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1                                              LINE retrotransposons actively shape mammalian genomes.
2                                              LINE-1 (L1) insertions comprise as much as 17% of the hu
3                                              LINE-1 (L1) retrotransposons are a noted source of genet
4                                              LINE-1 (L1) retrotransposons are mobile genetic elements
5                                              LINE-1 (L1) retrotransposons are mobile genetic elements
6                                              LINE-1 (L1) retrotransposons represent approximately one
7                                              LINE-1 (or L1) is an autonomous non-LTR retrotransposon
8                                              LINE-1 and AIM1 methylation status was assessed in paraf
9                                              LINE-1 and AluYb8 methylation levels were found to be si
10                                              LINE-1 derepression is associated with a number of disea
11                                              LINE-1 elements are retrotransposons that are capable of
12                                              LINE-1 hypomethylation and AIM1 hypermethylation have pr
13                                              LINE-1 hypomethylation of cell-free DNA has been describ
14                                              LINE-1 methylation was related to maternal RBC folate (P
15                                              LINE-1 protein expression is a common feature of many ty
16                                              LINE-1 retroelements are the only autonomously active el
17                                              LINE-1 retrotransposon overexpression is a hallmark of h
18                                              LINE-1 retrotransposons and specific miRNAs, lncRNAs, an
19                                              LINE-1 retrotransposons are abundant repetitive elements
20                                              LINE-1 retrotransposons are fast-evolving mobile genetic
21                                              LINE-1 shRNAs can abrogate the HUSH-dependent response,
22                                              LINE-1 U-Index (hypomethylation) and AIM1 were analyzed
23                                              LINE-1 U-Index level was elevated with increasing Americ
24                                              LINE-1s are active human DNA parasites that are agents o
25                                              LINEs and SINEs are retrotransposons; that is, they tran
26 cluding long interspersed nuclear element 1 (LINE-1 or L1) and human endogenous retrovirus, accompani
27                 Long Interspersed Element 1 (LINE-1 or L1) is capable of causing genomic instability
28             The long interspersed element 1 (LINE-1 or L1) ORF2 protein is the genomic source for RT
29 t for increased long-interspersed element 1 (LINE-1 or L1) retrotransposition.
30                 Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third
31 centage long interspersed nuclear element 1 (LINE-1) DNA demethylation for oral cedazuridine/decitabi
32 and the long interspersed nuclear element 1 (LINE-1) in genomic DNA extracted from whole blood in 913
33     The Long interspersed nuclear element 1 (LINE-1) is a primary source of genetic variation in huma
34 AcMNPV FP25K to long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p), which cont
35  of the long interspersed nuclear element 1 (LINE-1) retrotransposon and with aberrant expression of
36                 Long interspersed element 1 (LINE-1) retrotransposon is expressed in many carcinomas,
37 lation of young long interspersed element 1 (LINE-1) retrotransposons in cancer, often distinct to th
38 ent over long interspersed repeat element 1 (LINE-1).
39                 Long interspersed element-1 (LINE-1 or L1) amplifies via retrotransposition.
40 ngineered human Long INterspersed Element-1 (LINE-1 or L1) retrotransposition in HeLa cells.
41                 Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosa
42                 Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threa
43                 Long interspersed element-1 (LINE-1 or L1) retrotransposition poses a threat to genom
44                 Long interspersed element-1 (LINE-1 or L1) retrotransposons account for nearly 17% of
45                 Long interspersed element-1 (LINE-1 or L1) retrotransposons encode two proteins (ORF1
46 s in long interspersed nucleotide element-1 (LINE-1) and absent in melanoma-1 (AIM1; 6q21) associated
47 vels of long interspersed nuclear element-1 (LINE-1) and the Alu element AluYb8 were determined in 38
48 that revealed a long interspersed element-1 (LINE-1) insertion upstream of the IMPG2 gene.
49  active long interspersed nuclear element-1 (LINE-1) lacked CW methylations but not CG methylations.
50 f human long interspersed nuclear element-1 (LINE-1) quantitive real-time PCR.
51 port widespread long interspersed element-1 (LINE-1) repeat expression in human cancers.
52                 Long Interspersed Element-1 (LINE-1) retrotransposition contributes to inter- and int
53 osons including Long Interspersed Element-1 (LINE-1).
54                 Long interspersed element-1 (LINE-1, also known as L1), the only currently autonomous
55 fy and sequence long interspersed element-1 (LINE-1, L1) retrotransposon insertions selectively in th
56                 Long interspersed element-1 (LINE-1, or L1) is the only autonomous retrotransposon th
57 F1p, encoded by long interspersed element-1 (LINE-1; L1) retrotransposon, in PDAC.
58                Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity
59  predicted to mediate CNVs and identified 25 LINE-LINE rearrangements.
60 f all human cancers are immunoreactive for a LINE-1-encoded protein.
61 quencing of a PRA case, we have identified a LINE-1 insertion in the retinal candidate gene IMPG2 tha
62             For the new version of L1Base, a LINE-1 annotation tool, L1Xplorer, has been used to mine
63                     DNA hypomethylation of a LINE retrotransposon related to rice Karma, in the intro
64 y reported that in cancer, aberrantly active LINE-1 promoters can drive transcription of flanking uni
65 d with few exceptions there is a sole active LINE family (L1).
66         Epigenetic silencing defends against LINE-1 (L1) retrotransposition in mammalian cells.
67                       TP53 inhibition allows LINE-1(+) cells to grow, and genome-wide-knockout screen
68                 Retrotransposition amplifies LINE-1 (L1) to high copy number in mammalian genomes.
69 rth: IGF2 (P = 0.038), PEG3 (P < 0.001), and LINE-1 (P < 0.001).
70 3 (-0.5%; 95% CI: -0.9, -0.1; P = 0.018) and LINE-1 (-0.3%; 95% CI: -0.6, -0.04; P = 0.029).
71 nriched for endogenous retroviruses, Alu and LINE-1 elements.
72 roteins from a representative set of DNA and LINE transposable elements and used the obtained structu
73 vels and derepression of endogenous LTR- and LINE-repetitive DNA elements during differentiation of m
74 on of the histone methyltransferase MLL5 and LINE-1 elements transposons.
75 repeats, such as endogenous retroviruses and LINE-1 elements.
76 long interspersed nuclear elements (SINE and LINE), and the type I IFN pathway in responders, all ind
77 ecting hypomethylation hot spots of LTRs and LINEs.
78 argeting Class I/Copia-Ivana- Copia-SIRE and LINEs elements).
79 ution of SCOP classes in DNA transposons and LINEs indicates that the proteins of DNA transposons are
80 erminants of A3A deaminase activity and anti-LINE-1 activity are not the same.
81 uring cellular senescence, L1 (also known as LINE-1) retrotransposable elements become transcriptiona
82 ng interspersed element-1 (L1, also known as LINE-1) transposons.
83 , whereas several repeated elements, such as LINE 2, and several LTR elements, are hypomethylated in
84 viruses and endogenous retroelements such as LINE-1, but it can also edit genomic DNA, which may play
85 ity against mobile genetic elements, such as LINE-1, to protect the integrity of our genome.
86 ation status of repetitive elements, such as LINEs, in the human genome, thereby revealing the strong
87                   In this study, we assessed LINE-1 open reading frame 1 protein expression in 12 p53
88 -Hydroxymethylcytosine was found enriched at LINE-1 prior to a decrease in both 5-hydroxymethylcytosi
89 t of pervasive transcription from autonomous LINE-1 activity.
90  restriction-like endonuclease (RLE) bearing LINE.
91                                      Because LINE-1 elements are repetitive, it is difficult to quant
92                                       BOTTOM LINE Compared with serodiscordant couples without treatm
93                                       BOTTOM LINE Continuous macrolide antibiotic use for prophylaxis
94                                       BOTTOM LINE Weak opioids (such as codeine, dextropropoxyphene,
95 ments (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today.
96 is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilize in pluripot
97 on of RNA molecules into the human genome by LINE retrotransposons, contributing to the approximately
98  identified 516 CNVs potentially mediated by LINEs.
99                                   CAlifornia LINE Source Dispersion Modeling, version 4 (CALINE4) was
100 cides with upregulation of primate-conserved LINE-1s, as well as increased expression of full-length
101  classified into two types: those containing LINE transposable elements and those containing segmenta
102 sequences, cells need to efficiently control LINE-1 retrotransposition.
103 d TEs under darkness were enriched in Copia, LINE, and MuDR dispersed across chromosomes.
104 and sublineages of cells marked by different LINE-1 (L1) retrotransposition events and subsequent mut
105  upregulated neuronal genes or downregulated LINE transposon expression.
106  a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression af
107                                   TETs drive LINE-1 demethylation, but surprisingly, LINE-1s are kept
108 on-autonomous non-LTR retrotransposons, i.e. LINEs and SINEs, and with few exceptions there is a sole
109 bution of BovB, a long interspersed element (LINE) about 3.2 kb long, that has been found in ruminant
110 e distribution of long interspersed element (LINE) retrotransposon and their potential to mediate NAH
111  of a Tetrahymena Long interspersed element (LINE)-like retrotransposon are very frequently found phy
112 aralogous long interspersed nuclear element (LINE) or human endogenous retrovirus (HERV) repeats as a
113 ession of long interspersed nuclear element (LINE) sequences in Cstf2t(-/-) testes.
114 ts [e.g., long interspersed nuclear element (LINE)-1 repeats] were further confirmed by the increased
115       The long interspersed nuclear element (LINE-1) (L1) clade of non-LTR retrotransposons has been
116           Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first mo
117 ngineered long interspersed nuclear element (LINE-1; L1) mobilization have been in use for quite some
118 rgeting repetitive nuclear genomic elements (LINE-1) and mitochondrial genes.
119   Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobi
120                  Long INterspersed Elements (LINE-1s, L1s) are responsible for over one million retro
121 INE) and long interspersed nuclear elements (LINE), but not in long terminal repeats (LTR).
122 sites in long interspersed nuclear elements (LINE-1) retrotransposons, resulting in increased LINE-1
123 wo types of TEs: long interspersed elements (LINEs) and short interspersed elements (SINEs).
124                  Long Interspersed Elements (LINEs), also known as non-LTR retrotransposons, encode a
125 lements (SINEs), long interspersed elements (LINEs), and long terminal repeat (LTR) retroelements, wh
126                  Long interspersed elements (LINEs), through both self-mobilization and trans-mobiliz
127 (SINEs), long interspersed nuclear elements (LINEs) and the endogenous retrovirus (ERV) superfamily.
128 ation on long interspersed nuclear elements (LINEs) in germ cells.
129 res, and long interspersed nuclear elements (LINEs) to the neutrophil nuclear lamina.
130  such as long interspersed nuclear elements (LINEs).
131 asses and subclasses of repetitive elements (LINEs, endogenous retroviruses, DNA transposons, simple
132 1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotransposition-inde
133 the L1Hs insertions reside within endogenous LINE-1 sequences in the reference assembly and the analy
134 ponse, while overexpression of an engineered LINE-1 construct activates interferon signaling.
135                       Finally, ORF0 enhances LINE-1 mobility.
136 ia immunohistochemical staining and examined LINE-1 promoter methylation in representative cases.
137 w into the DNA of mammalian cells expressing LINE-1-like elements.
138 ovel retrotransposition-independent role for LINE-1 elements in malignancy.
139      Because recent reports suggest frequent LINE-1 (L1) retrotransposition in human brains, we perfo
140          Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as
141      TeXP builds mappability signatures from LINE-1 subfamilies to deconvolve the effect of pervasive
142                                 Furthermore, LINE-1 induction enabled by ODC1 interference provides a
143  and validated a method called TeXP to gauge LINE-1 activity accurately.
144    Genomic features mirror those of germline LINE element retrotranspositions, with frequent target-s
145                          When analyzed, high LINE-1 U-Index and/or AIM1 methylation in melanomas were
146 egulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth.
147                               We discuss how LINEs and SINEs have expanded in eukaryotic genomes and
148                               Although human LINE-1 (L1) elements are actively mobilized in many canc
149 ), impaired the mobility of engineered human LINE-1 (L1) and mouse intracisternal A-type particle ret
150 19) determined integration patterns of human LINE-1 (long interspersed element-1) retrotransposons hi
151 rame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein.
152  rhesus TRIM5alpha efficiently repress human LINE-1 retrotransposition.
153 , immunization of rhesus macaques with human LINE-1 open reading frame 2 (96% identity with macaque),
154              Together, our findings identify LINE-1 as important target of human TRIM5alpha, which re
155                      Despite its importance, LINE-1 activity remains difficult to study because of it
156 sites in p16 (n = 7) and p53 (n = 4), and in LINE-1 and Alu repetitive elements (3 CpG sites in each)
157                               Methylation in LINE-1 increased by 1.36% [95% confidence interval (CI):
158 ositively associated with DNA methylation in LINE-1 repeated elements, and to a lesser degree at CpG
159 derstanding of the requirements for ORF1p in LINE-1 retrotransposition and, more generally, nucleic a
160               Repetitive elements, including LINE-1 (L1), comprise approximately half of the human ge
161 y of repeat sequences (C0T-1 RNA), including LINE-1.
162 -1) retrotransposons, resulting in increased LINE-1 mRNA.
163 e 1 (HTLV-1), while significantly inhibiting LINE-1 retrotransposition.
164  carcinomas, respectively, exhibited intense LINE-1 immunoreactivity compared with adjacent, normal-a
165 urs is produced by exaptation of an intronic LINE-2A (L2A) endogenous retroelement in the CD274 gene,
166                                      The L1 (LINE 1) retrotransposable element encodes two proteins,
167                  Although members of the L1 (LINE-1) clade of non-LTR retrotransposons can be deleter
168 mon repetitive elements, including L1 and L2 LINEs, and DNA motifs that are significantly enriched ar
169 e evolved a lineage-specific TE called LAVA (LINE-AluSz-VNTR-Alu (LIKE)), which is still active in th
170                         As young full-length LINE-1 transposons are strongly enriched on the X chromo
171 reverse transcriptase-encoding elements like LINE-1 or endogenous retroviruses via a process termed r
172  adult central nervous system) showing lower LINE-1 activity.
173 tions the multiple reads aligned to the many LINE-1 instances in the genome into these two categories
174                         Differences in mean %LINE-1 demethylation between oral and IV were <=1%.
175 pplied our method to comprehensively measure LINE-1 activity across healthy somatic cells, while back
176                      A codon-optimized mouse LINE-1 element, ORFeus, exhibits dramatically higher ret
177                                          New LINE-1 insertions are thought to accumulate mostly durin
178 tromeric and pericentromeric repeats but not LINE-1 elements to the lamina.
179 arly identical active transposons, two novel LINE insertions of identity approximately 99% and length
180           Finally, a greater accumulation of LINE-1 was found in mice that lack IFNAR1 compared with
181         Our findings implicate activation of LINE-1 elements in subsequent epigenetic remodelling of
182                                Activation of LINE-1 occurs frequently in cancer and can enable LINE-1
183          Our data suggest that activation of LINE-1 regulates global chromatin accessibility at the b
184 onal experiments revealed that activation of LINE-1 retrotransposons increases the expression of IFNb
185 sely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched
186   Interestingly, we found that the amount of LINE-1 activity was associated with the with the amount
187 DNA methylation as determined by analysis of LINE-1 repeat elements.
188 odel to study mechanisms and consequences of LINE-1 activation in the etiology and progression of UC
189               Polycomb sites are depleted of LINE repeats but enriched for SINEs and simple repeats.
190                 Furthermore, the efficacy of LINE-1 replication was increased in isogenic cell lines
191 were lineage specific, and the enrichment of LINE/L1 and long term repeat/Copia elements in lineage 3
192 erve a significant age-associated erosion of LINE-1 methylation in cfDNA suggesting that the threshol
193 her confirmed by the increased expression of LINE-1 retrotransposon-associated repetitive elements in
194  are a previously unseen alternative fate of LINE retrotransposition, and may represent an unexpected
195 nome-wide LINE-1 demethylation, induction of LINE-1 transcripts and double-strand DNA breaks and decr
196 XP by independently estimating the levels of LINE-1 autonomous transcription using ddPCR, finding hig
197                         The current model of LINE retrotransposition, target-primed reverse transcrip
198             We present a stochastic model of LINE-1 (L1) transposition in human cancer.
199  the reporter genes, whereas the presence of LINE in P2 or gypsy LTR retrotransposon in P3 reduced ex
200 NF-kappaB, leading to the down-regulation of LINE-1 promoter activity.
201 cells with IFN suppressed the replication of LINE-1.
202 ex is necessary for epigenetic repression of LINE-1 elements.
203 y, IFI16 also inhibits retrotransposition of LINE-1, known to engage Sp1, and murine IFI16 homologs r
204 placing 82.8% of the human genome at risk of LINE-LINE-mediated instability.
205          To additionally assess the scale of LINE-LINE/NAHR phenomenon in the human genome, we tested
206  contains annotated full-length sequences of LINE-1 transposons including putatively active L1s.
207   We demonstrate that premature silencing of LINE-1 elements decreases chromatin accessibility, where
208 tein coding capability from other sources of LINE-1 RNA.
209 nsertions of the human-specific subfamily of LINE-1 (L1) retrotransposon are highly polymorphic acros
210  genomic instability; however, the timing of LINE-1 activation during this evolution has yet to be el
211 a selective increase in the transcription of LINE-1 and L1PA2 retroelements upon knockdown of URI.
212 nal data point to guide our understanding of LINE dynamics in eutherians.
213               The dual role of TET action on LINE-1s may reflect the evolutionary battle between TEs
214               Long INterspersed Element one (LINE-1, or L1), is a widely distributed, autonomous retr
215     Methylation of the control IL-2 Site7 or LINE-1 was not a significant predictor of asthma exacerb
216       We identified 17 005 directly oriented LINE pairs located <10 Mbp from each other as potential
217  Disruption of the repressive chromatin over LINE-1 elements in DTPs results in DTP ablation, which i
218 ASOR is required for H3K9me3 deposition over LINE-1 repeats and repetitive exons in transcribed genes
219 75%) of 112 ovarian carcinomas overexpressed LINE-1.
220 y (91.7%) of transcriptome reads overlapping LINE-1 derive from pervasive transcription.
221                                   Preventing LINE-1 activation and interfering with its silencing dec
222               Here, we show that the primate LINE-1 5'UTR contains a primate-specific open reading fr
223 pectation maximization algorithm to quantify LINE-1 RNA at each genomic locus, separating transcripts
224  are repetitive, it is difficult to quantify LINE-1 RNA at specific loci and to separate transcripts
225 he ability of dispersion (CALINE4, AERMOD, R-LINE, and QUIC) and regression models to predict PNC in
226                                    Recently, LINE-1 genomic repeat elements have been proposed as pot
227 tion, which is partially rescued by reducing LINE-1 expression or function.
228  global methylation, using repetitive region LINE-1 and ALUYb8 sequences.
229 d of hypomethylation sufficient for relevant LINE-1 activation and consequential harmful retrotranspo
230           Our qPCR assay utilized repetitive LINE-1 elements specific to the genome of Sus scrofa dom
231 ers, demethylation of genome-wide repetitive LINE-1 elements, and hypermethylation in specific promot
232 d IFN plays an important role in restricting LINE-1 propagation and discuss the putative role of IFN
233 mmune factor TRIM5alpha senses and restricts LINE-1 retroelements.
234 hway through exaptation of a retroduplicated LINE retrotransposon (EPCOT3) into an enhancer.
235                          The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposab
236 king correlation of FOA with retrotransposon LINE-1 (L1) expression in mice to understand how L1 acti
237            We now implicate retrotransposons LINE-1 (L1), activated during epigenetic reprogramming o
238                          A new model for RLE LINE integration is presented.
239 titive sequences, including major satellite, LINE-1, and ERV.
240    These include simple repeats, satellites, LINEs, and endogenous retroviruses as well as transposon
241  As part of the randomised open-label SECOND-LINE trial, second-line ART NtRTI selection was made by
242                Results of the 96 week SECOND-LINE randomised trial showed that NtRTI-sparing ART with
243 human TRIM5alpha, which restricts and senses LINE-1 via two distinct mechanisms.
244 e DNA, we used a targeted method to sequence LINE-1 insertion sites in matched PDAC and normal sample
245 e 12 p53 signatures demonstrated significant LINE-1 expression.
246 omes preferentially locate within young SINE/LINE transposons, suggesting that when subject to increa
247 he MITEs/DNA-transposase in plants and SINEs/LINEs in mammals.
248                                      Somatic LINE-1 (L1) retrotransposition during neurogenesis is a
249                                      Somatic LINE-1 (L1) retrotransposition has been detected in earl
250             We found evidence of 465 somatic LINE-1 insertions in 20 PDAC genomes, which were absent
251  recent study reported high rates of somatic LINE-1 element (L1) retrotransposition in the hippocampu
252  to genetic changes in cancers, with somatic LINE-1 insertions seen in selected types of human cancer
253 d expression of full-length hominid-specific LINE-1s that produce bidirectional RNAs, which may form
254 ve been developed to identify human-specific LINE-1 (L1Hs) insertions from short-read whole genome se
255 3' untranslated region of a primate-specific LINE-1 (long interspersed nuclear element 1) retrotransp
256 ver the complete sequences of tumor-specific LINE-1 insertions and their retrotransposition hallmarks
257 he IFN receptor chain IFNAR1 also stimulated LINE-1 propagation in vitro.
258 correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enh
259 rive LINE-1 demethylation, but surprisingly, LINE-1s are kept repressed through additional TET-depend
260 atin marks in the 5' sequence of a synthetic LINE-1 element.
261 iduals on a custom aCGH microarray targeting LINE elements predicted to mediate CNVs and identified 2
262                Our findings demonstrate that LINE-1 expression creates specific molecular vulnerabili
263           A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and
264                  Unexpectedly, we found that LINE-1 activity is present in many normal somatic cells.
265 open reading frame 1 protein, and found that LINE-1 open reading frame 1 protein is a surprisingly br
266                    Our results indicate that LINE-1 retrotransposons often become deregulated during
267                       Our data indicate that LINE-LINE-mediated NAHR is widespread and under-recogniz
268                              We propose that LINE-1-induced IFN plays an important role in restrictin
269             Together, our findings show that LINE-1 contributes to the genetic evolution of PDAC and
270  contrasts with earlier studies showing that LINE-1 has limited activity in healthy somatic tissues,
271                      Studies have shown that LINE-1 contributes to genetic changes in cancers, with s
272                   These results suggest that LINE-1s may drive physiological or autoinflammatory resp
273  the LINE-1 transcript, thus suggesting that LINE-1 functions primarily at the chromatin level.
274  An emerging body of evidence indicates that LINEs and SINEs function to regulate gene expression by
275                                          The LINE-1 U-Index of melanoma (n = 100) was significantly h
276 -) placentas and that protein encoded by the LINE-1 retrotransposon is upregulated in hypomethylated
277                       Hypomethylation of the LINE-1 promoter was found in all STICs exhibiting overex
278  of IL-2 (IL-2 Site7) and methylation of the LINE-1 repetitive element.
279 evels were assessed by pyrosequencing of the LINE-1 retroelement promoter in DNA from 55 salivary gla
280 es independently of the coding nature of the LINE-1 transcript, thus suggesting that LINE-1 functions
281 late this observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, an
282  P1 acts as an enhancer in contrast with the LINE in P2 and the gypsy LTR retrotransposon in P3 which
283 V breakpoints in each patient map within the LINE elements.
284 hat the SIN3A co-repressive complex binds to LINE-1s, ensuring their repression in a TET1-dependent m
285 us, followed by gene density and distance to LINE elements, are the prime determinants of the speed o
286 tigated chromosomal rearrangements linked to LINE sequences and also provoked inflammatory programs t
287  neuroendocrine-associated genes proximal to LINE-1 insertions.
288 activate interferon signaling in response to LINE-1.
289  of flanking unique sequences giving rise to LINE-1 chimeric transcripts (LCTs).
290                     We utilized a transgenic LINE-1 mouse model and tracked DNA methylation dynamics
291 full-length elements of actively transposing LINE families, demonstrating the remarkable ability of t
292              Furthermore, serum unmethylated LINE-1 was at higher levels in both stage III (n = 20) a
293                              To test whether LINE-1 expression leads to somatic insertions of this mo
294 sociated with gene pair rearrangement, while LINEs are associated with gene deletions.
295 kdown of ODC1 expression elicits genome-wide LINE-1 demethylation, induction of LINE-1 transcripts an
296 nnate immune signaling upon interaction with LINE-1 ribonucleoprotein complexes.
297                    TRIM5alpha interacts with LINE-1 ribonucleoprotein complexes in the cytoplasm, whi
298 ely at canonical GT-AG splice junctions with LINE and SINE elements forming the most RE splice juncti
299  5' UTR of full-length, evolutionarily young LINE-1 elements, a pattern that is conserved in human ES
300  demethylation of aberrantly expressed young LINE-1s in normal tissues.

 
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