules o

122 zole side-chain orientation in U-[13C6,15N3]-L-histidine x HCl x H2O.