ライフサイエンスコーパス: LES

1 LES contraction is mediated by the calcium-dependent PKC

2 LES practices were less likely to refer patients to seco

3 LES pressure (LESP) in the GERD group was significantly

4 LES relaxation and axial stretch were each significantly

5 LES sera more strongly reduced calcium currents in moton

6 A LES that is independent of mass- or area-normalization a

7 re the causal functional relationships among LES traits that give rise to their strong global covaria

8 orsal motor nucleus of the vagus to evoke an LES relaxation in decerebrate unanesthetized ferrets.

9 types of contractile activity in the ESO and LES are mediated by different PKC isozymes.

10 Esophageal and LES pressure, crural diaphragm electromyographs, and pH

11 The neurologic linkage of vagal fundic and LES relaxation may have clinical relevance, because it h

12 omen, forming an angle between the spine and LES.

13 s nerve-stimulated LES relaxation as well as LES cranial displacement.

14 d cranial displacement of the LES as well as LES relaxation in a dose-dependent manner.

15 not with either E2 or DHT alone, attenuated LES in castrated rats.

16 L-NAME (100 mg/kg, intravenously) attenuated LES relaxation to both stimuli (P < 0.05).

17 These data suggest that T attenuates LES, but not fear-potentiated startle, through a mechani

18 Basal LES pressure and swallow- and vagal-evoked LES relaxatio

19 t crus of the diaphragm CONCLUSIONS: Besides LES, the 3D pressure profile of the EGJ can indicate ana

20 secondary outcome was the difference between LES and non-LES practices for hospital first and follow-

21 nce in achievement of QOF indicators between LES and NLES practices.

22 or DM12(BP) and DM17(lipid) outcomes between LES and NLES practices.

23 that there are striking similarities between LES- and fundic-projecting preganglionic neurons in term

24 mature postnatal ages (15-17 d after birth) LES rat calyces showed prolonged spike latencies, indica

25 he nitrergic pathway has been shown to cause LES hypertension and impaired relaxation in achalasia.

26 d not have a hiatal hernia larger than 2 cm, LES pressure less than 8 mmHg, or Barrett's esophagus.

27 This combined LES/PMF computational approach, which offers a straightf

28 city in Galleria mellonella larvae of common LES phenotypes (ie, low production, intermediate product

29 However, interactions of common LES phenotypic variants with other members of the polymi

30 ing swallowing, and seven (33%) had complete LES relaxation.

31 t differences between patients with complete LES relaxation and those with incomplete LES relaxation

32 ere available for six patients with complete LES relaxation at manometry and 10 with incomplete relax

33 treatment in all six patients with complete LES relaxation.

34 Results derived from the coupled LES-NPZ model, run with and without the presence of Lang

35 r E2 in ovariectomized rats did not decrease LES.

36 A manometrically defective LES can be restored to normal sphincter, whereas a norma

37 ll, patients with a manometrically defective LES were restored 67% of the time to a normal sphincter

38 structurally defective or severely defective LES improved to a normal LES in 77% and 56% of patients,

39 ristalsis, (3) retained complete deglutitive LES relaxation, and (4) intact transient LES relaxation.

40 gal stimulation elicited frequency-dependent LES relaxation without evoking esophageal contractions a

41 that global-scale models may poorly describe LES covariation at non-global scales.

42 l lines [lox-containing ES lines (designated LES)] were created that contain a '-neo-lox' cassette in

43 ey concluded that an unmeasured trait drives LES covariation, sparking efforts to identify the latent

44 E-LES exhibited scattered erosions and displayed inflammat

45 E-LES muscle strips developed lower in vitro tone (0.78 g)

46 E-LES tone was essentially restored to normal by the H2O2

47 E-LES was examined histologically, and its in vitro circul

48 ned a human LES specimen with esophagitis (E-LES) and characterized its pathophysiologic mechanical a

49 her and H2O2 levels were 4 times higher in E-LES circular muscle (0.85 nmol/mg protein) than in N-LES

50 In E-LES, levels of PAF, PGE2, and F2-isoprostane were 4, 6,

51 transmission in the murine lower esophageal (LES) and pyloric sphincters (PS).

52 esophago-UES contractile reflex and esophago-LES relaxation response, and rapid air injection activat

53 Esophagus, LES, stomach, right and left crus of the diaphragm, and

54 In functional studies, centrally evoked LES relaxation (-73% +/- 8% mm Hg) was significantly att

55 l LES pressure and swallow- and vagal-evoked LES relaxations were quantified in wild-type, Nomega-nit

56 EGJ pressure was recorded at end-expiration (LES pressure) and at the peak of forced inspiration (hia

57 al unmeasured traits are required to explain LES covariation.

58 preganglionic neurons innervating the ferret LES, with special attention to their relationship with g

59 There were significantly fewer LES-labeled profiles that innervated the antrum (16 +/-

60 Furthermore, LES rat afferent fiber-evoked APs showed a pronounced lo

61 relations between N and LMA followed general LES theory, but topo-edaphic conditions strongly mediate

62 reassess these conclusions using both global LES data as well as data collected across scales in the

63 For global LES data, accounting for phylogenetic non-independence i

64 nNOS(-/-) mice have LES hypertension with impaired relaxation resembling ach

65 ta or LF according to size of hiatal hernia, LES pressure, Barrett's esophagus, and significant pulmo

66 Patients with larger hiatal hernias, LES pressure less than 8 mmHg, or Barrett's were offered

67 ents exhibit different GERD symptoms, higher LES pressures and a decreased prevalence of hiatal herni

68 However, LES practices were more likely to achieve the DM23(glyca

69 Human LES tone is maintained by the activity of sPLA2-I that p

70 for the first time, we have obtained a human LES specimen with esophagitis (E-LES) and characterized

71 sPLA2-I in the maintenance of tone in human LES samples obtained from organ donors.

72 orphology using a block containing the human LES and crural diaphragm, serially sectioned at 50 mum i

73 ibited the bethanechol-mediated hypertensive LES.

74 In contrast, W/W(v) mice have hypotensive LES with unimpaired relaxation, suggesting that ICC-IM d

75 receptor was highly expressed in identified LES-projecting preganglionic neurons.

76 or absence of primary peristalsis, impaired LES opening, esophageal dilatation, delayed emptying of

77 In LES single cells isolated by enzymatic digestion and per

78 hat Ca2+ channels may be broadly affected in LES patients.

79 There were no changes in LES or esophageal pressures during the study period in t

80 TH immunoreactivity was never identified in LES-projecting neurons.

81 d PKC-alpha, -betaII, and -gamma isozymes in LES circular muscle, but only PKC-betaII translocated fr

82 into the role of the longitudinal muscle in LES relaxation and descending relaxation of the esophagu

83 the loss of length there was a reduction in LES pressure (27.4-23.4 mm Hg, P = 0.02).

84 Fourteen patients (67%) had incomplete LES relaxation at manometry during swallowing, and seven

85 Six (60%) of 10 patients with incomplete LES relaxation had resolution of symptoms after treatmen

86 ete LES relaxation and those with incomplete LES relaxation in mean age (P = .59), duration of dyspha

87 Tetrodotoxin did not block the CGRP-induced LES relaxation.

88 Nitric-oxide-induced LES relaxation was not affected by fundoplication.

89 e data all suggest that GBR agonists inhibit LES relaxation via a site of action associated with vaga

90 CGRP 8-37 did not inhibit LES relaxation or esophageal contraction.

91 ntral subdiaphragmatic vagus causes isolated LES relaxation and activates neurons in select vagal sub

92 nduced contraction of enzymatically isolated LES smooth muscle cells were measured in the absence or

93 the abdominal vagal-afferent-evoked isolated LES relaxation.

94 duced and gastric afferent-mediated isolated LES relaxations.

95 sPLA2-I-induced contraction of isolated LES smooth muscle cells was reduced by indomethacin, per

96 failures at impressive rates of up to 1 kHz, LES calyces were unable to do so.

97 equire venting, and contains a modified LES (LES 2) to reduce the possibility of false positives.

98 W(v) mice lacking ICC-IM have achalasia-like LES dysfunction.

99 eflux and the hope that measurement of a low LES pressure would mark the presence of GERD.

100 tients with a normal preoperative manometric LES deteriorated to a lower category.

101 Mean LES resting and relaxation nadir pressure are lower afte

102 Mean LES resting and relaxation nadir pressure were lower aft

103 re was a significant reduction in the median LES length from 4 to 2.6 cm (P = 0.001).

104 iated with an overall increase in the median LES resting pressure (18 pre-MSA vs 23 mm Hg post-MSA; P

105 owever, how environmental conditions mediate LES trait interrelationships, particularly at large bios

106 sely, CDR3gamma and CDR3delta loops mediated LES TCR binding to endothelial protein C receptor, a clo

107 In anesthetized mice, LES pressures were recorded using a manometric technique

108 not require venting, and contains a modified LES (LES 2) to reduce the possibility of false positives

109 ested the hypothesis that baclofen modulates LES motor tone via GBR expressed by vagal efferent neuro

110 Wild-type mouse LES maintained a basal pressure (24 +/- 3 mm Hg; N = 8)

111 In contrast, W/W(v) mouse LES was significantly hypotensive (11 +/- 2 mm Hg; N = 6

112 ular muscle (0.85 nmol/mg protein) than in N-LES (0.19 +/- 0.05 nmol/mg protein).

113 and 40 times, respectively, higher than in N-LES.

114 duced dose-dependent reductions in tone of N-LES muscle strips.

115 tory mediators were compared with those of N-LES.

116 sed the normal lower esophageal sphincter (N-LES) of human organ donors to examine the physiologic si

117 eveloped lower in vitro tone (0.78 g) than N-LES (3.3 +/- 0.2 g).

118 When N-LES smooth muscle was incubated in H2O2 (70 micromol/L,

119 tcome was the difference between LES and non-LES practices for hospital first and follow-up appointme

120 severely defective LES improved to a normal LES in 77% and 56% of patients, respectively.

121 stored to normal sphincter, whereas a normal LES remains stable.

122 Much of the structure in the mass-normalized LES results from normalizing area-proportional traits by

123 undus both labels were noted in 56 +/- 3% of LES-labeled profiles overall.

124 In the rostral DMN, 15 +/- 4% of LES-projecting neurons also contained NADPH-diaphorase a

125 the current study, Western blot analysis of LES and ESO revealed PKC-alpha, -betaII, and -gamma isoz

126 -2-dioctanoylglycerol-induced contraction of LES and ESO smooth muscle cells.

127 Contraction of LES cells was reduced by the alpha beta gamma pseudosubs

128 ess climatic and geophysical determinants of LES traits and their interrelationships.

129 ot appreciably differ by the type or dose of LES consumed, cointervention type, or fasting glucose an

130 he effects did not differ by type or dose of LES, or fasting glucose or insulin levels.

131 ention studies examining the acute effect of LES intake on postprandial glucose (PPG) and postprandia

132 Pooled effects of LES intake on the mean change difference in PPG and PPI

133 ly significant differences in the effects of LES on PPG and PPI responses compared with control inter

134 We compared effects of LES sera on whole-cell currents of cultured nerve and mu

135 led to show a reduction in the expression of LES.

136 nested climatic and geophysical filtering of LES traits and their interrelationships, with important

137 r and can account for a clinical hallmark of LES, facilitation of neuromuscular transmission produced

138 im of the study was to examine the impact of LES in terms of diabetes Quality Outcome Framework (QOF)

139 Ingestion of LES, administered alone or in combination with a nutrien

140 our knowledge, the first biospheric maps of LES traits, here centered on 76 million ha of Andean and

141 rks through a stretch-sensitive mechanism of LES relaxation.

142 The neurochemistry of LES-projecting neurons was also investigated using two m

143 e central organization and neurochemistry of LES-projecting preganglionic neurons.

144 dopamine), is synthesized by a population of LES-projecting neurons.

145 The pathogenic potential of LES phenotypic variants can be enhanced by the presence

146 th air resulted in progressive shortening of LES (R = 0.89, P < 0.0001).

147 The CM fascicles on the ventral surface of LES are arranged in a helical/spiral fashion.

148 A robust numerical model based on LES method was developed and successfully validated agai

149 le of a specific beta3 agonist (CL316243) on LES pressure (LESP) in vivo.

150 a infection model, with killing dependent on LES phenotype and AGS species.

151 Overall, LES practices performed better in the achievement of DM2

152 r border (2.65 vs 4.1 cm; P = .027) and peak LES pressure (0.1 cm proximal vs 2.1 cm distal; P = .007

153 Preoperative LES pressure was higher in the Stretta group.

154 Elevated preoperative LES pressure represents the strongest positive outcome p

155 High preoperative LES pressure remained an independent predictor of excell

156 esophageal sphincter (LES) resting pressure, LES relaxation pressure, and intraesophageal-intragastri

157 for this receptor has been found in the rat LES in vitro.

158 In contrast to gonadally intact male rats, LES was seen reliably in castrated male rats and in fema

159 Fundoplication reduces LES relaxation by interfering with axial stretch on the

160 prostane, which are responsible for reducing LES tone in human esophagitis.

161 e cells in the lateral extrastriolar region (LES) mostly formed at E13.5.

162 REK-LES promotes and regulates the extent of Bright multimer

163 Resting and residual LES pressures were recorded to determine whether LES rel

164 ed annealing with locally enhanced sampling (LES) in a primary hydration shell (PHS) aqueous environm

165 dynamics (MD) and locally enhanced sampling (LES) methods in order to predict the favourable topologi

166 We now report a locally enhanced sampling (LES) strategy for modeling ammonia transfer between the

167 ting, and contains a liquid emulsion sensor (LES).

168 In the UK, Local Enhanced Services (LES) have been commissioned for diabetes.

169 tory brainstems using the Long-Evans Shaker (LES) rat, a spontaneous mutant where compact myelin wrap

170 al axons and those of the Long-Evans shaker (LES) rat, which lacks compact myelin.

171 of the coupling of a large-eddy simulation (LES) model of the mixed layer with an advection-diffusio

172 ant in the context of large eddy simulation (LES), where the response of small-scale structures to th

173 The presence of NOS in some LES-projecting neurons may contribute to LES relaxation,

174 asshouse study, for leaf economics spectrum (LES) and related traits: photosynthesis (A(mass), A(area

175 asshouse study, for leaf economics spectrum (LES) and related traits: photosynthesis (A(mass), A(area

176 The leaf economics spectrum (LES) describes consistent correlations among a variety o

177 The leaf economics spectrum (LES) describes multivariate correlations that constrain

178 The leaf economics spectrum (LES) is a prominent ecophysiological paradigm that descr

179 Leaf economics spectrum (LES) theory suggests a universal trade-off between resou

180 eparation of the lower esophageal sphincter (LES) and crural diaphragm was quantified by measuring th

181 h muscles of the lower esophageal sphincter (LES) and skeletal muscle of the crural diaphragm (esopha

182 a morphological lower esophageal sphincter (LES) and those who did not.

183 elaxation of the lower esophageal sphincter (LES) are mediated by nitric oxide (NO.)-producing myente

184 In contrast, lower esophageal sphincter (LES) circular muscle maintains spontaneous tone and rela

185 transduction of lower esophageal sphincter (LES) circular muscle.

186 The lower esophageal sphincter (LES) in patients with gastroesophageal reflux disease of

187 er border of the lower esophageal sphincter (LES) in subjects with a large WC (2.77 vs 3.54 cm; P = .

188 r control of the lower esophageal sphincter (LES) is critical for normal swallowing and emesis, as we

189 tor sites in the lower esophageal sphincter (LES) of animals and humans.

190 re and increased lower esophageal sphincter (LES) pressure and length based on objective testing over

191 igher preoperative low esophageal sphincter (LES) pressure than nonresponders: 42.6 +/- 13.1 versus 2

192 y have low or no lower esophageal sphincter (LES) pressure.

193 Isolated lower esophageal sphincter (LES) relaxation associated with belching and vomiting an

194 a long-duration lower esophageal sphincter (LES) relaxation that is an important feature of a transi

195 c nerves mediate lower esophageal sphincter (LES) relaxation with intramuscular interstitial cells of

196 during transient lower esophageal sphincter (LES) relaxation, longitudinal muscle contracts independe

197 during transient lower esophageal sphincter (LES) relaxation-associated reflux in GERD patients.

198 that it reduces lower esophageal sphincter (LES) relaxation.

199 nce of transient lower esophageal sphincter (LES) relaxations.

200 gation velocity, lower esophageal sphincter (LES) resting pressure, LES relaxation pressure, and intr

201 cat spontaneous lower esophageal sphincter (LES), tone is maintained by the activity of group I secr

202 ophagus, and the lower esophageal sphincter (LES).

203 ion (MSA) on the lower esophageal sphincter (LES).

204 unterpart of the lower esophageal sphincter (LES).

205 Lower oesophageal sphincter (LES) pressure was higher in patients with T2D (median 10

206 The spine-LES angle was smaller in patients with achalasia (104 de

207 previously shown that in vitro, spontaneous LES tone and contraction of ESO in response to acetylcho

208 a phenomenon called light-enhanced startle (LES), is dependent on the bed nucleus of the stria termi

209 f the anthracene to a locally excited state (LES) is followed by concerted electron transfer from the

210 ed axial stretch- and vagus nerve-stimulated LES relaxation as well as LES cranial displacement.

211 omonas aeruginosa Liverpool epidemic strain (LES) is an important cystic fibrosis (CF) pathogen and i

212 , which are increasingly being used to study LES relaxation.

213 s been suggested that low-energy sweeteners (LES) may be associated with an increased risk of metabol

214 as demonstrated that Lambert-Eaton syndrome (LES) antibodies reduce calcium currents in nonneuronal c

215 autoimmune disorder, Lambert-Eaton syndrome (LES).

216 and specifically to a human Vgamma4(+) TCR, "LES" with an affinity (~15-25 muM) comparable to many al

217 a better and more integrated parameter than LES pressure for determining efficacy of treatment for p

218 ility by EndoFLIP is a better parameter than LES pressure for evaluating efficacy of treatment for ac

219 trasts with untreated cells and suggest that LES sera primarily spare L-type currents in motoneurons.

220 The LES and PS contain spindle-shaped IC-IM, which form clos

221 The LES in nNOS(-/-) was significantly hypertensive (36 +/-

222 The LES pressure was monitored with a 2F solid-state pressur

223 The LES turns to the left as it entered from the chest into

224 evidence of excessive reflux 5 cm above the LES in either group.

225 In addition, the LES formed pathogenic partnerships with AGS in the G. me

226 We assessed the LES and esophageal hiatus morphology using a block conta

227 S and gastric fundus is logical, because the LES has similar functions to the fundus, which relaxes t

228 rt the hypothesis that CGRP may decrease the LES basal tone and modulate the timing and amplitude of

229 Smooth muscle strips from the LES and the body of the esophagus were stimulated by an

230 alternative pathway for fast decay from the LES to the ground state and thereby preclude detection o

231 IC-IM were absent in the LES and PS of c-kit (W/Wv) mutant mice.

232 d whether IC-IM mediate neural inputs in the LES and PS.

233 ole in NO-dependent neurotransmission in the LES and PS.

234 ncorporation of a 'vortex-force' term in the LES code in order to generate Langmuir circulations.

235 c(1) and c(2) on the number of copies in the LES method and the thickness of the PHS.

236 tion of temperature, number of copies in the LES method, and shell thickness.

237 at the heminode and terminal was lost in the LES rat.

238 arization peak following the AP spike in the LES rat.

239 erent fluorescent tags was injected into the LES and fundus both labels were noted in 56 +/- 3% of LE

240 ange occurred in the abdominal length of the LES (2.6-1.4 cm [P = 0.001]) and not in the thoracic len

241 ve shortening of the abdominal length of the LES and a reduction in its pressure.

242 propose that circumferential squeeze of the LES and crural diaphragm is generated by a unique myo-ar

243 it helps explain why motor disorders of the LES and fundus frequently occur together.

244 Coinnervation of the LES and gastric fundus is logical, because the LES has s

245 e 3-dimensional (3D) pressure profile of the LES and hiatal contraction between healthy subjects and

246 int was 0.5 cm above the lower border of the LES and with distension moved a median of 1 cm cephalad

247 mulation induced cranial displacement of the LES as well as LES relaxation in a dose-dependent manner

248 s were then targeted to the lox sites of the LES cell lines.

249 The discovery of the LES focused attention on the sphincter as the main deter

250 The presented global quantifications of the LES in wetland plants enhance our understanding of wetla

251 ne abolished nerve-induced relaxation of the LES muscle and the esophageal off-response but not the r

252 Cranial displacement of the LES was recorded using piezoelectric crystals.

253 in significant manometric improvement of the LES without apparent deleterious effects on the esophage

254 The large WC group had shortening of the LES, attributable to loss of the distal component (total

255 e effacement of the abdominal portion of the LES, exposing it to acid injury resulting in mucosal and

256 H monitoring led to the understanding of the LES, its contribution to GERD, and the complication of B

257 roxidase (HRP) into the muscular wall of the LES-labeled profiles throughout the rostrocaudal extent

258 end to cluster at the acquisitive end of the LES.

259 se, and it increased the resting tone of the LES.

260 logical trait underlying the 'origin' of the LES.

261 ith the more resource-acquisitive end of the LES.

262 hageal reflux disease, but its effect on the LES has not been elucidated.

263 ects the effect of gastric distension on the LES length and pressure and its exposure to acid gastric

264 the esophagus to exert axial stretch on the LES, and the vagus nerve was isolated in the neck for el

265 ion by interfering with axial stretch on the LES.

266 ency of the off-response, and it relaxed the LES.

267 CGRP relaxes the LES and decreases the amplitude of esophageal peristalsi

268 This suggests that the LES approach is beneficial and needs to be further explo

269 h expanded first toward the MES, then to the LES by E15.5.

270 All practices in the PCT were invited to the LES initiative, which ensured avoiding selection bias.

271 n associated with vagal motor outflow to the LES.

272 So far, whether the LES holds in wetland plants at a global scale has been u

273 acidity extended more proximally within the LES in the large WC group, compared with the upper borde

274 n moved a median of 1 cm cephalad within the LES.

275 Eleven asymptomatic volunteers had their LES length and pressure measured before and during gastr

276 Thus, even though LES is expressed as a neuromuscular and autonomic disord

277 increased by almost 10% when GPs belonged to LES groups compared with GPs in NLES group.

278 patients with achalasia and, in contrast to LES pressure, is associated with esophageal emptying and

279 ome LES-projecting neurons may contribute to LES relaxation, as it does in the case of fundic relaxat

280 ertain whether the impact exerted was due to LES.

281 ted a smaller PPG response after exposure to LES compared with the control (-0.3 mmol/L; 95% CI: -0.5

282 effects on PPG and/or PPI after exposure to LES, either alone, with a meal, or with other nutrient-c

283 rom general practices (GPs) who signed up to LES were given additional training (and a monetary incen

284 table to loss of the distal component (total LES length, 3 vs 4.5 cm; P = .043).

285 that is an important feature of a transient LES relaxation.

286 the constituents of reflux during transient LES relaxation.

287 ive LES relaxation, and (4) intact transient LES relaxation.

288 with belching and vomiting and the transient LES relaxation associated with gastroesophageal reflux a

289 In vitro LES tone and sPLA2-I-induced contraction of enzymaticall

290 In vitro LES tone was reduced by inhibitors of sPLA2-I, by indome

291 eading to the EGJ opening during tLESRs were LES relaxation, crural diaphragm inhibition, esophageal

292 challenging task becomes more demanding when LES of premixed flames are considered, as heat release a

293 Even when LES pressure was low, EGJ distensibility could be reduce

294 pressures were recorded to determine whether LES relaxation was complete or incomplete.

295 This model may explain why LES is expressed as a neuromuscular disorder and can acc

296 Relaxation of crural diaphragm along with LES relaxation is essential for the occurrence of gastro

297 hagia, and weight loss) were correlated with LES relaxation at manometry.

298 Patients with LES pressure >35 mm Hg had an odds ratio of 21.3, making

299 elief after myotomy compared with those with LES pressure < or =35 mm Hg (odds ratio, 21.3; 95% confi

300 ng preloads to the same intervention without LES were eligible for inclusion.