ライフサイエンスコーパス: L-tyrosine

1 y modulate operator binding (gamma-S-ATP and L-tyrosine).

2 L-lysine, L-phenylalanine, L-tryptophan, and L-tyrosine.

3 kinetic activity toward L-phenylalanine over L-tyrosine.

4 -alkyl-l-cysteines, l-tyrosine, and 3-fluoro-l-tyrosine.

5 in a single step from carbobenzoxy-protected l-tyrosine.

6 thyl-l-tyrosine preferentially compared with l-tyrosine.

7 that required myeloperoxidase, H(2)O(2), and L-tyrosine.

8 ered radical located on the aromatic ring of L-tyrosine.

9 ect the cellular L-phenylalanine turnover to L-tyrosine.

10 or = 3 h by supplementation of the diet with L-tyrosine.

11 tyrosine to form the stable product 3-nitro-L-tyrosine.

12 uoro-L-tyrosine reacted at twice the rate of L-tyrosine.

13 fluoro-L-tyrosine was comparable to that for L-tyrosine.

14 c marker for Cl2-dependent oxidation of free L-tyrosine.

15 k showed pABA formation by CADD derives from l-tyrosine.

16 he presence of the substrate analog 3-fluoro-l-tyrosine.

17 [FeFe] hydrogenase originate from exogenous l-tyrosine.

18 in synthesis was imaged using 2-(18)F-fluoro-l-tyrosine.

19 order and for its substrate specificity for L-tyrosine.

20 L-tyrosine, (3) 5 mm BH(4), and (4) BH(4) + L-tyrosine.

21 para carbon-carbon bond formation to furnish L-tyrosines.

22 Analogues Dmt-Tic (2',6'-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic a

23 e value of PET using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET PET) during treatment.

24 O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) (7 studies, 172 lesions) demonstr

25 -established tracers O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) and (18)F-FDG in a murine model o

26 to investigate uptake of 2-(18)F-fluoroethyl-l-tyrosine ((18)F-FET) and l-[methyl-(3)H]-methionine ((

27 acid transport using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) and proton MR spectroscopy (MRS)

28 he amino-acid analog O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) enables the simultaneous assessme

29 ns using the tracer O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) from 555 brain tumor patients at

30 PET using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) has been shown to be a useful too

31 olabeled amino acid O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) has been shown to be of value for

32 PET with O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) has gained increasing importance

33 O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) is a radiolabeled artificial amin

34 T using the tracer O-(2-[(18)F]-fluoroethyl)-l-tyrosine ((18)F-FET) is the differentiation of tumor r

35 PET using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) is useful to detect residual tumo

36 cated that PET using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) may be helpful for solving this d

37 have suggested that O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET adds valuable clinical inform

38 ate the potential of O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET for differentiating local rec

39 st-enhanced MRI and O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) PET for response assessment in gl

40 tigated the value of O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET for treatment monitoring of i

41 Experience regarding O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET in children and adolescents w

42 he clinical value of O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET in the initial diagnosis of c

43 O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET is a well-established method

44 ted the potential of O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET to noninvasively detect malig

45 tients using dynamic O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET.

46 the value of dynamic O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET.

47 h suspected glioma, O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) PET; 3-T MRSI with a short echo t

48 PET using O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) provides important diagnostic inf

49 T with the amino acid O-(2-(18)F-fluorethyl)-L-tyrosine ((18)F-FET) to search for focal changes of di

50 ne ((18)F-FLT), and O-(2-(18)F-fluoro-ethyl)-l-tyrosine ((18)F-FET) were used as surrogate markers of

51 id transport such as O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET), 3,4-dihydroxy-6-(18)F-fluoro-l-p

52 and, for comparison, O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET).

53 amino acid tracer, O-(2-[(18)F]fluoroethyl)-l-tyrosine ([(18)F]FET), in the delayed brain tumor (DBT

54 The SgcC4 l-tyrosine 2,3-aminomutase (SgTAM) catalyzes the formati

55 In constrast, complexes with 2-fluoro-L-tyrosine, 2,3-difluoro-L-tyrosine, 2,5-difluoro-L-tyro

56 lexes with 2-fluoro-L-tyrosine, 2,3-difluoro-L-tyrosine, 2,5-difluoro-L-tyrosine, and 2,6-difluoro-L-

57 quinonoid absorbance peak at 500 nm, whereas L-tyrosine, 2-fluoro-L-tyrosine, and all difluoro-L-tyro

58 ansferred from a polarized Raman analysis of L-tyrosine-2,3,5,6-d(4) single crystals.

59 A (1) was determined to be (R)-beta-methoxy-L-tyrosine, (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxy

60 moc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine 3.

61 bond cleavage when challenged with 3-fluoro-l-tyrosine (3-F-Tyr) as a substrate.

62 n in water and a genetically encoded 3-amino-L-tyrosine (3-NH(2)Tyr) amino acid.

63 spectra of 2-fluoro-L-tyrosine and 3-fluoro-L-tyrosine (3-Y(f)) obtained with 229 nm excitation are

64 of (1) Ringer solution (control), (2) 0.5 mm L-tyrosine, (3) 5 mm BH(4), and (4) BH(4) + L-tyrosine.

65 acid identity (approximately 65%) with plant L-tyrosine/3,4-dihydroxy-L-phenylalanine and L-tryptopha

66 ecularly imprinted polymer (MIP) for 3-nitro-L-tyrosine (3NT), an oxidative stress marker associated

67 peptide N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4- methylcoumarin or the microtubule-

68 bstrate N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4-methylcouma rin, as well as the end

69 PAH) hydroxylates L-phenylalanine (L-Phe) to L-tyrosine, a precursor for neurotransmitter biosynthesi

70 A inhibition by peroxynitrite, and exogenous L-tyrosine abrogated the inhibition by peroxynitrite.

71 , and dithiothreitol, reversed and exogenous L-tyrosine abrogated the peroxynitrite-induced NCA inhib

72 table ligand for constructing a Sepharose 4B-L-tyrosine affinity matrix.

73 Comparison of the structure of SgTAM to the l-tyrosine ammonia lyase from Rhodobacter sphaeroides pr

74 se oxidation of synthetic 3-nitroso-N-acetyl-L-tyrosine and 2) peroxidase oxidation of free L-tyrosin

75 fically, resonance Raman spectra of 2-fluoro-L-tyrosine and 3-fluoro-L-tyrosine (3-Y(f)) obtained wit

76 Both l-tyrosine and 3-fluoro-l-tyrosine exhibit kinetic isoto

77 six non-natural alkaloids, in cascades from l-tyrosine and analogues.

78 pHA-lysine formation required L-tyrosine and cell activation; it was inhibited by pero

79 ntitative at physiological concentrations of L-tyrosine and chloride.

80 ated neutrophils at plasma concentrations of L-tyrosine and chloride.

81 y prepared in chiral nonracemic fashion from L-tyrosine and do not show a propensity to undergo racem

82 2-benzoylphenyl moiety were synthesized from L-tyrosine and evaluated as PPARgamma agonists.

83 that wild-type and mutant proteins can bind L-tyrosine and form quinonoid complexes with similar rat

84 was undetectable when BSA was incubated with L-tyrosine and HOBr, peroxynitrite, hydroxyl radical, or

85 vealed similar catalytic efficiency for both L-tyrosine and hydrogen peroxide.

86 ies at the B3LYP/6-31G** level of theory for L-tyrosine and its 3-fluorine substituted analog are com

87 This activity is subject to inhibition by L-tyrosine and its analogues and by ATP and ATP analogue

88 yproduct and two substrates: N(alpha)-acetyl-L-tyrosine and NA-DCVC.

89 ted gel validates the recognition pattern of L-tyrosine and optimizes the structure of the polymer it

90 s as a competitive inhibitor with respect to L-tyrosine and serves as an alternative substrate for th

91 significant discrimination between O-methyl-l-tyrosine and tyrosine.

92 , Wistar rats were treated with alpha-methyl-L-tyrosine and tyrosol.

93 Because l-tyrosine and uric acid are the only required germinant

94 ilar pathways (beginning with the amino acid L-tyrosine), and the pathway has been completely delinea

95 osine, 2,3-difluoro-L-tyrosine, 2,5-difluoro-L-tyrosine, and 2,6-difluoro-L-tyrosine exhibited much l

96 n reactions of TPL with S-alkyl-l-cysteines, l-tyrosine, and 3-fluoro-l-tyrosine.

97 peak at 500 nm, whereas L-tyrosine, 2-fluoro-L-tyrosine, and all difluoro-L-tyrosines, had a much red

98 e generation required myeloperoxidase, H2O2, L-tyrosine, and chloride ion; it was inhibited by the H2

99 were first exposed to myeloperoxidase, H2O2, L-tyrosine, and Cl- and then reduced with NaCNBH3.

100 l2, and 1 mM each phenylthiocarbamide (PTC), L-tyrosine, and denatonium benzoate.

101 etected in reduced reaction mixtures of BSA, L-tyrosine, and reagent HOCl.

102 al in the hydroxylation of L-phenylalanine-, L-tyrosine-, and L-tryptophan-regulating catecholamine a

103 pathways to lignin from L-phenylalanine and L-tyrosine are distinct beyond the formation of 4-coumar

104 L-phenylalanine and L-tyrosine are the only two natural substrates identifie

105 ability to utilize either L-phenylalanine or L-tyrosine as a sole source of carbon for growth.

106 thesis, exhibits minimal activity with 2-aza-L-tyrosine as an alternative substrate but generating (S

107 ble activity toward 2-aza-L-phenylalanine or L-tyrosine as an alternative substrate.

108 aled the identification of a C(3)-prenylated l-tyrosine as enzyme product.

109 irst report on an enzymatic C-prenylation of l-tyrosine as free amino acid and altering the substrate

110 7-DMATS was found to accept l-tyrosine as substrate as well and converted it to an O

111 no detectable beta-elimination activity with L-tyrosine as substrate.

112 by coupling sulphanilamide as the ligand and L-tyrosine as the spacer arm to a cyanogen bromide (CNBr

113 engineered to express tyrosinase, which uses L-tyrosine as the substrate to produce the strong optoac

114 two unnatural amino acids, hGln and O-methyl-L-tyrosine, at distinct positions within myoglobin.

115 The strained and distorted l-tyrosine-based biaryl system characteristic for mycocy

116 In particular, some members of a class of L-tyrosine-based compounds designed as selective agonist

117 the SgcC4-catalyzed interconversion between L-tyrosine, beta-tyrosine, and 4-hydroxycinnamate was me

118 c acid to p-hydroxyphenylpyruvic acid in the l-tyrosine biosynthetic pathway.

119 these were identified as L-phenylalanine and L-tyrosine but it may be that metabolically-related comp

120 ellular system could be replaced by HOCl and L-tyrosine but not by a wide variety of other oxidation

121 e generated p-hydroxyphenylacetaldehyde from L-tyrosine by a pathway inhibited by azide, cyanide, and

122 An acceptance of l-tyrosine by FgaPT2 was also observed in this study.

123 investigations indicated that activation of l-tyrosine by the K233A variant of Bacillus stearothermo

124 pe tyrosyl-tRNA synthetase and activation of l-tyrosine by the K233A variant.

125 In vitro results show that L-tyrosine can be hydroxylated nonenzymatically to the D

126 N-[3',4'-dihydroxy-(E)-cinnamoyl]-3-hydroxy-l-tyrosine (clovamide).

127 red by self-assembly of poly(L-glutamic acid-L-tyrosine) co-polymer with hematoporphyrin.

128 ctivation of human neutrophils adherent to a L-tyrosine coated glass surface also stimulated 3-chloro

129 nnosyltryptophan, pseudouridine, and O-sulfo-L-tyrosine concentrations associated with incident CKD (

130 ) residues and the bound l-phenylalanine and l-tyrosine, conferring the deamination reaction through

131 n the pH dependence of k(cat)/Km of TPL with L-tyrosine, conformational changes induced by binding of

132 required cofactor for catalysis, and maximal L-tyrosine conversion to L-DOPA is observed in the prese

133 N-termini consisting of Dmt (2',6'-dimethyl-l-tyrosine) coupled to a pyrazinone ring platform by mea

134 (k(cat)/K(m) = 4.1 x 10(4) M(-1) s(-1)), and l-tyrosine-d-leucine (k(cat)/K(m) = 1.5 x 10(4) M(-1) s(

135 lene hydrogen HFC data along with equivalent l-tyrosine data has led to a new computational method th

136 s recently biochemically characterized as an L-tyrosine decarboxylase (AtTYDC), whereas the function

137 l series of antidiabetic N-(2-benzoylphenyl)-L-tyrosine derivatives which are potent, selective PPARg

138 and C is reported that takes advantage of an l-tyrosine-derived diketopiperazine, a mycocyclosin anal

139 rted into hydroxytyrosol whilst alpha-methyl-L-tyrosine did not inhibit the biotransformation.

140 developed for the measurement of 3,5-diiodo-L-tyrosine (DIT) in serum.

141 orbance, as did the reaction of 3,5-difluoro-L-tyrosine, due to increased accumulation of quinonoid i

142 of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine, effective both in suppression of experimenta

143 Phagocytosis of L-tyrosine encapsulated in immunoglobulin- and complemen

144 (BAEE) and poly-l-lysine but not by benzoyl-l-tyrosine ethyl ester (BTEE).

145 tyl) amino]-1-cyclopentyl]carbonyl]-O-methyl-L-tyrosine ethyl ester), administered at 11.7 mg/kg po,

146 Both l-tyrosine and 3-fluoro-l-tyrosine exhibit kinetic isotope effects of approximat

147 e, 2,5-difluoro-L-tyrosine, and 2,6-difluoro-L-tyrosine exhibited much lower absorbance intensity at

148 s (e.g., Nalpha-acetyllysine and taurine) to L-tyrosine exposed to either HOBr/OBr- or the EPO-H2O2-B

149 Because L-tyrosine fate tracing is compatible with untargeted li

150 ta-tyrosine biosynthesis starting from 2-aza-L-tyrosine, featuring KedY4 as a putative MIO-containing

151 ) characteristics in O-(2-(18)F-fluoroethyl)-l-tyrosine (FET) PET and to evaluate its diagnostic pote

152 rognostic value of O-(2-[(18)F]-fluoroethyl)-L-tyrosine (FET) PET in not completely resectable glioma

153 urbed by replacement of Tyr225 with 3-fluoro-L-tyrosine (FlTyr) by in vitro transcription/translation

154 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-gly

155 erein is reported 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine (FOMT,6) a new fluorine-containing nonphospho

156 )) that continuously synthesizes L-DOPA from L-tyrosine for systemic distribution.

157 latent bioreactive amino acid fluorosulfate-L-tyrosine (FSY) was incorporated into human programmed

158 osine, 2-fluoro-L-tyrosine, and all difluoro-L-tyrosines, had a much reduced intensity for this peak.

159 Dietary supplementation with L-tyrosine has been inconsistent in these reported pregn

160 C was also examined after derivatization by L-tyrosine hydrazide.

161 within SM bundles were immunoreactive to PHA-L, tyrosine hydroxylase, and dopamine beta-hydroxylase,

162 onal antibodies were used to demonstrate PHA-L, tyrosine hydroxylase, dopamine beta-hydroxylase, phen

163 Steady-state kinetic analysis of L-tyrosine hydroxylation revealed similar catalytic effi

164 res of human IYD and its complex with 3-iodo-l-tyrosine illustrate the ability of the substrate to pr

165 report here the detection of the non-protein L-tyrosine iminoxyl radical generated by two methods: 1)

166 studied the response to supplementation with L-tyrosine in five maternal PKU pregnancies.

167 tyrosine and 2) peroxidase oxidation of free L-tyrosine in the presence of nitric oxide.

168 When this system acts on L-tyrosine in vitro, it forms o, o'-dityrosine, which is

169 The binding conformation of l-tyrosine indicates that C-H bond hydroxylation is init

170 ine family of enzymes that transforms Fe and L-tyrosine into an [Fe(CO)2(CN)] synthon that is incorpo

171 Among them, HydG converts l-tyrosine into CO and CN(-) to produce a unique l-cyste

172 hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the rate-limiting step

173 oration of the synthetic amino acid O-methyl-l-tyrosine into protein in response to an amber nonsense

174 The local infusion of L-tyrosine into the striatum or hippocampus during MDMA

175 e that adding a tyrosine derivative, 3-Nitro-L-tyrosine, into DMEM can mitigate the degradation of PS

176 trochemical point-of-care testing device for L-tyrosine is 0.1-100 muM in actual human fluids, which

177 L-tyrosine is a recognized biomarker of albinism, whose

178 l-Tyrosine is an essential aromatic amino acid required

179 The K(i) value of 2-aza-L-tyrosine is half that of 2-aza-DL-tyrosine, indicating

180 L-Tyrosine is the best substrate among those tested and

181 However, 2-aza-L-tyrosine is the most potent competitive inhibitor of T

182 roxyphenylalanine (L-DOPA), synthesized from L-tyrosine, is a direct precursor to dopamine.

183 oxyphenylalanine, an important metabolite of L-tyrosine, is differentially controlled by multiple fac

184 with an 8.5-fold lower affinity than that of l-tyrosine (K (D-Tyr)(d) = 102 microm) and exhibits a 3-

185 pproximately KIK(Abz)-NH(2) (Y(NO2), 3-nitro-L-tyrosine; K(Abz), epsilon-(2-aminobenzoyl)-L-Lys; hydr

186 bated with the dopamine precursor, 3-hydroxy-L-tyrosine (L-dopa), produce dopamine.

187 they were employed for the determination of l-tyrosine (l-Tyr) in human plasma from tyrosinemia-diag

188 omatic amino acid l-phenylalanine (L-Phe) to l-tyrosine (L-Tyr).

189 ted terphenyls)) on monolayers of l-cysteine-l-tyrosine, l-cysteine-l-phenylalanine, or l-cysteine-l-

190 s a random synthetic amino acid copolymer of L-tyrosine, L-glutamic acid, L-alanine, and L-lysine tha

191 nce of other aromatic amino acids, including l-tyrosine, l-phenylalanine, and l-tryptophan, in the re

192 ntial of three amino acids (l-phenylalanine, l-tyrosine, l-tryptophan) and a polypeptide (epsilon-pol

193 catalyzed transamination of l-phenylalanine, l-tyrosine, l-tryptophan, l-methionine, and l-leucine, a

194 , a mixture of various biologically relevant l-tyrosines, l-DOPA, and several catecholamines were res

195 ptor antagonist H-Dmt-Tic-OH (2',6'-dimethyl-L-tyrosine-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylat

196 te containing a diketopiperazine ring, cyclo(l-tyrosine-l-tyrosine) (cYY).

197 actual human fluids, which fully covers the L-tyrosine levels of healthy individuals and people with

198 An analogue of MACE2 containing 2,6-dimethyl-l-tyrosine (MACE4) showed the best potency and in vivo a

199 trong binding of this compound suggests that L-tyrosine may be bound to the active site of TPL as the

200 nthetic persulfide donor and an N-iodoacetyl l-tyrosine methyl ester (TME-IAM) trapping agent to expe

201 re prepared starting from l-phenylalanine or l-tyrosine methyl esters and supporting the imidazolidin

202 (short ragweed pollen allergoid adsorbed to L-Tyrosine + MPL) versus placebo in reducing allergic rh

203 1)C]-methionine and O-(2-[(18)F]fluoroethyl)-l-tyrosine (n = 1), and 6-[(18)F]fluoro-L-dopa (n = 2),

204 methionine (n = 6), O-(2-[(18)F]fluoroethyl)-l-tyrosine (n = 3), methyl-[(11)C]-methionine and O-(2-[

205 The mpk6-2 mutant was sensitive to 3-nitro-l-tyrosine (NO2 -Tyr) treatment with respect to mitotic

206 L-Tyrosine-oleylamine nanomicelles (MTyr-OANPs) were con

207 xiliary is prepared in four steps from N-Boc-L-tyrosine on a multigram scale in high yield and attach

208 e engineered E. coli strains produced 0.91 g/L tyrosine or 0.41 g/L l-DOPA from 22.5 g/L unpurified S

209 nd potassium cyanide, but preincubation with L-tyrosine or 4-hydroxycinnamate largely prevents this i

210 duced coordinately in the presence of either L-tyrosine or L-phenylalanine, but PhhB exhibits a signi

211 mine auxotrophy that was corrected by either L-tyrosine or thiazole (ThiH* mutants).

212 e of these compounds is the incorporation of l-tyrosine- or l-leucine-derived 4-alkyl-l-proline deriv

213 noxy]tyrosine), a non-fluorescent product of L-tyrosine oxidation by human phagocytes.

214 ylacetaldehyde (pHA) is the major product of L-tyrosine oxidation by the myeloperoxidase/hydrogen per

215 dihydroxyphenylalanine (L-DOPA) derived from L-tyrosine oxidation is a key post-translational modific

216 ficantly higher in B16F10 cells treated with l-tyrosine (P < 0.001).

217 e 3-carbomethoxypropionyl-L-arginyl-L-prolyl-L-tyrosine-p-nitroanili ne- HCl (S-2586).

218 nsport imaging using O-(2-(18)F-fluoroethyl)-l-tyrosine PET ((18)F-FET) and investigate whether (123)

219 ammonia is catalyzed by the inducible enzyme L-tyrosine phenol lyase (EC 4.1.99.2).

220 and N-(3-dehydrophenyl)pyridinium (c) toward L-tyrosine, phenylalanine, and tryptophan was investigat

221 oyl-L-serine-phosphoric acid and N-palmitoyl-L-tyrosine-phosphoric acid, which had been previously sh

222 larvae spores germinated only in response to l-tyrosine plus uric acid under physiologic pH and tempe

223 tyrosyl tRNA synthetase to activate O-methyl-l-tyrosine preferentially compared with l-tyrosine.

224 roughput L-tyrosine screen towards improving L-tyrosine production in Escherichia coli.

225 unction such as dimethylglycine and N-acetyl-L-tyrosine profiles as compared to C3GnT(+/+) littermate

226 d l-tryptophan radicals as has been done for l-tyrosine radicals.

227 f the rate of L-tyrosine, while 2,3-difluoro-L-tyrosine reacted at twice the rate of L-tyrosine.

228 However, 3,5-difluoro-L-tyrosine reacted to form a quinonoid intermediate at a

229 3-Fluoro-L-tyrosine reacted with tryptophan indole-lyase to produ

230 vivo site-specific incorporation of O-methyl-L-tyrosine reported previously, demonstrate that this me

231 e tyrosyl radical initiates cross-linking of L-tyrosine residues in proteins.

232 thetic polypeptide composed of glutamate and L-tyrosine residues to the myeloperoxidase-H2O2-L-tyrosi

233 y wall proteins in vivo, cross-linking their L-tyrosine residues.

234 es of 3.4 mM and 135 microM for 3- and 2-aza-L-tyrosine, respectively.

235 the reaction of tryptophan indole-lyase with L-tyrosine resulted in formation of external aldimine, w

236 Reaction of synthetic Cl-NO2 with N-acetyl-L-tyrosine results in the formation of 3-chlorotyrosine

237 of iodine substituents onto cyclo(l-tyrosyl-l-tyrosine) results in sub-muM binding affinity for the

238 machinery engineering and a high-throughput L-tyrosine screen towards improving L-tyrosine productio

239 In particular, we found that 3-SH-L-tyrosine shows excellent water solubility and incorpor

240 ing the 4-aminobenzohydrazide ligand and the l-tyrosine spacer-arm to CNBr-activated-Sepharose-4B.

241 introduce a new enzymatic transformation for L-tyrosine synthesis by demonstrating that the beta-subu

242 yrosine residues to the myeloperoxidase-H2O2-L-tyrosine system.

243 - as a substrate in the myeloperoxidase-H2O2-L-tyrosine system.

244 which showed much higher specificity toward l-tyrosine than l-tryptophan.

245 he presence of ring fluorine substituents in L-tyrosine that are remote from the site of the chemical

246 A series of analogues of cyclo(l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium tubercul

247 n reactions of both molecules, as well as of L-tyrosine, the amino-acid precursor of dopamine.

248 talyzes the conversion of L-phenylalanine to L-tyrosine, the rate-limiting step in the oxidative degr

249 ols, including nine amino acids (isoleucine, L-tyrosine, threonine, DL-tryptophan, L-valine, methioni

250 nd rpoD) exhibiting up to a 114% increase in L-tyrosine titer over a rationally engineered parental s

251 ecifically catalyzes the conversion of 2-aza-L-tyrosine to (R)-2-aza-beta-tyrosine, exhibiting no det

252 aminomutase that catalyzes the conversion of L-tyrosine to (S)-beta-tyrosine and employs 4-methyliden

253 ereospecifically catalyzes the conversion of L-tyrosine to (S)-beta-tyrosine in C-1027 biosynthesis,

254 The SgcC4-catalyzed conversion of L-tyrosine to (S)-beta-tyrosine proceeds via 4-hydroxyci

255 ls of phagocytosis human neutrophils convert L-tyrosine to 3-chlorotyrosine, indicating that a Cl2-li

256 is the key enzyme ensuring the conversion of l-tyrosine to dopaquinone, thereby initiating melanin sy

257 Exposure of the amino acid L-tyrosine to EPO, H2O2, and physiological concentration

258 ndicate that peroxidases use H2O2 to convert L-tyrosine to free tyrosyl radical.

259 reospecific 1,2-amino shift in the substrate l-tyrosine to generate (S)-beta-tyrosine.

260 vity of Orf13 for the ortho-hydroxylation of L-tyrosine to L-DOPA by a molecular oxygen dependent pat

261 roxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA.

262 xidase catalyzing the ortho-hydroxylation of L-tyrosine to L-DOPA.

263 e myeloperoxidase-H2O2-Cl- system to convert L-tyrosine to p-hydroxyphenylacetaldehyde (pHA).

264 loperoxidase-H2O2-chloride system to convert L-tyrosine to p-hydroxyphenylacetaldehyde.

265 The ability of microorganisms to degrade L-tyrosine to phenol, pyruvate, and ammonia is catalyzed

266 s an enzyme that catalyzes the conversion of L-tyrosine to phenol, pyruvate, and ammonia.

267 nosylmethionine (SAM) enzyme HydG lyses free l-tyrosine to produce CO and CN(-) for the assembly of t

268 execute the chloride-dependent conversion of L-tyrosine to the lipid-soluble aldehyde, p-hydroxypheny

269 , and Cl- to oxidize the aromatic amino acid l-tyrosine to the reactive aldehyde p-hydroxyphenylaceta

270 lyzes robust Na+-dependent, highly selective l-tyrosine transport.

271 The additions of 4 mM of L-Tyrosine (Tyr) and L-Aspartic acid (Asp) reduce produc

272 are synthesized from the aromatic amino acid l-tyrosine (Tyr) and replaced the otherwise ubiquitous p

273 genate pathway for L-phenylalanine (Phe) and L-tyrosine (Tyr) biosynthesis.

274 Furthermore, as is the case for l-tyrosine, tyrosyl-tRNA synthetase exhibits "half-of-th

275 ginosa metabolically prelabeled with [(13)C]-l-tyrosine, unveiling defective intraphagolysosomal HOCl

276 es the hydroxylation of l-phenylalanine into l-tyrosine utilizing the cofactors (6R)-l-erythro-5,6,7,

277 inonoid intermediate formation from 3-fluoro-L-tyrosine was comparable to that for L-tyrosine.

278 as measured, and its inhibition by O-phospho-L-tyrosine was determined.

279 Its catalytic efficiency toward l-tyrosine was found to be 4.9-fold in comparison with t

280 Finally, the (15)N(2)-diazirine from l-tyrosine was hyperpolarized by a parahydrogen-based me

281 d L-phenylalanine uptake and its turnover to L-tyrosine was identified in normal human melanocytes (n

282 at chlorination of the aromatic ring of free L-tyrosine was mediated by Cl2 and not by HOCl/ClO-.

283 The oxidative cyclization of L-tyrosine was optimized to avoid partial racemization a

284 e.g., Nalpha-acetyl,Nepsilon-bromolysine) by L-tyrosine was shown to result in the loss of reactive h

285 The turnover to L-tyrosine was significantly slower.

286 A single dose of 1.3 g L-tyrosine was sufficient to raise plasma tyrosine conce

287 tion partially depended on whether L-dopa or L-tyrosine was the substrate, suggesting that tyrosinase

288 -1-oxobutyl) amino]-1-cyclopentyl]-carbonyl]-L-tyrosine) was a potent dual inhibitor in vitro (IC50 (

289 The desired product, 3-ethynyl-L-tyrosine, was released from the complex by simply dilu

290 containing horseradish peroxidase, H2O2, and L-tyrosine, we detected free tyrosyl radical (a2,6H = 6.

291 asts, whereas the differences in turnover to L-tyrosine were insignificant, suggesting a pooling of L

292 s (l-histidine, l-tryptophan, l-proline, and l-tyrosine) were evaluated as chiral selectors (CS) to p

293 e of 5.5 for the aryl thiol modality of 3-SH-L-tyrosine, which matches the pH-dependent reactivity pr

294 onoid intermediate at about half the rate of L-tyrosine, while 2,3-difluoro-L-tyrosine reacted at twi

295 Complexation of 3-iodo-L-tyrosine with 9-borabicyclo[3.3.1]nonane (9-BBN) provi

296 The reaction of N-acetyl-L-tyrosine with NO2-/HOCl or authentic Cl-NO2 also produ

297 Preincubation of L-tyrosine with Orf13 prior to the addition of hydrogen

298 hocholines with Alzheimer's disease, O-sulfo-L-tyrosine with Parkinson's disease, glycine, xanthine w

299 The reaction of 3-fluoro-L-tyrosine with tyrosine phenol-lyase resulted in a peak

300 The reaction of L-tyrosine with tyrosine phenol-lyase resulted in rapid