ライフサイエンスコーパス: L-ornithine

1 s associated with the binding of NADP(H) and l-ornithine.

2 d survival in vitro and in vivo by exporting L-ornithine.

3 exhibit higher activity than alpha-N-acetyl-L-ornithine.

4 shes feedback inhibition of P5CS activity by L-ornithine.

5 ic hydrolysis of l-arginine to form urea and l-ornithine.

6 putrescine, a polyamine, from extracellular L-ornithine.

7 ME but was blocked by the arginase inhibitor L-ornithine.

8 phosphate and a C-terminal domain that binds L-ornithine.

9 ncreasing the extracellular concentration of L-ornithine.

10 dependent on the transcellular transport of L-ornithine.

11 its amino acid substrate, only hydroxylating l-ornithine.

12 eld N(5)-((R)-3-hydroxybutyryl)-N(5)-hydroxy-l-ornithine.

13 y for N-succinyl-L-ornithine versus N-acetyl-L-ornithine.

14 emonstrated to be capable of decarboxylating l-ornithine.

15 olution on crystals grown in the presence of l-ornithine.

16 mpetes with iNOS by converting L-arginine to L-ornithine.

17 is action was antagonized in the presence of l-ornithine.

18 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (1, PT523), a nonpolyglutamatable antifolate

19 4-amino-4-deoxypteroyl)-N delta-isophthaloyl-L-ornithine (11), N alpha-(4-amino-4-deoxypteroyl)-N del

20 -amino-4-deoxypteroyl)-N delta-terephthaloyl-L-ornithine (12), and N alpha-(4-amino-4-deoxypteroyl)-N

21 pteroyl)-N delta-(4,5-dichlorohemiphthaloyl)-L-ornithine (13) were also synthesized.

22 -6-yl)ethyl]benzoyl]-N(delta)-hemipht haloyl-L-ornithine (2) and N(alpha)-[4-[5-(2,4-diaminoteridin-6

23 are hydroxylated, including 4R,5R-dihydroxy-L-ornithine, 4R-hydroxyl-L-proline, 3S,4S-dihydroxy-L-ho

24 of NOHA were antagonized in the presence of L-ornithine (500 microM), which suggests that in MDA-MB-

25 t-1-yn-4-yl]benzoyl]-N(delta)-h emiphthaloyl-L-ornithine (6) as analogues of N(alpha)-(4-amino-4-deox

26 H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were obs

27 nd produce sustained reduction in ammonia by L-ornithine acting as a substrate for glutamine synthesi

28 material via chemoselective acylation of the l-ornithine alpha-amino group using activated succinimid

29 h N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a PAD4 inactivator with

30 r N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a recently described pan

31 d N alpha-(4-amino-4-deoxy-10-methylpteroyl)-L-ornithine (AMPte-L-Orn, 3).

32 sponding bridged analogues of 5-deazapteroyl-L-ornithine and (6R,6S)-5-deaza-5,6,7, 8-tetrahydroptero

33 ation of N-acetyl-L-citrulline from N-acetyl-L-ornithine and carbamyl phosphate.

34 bridging water molecule between the shorter L-ornithine and key active site residues provides the st

35 fy candidate AdoMetDC/SpeD homologs encoding L-ornithine and L-arginine decarboxylases in bacteria an

36 putrescine, a polyamine, from extracellular L-ornithine and L-arginine.

37 ad dual specificity functioning well on both L-ornithine and L-lysine.

38 Moreover, poly-l-ornithine and laminin treatment restored YAP/TAZ level

39 sm-based NOS inhibitors, N(5)-(1-iminoethyl)-L-ornithine and N-(3-(aminomethyl)benzyl)acetamidine, pr

40 aims of this study were to determine whether L-ornithine and phenylacetate/phenylbutyrate (administer

41 this study provide proof of the concept that L-ornithine and phenylbutyrate/phenylacetate act synergi

42 pression of arginase in macrophages enhanced L-ornithine and putrescine production and consequently p

43 ginase and selected cells in media devoid of l-ornithine and putrescine, resulting in mixed populatio

44 0 cell line maintained its viability and its L-ornithine and spermine levels in the presence of NOHA.

45 roxy-nor-L-arginine, as well as the products L-ornithine and urea, complete a set of structural "snap

46 the urea cycle that converts L-arginine into L-ornithine and urea, is presently considered a pharmace

47 catalyzes the conversion of L-arginine into L-ornithine and urea, leading to the synthesis of polyam

48 SE I) and arginase II (ASE II) to synthesize L-ornithine and urea, the first being the precursor for

49 talyze the hydrolysis of L-arginine to yield L-ornithine and urea.

50 r pylori urea cycle hydrolyzes L-arginine to L-ornithine and urea.

51 loenzyme which hydrolyzes l-arginine to form l-ornithine and urea.

52 Arginase (RocF) hydrolyzes L-arginine to L-ornithine and urea.

53 ginase (EC 3.5.3.1) hydrolyzes l-arginine to l-ornithine and urea.

54 talyzes the hydrolysis of l-arginine to form l-ornithine and urea.

55 talyzes the hydrolysis of L-arginine to form L-ornithine and urea.

56 lloenzyme that hydrolyzes l-arginine to form l-ornithine and urea.

57 at catalyzes the hydrolysis of L-arginine to L-ornithine and urea.

58 Two functional pathways, L-ornithine and vitamin B6 biosynthesis, were associated

59 etection for Arg, Cit, L-arginino-succinate, L-ornithine, and L-arginine phosphate range from 50 amol

60 inhibitors (type 1), including L-isoleucine, L-ornithine, and L-citrulline, suppresses enzymatic acti

61 proceeds by hydroxylation and acetylation of L-ornithine, and later steps likely involve covalently b

62 and the rate of Schiff base interchange with L-ornithine are partially rate-limiting for the reaction

63 mino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L

64 ences, particularly the reduced affinity for L-ornithine, are sufficient to account for their biochem

65 We show that by using l-ornithine as a structure director, we can form new tem

66 of gigantic Mo Blue (MB) clusters 1-4 using l-ornithine as a structure-directing ligand.

67 RapL also accepts L-ornithine as a substrate, albeit with a significantly

68 utant enzymes, E274A ODC and C360A ODC, with L-ornithine as substrate the carbon isotope effect also

69 against OAT; measuring the transformation of L-ornithine at high concentrations by this assay is comp

70 a carbamoyl phosphate binding domain and an L-ornithine binding domain.

71 decay of this intermediate is accelerated by l-ornithine binding.

72 tructure of oxidized SidA without NADP(H) or l-ornithine bound (resting state).

73 L-Lysine and L-ornithine but not D-Arg produced currents with charact

74 in catalyzes the carbamylation of N-succinyl-L-ornithine but not L-ornithine or N-acetyl-L-ornithine,

75 of substrate binding for both l-arginine and l-ornithine, but it is not sufficient to encode the chan

76 )-methyl-L-arginine, and N(5)-(1-iminoethyl)-L-ornithine, but not the reversible inhibitor 7-nitroind

77 city of PDGF to up-regulate the transport of L-ornithine by inducing the expression of the genes for

78 he transcellular transport and metabolism of L-ornithine by vascular SMCs.

79 he decarboxylation of the optimal substrate, L-ornithine, by wild-type ODC, the observed carbon isoto

80 TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxyl

81 nge for the CD assay from 10 microM to 2.5 M L-ornithine concentration for this assay.

82 crystal structure of the N5-(1-iminopropyl)-L-ornithine:DDAH-1 complex indicates covalent bond forma

83 The E. coli argE-encoded N-acetyl-L-ornithine deacetylase has been cloned, expressed, and

84 east three times from AdoMetDC/SpeD, whereas L-ornithine decarboxylases arose only once, potentially

85 s of bona fide AdoMetDC/SpeD with homologous L-ornithine decarboxylases that possess two, unprecedent

86 Exogenous l-ornithine did not inhibit NOHA-induced caspase-8 activ

87 nhibitor); and (4) 10 mm N(5)-(1-iminoethyl)-l-ornithine dihydrochloride [endothelial NOS (eNOS) inhi

88 acid to protonate the leaving amino group of l-ornithine during catalysis, and this is a revised mech

89 idA forms a ternary complex with NADP(+) and l-ornithine during catalysis.

90 This siderophore contains N(5)-hydroxylated l-ornithines essential for iron binding.

91 N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo arginine biosynthesis and theref

92 N5-(1-iminopentyl)- and N(5)-(1-iminohexyl)-l-ornithine for neuronal NOS (1.7, 3, 20, >1,900 microM,

93 -L-ornithine but not L-ornithine or N-acetyl-L-ornithine, forming N-succinyl-L-citrulline.

94 The N(delta)-hemiphthaloyl-L-ornithine group of PT523 is less well defined, and the

95 e Cepsilon-NdeltaH2+ bond, yielding urea and L-ornithine(H+).

96 with the bisubstrate analog N-phosphonacetyl-L-ornithine has been solved at 1.85-A resolution by mole

97 opionic acid, 2, 4-diamino-L-butyric acid or L-ornithine, have been examined using circular dichroism

98 cB acts as a manganese-dependent N-carbamoyl-L-ornithine hydrolase that cleaves citrulline to form or

99 flavin- and NADPH-dependent hydroxylation of l-ornithine in ferrichrome biosynthesis.

100 ne and phosphate from carbamyl phosphate and L-ornithine in L-arginine biosynthesis.

101 ugh ATP-PP(i) exchange assay that EcdA loads L-ornithine in the first module.

102 le inhibitor of DDAH-1, N(5)-(1-iminopropyl)-l-ornithine, indicating this compound's bioavailability

103 c arginine analogues, including L-lysine and L-ornithine, inhibited L-arginine transport, whilst 2-me

104 em with Asp-263 and the alpha-amino group of L-ornithine, instead of with His-302 and Glu-310, as pre

105 Since L-ornithine is metabolized to growth-stimulatory polyami

106 High-quality data on the efficacy of L-ornithine L-aspartate (LOLA) in patients with cirrhosi

107 Data on the use of intravenous L-ornithine L-aspartate (LOLA) in the treatment of overt

108 ats treated with ammonia-lowering therapy by l-ornithine l-aspartate and rifaximin orally for 4 weeks

109 e (SNAP), and the NOS inhibitor N-iminoethyl-L-ornithine (L-NIO), we performed studies of isolated pe

110 idine-containing compound, N5-(1-iminoethyl)-L-ornithine (L-NIO).

111 mice and humans, converting L-citrulline to L-ornithine (L-Orn) and isocyanic acid and serving as a

112 h as L-lysine (L-Lys), L-arginine (L-Arg) or L-ornithine (L-Orn) induces acute pancreatitis in rodent

113 between rat nNOS and N5-(1-imino-3-butenyl)-L-ornithine (L-VNIO), a previously identified mechanism-

114 f NOS-1 with vinyl-L-N-5-(1-imino-3-butenyl)-L-ornithine (L-VNIO, 100 microM) or soluble guanylyl cyc

115 of NOS1 with vinyl-L-N-5-(1-imino-3-butenyl)-L-ornithine (L-VNIO, 500 micromol/L).

116 nce was found for the binding of L-arginine, L-ornithine, L-2,4-diaminobutyric acid, and L-alanine.

117 produced by pyridoxal 5'-phosphate-dependent L-ornithine, L-arginine, and L-lysine decarboxylases (OD

118 The cationic amino acids L-ornithine, L-lysine, L-homoarginine (which is not meta

119 rs of response to lactulose, probiotics, and L-ornithine-L-aspartate therapy in minimal hepatic encep

120 ors of response to lactulose, probiotics and L-ornithine-L-aspartate therapy in minimal hepatic encep

121 Lactulose, probiotics, L-ornithine-L-aspartate, and potassium-iron-phosphate-ci

122 ort that vinyl-L-NIO (N5-(1-imino-3-butenyl)-L-ornithine; L-VNIO) binds to and inhibits nNOS in compe

123 lectric field (dcEF) when cultured on a poly-L-ornithine/laminin coated surface, while the fetal-deri

124 rting from methyl N(delta)-benzyloxycarbonyl-L-ornithine led to 2-L-[5-[N-(2-amino-4(3H)-oxopyrido[2,

125 ne and L-arginine (tightly) and L-lysine and L-ornithine (less tightly) in the periplasm, interacts w

126 utants display markedly reduced affinity for L-ornithine, loss of substrate inhibition, alkaline shif

127 Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxyla

128 fining the contribution of the hemiphthaloyl-L-ornithine moiety to the exceptional in vitro antitumor

129 methods, using heterologously expressed N(5)-l-ornithine monooxygenase from the pathogenic fungus Asp

130 The remarkable specificity of the N(5)-l-ornithine monooxygenase-catalyzed reaction suggests ad

131 avoprotein VbsO acts as a pathway-initiating l-ornithine N(5)-hydroxylase, followed by VbsA, which tr

132 sid1 encodes L-ornithine N(5)-oxygenase, which catalyzes hydroxylatio

133 The sid1 and urbs1 genes encode L-ornithine N5-oxygenase and a GATA family transcription

134 doMetDC activity, and functional presence of L-ornithine or L-arginine decarboxylase activity in prot

135 AdoMetDC activity and instead decarboxylate L-ornithine or L-arginine.

136 -arginine is 550-fold higher than for either l-ornithine or l-lysine, which were decarboxylated with

137 xylation of the primary amine side chains of l-ornithine or l-lysine.

138 bamylation of N-succinyl-L-ornithine but not L-ornithine or N-acetyl-L-ornithine, forming N-succinyl-

139 Individually, L-ornithine or phenylbutyrate were similar to the BDL gr

140 e N(delta)-(phosphonoacetyl)-N(alpha)-acetyl-l-ornithine (PALAO) indicates that the carboxyl group on

141 th the bisubstrate analog N-(phosphonacetyl)-L-ornithine (PALO) has been determined at 2.8-A resoluti

142 talyzes the hydrolysis of L-arginine to form L-ornithine plus urea.

143 fective as a substrate for arginase-mediated L-ornithine production compared with L-arginine directly

144 Binding of N-phosphonacetyl-L-ornithine promotes domain closure.

145 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-l-ornithine (PT523) in comparison with RFC irrespective

146 -amino-4-deoxypteroyl)-Ndelta-hemiphthaloy l-L-ornithine (PT523, 3) were synthesized with a view to d

147 -amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523, 4) were synthesized via straightforw

148 ein suggest that B. fragilis uses N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo

149 -amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], reduced nicotinamide adenine dinucleotide

150 hich generates the polyamine putrescine from l-ornithine, reduces gastritis in mice and adenocarcinom

151 ized as a structurally unique eight-membered l-ornithine ring-containing jadomycin.

152 mined whether the transcellular transport of L-ornithine, the cationic amino acid precursor of polyam

153 -oxygenase, which catalyzes hydroxylation of L-ornithine, the first committed step of ferrichrome and

154 talyzes the NADPH-dependent hydroxylation of l-ornithine through a multistep oxidative mechanism, uti

155 e cyclodeaminase catalyzes the conversion of L-ornithine to L-proline by an NAD(+)-dependent hydride

156 annaschii have been shown to readily convert L-ornithine to L-proline.

157 thine decarboxylase (ODC), which metabolizes L-ornithine to polyamines, was also induced in H. pylori

158 ne decarboxylase (ODC)-catalyzed reaction of L-ornithine to putrescine and CO2.

159 al 5'-phosphate-dependent decarboxylation of l-ornithine to putrescine, a vital step in polyamine bio

160 N-Acetyl-l-ornithine transcarbamylase (AOTCase), rather than orni

161 in with those recently reported for N-acetyl-L-ornithine transcarbamylase indicates that amino acid r

162 upon substrate binding occurs in N-succinyl-L-ornithine transcarbamylase, while movement of the 80 l

163 ence that this protein is a novel N-succinyl-L-ornithine transcarbamylase.

164 Pea (Pisum sativum L.) ornithine transcarbamylase (OTC) antisera were used

165 The ability of thrombin to upregulate L-ornithine transport and direct its metabolism to growt

166 The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by h

167 40% stimulation of L-arginine, L-lysine and L-ornithine transport.

168 thrombin initially (0 to 2 hours) decreased L-ornithine uptake, whereas longer exposures (6 to 24 ho

169 ferring substrate specificity for N-succinyl-L-ornithine versus N-acetyl-L-ornithine.

170 rboxyl group is involved in binding N-acetyl-l-ornithine via a water molecule.

171 The potentiating effect of L-ornithine was reversed by the competitive inhibitor of

172 finding that PBCV-1 DC prefers l-arginine to l-ornithine was unexpected based on evolutionary analysi

173 or, N(alpha)-acetyl-N(delta)-phosphonoacetyl-L-ornithine, was synthesized and showed a midpoint of in

174 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an inhibition constant (

175 eal saline (placebo), OP, phenylbutyrate, or L-ornithine were administered after randomization.

176 d (6R,6S)-5-deaza-5,6,7, 8-tetrahydropteroyl-L-ornithine were also synthesized as potential inhibitor

177 ne, alpha-ketoglutarate, glyoxylic acid, and L-ornithine were used as dead-end analogues of saccharop

178 s associated with a decrease in affinity for L-ornithine, whereas stimulation was mediated by an incr

179 , and Aquifex showed a strong preference for L-ornithine, whereas the enzyme from Vibrio vulnificus (

180 le to interact with the delta-amino group of L-ornithine which attacks the carbonyl carbon of carbamo

181 er was resistant to cadaverine, L-lysine and L-ornithine, which inhibit the E. coli AdiC antiporter.

182 Arginase converts L-arginine to L-ornithine, which is the precursor of polyamines, which

183 typical saturation kinetics with respect to l-ornithine while substrate inhibition was observed at h

184 y and that the short isoform is inhibited by L-ornithine with a Ki of approximately 0.25 mM.