ライフサイエンスコーパス: L-serine

1 f d-serine dependent on astrocytic supply of l-serine.

2 domain acts as a codomain for the action of L-serine.

3 of synthesizing L-tryptophan from indole and L-serine.

4 ntermediate at any concentration of O-acetyl-l-serine.

5 a decrease in the affinity of the enzyme for L-serine.

6 ed by the endogenous compound N-arachidonoyl l-serine.

7 ct acetate and of the external aldimine with l-serine.

8 approximately 10-fold lower Km for O-acetyl-l-serine.

9 and to aminoacylate total E. coli tRNA with L-serine.

10 tural similarities to the natural substrate, L-serine.

11 The mammalian enzymes are not inhibited by L-serine.

12 a model protein, by a pathway that required L-serine.

13 e > phosphatidylethanolamine >> phosphatidyl-l-serine.

14 ed in solutions weakly buffered by substrate L-serine.

15 pyrrolidines 4, 5, and 6, from either D- or L-serine.

16 e structure of the binding site complex with L-serine.

17 harge and specific interactions with phospho-l-serine.

18 s obtained in the forward half-reaction with L-serine.

19 tris-2,3-dihydroxybenzoyl-L-serine and acyl-L-serine.

20 moc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine 1, N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cy

21 ipid bilayer 2-dioleoyl-sn-glycero-3-phospho-L-serine/1-palmitoyl-2-oleoyl-sn-glycero-3-phosph oethan

22 modest inhibitor, whereas the dithiophospho-l-serine 10 was a somewhat weaker inhibitor.

23 Maximal inhibitory concentration of L-serine (10 mM) alone had a rather modest inhibitory ef

24 H2S precursor l-cysteine (10 mm) but not by l-serine (10 mm) or either amino acid in the presence of

25 The primary deuterium isotope effect using L-serine 2-D is one on (V/K)serine and V in the steady s

26 is no primary deuterium isotope effect with L-serine 2-D.

27 2 microM), taurine (5.5 +/- 2.1 microM), and l-serine (2.8 +/- 1.0 microM) were identified in the per

28 .2 microM), GABA (0.11 +/- 0.04 microM), and L-serine (23 +/- 4 microM) were measured.

29 ine-based cross-linker (N,O-bis-methacryloyl l-serine, 3), versus the aspartic-acid-based cross-linke

30 investigate the mechanisms mediating [(14)C]L-serine (a system L substrate) transport into human pla

31 -methyltetradecanoyl)oxy)hexadecanoyl)glycyl-l-serine, abbreviated as l-serine-(R+S)-Lipid 654, to de

32 O-Phospho-l-serine also prevented aggregation of the protein under

33 arachidonoyl glycine), NASer (N-arachidonoyl-l-serine), anandamide, NADA (N-arachidonoyl dopamine), N

34 5'-phosphate-dependent enzyme that converts l-serine and (6S)-tetrahydrofolate to glycine and 5,10-m

35 otope effect of about 2 was measured on (V/K)L-serine and (V/K)ketomalonate and about 5.5 on V.

36 roxymalonyl-ACP from the primary metabolites l-serine and 1,3-bisphospho-d-glycerate.

37 ple, we find that Km(app) = 1.2+/-0.2 mM for L-serine and 5.6+/-2.2 mM for cysteamine, with kcat = 1.

38 his assay yielded Km(app) = 2.2+/-0.5 mM for L-serine and 6.6+/-2.2 for cysteamine, with kcat = 2.5+/

39 ar membranes formed from the condensation of L-serine and a long-chain acyl thioester.

40 cyclic lactone of tris-2,3-dihydroxybenzoyl-L-serine and acyl-L-serine.

41 famidates were synthesized in 60% yield from L-serine and allo-L-threonine, respectively.

42 s that are important for both recognition of l-serine and catalysis of ester formation.

43 gle time point assay using 14C-(C-1)-labeled L-serine and cysteamine as substrates, counting the thia

44 o be critical for the attractant response to L-serine and DHMA.

45 intermediates 4 and 5 from N-Cbz- and N-Boc-l-serine and diastereoselective reduction of the enones.

46 t of a large number of microswimmers towards L-serine and elucidate the associated collective chemota

47 The dissociation constants for the enzyme.L-serine and enzyme.H4folate complexes were determined a

48 enzyme that catalyzes the interconversion of L-serine and glyoxylate to hydroxypyruvate and glycine.

49 ize a range of noncanonical amino acids from l-serine and indole derivatives or other nucleophiles.

50 (TrpB), which catalyzes the condensation of l-serine and indole to l-tryptophan, to synthesize a ran

51 Monomers derived from l-serine and l-aspartic acid were synthesized and used t

52 The reactions of L-serine and L-cysteine with CBS resulted in the formati

53 a series of intermediates in the reaction of L-serine and L-homocysteine to form L-cystathionine.

54 strated increased maternal-fetal transfer of L-serine and L-leucine, but not glycine, following bolus

55 ligands derived from the natural amino acids l-serine and l-methionine.

56 s, viscosities and enthalpies of dilution of l-serine and l-proline have been determined in water and

57 ges in taste quality and hydration number of l-serine and l-proline in the presence of the studied pr

58 The SstT protein functions to transport L-serine and L-threonine by sodium transport into the ce

59 alitatively similar to the taste of sucrose, L-serine and L-threonine generate distinctive percepts.

60 e able to reliably discriminate sucrose from L-serine and L-threonine.

61 utions of [l-Ser + M + H](+) (where l-Ser is l-serine and M is a given monosaccharide), [l-Phe-Gly +

62 a catalyzes an NAD(+)-dependent oxidation of l-serine and methyl-l-serine but exhibits low activity a

63 biosynthesis begins with the condensation of L-serine and palmitoyl-CoA catalyzed by the PLP-dependen

64 synthesis commences with the condensation of L-serine and palmitoyl-CoA to produce 3-ketodihydrosphin

65 hat is normally formed by the conjugation of l-serine and palmitoyl-CoA.

66 did not show CBS activity with the substrate L-serine and required OAS exclusively.

67 ermediates in the forward half-reaction with L-serine and that the external aldimine of aminoacrylate

68 The coreceptor was inhibited by phospho-l-serine and to a lesser extent by phospho-d-serine but

69 S (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine) and neutral POPC (1-palmitoyl-2-oleoyl-sn-glyc

70 f the alpha-proton and the hydroxyl group of L-serine, and (3) that the rate of the overall reaction

71 e, L-vanyl-L-vanyl-L-valine, L-seryl-L-seryl-L-serine, and L-lysyl-L-lysyl-L-lysine at acid, neutral,

72 (SAT, EC 2.3.1.30), which produces O-acetyl-L-serine, and O-acetyl-L-serine sulfhydrylase (OASS, EC

73 nly found in the LFM composition-oleic acid, l-serine, and squalene.

74 ogenase has been solved with bound effector, l-serine, and substrate, hydroxypyruvic acid phosphate,

75 Once acetyl-CoA and l-serine are bound, an enzymic general base accepts a pr

76 cantly blunted when amino acids-particularly L-serine-are removed from the diet.

77 L-lysine, L-glutamic acid, or diglycine with L-serine as a major component.

78 etically encoded 4,5-dimethoxy-2-nitrobenzyl-l-serine as a transient active-site block, and its subse

79 lmitoyltransferase uses l-alanine instead of l-serine as its amino acid substrate.

80 d dual imprinted polymers to quantify D- and L-Serine at ultra trace level in aqueous and real sample

81 hough having no effect alone, N-arachidonoyl l-serine attenuated inhibition of human neutrophil migra

82 ding moieties are directly attached to a tri-l-serine backbone; although apparently minor, these stru

83 d media (CRCM) as functional molecules, with L-serine being a particularly strong candidate.

84 l differences seen in the native enzyme upon L-serine binding are not critical for inhibition, wherea

85 336V demonstrates that the minimal effect of L-serine binding leading to inhibition of enzyme activit

86 Pre-steady-state kinetic analysis of L-serine binding to lpLSD demonstrates that L-serine bin

87 main rotation of the subunits in response to L-serine binding.

88 We found that lactadherin, a phosphatidyl-l-serine-binding protein, blocked >99% of prothrombinase

89 of identical subunits that is inhibited when l-serine binds at allosteric sites between subunits.

90 L-serine binding to lpLSD demonstrates that L-serine binds to a second noncatalytic site and produce

91 In PGDH, L-serine binds to the ACT domain to inhibit catalytic ac

92 lusion chromatography) showed that O-phospho-l-serine binds to the phospholipid-binding region in the

93 C 1.1.1.95) is the first committed enzyme of l-serine biosynthesis in the phosphorylated pathway.

94 losis genome harbors all enzymes involved in l-serine biosynthesis including two PSP homologs: Rv0505

95 ur understanding of NLS as a disorder of the L-serine biosynthesis pathway and suggest that NLS repre

96 s in all three genes encoding enzymes of the L-serine biosynthesis pathway.

97 e involved in the first and limiting step in L-serine biosynthesis, were recently identified as the c

98 e that catalyzes the first committed step of l-serine biosynthesis.

99 ansferase, the enzyme for the second step in L-serine biosynthesis.

100 hosphatase, which catalyzes the last step of L-serine biosynthesis.

101 LS-linked mutants was dysregulation of the d/l-serine biosynthetic pathway, previously linked to both

102 )-dependent oxidation of l-serine and methyl-l-serine but exhibits low activity against beta-hydroxyi

103 so be induced by the external application of l-serine but not glycine to the Arabidopsis wild type, s

104 e sensitivity of the enzyme to inhibition by L-serine but not the extent of inhibition.

105 Pyruvate activation is competitive with L-serine, but activation of the enzyme is not compatible

106 cluding d-alanine, beta-alanine, glycine and l-serine, but not d-serine, triggered similar depolarizi

107 cement of the beta-acetoxy group of O-acetyl-l-serine by a thiol to give l-cysteine.

108 D-Serine, formed from L-serine by serine racemase (SR), is a physiologic coago

109 A receptor and is created by conversion from L-serine by serine racemase.

110 endogenous ligand for NMDARs generated from l-serine by the enzyme serine racemase (Srr).

111 agonist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR).

112 led from 2,3-dihydroxybenzoate (2,3-DHB) and l-serine by the nonribosomal peptide synthetases EntB an

113 our sites for dicaproyl-sn-glycero-3-phospho-L-serine (C(6)PS, a soluble form of PS); the heavy and l

114 ylserine, 1,2-dicaproyl-sn-glycero-3-phospho-l-serine (C6PS), binds to discrete sites on FXa, FVa, an

115 However, L-serine catabolism has a minimal effect on its fitness

116 act infection (UTI), but loss of both D- and L-serine catabolism results in attenuation.

117 lH4, and condensation of the 15N-indole with L-serine, catalyzed by tryptophan synthase.

118 binds AI-2 in the periplasm, and Tsr is the l-serine chemoreceptor.

119 titers were lower for factor VIII-O-phospho-l-serine complex compared with factor VIII alone.

120 r results suggest that factor VIII-O-phospho-l-serine complex may be beneficial to increase the physi

121 immunogenicity of the factor VIII-O-phospho-l-serine complex was evaluated in hemophilia A mice.

122 f important neuromessengers including D- and L-serine, D- and L-asparate, glutamate, GABA, serotonin,

123 We report here the characterization of L-serine deaminase from Escherichia coli, which is the p

124 L-Serine deaminases catalyze the deamination of L-serine

125 we show that deletion of the genes encoding L-serine deaminases SdaA and SdaB resulted in a mutant t

126 formation, pyridoxal 5'-phosphate-dependent l-serine decarboxylase (SDC) activity was readily detect

127 The L-serine dehydratase from Legionella pneumophila (lpLSD)

128 SDH (L-serine dehydratase, EC 4.3.1.17) catalyzes the pyridox

129 Bacterial L-serine dehydratases differ from mammalian L- and D-ser

130 reveals striking kinetic differences between L-serine dehydratases from Bacillus subtilis (bsLSD, typ

131 ence homology to be present in all bacterial L-serine dehydratases that utilize an Fe-S catalytic cen

132 solved in the presence and in the absence of L-serine demonstrated a clustering of significant angle

133 rocyclic cores allowed the identification of l-serine derived macrocycle 32 (Ki* = 3 nM, EC90 = 30 nM

134 BS-protected propargylic ethers 25 and 32 to l-serine-derived aldehyde 26, respectively, afforded oxa

135 The synthesis features the use of an L-serine-derived E-selective modified Julia olefination

136 Conversely, the binding of l-serine did not have a significant effect on the stoich

137 mprising either acidic DL-alpha-phosphatidyl-L-serine, dipalmitoyl (DPPS) or zwitterionic L-alpha-pho

138 show that 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] (DOPS) small unilamellar vesicles (SUVs) drama

139 sphoglycerol (DPPG), and dipalmitoyl phospho-l-serine (DPPS).

140 e C133W SPTLC1 mutant linked to HSAN1, a 10% L-serine-enriched diet reduced dSL levels.

141 One of the compounds, the l-serine ester serine biphenyl-4-carboxylate reversibly

142 H) reveals that the physiological inhibitor, l-serine, exerts its effect on at least two steps in the

143 e was observed in the progress curve for the L-serine external aldimine formation, indicating a hyste

144 esis was not detected in the T148A-catalyzed L-serine external aldimine formation.

145 d sulfate in preventing the formation of the L-serine external aldimine.

146 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly),

147 (Phgdh) enzyme required for the synthesis of l-serine from glucose.

148 Alternatively, elaboration of l-serine gave the corresponding enantiopure N,N-dibenzyl

149 LP enzymes were observed with the substrates L-serine, glyoxylate, and hydroxypyruvate.

150 icantly more persistent when it moves up the L-serine gradient than when it travels down the gradient

151 strong heading preference for moving up the L-serine gradient, while their speed does not change con

152 L-serine had no significant effect on hyperglycemia, bod

153 he well known role of d-serine in the brain, l-serine has recently been implicated in breast cancer a

154 ipids 2-10 having choline, ethanolamine, and l-serine headgroups were synthesized, and the inhibitory

155 these polar residues for selecting substrate L-serine, however, did show activity with OAS.

156 of the external aldimines with L-cysteine or L-serine; (ii) chloride and sulfate increase the externa

157 Likewise, enzymatic removal of extracellular l-serine impaired LTP, supporting an l-serine shuttle me

158 s C), this electrode was again modified with L-Serine imprinted acrylamide functionalized fullerene m

159 ation of k-OptForce to the overproduction of L-serine in E. coli and triacetic acid lactone (TAL) in

160 e report that l-threonine may substitute for l-serine in the beta-substitution reaction of an enginee

161 enantioselectively esterify citric acid with l-serine in the first committed step of achromobactin bi

162 oli LF82 shifts its metabolism to catabolize L-serine in the inflamed gut in order to maximize its gr

163 tation by abstraction of the alpha proton of L-serine in the SGAT reaction.

164 acteria, but contains L-theronine instead of L-serine in the trilactone backbone.

165 Thus, the ability to catabolize L-serine increases bacterial fitness and provides Entero

166 rence for d-glucose compared with isocaloric l-serine independently of the perception of sweetness.

167 is found to contain homochiral L-alanine and L-serine indicating the presence of extant or recently e

168 (Y158F/Y226V) did not display activity with L-serine, indicating indispensability of these polar res

169 must be bound to the anion-binding site for l-serine inhibition, providing a potential mechanism for

170 L-Serine inhibits the catalytic activity of Escherichia

171 Indeed, supplementing L-serine into NR cultures extended CLS through a mechani

172 cine (L-pHPG) into positions 1, 3, and 5 and L-serine into position 4.

173 at the formation of the external aldimine of L-serine is faster than the formation of the aminoacryla

174 The concentration of luminal L-serine is largely dependent on dietary intake.

175 The second, noncatalytic site for L-serine is likely to be the ASB domain (beta domain) of

176 Whereas l-serine is not transported, serine racemase, the synthe

177 a coli d-3-phosphoglycerate dehydrogenase by l-serine is positively cooperative with a Hill coefficie

178 O-acetyl-L-serine, suggesting that O-phospho-L-serine is the likely substrate in vivo.

179 serine-O-phosphate (L-SOP), the precursor of L-serine, is a potent agonist against the group III meta

180 racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylin

181 vation can be eliminated by higher levels of L-serine, it may be that this second site is actually a

182 e product, SbnI, was determined to be a free l-serine kinase that produces O-phospho-l-serine (OPS),

183 further modified with l-cysteine (l-Cys) and l-serine (l-Ser).

184 f a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-

185 threonine, l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

186 ty and chemotactic responses to L-aspartate, L-serine, L-leucine, and Ni(2+) of WT and chemotactic-mu

187 regulating seven of those polar metabolites (L-serine, L-leucine, glucose, fructose, myo-inositol, ci

188 nsor is high over other amino acids, such as L-serine, L-leucine, L-aspartic acid, L-glutamic acid, h

189 aldimine dissociation constants for O-acetyl-L-serine, L-methionine, and 5-oxo-L-norleucine; (iii) ch

190 some difficulty discriminating sucrose from L-serine, L-threonine, maltose, fructose, and glucose.

191 A mechanism whose overall effect is to keep L-serine levels from accumulating to high levels while n

192 te-limiting step in the reaction at limiting l-serine levels is likely formation of the tetrahedral i

193 fferent amounts, but only the (R)-isoform of l-serine-Lipid 654.

194 Two PSMA-I&T-derived inhibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moie

195 based on the initial amount of the starting L-serine material.

196 ide (12) and sulfone (18) derived from N-Boc-L-serine methyl ester acetonide (9), affording two novel

197 o aziridinomitosenes had been developed from l-serine methyl ester hydrochloride.

198 ting from commercial N-tert-butyloxycarbonyl-L-serine methyl ester is described.

199 esis of (+)-saxitoxin in 14 steps from N-Boc-l-serine methyl ester.

200 3,4-bis(acetyloxy)phenyl] -1-oxo-2-propenyl]-L-serine methyl ester; compound 1] that selectively modi

201 Products of the CysE enzyme (OAS, N-acetyl-L-serine [NAS], O-acetyl-L-threonine, and N-acetyl-L-thr

202 dent degradation of the isoindole derivative L-serine-NDA-beta-mercaptoethanol was found to follow ps

203 r 1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-L-serine] (negatively charged, POPS) or 1-palmitoyl-2-ol

204 sphatidylserine synthase (CDP-diacylglycerol:l-serine O-phosphatidyltransferase, EC 2.7.8.8) is one o

205 oic acid (2-PMPA), quisqualic acid (QA), and L-serine O-sulfate (L-SOS), at 1.72, 1.62, and 2.10 A re

206 L-serine-O-phosphate (L-SOP), the precursor of L-serine,

207 t binds weakly to another endogenous ligand, L-serine-O-phosphate (L-SOP), which antagonizes the effe

208 reported previously, the clear exception is L-serine-O-phosphate (L-SOP), which strongly activates g

209 R agonists l-2-amino-4-phosphonobutyrate and l-serine-O-phosphate or the physiological ligand l-gluta

210 avor of l-serine over the normally preferred l-serine-O-sulfate ( approximately 1200-fold change in k

211 nding and properly positioning the l-THA and l-serine-O-sulfate substrates and the l-erythro-beta-hyd

212 es the synthesis of l-cysteine from O-acetyl-l-serine (OAS) and inorganic bisulfide.

213 cement of the beta-acetoxy group of O-acetyl-L-serine (OAS) by a thiol to give L-cysteine.

214 in which the beta-acetoxy group of O-acetyl-L-serine (OAS) is replaced by bisulfide to give L-cystei

215 tution of the beta-acetoxy group of O-acetyl-l-serine (OAS) with inorganic bisulfide.

216 entrations of glutathione, Cys, and O-acetyl-l-serine (OAS), in shoot tissue, are strongly correlated

217 talyzes the conversion of serine to O-acetyl-L-serine (OAS).

218 noleic acid, pyruvic acid, palmitoleic acid, L-serine, oleic acid, myo-inositol, dodecanoic acid, L-m

219 free l-serine kinase that produces O-phospho-l-serine (OPS), a substrate for SB biosynthesis.

220 ndicate that PvSHMT can bind first to either L-serine or H4folate.

221 MurM is an aminoacyl ligase that adds l-serine or l-alanine as the first amino acid of a dipep

222 MurM, an aminoacyl-tRNA ligase that attaches L-serine or L-alanine to the stem peptide lysine of Lipi

223 ino acid derivatives which are prepared from L-serine or L-aspartic acid, respectively.

224 Supplementation with l-serine or removal of l-alanine independently restored

225 limination substrate specificity in favor of l-serine over the normally preferred l-serine-O-sulfate

226 r actions, alleviates negative regulation of L-serine:palmitoyl-CoA acyltransferase, upregulating pro

227 In the presence of N-palmitoyl L-serine phosphoric acid, a competitive inhibitor for th

228 Moreover, TNFalpha enhanced FLIP(L) serine phosphorylation, which was increased by activa

229 gh levels while not completely depleting the L-serine pool in the bacterial cell is proposed.

230 nd 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) 3:1 mol/mole and at neutral pH, the pept

231 C)/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS)) (2:1) but not from liposomes composed o

232 nd 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS), a negatively charged phospholipid, was

233 e, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS), and cholesteryl hemisuccinate (CHS).

234 PC), POPC, 1-palmitoyl-2-oleoyl-phosphatidyl-L-serine (POPS), or POPS mixed with 1-palmitoyl-2-oleoyl

235 erine deaminases catalyze the deamination of L-serine, producing pyruvate and ammonia.

236 The anionic phospholipid, phosphatidyl-L-serine (PS), is sequestered in the inner layer of the

237 Lactadherin is a phosphatidyl-L-serine (Ptd-L-Ser)-binding protein that decorates memb

238 L-aspartate but not on the key C3 compounds L-serine, pyruvate and L-lactate, showing that CanB is c

239 hexadecanoyl)glycyl-l-serine, abbreviated as l-serine-(R+S)-Lipid 654, to develop a method that combi

240 As oral L-serine reduces the severity of neuropathy in the mouse

241 tment of the dithionite-reduced protein with L-serine results in a slight broadening of the feature a

242 III administered as a complex with O-phospho-l-serine retained in vivo activity in hemophilia A mice.

243 ion, transport experiments with radiolabeled l-serine reveal that the sloR operon is required for rap

244 CI, Garofalo and colleagues report that oral L-serine reverses the accumulation of deoxysphingolipids

245 ellular l-serine impaired LTP, supporting an l-serine shuttle mechanism between glia and neurons in g

246 zymic general base accepts a proton from the l-serine side chain hydroxyl as it undergoes a nucleophi

247 The dissolved chemoattractant (l-serine) significantly increases the accumulation and c

248 S (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (sodium salt)), and ganglioside GM1.

249 (DOPG)</=1,2-dioleoyl-sn-glycero-3-[phospho-l-serine] sodium salt (DOPS), indicating that the anioni

250 p-(hydroxyphenyl)glycine (pHPG) residues and L-serine, some where the latter is O-phosphorylated, O-a

251 ate to bind GLA domains by providing phospho-L-serine-specific and phosphate-specific interactions, r

252 The model invokes a single "phospho-L-serine-specific" interaction and multiple "phosphate-s

253 iral chromatographic analysis confirmed that L-serine sublimation produced DL-alanine, glycine, and e

254 contrast to wild-type mALAS2, is active with L-serine, suggest that active site Thr-148 modulates ALA

255 ter for O-phospho-L-serine than for O-acetyl-L-serine, suggesting that O-phospho-L-serine is the like

256 ich produces O-acetyl-L-serine, and O-acetyl-L-serine sulfhydrylase (OASS, EC 2.5.1.47), which conver

257 L-serine supplementation also improved measures of motor

258 hysiology of HSAN1 and raise the prospect of l-serine supplementation as a first treatment option for

259 d in patients with type 2 diabetes mellitus, L-serine supplementation could also be a therapeutic opt

260 lved in the pathology of DN and that an oral L-serine supplementation could be a novel therapeutic op

261 L-serine supplementation is a possible candidate therapy

262 creased plasma 1-deoxySL concentrations, and L-serine supplementation lowered 1-deoxySL concentration

263 In a pilot study with 14 HSAN1 patients, L-serine supplementation similarly reduced dSL levels.

264 Oral L-serine supplementation suppressed the formation of 1-d

265 t accumulates higher intracellular levels of L-serine than CFT073.

266 is more than 500-fold greater for O-phospho-L-serine than for O-acetyl-L-serine, suggesting that O-p

267 cytes affect d-serine levels by synthesizing l-serine that shuttles to neurons to fuel the neuronal s

268 he hypothesis that complexation of O-phospho-l-serine, the head group of phosphatidylserine, with the

269 By incorporating L-alanine in place of L-serine, the mutant HSAN1-associated serine palmitoyltr

270 The l-serine-thioheptose dipeptide partial structure, known

271 kinase C alpha to activate the conversion of l-serine to d-serine by serine racemase.

272 d the most strongly associated locus for the L-serine to D-serine ratio in CSF.

273 cytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA r

274 ne racemase (SR) is the enzyme that converts L-serine to D-serine.

275 tylation of the side chain hydroxyl group of l-serine to form O-acetylserine, as the first step of a

276 c enzyme involved in conversion of O-phospho-l-serine to l-serine, was characterized in this study.

277 tack of the enzyme-bound citryl adenylate by l-serine to produce the homochiral ester.

278 atalyzes a hydroxymethyl group transfer from L-serine to tetrahydrofolate (H4folate) to yield glycine

279 show a shift from their canonical substrate L-serine to the alternative substrate L-alanine.

280 5'-phosphate (PLP)-dependent dehydration of L-serine to yield pyruvate and ammonia.

281 ely 2, whereas the binding of the inhibitor, l-serine, to the apoenzyme displays positive cooperativi

282 n difluoride)undecanoyl-sn-glycero-3-phospho-L-serine (TopFluor-PS), a synthetic fluorescent PS analo

283 es of system L were distributed to MVM, with L-serine transport attributed to LAT2.

284 tive framework to test the 2 hypotheses that l-serine transport occurs by either obligate exchange or

285 nes of both siderophores, while only the tri-l-serine trilactone is a substrate of Fes.

286 l could only account for experimental [(14)C]L-serine uptake data when the transporter was not exclus

287 In fact, the absence of genes involved in L-serine utilization reduces the competitive fitness of

288 anobilayers in which PS headgroups contained l-serine versus d-serine.

289 hat valanimycin is derived from l-valine and l-serine via the intermediacy of isobutylamine and isobu

290 hat valanimycin is derived from L-valine and L-serine via the intermediacy of O-(L-seryl)isobutylhydr

291 Astrocytic l-serine was proposed to regulate NMDAR activity by shut

292 When instead of glycine, L-serine was reacted with ALAS, a lag phase was observed

293 olved in conversion of O-phospho-l-serine to l-serine, was characterized in this study.

294 uses l-alanine over its canonical substrate l-serine, we also investigated the effects of substrate

295 ese residues are necessary for inhibition by l-serine when it binds to the regulatory domain.

296 The enzyme catalyzes the reaction of L-serine with L-homocysteine to form L-cystathionine thr

297 a-synthase (CBS) effects the condensation of l-serine with l-homocysteine to form l-cystathionine.

298 could be observed for glycine, d-serine, and l-serine with statistical confidence.

299 termediate can be formed from l-cysteine and l-serine with the S272A,D mutant enzymes, but not with t

300 H that it is very sensitive to inhibition by L-serine, with an I(0.5) = 30 microm.

301 , while in the presence of hydrogen sulfide, L-serine yielded L-cysteine.