ライフサイエンスコーパス: LAMP1

1 LAMP1 and LAMP2 proteins are highly abundant, ubiquitous

2 LAMP1 contains an IgA1-like hinge region with potential

3 LAMP1(+)TRAIL(+) astrocytes limit inflammation in the CN

4 lysosome-associated membrane glycoprotein 1 (LAMP1), and nicastrin (NCSTN) are highly enriched in CDV

5 and Lysosomal Associated Membrane Protein 1 (LAMP1) abundance.

6 d in lysosome associated membrane protein 1 (LAMP1) and is needed for growth of Salmonella induced fi

7 sed lysosomal-associated membrane protein 1 (LAMP1) and lysosomal-associated membrane protein 2 (LAMP

8 aves lysosome-associated membrane protein 1 (LAMP1) at pHs characteristic of the plasma membrane, ear

9 of lysosomal-associated membrane protein 1 (LAMP1) into culture media was significantly attenuated.

10 S-1, lysosome associated membrane protein 1 (LAMP1), and LAMP3 were localized to abnormal large granu

11 ined lysosome-associated membrane protein 1 (LAMP1), suggesting the possibility of OMV convergence wi

12 or, lysosomal-associated membrane protein 1 (LAMP1), to trigger virus fusion.

13 with lysosome-associated membrane protein 1 (LAMP1)-positive and LysoTracker-positive late phagosomes

14 and lysosome-associated membrane protein 1 (LAMP1)-positive intracellular compartment.

15 ar, lysosomal-associated membrane protein 1 (LAMP1)-positive organelles.

16 s of lysosome-associated membrane protein 1 (LAMP1).

17 and lysosome-associated membrane protein 1 (LAMP1).

18 of lysosomal-associated membrane protein 1 (LAMP1).

19 ruit lysosome-associated membrane protein 1 (LAMP1); the mechanism of LAMP1 recruitment remains uncle

20 sosomal associated membrane protein 1 and 2 (LAMP1/2) and is restored by the combined use of mTORC1 a

21 a normal granular expression; and in HPS-3, LAMP1, and LAMP3 exhibited a distinct less granular and

22 hat undergo internalization and routing to a LAMP1-enriched, lysosome-related organelle.

23 ARPE-19 CLN3-KO cells accumulate LAMP1 positive organelles and show lysosomal storage of

24 ufficient to pilot the effector to acidified LAMP1-positive lysosomal compartments, where WipB intera

25 mounts of Syntaxin6 and is unable to acquire LAMP1.

26 lla-containing phagosomes (SCP) and acquires LAMP1 by fusing with LAMP1-containing Golgi-derived vesi

27 el mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction prob

28 n iga mutant of N. gonorrhoeae cannot affect LAMP1 turnover and its growth in epithelial cells is dra

29 1 (AMP1) and its putative paralog LIKE AMP1 (LAMP1) impair RNA silencing by repressing the biogenesis

30 AMP1 and LAMP1 inhibit Pol II-dependent IR gene transcription by

31 We also show that AMP1 and LAMP1 inhibit siRNA-mediated silencing in a different me

32 RAB43 expression to the Golgi apparatus and LAMP1(-) cytoplasmic vesicles.

33 formation of LC3-positive autophagosomes and LAMP1-positive lysosomes.

34 ve late endosomes/multivesicular bodies, and LAMP1-positive lysosomes and (b) inhibition of its down-

35 ated membrane glycoproteins (LAMPs) CD63 and LAMP1 and the acid hydrolase cathepsin D.

36 rane, where LAMP1 was decreased and CD63 and LAMP1 redistributed from a punctate to uniform localizat

37 interaction between AP-1 sorting complex and LAMP1 on the surface of the transport vesicles is import

38 1 (Tyrp1), dopachrome tautomerase (Dct), and LAMP1 and 3 localization in HPS-3 melanocytes, as evalua

39 al proteins, such as TFEB, TMEM175, GBA, and LAMP1/2, marks the rising awareness about the importance

40 roteins and the prelysosomal markers HRS and LAMP1.

41 ker nor the endosomal markers EEA1, Hrs, and LAMP1.

42 An elevation of LC3-II and LAMP1 and downregulation of Mfn2 in mitochondrial fracti

43 agy-lysosomal proteins, including LC3-II and LAMP1.

44 t show increased presence of CD63(LAMP3) and LAMP1 indicating enhancement of the endolysosomal compar

45 agy effectors (such as ATG5, ATG12, LC3B and LAMP1) and AMPK-dependent activation of the transcriptio

46 ysosomal marker (LAMP1), increased LC3B- and LAMP1 interaction, and decreased interaction of sequesto

47 CvpD, and CvpE, labeled the PV membrane and LAMP1-positive vesicles when ectopically expressed as fl

48 cted by transmission electron microscopy and LAMP1 levels.

49 ins including the class II MHC molecules and LAMP1, a lysosomal resident protein, as well as CD63 and

50 d pronounced colocalization between MUC4 and LAMP1/LC3 (microtubule-associated protein 1A/1B-light ch

51 discovery of the lysosomal proteins NPC1 and LAMP1 as intracellular receptors for Ebola virus and Las

52 e to a shift in the localization of NPC1 and LAMP1 from LE/LY to biosynthetic vesicles called LAMP ca

53 ased interaction of sequestosome-1 (p62) and LAMP1 in DARPP-32-positive medium spiny neurons in HD mi

54 te in all cases intact AP3 being present and LAMP1 trafficking being rescued.

55 n of Lamp1, a lysosmal membrane protein, and LAMP1-positive aggregates; and (5) reduced clearance of

56 tochondrial material, autophagy proteins and LAMP1 form during hypoxia and that depletion of SYTL5 an

57 active zone or synaptic vesicle proteins and LAMP1, a lysosomal membrane protein.

58 acquired the endo-lysosomal markers Rab7 and LAMP1 and underwent exclusive retrograde movement.

59 EGR1; autophagy proteins MLP3B, SQSTM1, and LAMP1; and reduction of the endosomal protein RAB5A.

60 ein LAMP1 and that the frequency of YopD and LAMP1 association correlated with the level of caspase-1

61 auses inhibition of NK-cell cytotoxicity, as LAMP1 RNA interference (RNAi) cells fail to deliver gran

62 dance of lysosomal membrane proteins such as LAMP1.

63 s with pathological forms of tau, as well as LAMP1 and p62 in the hippocampal neurons of tauopathy mi

64 tro by DPPA3(1-60) and to a lesser extent by LAMP1/2.

65 e morphology or degranulation, but it causes LAMP1(+) lysosomes to engorge.

66 ly enhanced T-cell activation [CD69, CD107A (LAMP1), HLA-DR and PD-1(PDCD1) expression] and stimulate

67 nscription, and the expression of CD107a(+) (LAMP1) and granzyme B (GZMB) on CD8(+) T cells.

68 A four-gene classifier combining CEACAM4, LAMP1, PLA2G7, and PLAC8 RNA biomarkers was identified.

69 IgA proteases B1 and B2 cleave LAMP1 and mediate intracellular survival in respiratory

70 IgA proteases B1 and B2 cleave LAMP1.

71 ted that the Neisseria IgA1 protease cleaves LAMP1 (lysosome-associated membrane protein 1), a major

72 was observed for the amplification of CUL4A, LAMP1, TFDP1, and GAS6 genes (P < 0.001).

73 conclusion, our findings suggest that CUL4A, LAMP1, TFDP1, and GAS6 are targets for overexpression an

74 but not laforin (Epm2a(-/-) cells) decreased LAMP1, a lysosomal marker.

75 epileptic encephalopathies showed decreased LAMP1 expression, Lysotracker staining and increased org

76 Rab9 can measurably reverse SifA-dependent LAMP1 recruitment and the perinuclear location of the SC

77 of mice vaccinated with the chimeric Sig/E7/LAMP1 vaccinia remained tumor free 3 months after tumor

78 in early (Rab7 positive) and late endosomal (LAMP1 positive) sorting compartments, before targeting t

79 endo-lysosomal vesicle that is positive for LAMP1.

80 r553Cys), but not ClC-6(WT), generated giant LAMP1-positive vacuoles that were poorly acidified.

81 cumulations in neurons [beta-hexosaminidase, LAMP1(lysosome-associated membrane protein 1), SCMAS (su

82 We show here that human LAMP1 and LAMP2 bind cholesterol in a manner that buries

83 xport of APP from the Golgi, and we identify LAMP1(+) structures as the proximal destination of APP a

84 In LAMP1 RNAi cells, more perforin is retained outside of l

85 pH result in accumulation of HLA-B*35:01 in LAMP1(+) compartments and increase HLA-B*35:01 peptide r

86 e of IL-36, IL-36R increased accumulation in LAMP1+ lysosomes.

87 n of myelin-associated glycoprotein (MAG) in LAMP1(+)perinuclear vesicles that fail to migrate to the

88 anelle pH and no significant modification in LAMP1 expression.

89 A single glycosylated residue in LAMP1, present in susceptible species but absent in bird

90 overexpressing AGAP1 also exhibit increased LAMP1 trafficking via the plasma membrane.

91 rotein kinase Calpha levels while increasing LAMP1 abundance.

92 define how interferon signaling induces LAMP1(+)TRAIL(+) astrocytes, which cause death of inflam

93 shRNA in macrophages significantly inhibits LAMP1 recruitment on SCP.

94 ling endosomes, inhibited beta1AR entry into LAMP1(+) lysosomes, and as a result enhanced beta1AR rec

95 A candidate gene from human chromosome 13 is LAMP1, which encodes lysosomal membrane protein 1.

96 ted a comparative evaluation between this KI-LAMP1-APEX method and our two overexpression LAMP1-APEX

97 imary OLs deficient in Fig4 accumulate large LAMP1(+) and Rab7(+) vesicular structures and exhibit re

98 ion of early p40phox(+) phagosomes into late LAMP1(+) phagosomes.

99 ly (EEA1 and transferrin receptor) and late (LAMP1) endosomes.

100 ive for late endosomal (Rab7) and lysosomal (LAMP1) markers.

101 of phagosomal (EEA1 and Rab7) and lysosomal (LAMP1) proteins, thereby resulting in the reduction of t

102 Autophagic (LC3, p62), lysosomal (LAMP1, cathepsins), and cell death (TUNEL, caspase-3) ma

103 dly elevated markers specific for lysosomes (LAMP1 and LAMP2) and autophagosomes (LC3-II/I).

104 duced level of the lysosomal activity marker LAMP1 suggested impaired autophagosome-lysosome fusion.

105 localize with the lysosomal/endosomal marker LAMP1, forming discrete, punctate intracellular vesicles

106 ls, but rather with the late endosome marker LAMP1, as well as with Rab34 GTPase that is known to reg

107 lycogen, the late endosomal/lysosomal marker LAMP1 and the autophagy protein GABARAPL1.

108 uld be colocalized with the lysosomal marker LAMP1 but not with Golgi or nuclear markers.

109 with the appearance of the lysosomal marker LAMP1 on the cell surface, further suggesting the role f

110 ophagy protein LC3, and the lysosomal marker LAMP1 to Mtb-associated structures and are more permissi

111 -SMase colocalized with the lysosomal marker LAMP1, whereas V5-aSMase localized to the Golgi secretor

112 co-localization with the phagolysomal marker LAMP1; this signified altered intracellular trafficking

113 ween mHtt inclusions and a lysosomal marker (LAMP1), increased LC3B- and LAMP1 interaction, and decre

114 proteins, P62/LC3, and the lysosomal marker, LAMP1.

115 ion of the late phagosome maturation markers LAMP1 and lysosomal cathepsin, indicating delayed format

116 f lysosomes as a result of protease-mediated LAMP1 degradation.

117 ze the trafficking of Neuropeptide Y (NPY)-, LAMP1-, and RAB7-tagged organelles in thalamocortical ax

118 endent protein cleavage, and accumulation of LAMP1- and RAB7-positive organelles.

119 presence of CD63 on internal lamellae and of LAMP1 on the membrane surrounding the inclusions, indica

120 Thus, IgA1 protease cleavage of LAMP1 promotes intracellular survival of pathogenic Neis

121 result of IgA1 protease-mediated cleavage of LAMP1.

122 In addition, we observed global collapse of LAMP1(+) lysosomes, with some lysosomal membrane domains

123 ae (GC) increases the rate of degradation of LAMP1, a major integral membrane glycoprotein of late en

124 Disruption of expression of LAMP1 binding partner, adaptor protein 1 (AP-1) sorting

125 eased level of perforin in lytic granules of LAMP1-deficient cells, combined with disturbed motility

126 Inhibition of LAMP1 and LAMP2 promotes exosome release in ALD.

127 ing PLAC8 to colocalize with LC3B instead of LAMP1.

128 omycin A1 treatment, and increased levels of LAMP1, LAMP2, and RAB7 proteins required for lysosomal b

129 membrane protein 1 (LAMP1); the mechanism of LAMP1 recruitment remains unclear.

130 haves similarly to the general population of LAMP1-positive vesicles in terms of pH response to pharm

131 Reduction of LAMP1 expression affects the movement of lytic granules

132 sults in IgA1 protease-mediated reduction of LAMP1.

133 Mechanistically, down-regulation of LAMP1 or LAMP2 increased exosome release in hepatocytes

134 AP-3 deficiencies affected the targeting of LAMP1, phosphatidylinositol-4-kinase type II alpha, and

135 n of DAT and leads to accumulation of DAT on LAMP1-positive endosomes.

136 y reporting that RNA granules 'hitchhike' on LAMP1-positive organelles using annexin A11 as a tether.

137 stasis and mitochondria, e.g. ATIC, RAB9A or LAMP1.

138 LAMP1-APEX method and our two overexpression LAMP1-APEX probes, achieving complementary coverage of b

139 KIP and Rab9 function to maintain peripheral LAMP1 distribution in cells.

140 DCmat infected with rVV-Sig-pp65-LAMP1 induced proliferation of pp65-specific CD4(+) clon

141 reover, infection of DCmat with rVV-Sig-pp65-LAMP1 resulted in at least equivalent presentation to CD

142 brane protein 1 targeting sequence (Sig-pp65-LAMP1) to target pp65 to the class II compartment.

143 ed with the late endosomal/lysosomal protein LAMP1 and that the frequency of YopD and LAMP1 associati

144 rocytes that expresses the lysosomal protein LAMP1(2) and the death receptor ligand TRAIL(3).

145 uired the late endosome and lysosome protein LAMP1.

146 M labeling with the lysosomal marker protein LAMP1.

147 he major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycopr

148 sed levels of the lysosomal membrane protein LAMP1, and increased levels of the autophagic markers LC

149 ular receptor, the lysosome-resident protein LAMP1.

150 n the amounts of the late endosomal proteins LAMP1 and CD63 and an increase in the amount of LAMP2.

151 Knockdown of the lysosomal membrane proteins LAMP1 and LAMP2 resulted in decreased cell viability, as

152 the distribution of seven key LEL proteins (LAMP1, LAMP2, CD63, Cathepsin D, TMEM192, NPC1, and LAMT

153 , the lysosome-associated membrane proteins, LAMP1 and LAMP2, from Pompe iPSC-CMs demonstrated higher

154 serial type 2 IgA1 protease cleaves purified LAMP1 in vitro.

155 intracellular storage of antigen in Rab11(+)LAMP1(+) compartments.

156 on of late endosomal proteins, such as Rab7, LAMP1, and CD63.

157 ith interactions with the endosomal receptor LAMP1 or interfere at another stage in entry that is com

158 ipB(-), sipD(-), sopB(-), or sopE(-) recruit LAMP1, demonstrating the specificity of SipC in this pro

159 by other intracellular pathogens to recruit LAMP1.

160 that mitochondrial-localized VPS41 recruited LAMP1- and LAMP2A-positive vesicles resembling LAMP carr

161 nd membrane contents, in addition to reduced LAMP1 membrane recruitment.

162 is increased by alcohol, targets mTOR, Rheb, LAMP1, and LAMP2 in the authophagy pathway.

163 if than our previous ratiometric sensor, RpH-LAMP1, is well tolerated by the model organism Drosophil

164 Therefore, we sequenced LAMP1 cDNAs from homozygous mnd mice and unrelated wildt

165 In addition, we found that serum LAMP1 and beta-galactosidase levels were significantly d

166 ned, and expression analysis shows a similar LAMP1 protein distribution in wildtype and mutant mice,

167 ha, BLOC-1, or AP-3 complexes led to similar LAMP1 phenotypes.

168 re selectively in anterograde direction than LAMP1 and RAB7.

169 We found that LAMP1 in the mouse lies within the region of the mnd mut

170 This revealed that LAMP1- and RAB7-tagged organelles move significantly fas

171 We show that LAMP1 silencing causes inhibition of NK-cell cytotoxicit

172 Altogether, we show that LAMP1(+)TRAIL(+) astrocytes limit CNS inflammation by in

173 A1 protease is directly responsible for this LAMP1 degradation.

174 EGF exhibited delayed trafficking of EGF to LAMP1-positive late endosomes and lysosomes and slowed E

175 the cell surface, while IFITM3 localizes to LAMP1-containing compartments.

176 r intracellular compartments but migrates to LAMP1(+) endosomes on stimulation with a TLR3 ligand.

177 oincided with an altered CCV membrane, where LAMP1 was decreased and CD63 and LAMP1 redistributed fro

178 While LAMP1, LAMP2, and Cathepsin D were abundant across LELs,

179 ic pH optimum (~4.6) and colocalization with LAMP1 verified lysosomal functioning of ARSK.

180 We observed VacA colocalization with LAMP1- and LC3-positive vesicles in both the presence an

181 ng endosomes and reduced colocalization with LAMP1-positive lysosomes.

182 PRCP antigen does not colocalize with LAMP1 on nonpermeabilized HUVECs, but it partially coloc

183 lls and found the majority colocalizing with LAMP1-positive compartment and not with the peroxisomal

184 omes (SCP) and acquires LAMP1 by fusing with LAMP1-containing Golgi-derived vesicles.

185 e interaction of the virus glycoprotein with LAMP1.

186 ) and early endosome antigen 1, but not with LAMP1 protein.

187 capsids fail to uncoat and accumulate within LAMP1(+) endolysosomes.

188 r Tim-3 colocalized with p85 and IRF7 within LAMP1(+) lysosomes, suggestive of a role in degradation.