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1                                              LDH-A gene expression is believed to be upregulated by b
2                                              LDH-A overexpression is required for c-Myc-mediated tran
3 egulating molecules lactate dehydrogenase A (LDH-A) and heat shock factor 1 (HSF1).
4                     Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyru
5 olite labeling with lactate dehydrogenase A (LDH-A) expression and some immunohistochemical markers.
6                 The lactate dehydrogenase A (LDH-A) gene, whose product participates in normal anaero
7 factor 1 (HSF1) and lactate dehydrogenase A (LDH-A) in ErbB2-positive cancer cells, resulting in tumo
8 ed stabilization of lactate dehydrogenase A (LDH-A) mRNA and identified four cytoplasmic proteins of
9 plex binding to the lactate dehydrogenase A (LDH-A) promoter was characterized.
10                     Lactate dehydrogenase A (LDH-A) regulates the last step of glycolysis that genera
11 es, such as rcl and lactate dehydrogenase A (LDH-A), is critical for understanding the mechanisms of
12 ologous homologs of lactate dehydrogenase-A (LDH-A) (EC 1.1.1.27; NAD+:lactate oxidoreductase) of six
13 acrophage-expressed lactate dehydrogenase-A (LDH-A) to tumor formation in a K-Ras murine model of lun
14 am islets including lactate dehydrogenase-A (LDH-A), lactate (monocarboxylate) transporters, glucose-
15                     Lactate dehydrogenase-A (LDH-A), responsible for conversion of pyruvate to lactat
16 ctate by the enzyme lactate dehydrogenase-A (LDH-A), suggesting a possible vulnerability at this targ
17 omplexes was absolutely necessary to achieve LDH-A mRNA stabilization.
18      However, how oncogenic signals activate LDH-A to regulate cancer cell metabolism remains unclear
19  Moreover, increased glycolysis via HSF1 and LDH-A contributes to trastuzumab resistance.
20        In this study, we report that Rcl and LDH-A act synergistically to induce anchorage-independen
21               These findings confirm Rcl and LDH-A as critical components of the cell transformation
22                Cells expressing both Rcl and LDH-A form tumors after s.c. injection into nude mice, a
23                     The inability of Rcl and LDH-A to fully recapitulate c-Myc activity, however, ind
24 because lowering its level through antisense LDH-A expression reduces soft agar clonogenicity of c-My
25 mply a cause and effect relationship between LDH-A mRNA stabilization and CSR-phosphoprotein binding
26 ells (MDSCs) in the spleens of mice carrying LDH-A-depleted tumors.
27                      In rat C6 glioma cells, LDH-A mRNA is stabilized by activation and synergistic i
28 er cells with stable knockdown of endogenous LDH-A and rescue expression of a catalytic hypomorph LDH
29 ggest that tyrosine phosphorylation enhances LDH-A enzyme activity to promote the Warburg effect and
30      Phosphorylation at Y10 and Y83 enhances LDH-A activity by enhancing the formation of active, tet
31 d cAMP-stabilizing region (CSR) required for LDH-A mRNA stability regulation by the protein kinase A
32                                NK cells from LDH-A-depleted tumors had improved cytolytic function.
33            The lactate dehydrogenase-A gene (LDH-A), whose product participates in normal anaerobic g
34 d rescue expression of a catalytic hypomorph LDH-A mutant, Y10F, demonstrate increased respiration th
35 irpin RNA-mediated knockdown of hypothalamic LDH-A, an astrocytic component of the ANLS, also blunted
36 ss I: B23 (NPM1), CAD, CDK4, cyclin D2, ID2, LDH-A, MNT, PTMa, ODC, NM23B, nucleolin, prohibitin, SHM
37 he existence of a cAMP-stabilizing region in LDH-A 3'-UTR.
38 These observations suggest that an increased LDH-A level is required for the growth of a transformed
39 RNA and subsequent increase of intracellular LDH-A mRNA levels.
40 ression of ALDH1 in lung metastasis and MDR1/LDH-A expression in liver metastasis compared to human p
41 ical determinant for the (Sp)-cAMPS-mediated LDH-A mRNA stabilizing activity.
42  Correspondingly, adenoviral vector-mediated LDH-A overexpression reduced insulin secretion stimulate
43                   Lentiviral vector-mediated LDH-A short hairpin RNA knockdown Pan02 pancreatic cance
44 chemical optimization, resulted in nanomolar LDH-A inhibitors that demonstrated stoichiometric bindin
45 tantly, PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription facto
46  active, tetrameric LDH-A and the binding of LDH-A substrate NADH, respectively.
47          We used a full-length cDNA clone of LDH-A of S. lucasana to test, by site-directed mutagenes
48 h RSW extracts, and the kinetics of decay of LDH-A mRNA was determined.
49                 Myeloid-specific deletion of LDH-A promoted accumulation of macrophages with a CD86(h
50                        Ectopic expression of LDH-A alone in Rat1a fibroblasts was sufficient to induc
51 regulation of HSF1 reduced the expression of LDH-A and subsequently decreased cancer cell glycolysis
52             Although antisense expression of LDH-A did not affect the growth of c-Myc-transformed fib
53      Our results suggest that expressions of LDH-A and lactate by macrophage in the tumor microenviro
54 tudies have linked c-Myc to the induction of LDH-A, whose expression increases lactate production and
55                            The inhibition of LDH-A by small molecules is therefore of interest for po
56  we used FX11, a small-molecule inhibitor of LDH-A, to investigate this possible vulnerability in a p
57 cribe the identification and optimization of LDH-A inhibitors by fragment-based drug discovery.
58             Moreover, Y10 phosphorylation of LDH-A is common in diverse human cancer cells, which cor
59 responsible for the relatively rapid rate of LDH-A mRNA turnover in the cytoplasm.
60                              The sequence of LDH-A from S. lucasana differs from that of S. idiastes
61 occurs through PKA-mediated stabilization of LDH-A mRNA and subsequent increase of intracellular LDH-
62  regulates the PKA-mediated stabilization of LDH-A mRNA.
63 ly through the HSF1-mediated upregulation of LDH-A.
64 on on the 3'-untranslated region (3'-UTR) of LDH-A mRNA.
65  and PKC results in a potentiating effect on LDH-A mRNA stabilization.
66 l techniques, that the muscle form (M-LDH or LDH-A) and the heart form (H-LDH or LDH-B) of lactate de
67 tion into nude mice, although neither Rcl or LDH-A overexpression alone induces tumorigenesis.
68 ansfected Rat1a fibroblasts that overexpress LDH-A alone or those transformed by c-Myc overproduce la
69 yrosine kinase FGFR1 directly phosphorylates LDH-A.
70  PKA and PKC act synergistically and prolong LDH-A mRNA half-life more than 21-fold.
71 oncogenic driver of Ewing sarcoma, regulated LDH A (LDHA) expression.
72  supporting the concept of targeting stromal LDH-A as an effective strategy to blunt tumoral immune e
73 sion of the lactate dehydrogenase A subunit (LDH-A) gene can be controlled by transcriptional as well
74 nhancing the formation of active, tetrameric LDH-A and the binding of LDH-A substrate NADH, respectiv
75 pendent growth in Ratla fibroblasts and that LDH-A is required for cell transformation by c-Myc.
76 t not with serum withdrawal, suggesting that LDH-A mediates the unique apoptotic effect of c-Myc when
77                                  In both the LDH-A promoter and the erythropoietin 3' enhancer, forma
78 cAMP-stabilizing region (CSR) located in the LDH-A 3'-untranslated region which, in combination with
79 ansactivation) of the VEGF promoter than the LDH-A promoter.
80 R) of beta-globin had been replaced with the LDH-A 3'-UTR.
81 t at least three sequence domains within the LDH-A 3'-UTR consisting of nucleotides 1286-1351, 1453-1
82 o identify low affinity fragments binding to LDH-A.
83  that demonstrated stoichiometric binding to LDH-A.
84                                HSF1 bound to LDH-A promoter and the downregulation of HSF1 reduced th
85 cer as a biomarker to predict sensitivity to LDH-A inhibition, with regard to both real-time noninvas
86  and the LP ratio was weakly correlated with LDH-A expression in biopsy samples (rho = 0.43, P = .04)