ライフサイエンスコーパス: L-tryptophan

1 e by catalyzing the oxidative degradation of l-tryptophan.

2 a coli and of Proteus vulgaris is induced by L-tryptophan.

3 nd NO to nitrate aromatic substrates such as L-tryptophan.

4 doline), which slowly converts to dihydroiso-l-tryptophan.

5 chloro-L-tryptophan to generate 6,7-dichloro-L-tryptophan.

6 n free L-tryptophan to generate 6,7-dichloro-L-tryptophan.

7 cts first to chlorinate at the 7-position of L-tryptophan.

8 yme and is highly specific for its substrate l-tryptophan.

9 to bind RNA by binding up to 11 molecules of L-tryptophan.

10 a complex that catalyzes the biosynthesis of L-tryptophan.

11 el compounds, including (R/S)-warfarin and D/L-tryptophan.

12 ), which is activated to bind RNA by binding l-tryptophan.

13 icity of BsTrpRS to uniquely charge 5-hydoxy-l-tryptophan.

14 n chiral separations of (R/S)-warfarin and D/L-tryptophan.

15 e activity of the immobilized HSA for D- and L-tryptophan.

16 eroxide dismutase, catalase, or supplemental L-tryptophan.

17 etabolism in response to the accumulation of l-tryptophan.

18 with the same side chain length as N-methyl-L-tryptophan.

19 compete with turnover of MTOX with N-methyl-L-tryptophan.

20 petitive inhibitors with respect to N-methyl-L-tryptophan.

21 he last two reactions in the biosynthesis of L-tryptophan.

22 ent reaction of L-serine with indole to form L-tryptophan.

23 of fluorescence in presence of co-repressor, l-tryptophan.

24 ), which is activated to bind RNA by binding l-tryptophan.

25 uced by simultaneous injection of unlabelled L-tryptophan.

26 n the catabolism of the essential amino acid L-tryptophan.

27 high temperatures in the presence of excess L-tryptophan.

28 he most significant improvement observed for l-tryptophan.

29 he formation of 3-methyl-2-indolic acid from l-tryptophan.

30 responsible for the specific recognition of l-tryptophan.

31 ethylation of carbon 2 of the indole ring of L-tryptophan.

32 electivity from the C4 to the C5 position of L-tryptophan.

33 nding attenuation protein), which recognizes l-tryptophan.

34 ch higher specificity toward l-tyrosine than l-tryptophan.

35 tioclavine, two building blocks derived from L-tryptophan.

36 arrier-added (18)F fluorination of 5-hydroxy-l-tryptophan.

37 gatively associated with decreased levels of L-tryptophan.

38 off by low doses (500 muM) of the amino acid l-tryptophan.

39 petent to form a quinonoid intermediate from l-tryptophan.

40 non-nucleoside DNMT inhibitors, N-phthaloyl-l-tryptophan 1 (RG108) was first identified as inhibitor

41 1-15N-L-Tryptophan (1-15N-L-Trp) was synthesized from 15N-anil

42 the newly developed 1-(2-[(18)F]fluoroethyl)-L-tryptophan (1-L-[(18)F]FETrp) as a PET imaging probe f

43 ancreas using the PET tracer (11)C-5-hydroxy-l-tryptophan ((11)C-5-HTP).

44 alpha-(11)C-methyl-l-tryptophan ((11)C-AMT) is an amino acid PET tracer tha

45 alpha-(11)C-methyl-l-tryptophan ((11)C-AMT) PET imaging demonstrated increa

46 epileptic cortex, we used alpha-[11C]methyl-L-tryptophan ([11C]AMT) positron emission tomography (PE

47 he novel radiotracer 1-(2-(18)F-fluoroethyl)-l-tryptophan ((18)F-FETrp) may be useful to assess trypt

48 d tryptophan analog 5-(2-(18)F-fluoroethoxy)-l-tryptophan ((18)F-l-FEHTP) as a PET probe for tumor im

49 ile and indole (1.96-4.94mg/100g dw) whereas l-tryptophan (2.78mg/100g dw) and tryptamine (2.77mg/100

50 a, respectively; however, addition of excess L-tryptophan (200 microg/mL) to monolayers infected with

51 in 1 receptor antagonist [L732,138 (N-acetyl-L-tryptophan 3,5-bis(tri-fluoromethyl)benzyl ester)] nor

52 valine (1), L-leucine (2), L-isoleucine (3), L-tryptophan (4), L-phenylalanine (5), L-arginine (6) ha

53 Serotonin and 5-hydroxy-L-tryptophan (5-HTP) induce a head-twitch response in wi

54 cessed C. cibarius fruiting bodies contained l-tryptophan, 5-methyltryptophan, tryptamine, melatonin,

55 cterized enzymes exclusively produce 5-nitro-L-tryptophan, a previously unknown biosynthetic intermed

56 However, additional analyses revealed that L-tryptophan action in the P. vulgaris tna operon involv

57 says were used to study interactions between L-tryptophan-activated TRAP and synthetic RNAs.

58 Overall, our findings suggest that each L-tryptophan-activated TRAP subunit can bind one (G/U)AG

59 Cooperative binding of L-tryptophan activates TRAP so that it can bind to RNA.

60 mpetitive inhibitor with respect to N-methyl-L-tryptophan, acts as a noncompetitive inhibitor with re

61 n color increased from 2 days to 6 days with l-tryptophan addition.

62 nly displays in vitro activity with 7-chloro-l-tryptophan after reactivation with crude extract from

63 ptophan levels, and feeding worms with extra L-tryptophan also suppresses toxicity, suggesting that t

64 alpha-(11)C-methyl-L-tryptophan (AMT) PET allows evaluation of brain seroto

65 e the in vivo kinetics of alpha-(11)C-methyl-l-tryptophan (AMT), a PET tracer for tryptophan metaboli

66 es, including substrates (L-Trp and 1-methyl-L-tryptophan), an effector (3-indole ethanol), and an un

67 tophan sensing we examined the ability of 11 L-tryptophan analogues to support lymphocyte proliferati

68 little or no difference was seen for D- and L-tryptophan (analytes with weak retention).

69 dicating that both proteins are activated by l -tryptophan and bind RNA in essentially the same way.

70 ((1)H NMR) analysis revealed the presence of L-tryptophan and 1-carboxy-1-methyltetrahydro-beta-carbo

71 In contrast, L-tryptophan and 11 other D-amino acids were inactive.

72 Levels of 5-HT, its precursors L-tryptophan and 5-hydroxytryptophan and the metabolite

73 inary complex structures of PrnB with d- and l-tryptophan and d- and l-7-chloro-tryptophan.

74 allyltryptophan synthase were determined for L-tryptophan and DMAPP at 34 and 76 muM, respectively.

75 .1 s(-1) was calculated from kinetic data of L-tryptophan and DMAPP.

76 nit which is involved in the biosynthesis of L-tryptophan and folic acid.

77 X oxidation of the carbinolamine formed with L-tryptophan and formaldehyde yields N-formyl-L-tryptoph

78 sarcosine, or the carbinolamine formed with L-tryptophan and formaldehyde.

79 associated with MDD, particularly decreased L-tryptophan and kynurenic acid levels, and alterations

80 L-tryptophan and kynurenic acid were consistently downre

81 the Ki values for competitive inhibition by L-tryptophan and L-phenylalanine are similar for wild-ty

82 The release of 5-hydroxy-l-tryptophan and l-tryptophan was found in the greatest

83 ting a mixture of model fluorophores, glycyl-L-tryptophan and L-tryptophan with Cu2+ at pH 6.

84 yzes the oxidative demethylation of N-methyl-L-tryptophan and other N-methyl amino acids, including s

85 en at different ages, using alpha[11C]methyl-L-tryptophan and positron emission tomography.

86 properties of copolymers imprinted for Fmoc-l-tryptophan and prepared by two different methods.

87 microbiota-generated metabolites (5-hydroxy-L-tryptophan and salicylate) as activators of the aryl h

88 med preincubation experiments with 5-hydroxy-L-tryptophan and serotonin.

89 Computer simulations of the ESR spectra from l-tryptophan and several isotopically modified forms str

90 s in combination with enzyme kinetics (using l-tryptophan and substrate analogs) identified Arg(64),

91 Serotonin enhancing drugs, including L-tryptophan and, more recently, fluoxetine and paroxeti

92 ee amino acids (l-phenylalanine, l-tyrosine, l-tryptophan) and a polypeptide (epsilon-poly-l-lysine)

93 eroxide dismutase, mannitol, or supplemental L-tryptophan, and endothelial rickettsicidal activity ag

94 ulation of the repressor by its corepressor, L-tryptophan, and in addition may allow for recognition

95 H(2)O(2)-mediated oxidation of L-methionine, L-tryptophan, and L-cysteine residues in its active site

96 acids L-arginine, L-lysine, L-phenylalanine, L-tryptophan, and L-tyrosine.

97 he S377D alpha2 beta2 complex with L-serine, L-tryptophan, and other substrates results in the accumu

98 4-Aza-, 5-aza-, 6-aza-, and 7-aza-L-tryptophan are all very slow substrates (kcat < 1% of

99 ccamycin and staurosporine, two molecules of L-tryptophan are processed to a pyrrole-containing five-

100 ran-4-one (DDMP), N-(1-deoxy-d-fructos-1-yl)-l-tryptophan (ARP), Tryptophol (TRO), 2-(2-formyl-5-(hyd

101 The recent discovery of L-tryptophan as a potent attractant to red abalone (Hali

102 kynR renders P. aeruginosa unable to utilize L-tryptophan as a sole carbon source and decreases PQS p

103 Using alpha-[11C]methyl-L-tryptophan as a tracer for serotonin synthesis with po

104 ted very well simple indole derivatives with L-tryptophan as the best substrate.

105 Double reciprocal plots with N-methyl-L-tryptophan as the varied substrate are nearly parallel

106 d by the binding of the co-repressor ligand, l-tryptophan, as well as by conformational and dynamic p

107 and immunogenetic features of a new case of L-tryptophan-associated EMS, along with evidence of acti

108 protein has been determined in complex with L-tryptophan at 2.5 A resolution.

109 es of 5-dimethylallyltryptophan synthase for L-tryptophan at 25,588 s(-1).M(-1) and for other 11 simp

110 ues +36 to +92 of the trp leader RNA in 1 mM L-tryptophan at 37 degrees C.

111 substrate L-serine (betaK87T-Ser) or product L-tryptophan (betaK87T-Trp) at the active site of the be

112 However, the mode of L-tryptophan binding and the proposed RNA binding surfac

113 L-Tryptophan binding decreased kcat, increased affinity

114 s showed that ebselen enhanced nonproductive l-tryptophan binding, while circular dichroism indicated

115 s and measured the thermodynamics of ligand (L-tryptophan) binding by isothermal titration calorimetr

116 eductions, including loss of L-histidine and L-tryptophan biosynthesis.

117 Pd(0)-catalyzed linear prenylation at C4 of l-tryptophan boronic pinacol ester derivate, the latter

118 RebD on its own is incompetent with L-tryptophan but will convert the imine of indole-3-pyru

119 ves dissociating 2:1 complexes in EMSAs with L-tryptophan, but both 1:1 and 2:1 complexes are observe

120 5-hydroxy-l-tryptophan, but not 2-aminobicyclo-(2,2,1)-heptane-2-c

121 Indole, which is produced from l-tryptophan by commensal bacteria expressing tryptophan

122 S) that makes and releases cyclo-acetoacetyl-L-tryptophan (cAATrp), the tetramic acid that serves as

123 (PKS-NRPS) that generates cyclo-acetoacetyl-L-tryptophan (cAATrp).

124 Trazodone with L-tryptophan can treat sleep-disordered breathing (SDB)

125 n placental indoleamine 2,3-dioxygenase, the L-tryptophan-catabolising enzyme recently shown to regul

126 enine pathway (KP) is the principal route of L-tryptophan catabolism leading to the formation of the

127 poor survival and correlates negatively with L-tryptophan catabolism pathway.

128 e disorder of l-lysine, l-hydroxylysine, and l-tryptophan catabolism, associated with clinical presen

129 Trazodone/L-tryptophan caused dose-dependent reductions in respira

130 rator complex (trp-rep/op) with [ul-13C/15N]-L-tryptophan corepressor using a computer program implem

131 nts, L75F-TrpR and A77V-TrpR, in their holo (l-tryptophan corepressor-bound) form have been character

132 pR) of Escherichia coli in its apo (i.e., no l-tryptophan corepressor-bound) form.

133 L-tyrosine/3,4-dihydroxy-L-phenylalanine and L-tryptophan decarboxylases.

134 tep for indoleamine 2,3-dioxygenase-mediated L-tryptophan degradation and therefore for the normal ph

135 This also applies when L-tryptophan degradation has been stimulated by interfer

136 rboxylase (ACMSD) plays an important role in l-tryptophan degradation via the kynurenine pathway.

137 inhibit indoleamine 2,3-dioxygenase-mediated L-tryptophan degradation.

138 Induction was shown to be L-tryptophan dependent; however, the range of induction

139 In addition, ds2-try B 11 is comprised of an L-tryptophan derivative coupled to a D-proline moiety, t

140 Pictet-Spengler reaction by condensation of l-tryptophan derivatives with electron-poor and electron

141 inophilia-myalgia syndrome from contaminated L-tryptophan, diethylene glycol poisoning in Haiti, afla

142 lytic cycle, the novel amino acid dihydroiso-L-tryptophan (DIT) was used as an analogue of L-Trp.

143 d that when the novel amino acid, dihydroiso-L-tryptophan (DIT), reacts with the beta-site, the alpha

144 The backbone resonances of the TrpR-L-tryptophan-DNA complexes were assigned using triple-re

145 Trazodone/ L-tryptophan dose-dependently reduced sleep fragmentatio

146 han, N-acetylserotonin, 3-indoleacetic acid, l-tryptophan ethyl ester) in commercial beers is reporte

147 of RNAs from tryptophan-Sepharose using free L-tryptophan evokes one sequence predominantly (K(D) = 1

148 3-dioxygenase) is a competitive inhibitor of L-tryptophan flux through this transport system (Ki = 11

149 identical polymers, one imprinted with Fmoc-L-tryptophan (Fmoc-L-Trp) (MIP), the other nonimprinted

150 in a detailed thermodynamic study of a Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, eluted with

151 The crystal structure revealed that L-tryptophan forms nine hydrogen bonds with various amin

152 on TmTrpB's primary activity of synthesizing L-tryptophan from indole and L-serine.

153 shifted the pH optimum for the synthesis of L-tryptophan from pH 7.5 to 8.8.

154 UV-Vis spectroscopy, and bioassays, L-glycyl-L-tryptophan (Gly-Trp) was found to be the only dipeptid

155 mine 2,3-dioxygenase-mediated degradation of L-tryptophan has been studied using human placental chor

156 l-Tryptophan HFCs facilitated the simulation of fast-flo

157 -tryptophan and formaldehyde yields N-formyl-L-tryptophan in a relatively slow reaction that does not

158 red for NOS efficacy and is synthesized from l-tryptophan in a series of reactions that have not been

159 e absence of bound Ca2+, compared to that of L-tryptophan in aqueous solution (0.14).

160 tical carrier-mediated transport systems for L-tryptophan in brush border and basal membranes.

161 Blocking IDO activity with 1-methyl-d,l-tryptophan in hemTg mLECs prevented KYN formation, KYN

162 e to changes in intracellular levels of free l-tryptophan in many Gram-positive bacteria.

163 to bind RNA by binding up to 11 molecules of l-tryptophan in pockets formed by adjacent subunits.

164 The content of 5-hydroxy-l-tryptophan in the investigated samples ranged from 86.

165 Reaction of L-tryptophan in the presence of benzimidazole results in

166 After the enzyme is mixed with L-tryptophan in the rapid-scanning stopped-flow spectrop

167 droxylase oxidizes L-tryptophan to 5-hydroxy-L-tryptophan in the rate-determining step of serotonin b

168 mbination of serotoninergics, trazodone, and L-tryptophan, in our animal model of OSAHS, the English

169 , including l-tyrosine, l-phenylalanine, and l-tryptophan, in the reaction did not show any competiti

170 hibits ribosomal activity in the presence of l-tryptophan, inducing expression of the tnaCAB operon i

171 In the present study, we investigated L-tryptophan induction of the P. vulgaris tna operon, tr

172 ues in TnaC of P. vulgaris are essential for L-tryptophan induction, and for inhibition of peptide el

173 L-Tryptophan influx into villous explants is supported e

174 L-Tryptophan influx is enhanced 2.3-fold following in vi

175 2,3-dioxygenase expression, has no effect on L-tryptophan influx.

176 nce quenching measurements revealed that the l-tryptophan interacted with anthocyanins mainly through

177 n, we report the unprecedented conversion of l-tryptophan into l-4-Cl-Kyn catalyzed by four enzymes i

178 ent and selective incorporation of 5-hydroxy-l-tryptophan into mammalian proteins in response to the

179 biosynthesis is the oxidative conversion of l-tryptophan into the corresponding alpha-imine catalyze

180 These findings show transport of L-tryptophan into the trophoblast to be a rate-limiting

181 L-Tryptophan is an essential amino acid required for pro

182 An induction site activated by l-tryptophan is created in the translating ribosome duri

183 Basal membrane transport of L-tryptophan is more complex.

184 nt for quinonoid intermediate formation from L-tryptophan is reduced by at least 400-fold by treatmen

185 Brush border vesicle uptake of L-tryptophan is substantially into an osmotically active

186 expression of trpBA at a level analogous to L-tryptophan itself.

187 yzes the oxidative demethylation of N-methyl-L-tryptophan (k(cat) = 4600 min(-1)).

188 , L-methionine, hypoxanthine, palmitic acid, L-tryptophan, kynurenic acid, taurine, and 25-hydroxyvit

189 enase (IDO) is a rate-limiting enzyme in the L-tryptophan-kynurenine metabolic pathway.

190 cinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotid

191 iated transcription of enzymes implicated in L-tryptophan/kynurenine/nicotinamide adenine dinucleotid

192 (2+)) form and in complex with its substrate l-tryptophan ( l-Trp) was recently reported and revealed

193 A serotonergic precursor, 5-hydroxy-L-tryptophan (L-5HTP) (oxitriptan) (0.8 mg/kg), was admi

194 Amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) activat

195 The mutant protein binds the corepressor l-tryptophan (l-Trp) approximately ten times more weakly

196 site-directed variants during turnover with L-tryptophan (L-Trp) can be accounted for by the sequent

197 The kynurenine pathway is the major route of L-tryptophan (L-Trp) catabolism in biology, leading ulti

198 zes the initial and rate-determining step of l-tryptophan (l-Trp) metabolism via the kynurenine pathw

199 zes the initial and rate-determining step of L-tryptophan (L-Trp) metabolism via the kynurenine pathw

200 zes the initial and rate-determining step of L-tryptophan (L-Trp) metabolism via the kynurenine pathw

201 lator of immune responses through catalyzing l-tryptophan (l-Trp) oxidation.

202 se catalyzes the O(2)-dependent oxidation of L-tryptophan (L-Trp) to N-formylkynurenine (NFK) as part

203 that catalyzes the oxidative degradation of L-tryptophan (L-Trp) to N-formylkynurenine (NFK).

204 zes oxidative cleavage of the indole ring of L-tryptophan (L-Trp), converting it to N-formylkynurenin

205 tic potential, but rather to a deficiency in L-tryptophan (L-Trp), or in a L-Trp derivative.

206 ormation of indole-3-pyruvic acid (IPA) from L-tryptophan (L-Trp), the first step in a previously pro

207 ory nascent TnaC peptide in response to free L-tryptophan (L-Trp).

208 ansamination of l-phenylalanine, l-tyrosine, l-tryptophan, l-methionine, and l-leucine, are converted

209 on minimal media but not induced by N-methyl-L-tryptophan, L-tryptophan, or 3-indoleacrylate.

210 y the TRAP protein in response to changes in l-tryptophan levels.

211 , and xanthurenic acid excretion after a 2-g L-tryptophan load.

212 ess the utility of this approach, samples of L-tryptophan (LT) drug substance were analyzed from comm

213 Moreover, photooxidation of L-tryptophan mediated by TCP-C60 films was found in wate

214 This review will briefly describe L-tryptophan metabolism and present and discuss the most

215 Disruptions in L-tryptophan metabolism are reported in several neurolog

216 se 1 (IDO) catalyzes 1 rate-limiting step of L-tryptophan metabolism, and emerges as an important reg

217 Only L-tryptophan methyl and ethyl esters were able to stimul

218 e gram-scale synthesis of C7-boronated N-Boc-L-tryptophan methyl ester and the rapid synthesis of C7-

219 the 3,12-(Z)-isomer of roquefortine C, from L-tryptophan methyl ester hydrochloride and 4(5)-(hydrox

220 ydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide (GM 6001) increased brain inter

221 ydroxamidocarbonylmethyl)-4-methylpantanoyl]-l-tryptophan methylamide primarily blocked the degenerat

222 x electrons compared to the starting pair of L-tryptophan molecules.

223 Additionally, other compounds derived from l-tryptophan occurred during fermentation.

224 -HT and 5-hydroxyindole acetic acid, but not L-tryptophan or 5-hydroxytryptophan, were reduced in the

225 tor sequences, trpR(S)() and trpO(M)(), with L-tryptophan or 5-methyltryptophan as corepressor.

226 ia but not induced by N-methyl-L-tryptophan, L-tryptophan, or 3-indoleacrylate.

227 tzR, with a 120 fold preference for 7-chloro-L-tryptophan over L-tryptophan, then installs the second

228 ing alpha-imine catalyzed by the flavoenzyme l-tryptophan oxidase (VioA).

229 RebO is an L-tryptophan oxidase flavoprotein and RebD a heme protei

230 -phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluorophenyl ester (Fmoc-L-Trp(OPfp)),

231 hemisuccinate/R-oxazepam hemisuccinate, and L-tryptophan/phenytoin during their binding to HSA.

232 The use of alpha [11C] methyl-L-tryptophan positron emission tomography scanning has p

233 rms strongly support the conclusion that the l-tryptophan radical cation has been detected by ESR for

234 cilitate protein site assignment of observed l-tryptophan radicals as has been done for l-tyrosine ra

235 al level, the mechanism of C4-prenylation of l-tryptophan recently has surfaced to engage a debate be

236 lation of L-phenylalanine-, L-tyrosine-, and L-tryptophan-regulating catecholamine and serotonin synt

237 Peptides rich in L-histidine and L-tryptophan residues are selectively retained on most o

238 of sarcosine (N-methylglycine) and N-methyl-L-tryptophan, respectively.

239 at effectively prenylates the C3 position of l-tryptophan, resulting in products that mimic the struc

240 Reaction with [alpha-2H]-L-tryptophan results in significant primary kinetic isot

241 f the DNMT1 competitive inhibitor N-phthalyl-l-tryptophan (RG108).

242 ntal and computational efforts to understand l-tryptophan's role in protein catalysis of oxidation-re

243 d form upon anaerobic reaction with N-methyl-L-tryptophan, sarcosine, or the carbinolamine formed wit

244 to vinyl chloride, adulterated cooking oils, L-tryptophan, silica, silicone breast implants, organic

245 aman tensors from a recent study of N-acetyl-L-tryptophan single crystals.

246 ic oxide, reactive oxygen intermediates, and L-tryptophan starvation.

247 c amino acids, including l-phenylalanine and l-tryptophan, stereoselectively mobilized Ca(2+) ions in

248 bO shows significant preference for 7-chloro-L-tryptophan, suggesting its likely role as the natural

249 of EMS in 1989 was linked to consumption of L-tryptophan that had originated from a single source.

250 (A = GSK2251052A or its R-enantiomer, ref* = L-tryptophan) that gives rise to Cu(II)-bound dimeric co

251 and Drug Administration (FDA) on the sale of L-tryptophan, the incidence of EMS declined rapidly.

252 ld preference for 7-chloro-L-tryptophan over L-tryptophan, then installs the second chlorine at the 6

253 Tryptophan hydroxylase oxidizes L-tryptophan to 5-hydroxy-L-tryptophan in the rate-deter

254 Changing the corepressor from L-tryptophan to 5-methyltryptophan causes effects at res

255 ciated with the stereoselective oxidation of L-tryptophan to a tricyclic hydroperoxide via a previous

256 -dependent unidirectional stereoinversion of l-tryptophan to d-tryptophan with complete conversion.

257 econd chlorine at the 6-position of 7-chloro-L-tryptophan to generate 6,7-dichloro-L-tryptophan.

258 t halogenases that work sequentially on free L-tryptophan to generate 6,7-dichloro-L-tryptophan.

259 Results are presented for the binding of L-tryptophan to human serum albumin to exemplify the met

260 e which catalyzes the hydrolytic cleavage of L-tryptophan to indole and ammonium pyruvate.

261 e-lyase catalyzes the hydrolytic cleavage of L-tryptophan to indole and ammonium pyruvate.

262 ase can activate AHR signaling by converting l-tryptophan to indole-3-pyruvate.

263 the same oxidative ring cleavage reaction of L-tryptophan to N-formyl kynurenine, the initial and rat

264 TDO catalyzes the irreversible oxidation of l-tryptophan to N-formyl kynurenine, which is the initia

265 hat catalyze the O(2)-dependent oxidation of L-tryptophan to N-formyl-kynurenine.

266 indoleamine 2,3-dioxygenase, which converts l-tryptophan to N-formylkynurenine.

267 tution of the full biosynthetic pathway from l-tryptophan to the staurosporine and rebeccamycin aglyc

268 s the condensation of l-serine and indole to l-tryptophan, to synthesize a range of noncanonical amin

269 The mechanisms responsible for L-tryptophan transport at both the maternal- and fetal-f

270 These findings are in keeping with L-tryptophan transport being exclusively via system L (i

271 The physiological importance of L-tryptophan transport for placental indoleamine 2,3-dio

272 Since depletion of the essential amino acid L-tryptophan (Trp) affects immune response mechanisms, w

273 T) synthesized in the placenta from maternal l-tryptophan (TRP) reaches the fetal brain.

274 Since depletion of the essential amino acid L-tryptophan (Trp) severely affects various immune respo

275 teins that degrade the essential amino acid, l-tryptophan (Trp), along the kynurenine pathway.

276 l-tryptophan (Trp), an essential amino acid for mammals,

277 yme regulating de novo synthesis of NAD from l-tryptophan (Trp), designated the Trp-NAD pathway.

278 TsrM catalyzes the methylation of C2 in l-tryptophan (Trp).

279 sole surrogate for the canonical amino acid L-tryptophan (Trp).

280 id, lauric acid ('C12'), and the amino acid, L-tryptophan ('Trp'), modulate gastrointestinal function

281 tely constructed 2-substituted derivative of l-tryptophan undergoes conversion to a prephalarine stru

282 All processed extracts were shown to contain l-tryptophan (up to 8.92mg/100g dw).

283 one component of sparsomycin is derived from L-tryptophan via the intermediacy of (E)-3-(4-oxo-6-meth

284 5-MTP was synthesized from L-tryptophan via tryptophan hydroxylase-1 and hydroxyind

285 The amount of l-tryptophan was determined within the range of 1.63-4.6

286 The release of 5-hydroxy-l-tryptophan and l-tryptophan was found in the greatest number of samples

287 -mutated FgaPT2, whereas the activity toward l-tryptophan was less than 0.4% of that of the wild-type

288 A new polymorph of l-tryptophan was prepared through crystallization from t

289 he main bitter compounds were reported to be L-tryptophan, Wessely-Moser isomers apigenin-6-C-galacto

290 phenomena have been studied for caffeine and L-tryptophan, which bind to human serum albumin, and the

291 Uptake of L-tryptophan, which is markedly stereospecific, has a Km

292 erence for phosphoramidates containing d- or l- tryptophan, while the ec/Hs chimera adopts the human

293 on of 6,7-thiatryptophan in a way similar to L-tryptophan, while benzimidazole does not affect the pr

294 t a free radical formed from the reaction of l-tryptophan with Ce (4+) in an acidic aqueous environme

295 model fluorophores, glycyl-L-tryptophan and L-tryptophan with Cu2+ at pH 6.

296 ion was detected in the reaction mixtures of L-tryptophan with geranyl or farnesyl diphosphate.

297 The interaction of L-tryptophan with human serum albumin was used as a mode

298 IM862 is a synthetic dipeptide (L-glutamine L-tryptophan) with in vitro and in vivo antiangiogenic p

299 e have also examined aza and thia analogs of L-tryptophan, with the benzene ring of the indole replac

300 liary was chosen here for the preparation of L-tryptophans would be available from D-valine while the