ライフサイエンスコーパス: LGE

1 LGE and ECV were significant predictors of FA, in line w

2 LGE burden was the best predictor of death/VT (area unde

3 LGE CMR of both atria was performed, and NEEES-based ana

4 LGE disappeared completely in 18 (10%) patients, the num

5 LGE extent (per 10% increase) corresponded to a 79% incr

6 LGE extent was analyzed with the software GT Volume.

7 LGE heterogeneity was defined as SD of LGE in the local

8 LGE imaging and left atrial activation mapping were perf

9 LGE imaging was typical in all patients with cardiac ATT

10 LGE is associated with future cardiovascular death and v

11 LGE located subepicardial basal inferolateral was detect

12 LGE significantly improved in 16 patients (67%); however

13 LGE was detected in 182 (96%) patients at CMR-I and in 1

14 LGE without edema could represent definite fibrosis wher

15 LGE+ regions were defined as signal intensity >2 SD than

16 LGE-dispersion mapping is a marker of scar heterogeneity

17 hythmia occurred in 41 LGE-positive versus 0 LGE-negative subjects (annualized incidence, 5.9% versus

18 Cardiovascular mortality occurred in 10 LGE-positive versus 2 LGE-negative subjects (annualized

19 tality occurred in 19 LGE-positive versus 17 LGE-negative subjects (annualized incidence, 3.1% versus

20 ythmia occurred in 64 LGE-positive versus 18 LGE-negative subjects (annualized incidence, 8.8% versus

21 All-cause mortality occurred in 19 LGE-positive versus 17 LGE-negative subjects (annualized

22 rtality occurred in 10 LGE-positive versus 2 LGE-negative subjects (annualized incidence, 1.9% versus

23 facilities that combust biogas onsite ($1.34/LGE and 24.3 gCO(2e)/MJ).

24 Two readers visually graded the 3D LGE images (conspicuity, artifact, noise) on a five-poin

25 iomyopathy (NICM) patients and to evaluate 4 LGE border-zone algorithms.

26 Ventricular arrhythmia occurred in 41 LGE-positive versus 0 LGE-negative subjects (annualized

27 ath or ventricular arrhythmia occurred in 64 LGE-positive versus 18 LGE-negative subjects (annualized

28 gas relative to other options (MESP of $0.72/LGE).

29 6%), T2-weighted imaging, T1 maps, and acute LGE.

30 Acute ECV maps were superior to acute LGE in terms of agreement with final IS.

31 emain significantly associated with advanced LGE following DRS stratification was stroke or TIA (haza

32 r the primary end point for patients with an LGE extent of 0% to 2.5%, 2.5% to 5%, and >5% compared w

33 In multivariable analyses, LGE was associated with 1.5-fold (hazard ratio, 1.45 [95

34 ation (SI-Z: coefficient, 0.004; P<0.001 and LGE: coefficient, 0.04; P<0.001) but not in ablation-nai

35 d with SI-Z (coefficient, 0.012; P=0.03) and LGE (coefficient, 0.035; P<0.001) only in ablation-naive

36 idence interval [CI]: 1.1, 8.1; P = .03; and LGE HR, 7.2; 95% CI: 1.5, 34; P = .01).

37 rged with reconstructed cardiac chambers and LGE volume measured.

38 resonance with T1 and T2 mapping, cines, and LGE imaging.

39 stress and rest myocardial perfusion CMR and LGE imaging had high diagnostic accuracy for CAD in 2 ph

40 study sought to evaluate the role of CMR and LGE in the prognosis of AM with preserved LVEF.

41 CMR predictors of CEs were LV dilation and LGE.

42 ECV and LGE have been independently linked with heart failure (H

43 presented a complete recovery from edema and LGE, 30 (16%) patients had edema with LGE, and 137 (73%)

44 and cardiac MR risk factors-including EF and LGE.

45 s of left and right ventricular function and LGE burden were measured in 205 patients with left ventr

46 ndings of ventricular fatty infiltration and LGE were frequent and were most often found in those who

47 Patients with ischemia and LGE both negative had low average annual cost spent on i

48 The combination of FT3 level and LGE provides useful information for assessing the progno

49 1 maps, 15-minute post-contrast T1 maps, and LGE.

50 mmol/kg) to assess myocardial perfusion and LGE in adult patients with known or suspected CAD.

51 and projection of cardiac MRI perfusion and LGE values onto the high spatial resolution LV from CT.

52 rides were not different in LGE-positive and LGE-negative subjects (P=0.47).

53 examine the relationship between rotors and LGE signal intensity in patients with persistent atrial

54 uding LVH (P = .15 for interaction term) and LGE (P = .38 for interaction term).

55 between left atrial conduction velocity and LGE in patients with atrial fibrillation.

56 imated scar volume (r = 0.85, P < .001) and %LGE (r = 0.83, P < .001).

57 f scar volume (r = 0.82-0.99, P < .001) and %LGE (r = 0.90-0.97, P < .001) for all sites and vendors.

58 rcomere mutation identified, and 50% had any LGE.

59 roups by presence of elevated ECV and of any LGE.

60 Finally, in multivariable analysis, AS LGE was the best independent CMR predictor of the combin

61 into 6 cardiac segments, each classified as LGE absent or present.

62 into 6 cardiac segments, each classified as LGE absent or present.

63 However, widespread adoption of atrial LGE has been hindered partly by nonstandardized image pr

64 ortantly, in ablation-naive patients, atrial LGE is associated with electrogram fractionation even in

65 ral network (CNN)-based method for automated LGE scar quantification in patients with HCM.

66 he corresponding anatomic sites on 469 axial LGE image planes.

67 10 left atria data sets, including 86 axial LGE CMR planes per atrium.

68 models, we evaluated the association between LGE and the composite primary end point of all-cause mor

69 We evaluated the association between LGE-CMR intensity and CV with multilevel linear mixed mo

70 retrospectively studied associations between LGE presence and adverse cardiovascular events in patien

71 We examined the associations between LGE, global ECV derived from myocardial tissue segments

72 ar risk of embolism as that detected by both LGE CMR and echocardiography.

73 LV thrombus detected by LGE CMR but not by echocardiography is associated with a

74 hrombotic treatment, LV thrombus detected by LGE CMR is associated with a 4-fold higher long-term inc

75 f left ventricular (LV) thrombus detected by LGE CMR is unknown.

76 among patients with LV thrombus detected by LGE CMR stratified by whether the LV thrombus was also d

77 adult patients with LV thrombus detected by LGE CMR who were matched on the date of CMR, age, and LV

78 ilator stress and rest perfusion followed by LGE imaging.

79 ntinuous net reclassification improvement by LGE markers.

80 he change of the mean of CV per unit change (LGE heterogeneity, wall thickness gradient).

81 Conclusions LGE in Fabry has chronic local T2 elevation that is stro

82 ormed to estimate the mean difference of CV (LGE+/-, wall thinning+/-), or the change of the mean of

83 ormalized variable, as well as a dichotomous LGE variable based on previously validated methodology.

84 spectively recruited for prior 3-dimensional LGE cardiovascular magnetic resonance.

85 lidated our methods on a large 3-dimensional LGE-cardiac magnetic resonance data set from 207 labeled

86 Three-dimensional LGE cardiovascular magnetic resonance-defined scar burde

87 extraorbital and intraorbital glands (double LGE) was performed in male and female C57BL/6J mice to i

88 A parametric map was generated from each LGE image.

89 identity in the lateral ganglionic eminence (LGE), despite upregulating the neurogenic factor Ascl1.

90 maging, including contrast material-enhanced LGE imaging and T1 mapping.

91 Patients with late gadolinium enhancement (LGE) and low lateral MAPSE had significantly reduced sur

92 local CV versus late gadolinium enhancement (LGE) and myocardial wall thickness in a swine model of h

93 nce (CMR), with late gadolinium enhancement (LGE) and T1 mapping, is emerging as a reference standard

94 dict dynamic of late gadolinium enhancement (LGE) as persistent LGE has been shown to be a risk marke

95 ve analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnos

96 replacement and late gadolinium enhancement (LGE) at cardiac magnetic resonance (MR) imaging in patie

97 Late gadolinium enhancement (LGE) border zone on cardiac magnetic resonance imaging h

98 the ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (MRI) to pred

99 no ischemia or late gadolinium enhancement (LGE) by CMR, observed in 1,583 patients (67%), experienc

100 Late gadolinium enhancement (LGE) cardiac magnetic resonance imaging is a unique tiss

101 Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging can

102 Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is

103 ly defined with late gadolinium enhancement (LGE) cardiovascular magnetic resonance but whether this

104 tigated whether late gadolinium enhancement (LGE) cardiovascular magnetic resonance identified patien

105 rction (STEMI), late gadolinium enhancement (LGE) has been demonstrated to overestimate MI size and T

106 nance (CMR) and late gadolinium enhancement (LGE) has not been clarified in acute myocarditis (AM) wi

107 nal left atrial late gadolinium enhancement (LGE) heterogeneity on magnetic resonance imaging.

108 Late gadolinium enhancement (LGE) imaging overestimates acute infarct size.

109 l perfusion and late gadolinium enhancement (LGE) imaging.

110 Areas of late gadolinium enhancement (LGE) in each image were assigned one of 10 possible micr

111 Late gadolinium enhancement (LGE) is an important prognostic marker in hypertrophic c

112 was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evalua

113 l/midmyocardial late gadolinium enhancement (LGE) on contrast-enhanced cardiac magnetic resonance (gr

114 t CMR including late gadolinium enhancement (LGE) parameters between 2002 and 2015 and were included

115 Currently, late gadolinium enhancement (LGE) scans provide the only noninvasive estimate of atri

116 und Cardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome pred

117 rophy (LVH) and late gadolinium enhancement (LGE) were independent predictors of the composite end po

118 eft atrial (LA) late gadolinium enhancement (LGE) with atrial voltage in patients with atrial fibrill

119 the presence of late gadolinium enhancement (LGE), (2) quantify their risk of death/ventricular tachy

120 T1 map, T2 map, late gadolinium enhancement (LGE), and automated extracellular volume fraction (ECV)

121 diastole, cine, late gadolinium enhancement (LGE), and extracellular volume (ECV) imaging at 3-T.

122 cent, segmental late Gadolinium enhancement (LGE), and extracellular volume fraction (ECV).

123 ibrosis through late gadolinium enhancement (LGE), extracellular volume fraction (ECV) measures by ca

124 l fibrosis, and late gadolinium enhancement (LGE), representing replacement fibrosis or scar.

125 F who underwent late gadolinium enhancement (LGE)-cardiac magnetic resonance imaging to quantify LA f

126 id storage) and late gadolinium enhancement (LGE, scar).

127 enhancement on late gadolinium enhancement [LGE] images >20%, n = 72) or small (enhanced volume </=2

128 brosis imaging (late gadolinium enhancement [LGE]), and (1)H magnetic resonance spectroscopy were per

129 and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density

130 ocardial edema, late gadolinium enhancement [LGE], and myocardial strain) parameters.

131 footprint ($1.38/liter gasoline equivalent (LGE) and 12.9 gCO(2e)/MJ) relative to facilities that co

132 Randomized controlled trials evaluating LGE-based care management strategies are warranted.

133 Lacrimal gland excision (LGE) induced dry eye produces more severe corneal damage

134 Patients with extensive LGE (>=15% of left ventricular mass) were at highest ris

135 Yet FA adjusted for LGE and ECV remained reduced in HCM (p = 0.028).

136 mained significant even after correcting for LGE, ECV, and wall thickness (p = 0.036).

137 r stiffness was an independent predictor for LGE (odds ratio, 1.6; 95% confidence interval: 1.2%, 2.1

138 erwent cardiovascular magnetic resonance for LGE evaluation.

139 CNN based on U-Net architecture was used for LGE scar quantification.

140 automatic estimation of fibrosis burden from LGE-cardiac magnetic resonance scans that is comparable

141 automated estimation of atrial fibrosis from LGE-cardiac magnetic resonance scans.

142 Noninvasive derivation of CV maps from LGE-CMR is feasible.

143 Areas with greater LGE heterogeneity ( P<0.001) and wall thickness gradient

144 Forty-one of 205 patients (20%) had LGE; 12 of 205 (6%) died or had VT during follow-up; of

145 Seventeen of the 43 patients (39%) had LGE patterns consistent with myocardial infarction.

146 tion class III to IV; 650 patients (39%) had LGE.

147 sence of LGE, myocardial wall thinning, high LGE heterogeneity, and a high wall thickness gradient.

148 ICM patients with primary prophylactic ICD, LGE border zone predicted ICD therapy in univariable and

149 ls and Methods We retrospectively identified LGE MRI data in a multicenter (n = 7) and multivendor (n

150 d right ventricular dysfunction can identify LGE+ patients at highest risk of death/VT.

151 Among the 374 patients with suitable images, LGE involved the subepicardial layer inferior and latera

152 maging, late gadolinium enhancement imaging (LGE) (replacement fibrosis), and T1 mapping for measurem

153 enhanced cardiac magnetic resonance imaging (LGE-CMR) in patients with ICM.

154 zing laboratory markers experienced improved LGE, in a small percentage LGE worsened.

155 Change in LGE >20% was considered significant.

156 arkers at baseline did not predict change in LGE at 3 months.

157 ocardial triglycerides were not different in LGE-positive and LGE-negative subjects (P=0.47).

158 rd ratios were calculated per 1% increase in LGE.

159 Significantly slower CV was observed in LGE+ (0.33+/-0.25 versus 0.54+/-0.36 m/s; P<0.001) and w

160 at have unique transcriptional signatures in LGE ventricular zone (VZ) cells.

161 After adjustments for covariates including LGE, the relationship persisted for death (HR, 1.82 [95%

162 Increased LGE burden and right ventricular dysfunction can identif

163 P and cTnT levels correlated with increasing LGE and extracellular volume in a graded fashion.

164 ex, diabetes, LV end-diastolic volume index, LGE, EF) (hazard ratio = 2.051 per mm decrease; 95% conf

165 In contrast, patients with ischemia+/LGE+ experienced a >4-fold higher annual primary outcome

166 oposed (kappa = 0.78-1) than reference 3D LA LGE (kappa = 0.44-0.75).

167 (SVS = 11) than reference (SVS = 9.5) 3D LA LGE images.

168 The proposed 3D LA LGE method produced clinically acceptable image quality

169 sought to examine the association between LA LGE on cardiac magnetic resonance and electrogram abnorm

170 Six (25%) had LA LGE.

171 ing patients with stage IV versus stage I LA LGE was 1.67 (95% confidence interval: 1.01 to 2.76) for

172 ere stratified according to Utah stage of LA LGE criteria, and observed for the occurrence of MACCE,

173 The association of LA LGE with voltage is modified by ablation.

174 ve analysis demonstrated that more severe LA LGE is associated with increased MACCE risk, driven prim

175 tained using a reference 3D left atrial (LA) LGE sequence with 1.3 mm x 1.3 mm x 2.5-mm spatial resol

176 have isolated basal septal hypertrophy, less LGE, and more LVOT obstruction.

177 es were RV fatty infiltration (28.9%) and LV LGE (35.5%).

178 Isolated nonischemic LV LGE with a stria pattern may be associated with life-thr

179 .001 per cm(3)), increased nonapical vent LV LGE (OR, 1.09; P=0.008 per cm(3)), older age (OR, 1.6; P

180 In patients with AM and preserved LVEF, LGE in the midwall layer of the AS myocardial segment is

181 The mean LGE burden for left atrium and right atrium was 23.9+/-1

182 Midwall LGE identifies a group of patients with dilated cardiomy

183 ing location and pattern, septal and midwall LGE showed strongest associations with MACE (HR: 2.55; 9

184 investigated the association between midwall LGE and the prespecified primary composite outcome of SC

185 In the multivariable model, LGE presence maintained significant association with MAC

186 After a median follow-up of 46 months, LGE-positive and FT3 < 2.77 pg/mL was identified as the

187 ulations were compared against morphological LGE features extracted from the images.

188 to have reverse septal curvature morphology, LGE, and no significant resting LVOT obstruction.

189 Cardiac MRI LGE showed myocardial scar in three of 17 cases (18%, sc

190 LV) in cardiac MRI perfusion and cardiac MRI LGE, co-registration of cardiac MRI to CT data, and proj

191 risk was increased in patients with multiple LGE patterns, although arrhythmic risk was higher among

192 sity ratio defined as left atrial myocardial LGE signal intensity divided by the mean left atrial blo

193 e detection and quantification of myocardial LGE in patients with previous myocardial infarction was

194 tly different from one another in myocardial-LGE interface length, number of components and entropy,

195 athletes with ventricular arrhythmias and no LGE (group B) and 40 healthy control athletes (group C).

196 group), and it was absent in 26 patients (no-LGE group).

197 For each 25% increase in normalized LGE intensity, CV decreased by 1.34-fold (95% CI, 1.25-1

198 In NICM patients, total LGE but not LGE border zone had predictive value for ICD therapy.

199 tion (bias range, -0.34 to 0.40; P > .05) of LGE.

200 d with the McNemar test, and the accuracy of LGE quantification was calculated with the paired t test

201 The area of LGE measured with synthetic IR techniques showed excelle

202 The association of LGE with electrogram fractionation and delay remains to

203 /VT were associated with a greater burden of LGE (14+/-11 versus 5+/-5%, P<0.01) and right ventricula

204 c thickness >= 1.2 cm had a higher burden of LGE (4.1% vs 0.5% per segment), reduced MPRI (2.6 +/- 1.

205 -sensitive IR techniques in the detection of LGE were 90% and 95%, respectively, with patient-based a

206 Patients with increased extent of LGE (p = 0.02) had a worse prognosis than those with dec

207 The AS group had a greater extent of LGE and a higher LV end-diastolic volume index than othe

208 f regional association between the extent of LGE signal intensity and the presence of rotors.

209 V, in HCM patients, even in segments free of LGE.

210 determine whether size and heterogeneity of LGE predict appropriate implantable cardioverter defibri

211 stics curve, 0.80); for every 1% increase of LGE burden, the hazard of death/VT increased by 8%.

212 ted with the extent and anatomic location of LGE signal intensity from CMR.

213 mpletely in 18 (10%) patients, the number of LGE segments decreased in 87 (46%), unchanged in 58 (31%

214 sion analysis, the midwall septal pattern of LGE and the presence of LGE without edema at CMR-II were

215 oup C; P<0.001), whereas a spotty pattern of LGE localized at the junction of the right ventricle to

216 nts with cardiac amyloidosis, the pattern of LGE was always typical for amyloidosis (29% subendocardi

217 ndependently associated with the presence of LGE (OR: 0.140, 95% CI: 0.035-0.567), perfusion abnormal

218 with dilated cardiomyopathy, the presence of LGE showed strong prognostic value for identification of

219 The presence of LGE without edema at 6-month CMR is associated with wors

220 ll septal pattern of LGE and the presence of LGE without edema at CMR-II were independent predictors

221 Slower CV is observed in the presence of LGE, myocardial wall thinning, high LGE heterogeneity, a

222 on, LV systolic dysfunction, and presence of LGE.

223 ling rates as well as a higher prevalence of LGE compared with healthy control subjects.

224 ment for the detection and quantification of LGE was analyzed with kappa and Bland-Altman statistics,

225 LGE heterogeneity was defined as SD of LGE in the local neighborhood of 5 mm and wall thickness

226 corneal damage in female mice, yet signs of LGE-induced ocular pain and anxiety in male and female m

227 ter agreement with final IS than acute IS on LGE (ECV maps: bias, 1.9; 95% CI, 0.4-3.4 versus LGE ima

228 maps using the area-weighted average of only LGE-absent segments.

229 tients without dilated cardiomyopathy and/or LGE.

230 Patients without CMR ischemia or LGE experienced a low incidence of cardiac events, littl

231 ), compared with none of athletes with no or LGE spotty pattern and controls.

232 nd other segments in 59 patients (16%; other-LGE group), and it was absent in 26 patients (no-LGE gro

233 atty infiltration and/or nonischemic pattern LGE).

234 erienced improved LGE, in a small percentage LGE worsened.

235 e gadolinium enhancement (LGE) as persistent LGE has been shown to be a risk marker in myocarditis.

236 Positive LGE lesions (three of 11 [27%] vs 10 of 19 [53%] vs nine

237 had edema with LGE, and 137 (73%) presented LGE without edema.

238 men) were imaged at 1.5 T using the proposed LGE sequence with 1.3 mm x 1.3 mm x 2-mm spatial resolut

239 times, ECV, and qualitative and quantitative LGE).

240 ; P = .004) and correlated with quantitative LGE (r = 0.67; P < .001), myocardial T1 relaxation times

241 atory parameters do not sufficiently reflect LGE in myocarditis.

242 High-resolution LGE cardiac magnetic resonance was performed before elec

243 Results LGE in the basal inferolateral wall in FD had T2 elevati

244 An RV LGE volume of 25 cm(3) had 72% sensitivity and 81% speci

245 bivariable analyses after controlling for RV LGE volume (OR, 1.14; P=0.003).

246 ictors of inducible VT included increased RV LGE (odds ratio [OR], 1.15; P=0.001 per cm(3)), increase

247 or ruling-out and ruling-in inducible VT, RV LGE >10 cm(3) was 100% sensitive and >36 cm(3) was 100%

248 fferences in the per-patient and per-segment LGE detection rates between the synthetic and convention

249 In the acute setting, LGE does not mean definite fibrosis, and it may disappea

250 wo hundred ninety-four (44%) patients showed LGE presence, which was associated with a more than doub

251 Single LGE caused a reduction in palpebral opening and an incre

252 Furthermore, single LGE produced signs of increased anxiety in female but no

253 ion of either the extraorbital gland (single LGE), or both the extraorbital and intraorbital glands (

254 The majority of athletes with no or spotty LGE pattern had ventricular arrhythmias with a predomina

255 A stria LGE pattern with subepicardial/midmyocardial distributio

256 The use of T1 mapping to derive synthetic LGE images may reduce imaging times and operator depende

257 te of death/VT per year was >20x higher than LGE- (4.9 versus 0.2%, P<0.01); (2) death/VT were associ

258 d provides a better risk stratification than LGE presence and its extent in patients with hypertrophi

259 This allowed the LGE signal intensity to be projected onto the anatomy fr

260 In the LGE+ group (1) the rate of death/VT per year was >20x hi

261 ng follow-up; of these, 10 (83%) were in the LGE+ group.

262 We proposed a novel method, the LGE-dispersion mapping, to assess heterogeneity of scar,

263 th primary prevention ICD by quantifying the LGE border zone.

264 death/VT in the entire group and within the LGE+ group was determined using Cox proportional hazard

265 CE rates were 4.8% and 2.1% corresponding to LGE presence and absence, respectively (p < 0.001).

266 th replacement fibrosis as assessed by total LGE burden.

267 For NICM, total LGE by all 4 methods was the strongest predictor (hazard

268 In NICM patients, total LGE but not LGE border zone had predictive value for ICD

269 The total LGE burden was similar between the two groups (P = 0.47)

270 n deriving ECV, coronary artery disease type LGE, but not non-coronary artery disease type LGE, has b

271 GE, but not non-coronary artery disease type LGE, has been consistently excluded.

272 rognosis than those with decreased/unchanged LGE.

273 All patients underwent LGE-CMR and electroanatomic mapping (EAM) in sinus rhyth

274 HODS AND ICM and NICM patients who underwent LGE cardiac magnetic resonance imaging prior to ICD impl

275 Follow-up LGE imaging was used as the reference standard for final

276 of MI on nonenhanced cine MR images by using LGE imaging as the standard of reference.

277 LV fibrosis was detected by using LGE in 11 cases.

278 Ventricular LGE was segmented and merged with reconstructed cardiac

279 71% transmural), including right ventricular LGE (96%).

280 (ECV maps: bias, 1.9; 95% CI, 0.4-3.4 versus LGE imaging: bias, 10; 95% CI, 7.7-12.4).

281 to total left ventricle myocardial volume (%LGE) (r = 0.91, P < .001).

282 hundred and ninety-nine patients (29%) were LGE positive.

283 ovement was 0.39 (95% CI: 0.10 to 0.67) when LGE presence was added to the multivariable model for MA

284 volunteers 48.9+/-2.5 ms, P<0.001), but when LGE was present there was also global T2 elevation (53.1

285 an age 50 years, median LVEF 50%, 25.3% with LGE) followed for a median of 4.6 years, 18 of 101 (17.8

286 CV is inversely associated with LGE-CMR fibrosis density in patients with ICM.

287 When compared with LGE extent >15%, GDS improved the classification of risk

288 ma and LGE, 30 (16%) patients had edema with LGE, and 137 (73%) presented LGE without edema.

289 c involvement who underwent cardiac MRI with LGE with at least 12 months of either prospective or ret

290 At Kaplan-Meier curves, patients with LGE and without edema had worse prognosis than others (p

291 Sarcoidosis patients with LGE are at significant risk for death/VT, even with pres

292 f 4.6 years, 18 of 101 (17.8%) patients with LGE reached the prespecified end point, compared with 7

293 ECV may have a synergistic role with LGE in HF risk assessment.

294 f FT3, decreased percentage of segments with LGE and perfusion/metabolism abnormalities were found.

295 ntly reduced survival compared to those with LGE and high lateral MAPSE (log-rank P < .0001).

296 Ascl1-Gsx2 interactions are enriched within LGE VZ progenitors, whereas Ascl1-Tcf3 (E-protein) inter

297 DNA binding and limiting neurogenesis within LGE progenitors.

298 as present in segments both with and without LGE.

299 l ECV was derived from only segments without LGE.

300 % to 5%, and >5% compared with those without LGE were 10.6 (95% CI, 3.9-29.4), 4.9 (95% CI, 1.3-18.9)