ライフサイエンスコーパス: L-methionine

1 and generates homocysteine for conversion to l-methionine.

2 catalyze the high affinity uptake of D- and L-methionine.

3 lting peptide with tritiated S-(5'-adenosyl)-l-methionine.

4 heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

5 ar mechanism of CBS activation by S-adenosyl-l-methionine.

6 and without (2.0 A) its cofactor S-adenosyl-L-methionine.

7 with a fresh molecule of cofactor S-adenosyl-L-methionine.

8 to l-homocysteine, yielding two molecules of l-methionine.

9 te and methane in the presence of S-adenosyl-L-methionine.

10 anine (S(6)mG) in the presence of S-adenosyl-l-methionine.

11 ne and the methyl donor substrate S-adenosyl-l-methionine.

12 onditions, Met oxidation can be prevented by L-methionine.

13 rated by a reductive cleavage of S-adenosyl- l-methionine.

14 n or for allosteric regulation by S-adenosyl-L-methionine.

15 ed from the natural amino acids l-serine and l-methionine.

16 onded to allosteric activation by S-adenosyl-L-methionine.

17 l and 54.5 microm for S-[methyl-14C]adenosyl-l-methionine.

18 6-mercaptopurine but not K m for S-adenosyl- l-methionine.

19 t disrupt binding of the cofactor S-adenosyl-L-methionine.

20 e measured value for S-3',4'-anhydroadenosyl-l-methionine.

21 polymerase for the methyl donor, S-adenosyl-l-methionine.

22 rochloride (AAPH) in formulations containing l-methionine.

23 were promising particularly with the use of l-methionine.

24 s a methyl group originating from S-adenosyl-l-methionine.

25 H3K36 using specifically labeled S-adenosyl-l-methionine.

26 TPsiC-loop of tRNA, from cofactor S-adenosyl-L-methionine.

27 l-Methionine (1 mm), a specific TREK-1 inhibitor, dramat

28 l chains derived from the natural amino acid l-methionine (1) has been rationally prepared.

29 For S-(11)C-methyl)-l-methionine ((11)C-MET) (8 studies, 151 lesions), sensi

30 ollowed by PET using (18)F-FDG, (11)C-methyl-l-methionine ((11)C-MET), and 3'-deoxy-3'-(18)F-fluoroth

31 .04-fold), (123)I-MIBG (3.25-fold), and (3)H-l-methionine (3.11-fold).

32 mpared normal mice with mice pretreated with l-methionine (5.2 mmol/kg s.c. twice a day for 7 days) t

33 , 4-azidobut-2-enyl derivative of S-adenosyl-L-methionine (Ab-SAM) was reported as a suitable BPPM co

34 ombin levels, and the latter was reversed by L-methionine administration.

35 Recombinant TrmO employs S-adenosyl-L-methionine (AdoMet) as a methyl donor to methylate t(6

36 pA-RNA --> m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor.

37 of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source.

38 TrmD enzymes are known to use S-adenosyl-l-methionine (AdoMet) as substrate; we have shown that 3

39 The biological methyl donor S-adenosyl-l-methionine (AdoMet) is spontaneously degraded by inver

40 ilic attack of cytosine C5 on the S-adenosyl-L-methionine (AdoMet) methyl group is concerted with for

41 m Bacillus circulans (BtrN) is an S-adenosyl-l-methionine (AdoMet) radical enzyme.

42 Asp-134 and methyl transfer from S-adenosyl-L-methionine (AdoMet) to GAA are concerted.

43 e, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-adenosyl-l-ho

44 BS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domain, which ac

45 e transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cytosine resi

46 r one to three methyl groups from S-adenosyl-L-methionine (AdoMet) to the epsilon-amino group of the

47 te and the methyl donor cofactor, S-adenosyl-l-methionine (AdoMet), displayed AdoMet non-competitive

48 eavage of the sulfonium center of S-adenosyl-L-methionine (AdoMet), generating methionine and a trans

49 e of the CBS allosteric regulator S-adenosyl-l-methionine (AdoMet), only C15 and C431 of human CBS ar

50 xample, how both the methyl donor S-adenosyl-l-methionine (AdoMet), which is water-soluble, and the m

51 and found that it belongs to the S-adenosyl-L-methionine (AdoMet)-dependent alpha/beta-knot superfam

52 dification of protein residues by S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases impac

53 S-adenosyl-L-methionine (AdoMet)-dependent O-methyltransferases (OM

54 lavodoxin and a methyl group from S-adenosyl-L-methionine (AdoMet).

55 eine, methyltetrahydrofolate, and S-adenosyl-l-methionine (AdoMet).

56 ulatory C-terminal domain binding S-adenosyl-l-methionine (AdoMet).

57 me-coupled luminescence assay for S-adenosyl-l-methionine (AdoMet/SAM)-based PMTs.

58 ay to quantitatively characterize S-adenosyl-L-methionine (AdoMet/SAM)-dependent methyltransferase ac

59 S-adenosyl-L-methionine- (AdoMet-) dependent methyltransferases are

60 s VSCs by suppressing mgl, the gene encoding L-methionine-alpha-deamino-gamma-mercaptomethane-lyase,

61 , they demonstrate that supplementation with L-methionine, an essential amino acid that assists in th

62 Sinefungin (SIN), a natural S-adenosyl-L-methionine analog produced by Streptomyces griseolus,

63 -methionine, which is reductively cleaved to L-methionine and 5'-deoxyadenosine.

64 binding site for the methyl donor S-adenosyl-l-methionine and are inhibited by individual amino acid

65 rine lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier protein (A

66 we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protei

67 A redox-reconfigurable catalyst derived from L-methionine and incorporating catalytic urea groups has

68 (2-AP-6-SO3H) upon reaction with S-adenosyl-L-methionine and irradiation with UVA light, respectivel

69 does not interact strongly with N-palmitoyl-l-methionine and is found positioned at the enzyme-solve

70 ase (MGL) catalyzes the gamma-elimination of l-methionine and its derivatives as well as the beta-eli

71 abeled on-blot using [methyl-(3)H]S-adenosyl-L-methionine and recombinant PIMT.

72 ansfer fluorescence assays demonstrated that l-methionine and S-adenosyl methionine concentrations de

73 Two structures with bound S-adenosyl-L-methionine and S-adenosyl-L-homocysteine confirm that

74 ltiple kinetic isotope effects.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesize

75 e, and its non-reactive analogs Aza-adenosyl-L-methionine and Sinefungin, and characterized the bindi

76 a succinimide on incubation with S-adenosyl-l-methionine and the commercially available enzyme, prot

77 by mimicking each substrate, the S-adenosyl-l-methionine and the deoxycytidine, and linking them tog

78 ited by reagents that block TREK-1 channels, l-methionine and/or methioninol.

79 c-sestamibi (MIBI), (18)F- or (3)H-FDG, (3)H-l-methionine, and (3)H-thymidine.

80 r (18)F- or (3)H-FDG, 1.93 +/- 0.87 for (3)H-l-methionine, and 1.22 +/- 0.74 for (3)H-thymidine.

81 e catalytic tetrad, interact with S-adenosyl-l-methionine, and contribute to autoguanylation.

82 bunit methyltransferase, bound to S-adenosyl-L-methionine, and its non-reactive analogs Aza-adenosyl-

83 yruvate, one carbon from the methyl group of l-methionine, and one carbon directly from CO(2).

84 ution of MoaA incubated with GTP, S-adenosyl-L-methionine, and sodium dithionite in the absence of Mo

85 th (18)F- or (3)H-FDG, (123)I-MIBG, and (3)H-l-methionine, and the immunohistostaining findings, sugg

86 The SAM surrogate S-3',4'-anhydroadenosyl-L-methionine (anSAM) can replace SAM as a cofactor in th

87 ethyltransferase enzymes that use S-adenosyl-l-methionine as a cofactor.

88 n S-COMT in the presence of S-[(3)H]adenosyl-l-methionine as a methyl group donor.

89 ylating them in a reaction using S-adenosyl- l-methionine as the donor.

90 n and a third with bound cofactor S-adenosyl-L-methionine at 1.75 A each exhibit distinct relative po

91 ing from in situ demethylation of S-adenosyl-L-methionine, at 2.05 or 1.82 A resolution, respectively

92 stem that linked the viability of an E. coli L-methionine auxotroph to the activity of the improved e

93 ucts can be incorporated into proteins using L-methionine auxotrophs.

94 vert homoserine for downstream production of l-methionine, between IA3902 and W7, which could enable

95 light on the structural basis of S-adenosyl-L-methionine binding and methyltransferase activity.

96 ylation domain interrupted by the S-adenosyl-l-methionine binding region of a methyltransferase enzym

97 two methylase activities share an S-adenosyl-l-methionine-binding site and show that, in contrast to

98 posed intermediate in the radical S-adenosyl-L-methionine biogenesis of the M-cluster.

99 Bacterial L-methionine biosynthesis and a Ruminococcus species wer

100 , which could enable a secondary pathway for l-methionine biosynthesis in a W7 DeltaluxS but not in a

101 ous studies of the K41A mutant enzyme showed L-methionine bound in an external Schiff base (ESB) link

102 as determined to a resolution of 2.33 A with l-methionine bound in the active site.

103 including the first structure of S-adenosyl-l-methionine bound to a KsgA/Dim1 enzyme in a catalytica

104 ystal structure determination of N-palmitoyl-l-methionine bound to the heme domain of P450BM-3, appea

105 ete with the enzyme cofactor SAM (S-adenosyl-L-methionine) but not the substrate nucleosome.

106 l-Homocysteine can be remethylated to form l-methionine by betaine or N(5)-methyltetrahydrofolate.

107 Antioxidant seleno-l-methionine; chemical inhibitors of p38, ERK1/2, and mi

108 f this enzyme in complex with the S-adenosyl-l-methionine cofactor at 1.7 A resolution confirms that

109 ulfoxides (S) and (R), respectively, back to L-methionine consequently repairing oxidatively damaged

110 es the unique metabolite carboxy-S-adenosine-L-methionine (Cx-SAM) and catalyzes a carboxymethyl tran

111 escribe a new metabolite, carboxy-S-adenosyl-l-methionine (Cx-SAM), its biosynthetic pathway and its

112 co-crystallized with the cofactor S-adenosyl-l-methionine (d (min) = 1.6 angstrom), the product S-ade

113 (k(cat)/K(m) = 5.2 x 10(6) M(-1) s(-1)), and l-methionine-d-glutamate (k(cat)/K(m) = 3.4 x 10(5) M(-1

114 ylamino)azobenzene-4'-sulfonyl derivative of l-methionine (dabsyl Met), the product of the enzymatic

115 ate that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1) is dynamically control

116 S-adenosyl-l-methionine dependent methyltransferases catalyze methy

117 The role of Glu119 in S-adenosyl-L-methionine-dependent DNA methyltransferase M.HhaI-cata

118 RI, a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase, relies on

119 he methylthiolase MiaB, a radical S-adenosyl-L-methionine-dependent enzyme involved in the maturation

120 nsferases (MTs) that catalyze the S-adenosyl-L-methionine-dependent methylation of natural chemicals

121 RsmC is a class I S-adenosyl-L-methionine-dependent methyltransferase composed of two

122 ated that genetic deletion of the S-adenosyl-L-methionine-dependent methyltransferase from the PZN bi

123 The S-adenosyl-L-methionine-dependent methyltransferase KsgA introduces

124 We characterized Rv0560c as an S-adenosyl-L-methionine-dependent methyltransferase that N-methylat

125 n of a C. roseus cDNA encoding an S-adenosyl-L-methionine-dependent N methyltransferase that catalyze

126 from time course experiments and S-adenosyl-l-methionine-dependent O-methyltransferase inhibition st

127 NovP is an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyze

128 , unveiling that: (i) NcsB1 is an S-adenosyl-L-methionine-dependent O-methyltransferase; (ii) NcsB1 c

129 A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase, HUA ENHANC

130 o enzyme studies identified a new S-adenosyl-l-methionine-dependent S-MT (TmtA) that is, surprisingly

131 and characterization of a unique S-adenosyl-l-methionine-dependent sugar 1-O-methyltransferase (MeT1

132 oncentrations of choline chloride (CC) and D,L-methionine (DLM).

133 which is catalyzed by the radical S-adenosyl-l-methionine enzyme AbmJ.

134 The radical S-adenosyl-L-methionine enzyme DesII from Streptomyces venezuelae i

135 The radical S-adenosyl-L-methionine enzyme HydG lyses free tyrosine to produce

136 show that PhnJ is a novel radical S-adenosyl-L-methionine enzyme that catalyses C-P bond cleavage thr

137 yces venezuelae is a radical SAM (S-adenosyl-l-methionine) enzyme that catalyzes the deamination of T

138 Intriguingly, radical S-adenosyl-L-methionine enzymes are vital for the assembly of all t

139 HydG is a member of the radical S-adenosyl-L-methionine family of enzymes that transforms Fe and L-

140 id L-azidohomoalanine (AHA), a surrogate for l-methionine, followed by fluorescent labelling of AHA-c

141 bound with methylation cofactor, S-adenosyl-L-methionine from Pyrococcus furiosus, at 2.7 A.

142 mercury(II) using deoxyribonucleic acid/poly-L-methionine-gold nanoparticles/pencil graphite electrod

143 In a frying study with potato cubes, 5.5mM l-methionine had significantly stronger antioxidant acti

144 The radical S-adenosyl-l-methionine HydG, the best characterized of these prote

145 , oleic acid, myo-inositol, dodecanoic acid, L-methionine, hypoxanthine, palmitic acid, L-tryptophan,

146 Incorporation experiments with [(13)C-methyl]l-methionine implicated an alpha-dimethyl-beta-keto acid

147 l-Methionine is an essential amino acid and is required

148 g of microbial strains for the production of l-methionine is of major interest in industrial biotechn

149 cal data collectively reveal that S-adenosyl-L-methionine is selectively recognized through carbon-ox

150 eine, which is produced in the metabolism of l-methionine, is remethylated 2-4 times before it is des

151 er and other malignancies have revealed that l-methionine (l-Met) and its metabolites play a critical

152 To fabricate this biosensor, L-methionine (L-MET) was electropolymerized on the PGE s

153 NAC), or 0.25 M NaOAc containing 5 mg.mL(-1) l-methionine (L-MET).

154 ine (SAH) or 5'-deoxyadenosine (5'-dAdo) and l-methionine (l-Met).

155 is dominated by l-leucine but also includes l-methionine, l-isoleucine, and l-valine.

156 esides l-Lys, recombinant ALD1 transaminates l-methionine, l-leucine, diaminopimelate, and several ot

157 altered after H(2)O(2)-mediated oxidation of L-methionine, L-tryptophan, and L-cysteine residues in i

158 l-Methionine (Met) is an essential amino acid for humans

159 of mice exposed to protracted treatment with l-methionine (MET) is attributed to RELN and GAD(67) pro

160 receiving methyl supplementation via chronic l-methionine (MET) underwent either a sensitization regi

161 gated chemical compounds of selenium: seleno-l-methionine, methyl-seleno-l-cysteine, l-selenocystine,

162 However, only one S-adenosyl-L-methionine molecule and one substrate molecule, guanos

163 ition is due to noncompetitive inhibition by L-methionine, much like a negative feedback loop.

164 stent with a role for ADK and the S-adenosyl-L-methionine pathway in the control of root gravitropism

165 signed to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl transferase all

166 s that the genes metA and metB contribute to l-methionine production and chicken colonization by Camp

167 esults indicate that the ability to maintain l-methionine production in vivo, conferred by metA and m

168 er dabsyl l-methionine S-sulfoxide or dabsyl l-methionine R-sulfoxide is used as a substrate.

169 rovide the substrates of LipA, an S-adenosyl-L-methionine radical enzyme that inserts two sulfur atom

170 ss substrate for DNA methylation (S-adenosyl-L-methionine) rescues the suppression of mEPSCs by DNMT

171 Such high concentrations of H(2)O(2) oxidize L-methionine residues in proteins and peptides to (R and

172 rous cellular processes involving S-adenosyl-l-methionine result in the formation of the toxic by-pro

173 hylation site, in the presence of S-adenosyl-L-methionine, reveals a V-like protein structure and sug

174 ylcobalamin-dependent and radical S-adenosyl-l-methionine (RS) enzymes.

175 zed by S-adenosylmethionine synthetase (ATP: L-methionine S-adenosyltransferase (MAT)), which is a ta

176 f the enzymatic reactions when either dabsyl l-methionine S-sulfoxide or dabsyl l-methionine R-sulfox

177 f enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMet) to generate a 5'-deoxyadeno

178 catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyltransferase

179 S-adenosyl-L-methionine (SAM) acts as a signal and binds the methyl

180 ic PMTs are engineered to process S-adenosyl-L-methionine (SAM) analogs as cofactor surrogates and la

181 f vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor cofactor, we

182 sis of an azide-bearing N-mustard S-adenosyl-L-methionine (SAM) analogue, 8-azido-5'-(diaminobutyric

183 tic platform for the synthesis of S-adenosyl-L-methionine (SAM) analogues compatible with downstream

184 seq involves in vivo synthesis of S-adenosyl-L-methionine (SAM) analogues from cell-permeable methion

185 Radical SAM (RS) enzymes use S-adenosyl-l-methionine (SAM) and a [4Fe-4S] cluster to initiate a

186 omain and some of them presenting S-adenosyl-l-methionine (SAM) and nuclear receptor box (NRB) motifs

187 NSD2 binds to S-adenosyl-l-methionine (SAM) and nucleosome substrates to catalyze

188 zyme inaccessible to the cofactor S-adenosyl-l-methionine (SAM) and probably to the substrate tRNA.

189 l methyltransferases that utilize S-adenosyl-L-methionine (SAM) as a cofactor.

190 pA-RNA-->m(7)GpppAm-RNA, by using S-adenosyl-l-methionine (SAM) as a methyl donor.

191 olecular modeling and competitive S-adenosyl-l-methionine (SAM) binding assay suggest that these comp

192 Mutations to the S-adenosyl-l-methionine (SAM) binding motif in the nsp14 abolished

193 y on the resting oxidized and the S-adenosyl-l-methionine (SAM) bound forms of pyruvate formate-lyase

194 in the conversion of 5'-ClDA into S-adenosyl-l-methionine (SAM) but a reduced kcat value in the conve

195 iodiesel produces FAMEs by direct S-adenosyl-L-methionine (SAM) dependent methylation of free fatty a

196 chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferase (NirE).

197 S-adenosyl-l-methionine (SAM) dependent O-methyltransferases (OMTs)

198 ,3-aminomutase (LAM) is a radical S-adenosyl-L-methionine (SAM) enzyme and, like other members of thi

199 DesII, a radical S-adenosyl-l-methionine (SAM) enzyme from Streptomyces venezuelae,

200 ve mutations in MOCS1A, a radical S-adenosyl-l-methionine (SAM) enzyme involved in the conversion of

201 monstrate that a putative radical S-adenosyl-L-methionine (SAM) enzyme superfamily member encoded by

202 which is a member of the radical S-adenosyl-L-methionine (SAM) enzyme superfamily.

203 DesII is a radical S-adenosyl-l-methionine (SAM) enzyme that can act as a deaminase or

204 ptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation o

205 ting enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically

206 NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential for nitrogen

207 e photoproduct lyase is a radical S-adenosyl-l-methionine (SAM) enzyme with the unusual property that

208 erin is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown whether vip

209 SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, which uses a [4Fe-4S](+) clus

210 , which is annotated as a radical S-adenosyl-l-methionine (SAM) enzyme.

211 hat viperin is a putative radical S-adenosyl-l-methionine (SAM) enzyme.

212 Radical S-adenosyl-l-methionine (SAM) enzymes are widely distributed and ca

213 Radical S-adenosyl-l-methionine (SAM) enzymes initiate biological radical r

214 Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes involves electron transfer (E

215 e number of characterized radical S-adenosyl-l-methionine (SAM) enzymes is increasing, the roles of t

216 The radical S-adenosyl-L-methionine (SAM) enzymes RlmN and Cfr methylate 23S ri

217 Radical S-adenosyl-L-methionine (SAM) enzymes use an iron-sulfur cluster to

218 mily of proteins known as radical S-adenosyl-l-methionine (SAM) enzymes.

219 pe effects (BIEs) of the cofactor S-adenosyl-l-methionine (SAM) for SET8-catalyzed H4K20 monomethylat

220 (MATs) catalyze the formation of S-adenosyl-l-methionine (SAM) inside living cells.

221 ne-electron reductive cleavage of S-adenosyl-l-methionine (SAM) into methionine and the 5'-deoxyadeno

222 S-adenosyl-l-methionine (SAM) is a necessary cosubstrate for numero

223 S-adenosyl-L-methionine (SAM) is converted to 5'-chloro-5'-deoxyade

224 S-Adenosyl-l-methionine (SAM) is recognized as an important cofacto

225 S-Adenosyl-l-methionine (SAM) is the central cofactor in the radica

226 S-adenosyl-L-methionine (SAM) is the sole methyl-donor cofactor of

227 The radical S-adenosyl-L-methionine (SAM) methyl synthases, RlmN and Cfr, both

228 cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identifi

229 results indicate that the radical S-adenosyl-L-methionine (SAM) protein PylB mediates a lysine mutase

230 which encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synthesize BCh

231 urs upstream of genes involved in S-adenosyl-L-methionine (SAM) recycling in many Gram-positive and G

232 s that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously predicted

233 QueE is a member of the radical S-adenosyl-l-methionine (SAM) superfamily, all of which use a bound

234 l riboswitches were identified in S-adenosyl-l-methionine (SAM) synthetase metK genes in members of L

235 ne (Cyt) C6, methyl transfer from S-adenosyl-l-methionine (SAM) to Cyt C5, and proton abstraction fro

236 mino-3-carboxypropyl radical from S-adenosyl-L-methionine (SAM) to form a C-C bond.

237 eines in a CX(3)CX(2)C motif, and S-adenosyl-L-methionine (SAM) to generate a 5'-deoxyadenosyl radica

238 e transfer of a methyl group from S-adenosyl-L-methionine (SAM) to magnesium protoporphyrin IX (MgP)

239 -amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue of EF2, form

240 factor in order to stably bind to S-adenosyl-l-methionine (SAM), suggesting that it proceeds accordin

241 showed a single binding site for S-adenosyl-L-methionine (SAM), the methyl donor.

242 S-Adenosyl-l-methionine (SAM), the primary methyl group donor for e

243 a precursor for the synthesis of S-adenosyl-l-methionine (SAM), which is the most commonly used meth

244 The highly conserved S-adenosyl-l-methionine (SAM)-binding residues of the DxG motif are

245 es of Bud23-Trm112 in the apo and S-adenosyl-L-methionine (SAM)-bound forms.

246 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can cata

247 new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (SAM)-dependent enzymes and others that cat

248 rotein NifB catalyzes the radical S-adenosyl-L-methionine (SAM)-dependent insertion of carbide into t

249 es predicted EftM to be a Class I S-adenosyl-l-methionine (SAM)-dependent methyltransferase.

250 S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) ca

251 me evolution has been observed in S-adenosyl-L-methionine (SAM)-dependent methyltransferases involved

252 ethyltransferases, members of the S-adenosyl-l-methionine (SAM)-dependent O-methyltransferase superfa

253 o comprise two distinct groups of S-adenosyl-l-methionine (SAM)-dependent RNA enzymes, namely the Kgm

254 tion of the piperazyl scaffold is S-adenosyl-l-methionine (SAM)-dependent.

255 methyl group is assembled from an S-adenosyl-L-methionine (SAM)-derived methylene fragment and a hydr

256 accumulation of the methyl donor S-adenosyl-L-methionine (SAM).

257 amilies of riboswitches that bind S-adenosyl-l-methionine (SAM).

258 3-amino-3-carboxypropyl group of S-adenosyl-l-methionine (SAM).

259 S-box (SAM-I) riboswitch bound to S-adenosyl-L-methionine (SAM).

260 e for methyltransferase activity, S-adenosyl-l-methionine (SAM).

261 hly abundant methylation cofactor S-adenosyl-l-methionine (SAM).

262 Posttranslational methylation by S-adenosyl-L-methionine(SAM)-dependent methyltransferases plays ess

263 the remethylation of l-homocysteine to form l-methionine should be considered along with B vitamin s

264 In leukemic mice, administration of L-methionine significantly increased homocysteine levels

265 acupuncture, omega-3 fatty acids, S-adenosyl-L-methionine, St. John's wort [Hypericum perforatum]), e

266 The response to S-adenosyl-L-methionine stimulation or thermal activation varied.

267 amate analogues l-methionine sulfoximine and l-methionine sulfone as substrates, with Km(app) values

268 +/- 23 s-1 for l-methionine sulfoximine and l-methionine sulfone, respectively.

269 onformation was stabilized by phosphorylated L-methionine sulfoximine (MSX), fixing the enzyme in the

270 The glutamine synthetase inhibitor l-methionine sulfoximine abolished the ability of aspara

271 lease is significantly reduced by the toxins L-methionine sulfoximine and fluoroacetate, which reduce

272 tyltransferase using the glutamate analogues l-methionine sulfoximine and l-methionine sulfone as sub

273 values of 505 +/- 43 and 610 +/- 23 s-1 for l-methionine sulfoximine and l-methionine sulfone, respe

274 ita in complex with one of these substrates (l-methionine sulfoximine) has been solved, revealing the

275 in the absence of glutamine was inhibited by l-methionine sulfoximine, suggesting a role for pita in

276 Neither Gln nor l-methionine sulfoximine-induced ammonium accumulation w

277 e and hyperhomocysteinemia can be induced by L-methionine supplementation.

278 ained a cDNA encoding S-[methyl-14C]adenosyl-l-methionine:t-anol/isoeugenol O-methyltransferase 1 (AI

279 er acceptor of methyl groups from S-adenosyl-L-methionine than was malonyl-CoA.

280 Consequently, the antioxidant seleno-l-methionine, the specific ERK1/2 inhibitor PD98059, or

281 he strong electrophilic nature of S-adenosyl-l-methionine, the transmethylation of the demethylated p

282 sACS [encode enzymes that convert S-adenosyl-L-methionine to 1-aminocyclopropane-1-carboxylic acid (A

283 (S)G in DNA can be methylated by S-adenosyl-l-methionine to give S(6)-methylthioguanine (S(6)mG) and

284 transferring a methyl group from S-adenosyl-l-methionine to HA, and is the only well-known pathway f

285 y transfers the methyl group from S-adenosyl-L-methionine to O-4 of alpha-D-glucopyranosyluronic acid

286 ACC) synthases (ACS) that convert S-adenosyl-l-methionine to the immediate precursor ACC.

287 transfer of the methyl group from S-adenosyl-L-methionine to the lysine epsilon-amine has remained un

288 e transfer of a methyl group from S-adenosyl-L-methionine to the N6 position of an adenine, a process

289 sfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, resulting in fo

290 ed the ability of l-arginine, l-cysteine and l-methionine, to inhibit postharvest senescence of brocc

291 belongs to the diverse family of S-adenosyl-l-methionine transferases.

292 at are functionally assigned as (i) LipO, an L-methionine:uridine-5'-aldehyde aminotransferase; (ii)

293 of (18)F- or (3)H-FDG, (123)I-MIBG, and (3)H-l-methionine was significantly increased over the contro

294 Apparent K(m) values for S-adenosyl-l-methionine were 4.6, 3.1, and 11 mum for WT, Trp(173),

295 N-Palmitoyl-l-leucine and N-palmitoyl-l-methionine were found to have the highest affinity, wi

296 The roles of -NH(2), -CO(2)H, and -S- of l-methionine were investigated and found critical for th

297 ts.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesized from elemental sulfur usin

298 rface of EcoDam in the absence of S-adenosyl-L-methionine, which illustrates a possible intermediate

299 redox-active [4Fe-4S]-cluster and S-adenosyl-L-methionine, which is reductively cleaved to L-methioni

300 in a methionine auxotroph in the presence of l-methionine with the side chain methyl group (13)C-labe