ライフサイエンスコーパス: LCV

1 LCV forms predominated over the next 4 days, during whic

2 LCV has been associated with autoimmune diseases, infect

3 LCV is a rare dermatologic manifestation of Crohn's dise

4 LCV is a rare form of vasculitis and one of the rarest d

5 LCV RNA2 mutants with nucleotide deletions or replacemen

6 LCV should be considered in differential diagnosis of bi

7 LCVs can efficiently immortalize B lymphocytes from the

8 In a principal component analysis of 19 LCVs, the first principal component (PC1) explained 27.7

9 The strong increase for the youngest Euro 6 LCVs might rather reflect technology advances with succe

10 s are consistent with a metabolically active LCV and a structurally resistant SCV.

11 er lipid content of the metabolically active LCV.

12 nfected orally with LCV failed to develop an LCV-specific humoral response and viremia was more prono

13 s ancestral viral genes likely present in an LCV progenitor from viral genes acquired later as primat

14 w completed the first genomic sequence of an LCV infecting a New World primate by describing the uniq

15 omics, and isotopologue profiling to analyze LCV-LD interactions in the genetically tractable amoeba

16 ole was decorated with the T4SS effector and LCV marker SidC.

17 ER-derived lipid droplet (LD) formation, and LCV maturation.

18 n of infection by the CA inhibitors PF74 and LCV.

19 m viral genes acquired later as primates and LCV coevolved, providing a defining point in the evoluti

20 Silver-stained gels of SCV and LCV lysates separated by two-dimensional (2-D) gel elect

21 GE and silver staining of lysates of SCV and LCV purified by caesium chloride-equilibrium density cen

22 A subset of BILF1 receptors from EBV and LCVs from NHPs (chimpanzee, orangutan, marmoset, and sia

23 Four and 15 upregulated proteins of SCVs and LCVs, respectively, were identified by mass spectrometry

24 ER- associated LCV formation was unique to CLas, as we could not detect

25 and seroconversion followed by asymptomatic LCV persistence.

26 intravenous inoculation of 10(8) autologous, LCV-immortalized B cells in 4 additional immunosuppresse

27 s macaque lymphocryptoviruses (LCVs) (baboon LCV and rhesus LCV).

28 mplicons packaged in rhesus monkey or baboon LCV envelopes were also consistent with a species-restri

29 In this study, baboon LCV could not immortalize human peripheral blood B cells

30 uman B cells could be coinfected with baboon LCV, and the simian virus persisted and replicated in hu

31 In conclusion, LCV infection induces a variety of changes in B cells th

32 ce of autophagy adaptors by the Ub-decorated LCV.

33 tif that enables anchoring to the ER-derived LCV membrane.

34 f NO(x) and smoke emission rates from diesel LCV in the past two decades.

35 which is extremely divergent among different LCV was virtually identical between the 208-95 and LCL86

36 repeated i.v. MTX in the setting of low-dose LCV rescue was associated with a higher risk for acute N

37 e that the species restriction for efficient LCV-induced B-cell immortalization occurs beyond virus b

38 Thus, efficient LCV-induced B-cell immortalization across distant Old Wo

39 issue, we determined whether the endogenous LCVs of baboon (Cercopithecine herpesvirus 12) and rhesu

40 Finally, LCV infection also induced expression of LC3-II(+) cytos

41 e determinant of the species restriction for LCV-induced B-cell immortalization maps to the EBNA-3 lo

42 In addition, specificity for LCV infection and exclusion of potential cross-reactivit

43 e also observed in the same amino acids from LCV-grown L. pneumophila.

44 In contrast, similar regions from LCV RNA2, including those upstream of the YSS, did not.

45 ng SidD were defective for Rab1 removal from LCVs, identifying SidD as the missing link connecting th

46 epB inactivates Rab1 before its removal from LCVs.

47 tologous species, but the ability of a given LCV to immortalize B cells from other Old World primate

48 an primates are closely related to the human LCV, Epstein-Barr virus (EBV), and share similar genome

49 These biologic differences in LCV infection of New World versus human and Old World pr

50 oximately 29-kDa MOMP is highly expressed in LCV, down-regulated in SCV, and not apparent in SDC.

51 for studying the role of the EBNA-3 genes in LCV pathogenesis.

52 tern blot analysis detected abundant RpoS in LCV but not in SCV.

53 s were greater than twofold more abundant in LCVs than in SCVs, with six proteins greater than twofol

54 r than twofold more abundant in SCVs than in LCVs.

55 Spectral characteristics of intracellular LCV and SCV reveal a higher lipid content of the metabol

56 Ab NM7.3 reacted with a approximately 32-kDa LCV-upregulated antigen, and MAb NM183 reacted with a ap

57 Ab NM183 reacted with a approximately 45-kDa LCV-specific antigen.

58 lysis, confirming the identity of the 45-kDa LCV-specific antigen.

59 n B cells with simian LCV resulted in latent LCV EBNA-2 gene expression and activation of cell CD23 g

60 f the novel antiretroviral drug lenacapavir (LCV).

61 mens A and C v B), increased MTX-leucovorin (LCV) ratio (regimens A and C v B), and choice and timing

62 ngth and depth of immune control in limiting LCV-induced lymphoproliferative disease.

63 herpesvirus in the genus Lymphocryptovirus (LCV).

64 BV), the only known human lymphocryptovirus (LCV), displays a remarkable degree of genetic and biolog

65 rved in the rhesus monkey lymphocryptovirus (LCV).

66 infected with EBV-related lymphocryptovirus (LCV) are requisite APCs for MHC-E-restricted autoaggress

67 -Barr virus (EBV)-related lymphocryptovirus (LCV) genus and extended the known host range of LCVs bey

68 -Barr virus (EBV)-related lymphocryptovirus (LCV) naturally infecting common marmosets demonstrated t

69 es from a closely related lymphocryptovirus (LCV) which naturally infects rhesus monkeys.

70 at target the rhesus (rh) lymphocryptovirus (LCV) EBNA-1 to determine if ongoing T cell responses dur

71 We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity

72 The rhesus lymphocryptovirus (LCV) is an EBV-related herpesvirus that naturally infect

73 th the EBV-related rhesus lymphocryptovirus (LCV).

74 d herpesvirus in the same lymphocryptovirus (LCV) genera as EBV naturally infects rhesus monkeys and

75 irus which is in the same lymphocryptovirus (LCV) genus as and closely related to Epstein-Barr virus

76 herpesviruses in the same lymphocryptovirus (LCV) genus that naturally infect Old World nonhuman prim

77 and the related herpes lymphocryptoviruses (LCV) infecting baboons and rhesus macaques.

78 lated herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP

79 naturally infected with lymphocryptoviruses (LCV) that are closely related to Epstein-Barr virus (EBV

80 Lymphocryptoviruses (LCVs) naturally infecting Old World nonhuman primates ar

81 boon and rhesus macaque lymphocryptoviruses (LCVs) (baboon LCV and rhesus LCV).

82 nonhuman primate (NHP) lymphocryptoviruses (LCVs).

83 ins of nonhuman primate lymphocryptoviruses (LCVs), which bear a strong genetic and biological simila

84 immune evasion genes expressed during lytic LCV infection do not prevent L-specific CD8(+) T cell de

85 Like EBNA-3C, both BaLCV and rhesus macaque LCV (RhLCV) 3C proteins bound to J kappa and repressed t

86 The rhesus macaque LCV (rhLCV) contains a repertoire of genes identical to

87 that (i) both the baboon and rhesus macaque LCVs have a genomic locus that is highly homologous to t

88 effector SdhA, which is crucial to maintain LCV integrity, in the Galleria mellonella infection mode

89 Marmoset LCV transcripts encoding putative latent infection nucle

90 against lytic- and latent-infection marmoset LCV antigens in order to perform the first seroepidemiol

91 we found that the seroprevalence of marmoset LCV infection was not as ubiquitous as with EBV or Old W

92 The unusual gene repertoire of the marmoset LCV differentiates ancestral viral genes likely present

93 The marmoset LCV genome is also notable for the absence of viral inte

94 striction, we first cloned the rhesus monkey LCV major membrane glycoprotein and discovered that the

95 animals developed an aggressive, monoclonal LCV-positive lymphoma.

96 At 4 h postinoculation, mutant LCVs had a significantly reduced association with Rab1B,

97 quence divergence between human and nonhuman LCV observed to date.

98 pecific EBNA-1 mRNAs are present in nonhuman LCV-infected cells, demonstrating that these Qp homologs

99 Transcriptome comparison of LCV-infected B cells and CD20(+) spleen cells from rhesu

100 r Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.

101 us, malignant and inflammatory etiologies of LCV.

102 ore pronounced, but there was no evidence of LCV-induced lymphoproliferative disease.

103 entally tested in nonhuman primate models of LCV infection.

104 c LCV RNA2 replicons only in the presence of LCV RNA1, but both processes were impaired when the YSS

105 Clinical presentation of LCV is variable and frequently mistaken for cellulitis.

106 o tolerate ustekinumab without recurrence of LCV.

107 5' and YSS-containing 3' terminal regions of LCV RNA1 supported translation activity.

108 st compartments during the earliest steps of LCV biogenesis.

109 perform the first seroepidemiologic study of LCV infection in New World primates.

110 has important implications for the study of LCV infection in Old World primate models and for human

111 In addition, the YSS of LCV RNA1 and RNA2 were interchangeable without affecting

112 These double mutants drove the formation of LCVs that showed vacuole disintegration within 2 h of ba

113 ) genus and extended the known host range of LCVs beyond humans and Old World nonhuman primates.

114 defining point in the evolution of oncogenic LCVs.

115 cription (RT)-PCR assay to detect persistent LCV infection in rhesus monkey peripheral blood lymphocy

116 esponses important for control of persistent LCV infection and the role of the EBNA-1 GAR for immune

117 nodosum (EN) and pyoderma gangrenosum (PG), LCV requires biopsy for diagnosis.

118 fractory to bolus intravenous (IV) 5-FU plus LCV.

119 g primarily SCVs to one containing primarily LCVs.

120 Primary LCV infection after oral inoculation of 4 immunocompeten

121 LF1 family and into the evolution of primate LCVs may enable validation of EBV BILF1 as a drug target

122 the LMP1 and BHRF1 3'UTRs of several primate LCVs.

123 fluorescence-labeled D. discoideum producing LCV and LD markers revealed that Sey1 as well as the L.

124 S and the Ran GTPase activator LegG1 promote LCV-LD interactions.

125 To promote LCV expansion and prevent lysosomal targeting, effector

126 In vitro reconstitution using purified LCVs and LDs from parental or Deltasey1 mutant D. discoi

127 osomal pathway components partially restored LCV integrity.

128 e found that reduced fusion of Rh gL, EBV/Rh-LCV chimeras, and gL point mutants could be restored by

129 were made using rhesus lymphocryptovirus (Rh-LCV) gL (Rh gL), which shares a high sequence homology w

130 e common to the rhesus LCV EBNA-LP, a rhesus LCV EBNA2 homologue was cloned and expressed.

131 A rhesus LCV isolate (208-95) was derived from a B-cell lymphoma

132 naturally and experimentally acquired rhesus LCV (rhLCV) infection.

133 ombination between the EBV genome and rhesus LCV DNA was reasonably efficient.

134 The predicted baboon and rhesus LCV EBNA-LP amino acid sequences are 61 and 64% identica

135 tructure and function between EBV and rhesus LCV indicates that rhesus LCV infection of rhesus monkey

136 he relationship between these EBV and rhesus LCV latent infection genes, we asked if the rhesus LCV E

137 ocryptoviruses (LCVs) (baboon LCV and rhesus LCV).

138 Both rhesus LCV LMP2A and LMP2B genes were cloned and sequenced.

139 different rhesus LCV types, and both rhesus LCV types were found to be prevalent in the rhesus monke

140 LCL8664 strains, confirming a common rhesus LCV background.

141 The highly conserved rhesus LCV gene repertoire provides a unique animal model for t

142 defines the presence of two different rhesus LCV types, and both rhesus LCV types were found to be pr

143 V EBNA-LP was able to further enhance rhesus LCV or EBV EBNA2 transactivation 5- to 12-fold.

144 order to define a "gold standard" for rhesus LCV infection, we also cloned the EBV-encoded small RNA

145 ide ELISA and EBER RT-PCR results for rhesus LCV infection.

146 A 1 (EBER1) and EBER2 homologues from rhesus LCV and developed a reverse transcription (RT)-PCR assay

147 d to identify the presence of a lytic rhesus LCV infection in these proliferative, hyperkeratotic, or

148 studied to compare the prevalence of rhesus LCV infection in the two groups.

149 LCV sVCA are a reliable indicator of rhesus LCV infection.

150 ble diagnosis of acute and persistent rhesus LCV infections.

151 homologues from 208-95 and a previous rhesus LCV isolate (LCL8664) were polymorphic on immunoblotting

152 ny confirm the feasibility of raising rhesus LCV-naive animals.

153 een EBV and rhesus LCV indicates that rhesus LCV infection of rhesus monkeys can provide an important

154 sid antigen (sVCA) homologue from the rhesus LCV and developed a peptide enzyme-linked immunosorbent

155 We now show that the rhesus LCV can infect epithelial cells in immunosuppressed rhes

156 tent infection genes, we asked if the rhesus LCV EBNA-3 locus could be recombined into the EBV genome

157 wever, these studies suggest that the rhesus LCV EBNA-3 locus was not completely interchangeable with

158 The rhesus LCV EBNA-3A, -3B, and -3C homologues have 37, 40, and 36

159 anscription factor RBP-Jkappa and the rhesus LCV EBNA-3C encodes a Q/P-rich domain with transcription

160 nserved with the EBV genes, since the rhesus LCV EBNA-3s can interact with the transcription factor R

161 The rhesus LCV EBNA-LP was able to further enhance rhesus LCV or EB

162 ivating properties were common to the rhesus LCV EBNA-LP, a rhesus LCV EBNA2 homologue was cloned and

163 The rhesus LCV EBNA2 transcriptionally transactivates EBNA2-respons

164 The rhesus LCV encodes a repertoire identical to that of EBV, with

165 These studies demonstrate that the rhesus LCV has tropism for epithelial cells, in addition to B c

166 The rhesus LCV LMP2B gene is positionally conserved, and the EBNA-2

167 Evolution of the rhesus LCV LMP2B promoter and transcript despite the dynamic na

168 to determine whether epitopes in the rhesus LCV sVCA are a reliable indicator of rhesus LCV infectio

169 The rhesus LCV sVCA peptide ELISA provides a sensitive and reliable

170 The existence of two rhesus LCV types suggests that the selective pressure for the e

171 g, so the EBNA-2 genes from these two rhesus LCV were cloned, sequenced, and compared.

172 both unique SCV/LCV antigens and common SCV/LCV antigens that were often differentially synthesized.

173 ever, respectively, revealed both unique SCV/LCV antigens and common SCV/LCV antigens that were often

174 ient infections of human B cells with simian LCV resulted in latent LCV EBNA-2 gene expression and ac

175 d for human xenotransplantation where simian LCVs may be inadvertently introduced into humans.

176 icant replication were observed for specific LCV RNA2 replicons only in the presence of LCV RNA1, but

177 We found that LCV from rhesus monkeys did not immortalize human B cell

178 Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species

179 ent metabolic activities, we speculated that LCV and SCV are similar to typical logarithmic- and stat

180 These results suggest that LCV and SCV are not comparable to logarithmic and statio

181 We determined that LCVs are composed of both Bvg(+) and Bvg(-) phase bacter

182 ry of the cell, supports the hypothesis that LCVs are metabolically more active than SCVs.

183 The LCV phenotype was linked to the presence of a divergent

184 tifs despite poor overall homology among the LCV 3C proteins strongly suggests that the interactions

185 er to build ubiquitinated species around the LCV.

186 hat T2S promotes the interaction between the LCV and Rab1B via a novel mechanism.

187 The homologue of EBNA-3C encoded by the LCV that infects baboons (BaLCV) was found to be only 35

188 ucturally, the SCV is distinguished from the LCV by its smaller size and condensed chromatin.

189 ore exclude host autophagy adaptors from the LCV.

190 that the concentration of L-arginine in the LCV is sensed by ArgR to produce an intracellular transc

191 ed the robustness of amino acid usage in the LCV of A. castellannii.

192 uptake of Acanthamoeba amino acids into the LCV and further into L. pneumophila where they served as

193 ector of L. pneumophila is anchored into the LCV membrane by host-mediated farnesylation.

194 e ER retention motif to be anchored into the LCV membrane.

195 the replicative form of the organism is the LCV.

196 C) anchors to the cytoplasmic surface of the LCV and is important for the recruitment of host endopla

197 inated species present at the surface of the LCV and provide a molecular mechanism for the avoidance

198 dation of the biochemical composition of the LCV and the identification of the regulatory signals sen

199 Biogenesis of the LCV has been known to depend on host small guanosine tri

200 ns that participate in the conversion of the LCV into a replicative organelle.

201 30b is anchored to the cytosolic side of the LCV membrane through host-mediated farnesylation of its

202 r its anchoring to the cytosolic face of the LCV membrane, for its biological function within macroph

203 Biogenesis of the LCV requires substantial redirection of vesicle traffick

204 te hosts correlate with the evolution of the LCV viral gene repertoire.

205 oteins in preventing host degradation of the LCV was limited to the earliest stages of infection.

206 n ligase that triggers the decoration of the LCV with K(48)-linked polyubiquitinated proteins that ar

207 cellular proliferation and decoration of the LCV with polyubiquitinated proteins.

208 he host membranes, and for decoration of the LCV with polyubiquitinated proteins.

209 sed to modulate the lipid composition of the LCV.

210 polyubiquitinated proteins, assembled on the LCV by AnkB, generates amino acids required for intracel

211 On the LCV, AnkB triggers docking of K(48)-linked polyubiquitin

212 an intracellular niche for replication, the LCV helps to prevent the release of bacterial components

213 We found that in the absence of SdhA, the LCV in hemocytes showed signs of instability and leakage

214 secretory transport vesicles surrounding the LCV.

215 he recruitment of ER-derived vesicles to the LCV and that inhibiting Rab1 function abrogates intracel

216 ated on ER-derived vesicles recruited to the LCV and that Sec22b is delivered to the LCV membrane.

217 show that Rab10 protein is recruited to the LCV and ubiquitinated by the effectors SidC/SdcA.

218 d recruitment of the host GTPase Rab1 to the LCV by a process requiring the Dot/Icm system.

219 t farnesylation enzymes are recruited to the LCV in a Dot/Icm-dependent manner and are essential for

220 The AnkB-Paris effector is localized to the LCV membrane most likely through the ER-retention motif.

221 nd its anchoring of an F-box effector to the LCV membrane, and this is essential for biological funct

222 the LCV and that Sec22b is delivered to the LCV membrane.

223 Rab1 recruitment to the LCV precedes remodeling of this compartment by ER-derive

224 Our data show that Rab1 is recruited to the LCV within minutes of uptake.

225 ophila replication and ER recruitment to the LCV.

226 s as well as polyubiquitin conjugates to the LCV.

227 own for mediating Rab1B association with the LCV, indicating that T2S promotes the interaction betwee

228 t and fusion of ER-derived vesicles with the LCV, resulting in the formation of a specialized organel

229 AMP4-containing vesicles for fusion with the LCV, thus promoting its expansion.

230 he association of translocated LtpD with the LCV.

231 terial survival and proliferation within the LCV rely on hundreds of secreted effector proteins compr

232 carbon metabolism of the bacteria within the LCV.

233 All the LCVs were positively correlated with each other and shar

234 ricted latency have been conserved among the LCVs.

235 latory elements of Qp are conserved in these LCV genomes and compose promoters that are functionally

236 However, it is unclear whether these LCVs have adopted or maintained the same mechanisms used

237 y prerequisite for morphogenesis from SCV to LCV.

238 sis defined 3 BILF1 clades, corresponding to LCVs of New World monkeys (clade A) or Old World monkeys

239 e degree of genetic and biologic identity to LCVs that infect Old World primates.

240 To document changes in the ratio of SCVs to LCVs in response to environment, a protein specific to S

241 doplasmic reticulum (ER)-derived vesicles to LCVs.

242 (p.i.) and was primarily composed of SCV-to-LCV morphogenesis.

243 selective pressure for the evolution of two LCV types is shared by human and nonhuman primate hosts.

244 orthologues in 12 previously uncharacterized LCVs from nonhuman primates (NHPs) of Old and New World

245 Using LCV and B cells from multiple species of Hominidae and C

246 c side of the Legionella-containing vacuole (LCV) and is essential for intravacuolar proliferation wi

247 embrane-bound Legionella-containing vacuole (LCV) established by proteins translocated via the bacter

248 and forming a Legionella-containing vacuole (LCV) in which the bacteria replicate.

249 While the Legionella-containing vacuole (LCV) is coated with ubiquitin (Ub), it avoids recognitio

250 d amoeba, the Legionella-containing vacuole (LCV) membrane is derived from the ER.

251 horing to the Legionella-containing vacuole (LCV) membrane.

252 resembled the Legionella-containing vacuole (LCV) observed in macrophages.

253 ates within a Legionella-containing vacuole (LCV) of amoebae and macrophages.

254 sicles to the Legionella-containing vacuole (LCV) requires bacterial proteins that are translocated i

255 lum (ER)-like Legionella-containing vacuole (LCV) that supports bacterial replication.

256 oteins to the Legionella-containing vacuole (LCV) to enable intravacuolar proliferation in macrophage

257 ration of the Legionella-containing vacuole (LCV) with polyubiquitinated proteins within macrophages

258 mbrane of the Legionella-containing vacuole (LCV) with that of secretory transport vesicles surroundi

259 known as the Legionella-containing vacuole (LCV) within the host cells and rapidly subvert organelle

260 umbers in the Legionella-containing vacuole (LCV), as evident at 12 h.

261 nsport of the Legionella-containing vacuole (LCV), we have identified host proteins that participate

262 s Rab1 to the Legionella-containing vacuole (LCV), where it activates Rab1 and then AMPylates it by c

263 he called the Legionella-containing vacuole (LCV), which is permissive for intracellular bacterial pr

264 on called the Legionella-containing vacuole (LCV).

265 phages in the Legionella-containing vacuole (LCV).

266 ER-associated Legionella-containing vacuole (LCV).

267 iche known as Legionella-containing vacuole (LCV).

268 ve niche, the Legionella-containing vacuole (LCV).

269 mbrane of the Legionella-containing vacuole (LCV).

270 nt termed the Legionella-containing vacuole (LCV).

271 ls within the Legionella-containing vacuole (LCV).

272 cruitment to Legionella-containing vacuoles (LCV) emerged as major SidE targets.

273 tures into Liberibacter containing vacuoles (LCVs), in which bacterial cells seem to propagate.

274 ting for reactivity with large cell variant (LCV) and small cell variant (SCV) antigens to characteri

275 ore metabolically active large-cell variant (LCV) is sensitive to environmental stresses.

276 the transition from the large cell variant (LCV) to the small cell variant (SCV) at around day 6 and

277 l-cell variant (SCV) and large-cell variant (LCV).

278 logic forms, designated large cell variants (LCV) and small cell variants (SCV).

279 pmental cycle variants: large-cell variants (LCV), small-cell variants (SCV), and small dense cells (

280 cell variants (SCV) and large-cell variants (LCV).

281 CVs) are generated from large-cell variants (LCVs) is considered fundamental to the virulence of Coxi

282 We obtained large colony variants (LCVs) from the lungs of mice infected with B. bronchisep

283 he log-transformed coefficient of variation (LCV) for one year's worth of data from 580 hemodialysis

284 Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characteri

285 Light commercial vehicles (LCVs) account for about 10-15% of road traffic in Europe

286 ucts are detected with leuco crystal violet (LCV) dye by eye without a need for instrumentation.

287 bipartite genome of Lettuce chlorosis virus (LCV), a member in the genus Crinivirus (family Closterov

288 nii to Legionella pneumophila under in vivo (LCV) conditions.

289 The aim of this study was to determine why LCV infection is important for this pathogenic role of B

290 ntimicrobial therapy, she was diagnosed with LCV by skin biopsy.

291 munosuppressed macaques infected orally with LCV failed to develop an LCV-specific humoral response a

292 s not as ubiquitous as with EBV or Old World LCV.

293 RBX9 also yielded LCVs when switched from Bvg(-) phase conditions to Bvg(+