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1                                              L. mexicana Ag-stimulated lymph node cell culture from t
2     OPLS modelling of the activities against L. mexicana using the mass spectrometry produced a less
3 ighest levels of activity were found against L. mexicana.
4  strong protection in recipient mice against L. mexicana infection, suggesting that attenuated L. don
5 ly acting and possessed good potency against L. mexicana (EC(50) = 120 nM), 30-fold selectivity for t
6 ma significantly enhances resistance against L. mexicana that is associated with a significant suppre
7 derivatives of 1 display IC50 values against L. mexicana GAPDH of 16 and 4 microM, respectively (3100
8                                     Although L. mexicana infection was associated with minimal expans
9          L. major (LV39), L. amazonensis and L. mexicana were the most efficient utilizers of leucine
10 nlike mammalian aldolases, the T. brucei and L. mexicana aldolases contain nonameric N-terminal type
11 to use the X-ray structures of T. brucei and L. mexicana GAPDHs containing bound NAD+ to design adeno
12 nge 2-12 microM for T. brucei, T. cruzi, and L. mexicana GAPDH's, and these compounds did not inhibit
13 ngs of atypical cutaneous leishmaniasis, and L. mexicana from lesion aspirates from infected hamsters
14             Sand fly gut populations of both L. mexicana and L. infantum were significantly reduced i
15 peed videomicrographs showed that T. brucei, L. mexicana and a T. brucei RNAi morphology mutant have
16 of chronic cutaneous leishmaniasis caused by L. mexicana.
17 eatment of cutaneous leishmaniasis caused by L. mexicana.
18 ort a model in which ligation of FcgammaR by L. mexicana-bound immunoglobulin G promotes IL-10 produc
19 rd a Th1-like response and control cutaneous L. mexicana infection.
20 nses and has a role in controlling cutaneous L. mexicana infection.
21 gh IL-10-deficient mice infected with either L. mexicana or L. amazonensis failed to control the lesi
22 y combining differential expression data for L. mexicana, L. major and Leptomonas seymouri, we have i
23 se-ubiquitin ligase (TKUL), is essential for L. mexicana to sustain macrophage infections and that TK
24 We have now solved the structure of ICP from L. mexicana by NMR and shown that it adopts a type of im
25  can provide protection against heterologous L. mexicana parasites by induction of a strong T cell re
26 copy cysteine protease B (CPB) gene array in L. mexicana is associated with decreased parasite virule
27   BTB 06237 also reduced parasite burdens in L. mexicana-infected J774 macrophages at low micromolar
28  cytokine production and profound defects in L. mexicana-specific Ig isotype class switching to IgG1
29 L-10 generated by IgG-FcgammaR engagement in L. mexicana infection.
30 l, and genetic dissection of ARG function in L. mexicana promastigotes establishes: (i) that the enzy
31 by targeting single- and multi-copy genes in L. mexicana, L. major, L. donovani, and L. infantum, we
32 maRIII in suppressing protective immunity in L. mexicana infection, likely through macrophage IL-10 p
33 library delivered loss-of-function screen in L. mexicana.
34 t a significant amount of the Ca2+ stored in L. mexicana amazonensis promastigotes and amastigotes is
35                             However, lpg2(-) L. mexicana amastigotes similarly lacking PGs but otherw
36 ransfected with a cosmid expressing multiple L. mexicana CPB genes, this parasite induced a significa
37 c. inoculation with 5 x 10(6) amastigotes of L. mexicana into the shaven rump, STAT6+/+ mice develope
38                               In the case of L. mexicana complex parasites (L. mexicana, L. pifanoi,
39  and elucidate its role in the cell cycle of L. mexicana.
40 ted with L. mexicana was due to a failure of L. mexicana to activate T cells.
41 oach featuring arginase-deficient mutants of L. mexicana lacking both alleles of the gene encoding ar
42 L-4 signaling is critical for progression of L. mexicana infection in genetically susceptible mice an
43 ese data indicate that cysteine proteases of L. mexicana are critical in suppressing protective immun
44  of IL-10 or FcgammaR leads to resolution of L. mexicana disease and support a model in which ligatio
45 y reported orthorhombic crystal structure of L. mexicana GAPDH (LmGAPDH): the unusual conformation of
46                    Two crystal structures of L. mexicana glyceraldehyde-3-phosphate dehydrogenase in
47                              Transfection of L. mexicana amazonensis cells with this recombinant plas
48  dependent upon IL-12p40, since treatment of L. mexicana-infected IL-10-/- mice with anti-IL-12p40 mo
49                           Antibody-opsonized L. mexicana induced IL-10 production by B6 macrophages i
50 n the case of L. mexicana complex parasites (L. mexicana, L. pifanoi, and L. amazonensis), a critical
51 espite ample levels of T cell proliferation, L. mexicana fails to induce substantial lymph node expan
52 espects, the lpg2(-)REV amastigotes resemble L. mexicana amastigotes.
53     Furthermore, B6 FcRgamma-/- mice resolve L. mexicana lesions, and lymph node cells from these mic
54                                      Second, L. mexicana infection fails to drive the differentiation
55 ishmaniasis caused by the New World species, L. mexicana and L. amazonensis, we analyzed their course
56                  In this study, we show that L. mexicana cysteine proteases suppress the antileishman
57                      The study suggests that L. mexicana CPA and CPB perform similar roles to the asp
58                                          The L. mexicana GAPDH subunit exhibits substantial structura
59                     Here, we investigate the L. mexicana kinesin LmxKIN29 (LmxM.29.0350), also called
60  associated with infection by members of the L. mexicana complex.
61                               The tip of the L. mexicana flagellum was frequently intimately associat
62  signaling in the intracellular stage of the L. mexicana life cycle.
63  a systematic loss-of-function screen of the L. mexicana transportome.
64  We now show that C3H mice infected with the L. mexicana deletion mutant (Deltacpb) initially develop
65  T cells (both CD4+ and CD8+) and heal their L. mexicana lesions, with parasite control.
66  from wild-type T. brucei (highly chiral) to L. mexicana (near-axial symmetry).
67 ow that FcgammaRIII KO mice are resistant to L. mexicana infection, resolving lesions in association
68 hermore, we found that T cells responding to L. mexicana infection were less able to differentiate in
69 tage of T cells proliferating in response to L. mexicana and L. major.
70             The initial antibody response to L. mexicana is an immunoglobulin G1 (IgG1) response, and
71 stronger IgG2a/c, IgG3, and IgM responses to L. mexicana infection and yet are more resistant to the
72 y not be the mechanism for susceptibility to L. mexicana infection, unlike for L. major infection.
73 n was secreted/released by these transfected L. mexicana parasites and that it possessed functional c
74                Upon challenge with wild-type L. mexicana, mice immunized either for short or long per
75 ow at rates comparable to those of wild-type L. mexicana-infected mice.
76                                        Using L. mexicana, Cas9-driven gene deletions indicate that BD
77  results also provide an explanation for why L. mexicana CPA/CPB-deficient mutants transform to amast
78  the minimal immune response associated with L. mexicana infection.
79 her the nonhealing phenotype associated with L. mexicana was due to a failure of L. mexicana to activ
80 tion progressed, STAT6+/+ mice infected with L. mexicana displayed significantly higher titers of Lei
81 ceptibility of BALB/c mice to infection with L. mexicana and L. amazonensis, does play a significant
82 infected FcgammaRIII knockout (KO) mice with L. mexicana.