ライフサイエンスコーパス: LLE

1 LLE and SPE were employed for sample clean-up and enrich

2 LLE is sensible for the development stages but does not

3 LLE MHC I fibres were ~20% stronger, ~10% faster and ~30

4 LLE MHC I size (7624 2765 um(2) ) was 25-40% larger (P <

5 LLE using di-(2-ethylhexyl)phosphoric acid (D2EHPA) extr

6 LLE using dichloromethane as organic phase was combined

7 LLE were subdivided based on lifelong exercise intensity

8 rmalized power among OH (16.7 6.4 W L(-1) ), LLE (13.9 4.5 W L(-1) ) and YE (12.4 3.5 W L(-1) ).

9 the method employing florosil column after a LLE procedure was applied for wine samples with satisfac

10 In this study the feasibility of a LLE-GC-EI-MS method for the analysis of 43 phenolic acid

11 electron microscopy studies revealed that Ac-LLE formed bead-like microstructures, Ac-LVE and Ac-YYD

12 ly predicted tripeptides (Ac-LVE, Ac-YYD, Ac-LLE, Ac-YLD, Ac-MYD, Ac-VIE) were chosen for experimenta

13 f LLVY-methylcoumaryl-7-amide (LLVY-MCA) and LLE-beta-nitroanilide (LLE-betaNA) more than REGalpha or

14 The LLE-P and LLE-F had similar single fibre profiles with MHC I power

15 enrichment of N-glycans, permethylation, and LLE.

16 ction ability of SPE with the diol phase and LLE were similar.

17 n of extraction efficiencies between SPE and LLE.

18 bination of solid phase extraction (SPE) and LLE to produce a cleaner extract that can be easily conc

19 HS-SPME and LLE-GC/MS analyses revealed that metabolism of the compo

20 Lipophilic efficiency indices such as LLE and LELP were suggested to support balanced optimiza

21 This fully automated LLE methodology avoids several disjointed steps involved

22 miniaturized LLE procedures, fully automated LLE techniques allowing high-throughput bioanalytical st

23 bioanalytical method, based on the automated LLE and fast gradient LC-MS/MS, was validated and succes

24 The automated LLE methodology is universal and can be employed for sam

25 On average, LLE had exercised ~5 days week(-1) for ~7 h week(-1) ove

26 omparable fast fibre characteristics between LLE and OH, regardless of training intensity, suggest ot

27 Both LLE and LELP have significant impact on ADME and safety

28 d binding thermodynamics, we found that both LLE and LELP help identifying better quality compounds.

29 A combination of SPE (OasisHLB) followed by LLE was shown to maximize compound identification and qu

30 We compared recoveries by LLE, XAD resins, and a mixture of Phenomenex Sepra SPE s

31 ified at levels 10-33 times below comparable LLE methods with 10 times lower volumes of sample (10 mL

32 By contrast, LLE MHC IIa size (6466 2659 um(2) ) was similar to OH (6

33 p to 51%) vs. its non-sonicated counterpart (LLE-agitation) and n-hexane washing.

34 Here, we design LLE for palladium based on polyoxopalladates (POPs), whe

35 The developed LLE solvent prediction model is in- line with the global

36 Most effective LLE of Pd (>99.9%) are arsenate/phenylphosphonate/acetat

37 nM) with high lipophilic ligand efficiency (LLE = 8.5), which displays nanomolar potency in cells (p

38 with improved lipophilic ligand efficiency (LLE) consistent with the reduction of clogP.

39 on of cellular lipophilic ligand efficiency (LLE) in a series of 2-anilino-pyrimidine IGF-1R kinase i

40 ficiency (LE), lipophilic ligand efficiency (LLE), and lower carboaromaticity.

41 d or increased ligand lipophilic efficiency (LLE) compared to previously reported compounds led to th

42 ioactivity and ligand lipophilic efficiency (LLE) parameter were the principal guidelines in the lead

43 ponse weighted ligand lipophilic efficiency (LLE) termed AgLLE is discussed along with the issues of

44 y activity, ligand-lipophilicity efficiency (LLE), selectivity over sigma(1) receptors, and metabolic

45 Here, we introduce locally linear embedding (LLE), an unsupervised learning algorithm that computes l

46 aser at the Laboratory for Laser Energetics (LLE) or the National Ignition Facility at Lawrence Liver

47 ng three groups of men: lifelong exercisers (LLE) (n = 21, 74 4 years), old healthy non-exercisers (O

48 and people with lived or living experience (LLE) of substance use disorders.

49 In this work, liquid-liquid extraction (LLE) and solid phase extraction (SPE), of polyphenols fr

50 work, we combined liquid-liquid extraction (LLE) and solid-phase extraction (SPE) techniques to prep

51 on methods include liquid-liquid extraction (LLE) and solid-phase extraction (SPE), which may use eit

52 A method utilizing liquid-liquid extraction (LLE) coupled with liquid chromatography-tandem mass spec

53 ng method based on liquid-liquid extraction (LLE) followed by ultra performance liquid chromatography

54 SERS) coupled with liquid-liquid extraction (LLE) for quantification of p-coumaric acid (pHCA) in the

55 deconjugation and liquid-liquid extraction (LLE) for the determination of total BPA, and the results

56 ng the semirobotic liquid-liquid extraction (LLE) in deep-well 96-well plates was developed for the q

57 Liquid-Liquid extraction (LLE) is a common sample pretreatment technique often use

58 Additionally, a liquid-liquid extraction (LLE) method was developed for comparison of extraction e

59 ed high-throughput liquid-liquid extraction (LLE) methodology has been developed and utilized for the

60 ed high-throughput liquid-liquid extraction (LLE) methodology has been developed for preparation of b

61 Liquid-liquid extraction (LLE) of a 200 mL effluent sample showed the best perform

62 lues observed with liquid-liquid extraction (LLE) of a venipuncture sample.

63 Liquid-liquid extraction (LLE) paired with gas chromatography (GC)-mass spectromet

64 We modified our liquid-liquid extraction (LLE) procedure for F(2)-isoprostane analysis to use a co

65 n for bioanalysis, liquid-liquid extraction (LLE) represents an important step with the extraction so

66 ve separations via liquid-liquid extraction (LLE) requires molecular-level understanding and optimiza

67 permethylation and liquid-liquid extraction (LLE) steps are labor intensive and are thus not practica

68 eviously published liquid-liquid extraction (LLE) techniques using bis(2-ethylhexyl) phosphate as the

69 tion identified by liquid/liquid extraction (LLE) that are not detected with solid-phase extraction (

70 cheap single-step liquid-liquid extraction (LLE) using glycerol as a keeper for liquid chromatograph

71 tract, followed by liquid-liquid extraction (LLE) with organic solvents to recover target compounds.

72 s work showed that liquid-liquid extraction (LLE), a method commonly used in regulatory monitoring, h

73 rmining PAHs using liquid-liquid extraction (LLE), clean-up and detection by liquid chromatography wi

74 nder conditions of liquid-liquid extraction (LLE), purified receptors cis- and trans-2 were both foun

75 vaporation (SAFE), liquid-liquid extraction (LLE), solid phase extraction (SPE), and simultaneous dis

76 niscale version of liquid-liquid extraction (LLE), termed miniscale-LLE (msLLE), with automated full

77 further selective liquid-liquid extraction (LLE).

78 to performance (LLE-P) (n = 14) and fitness (LLE-F) (n = 7).

79 t work, a robust and reliable ANNs model for LLE solvent prediction was generated which could predict

80 HC I power driven by speed (LLE-P) or force (LLE-F), suggesting exercise intensity impacted slow musc

81 ss groups, with a hierarchical pattern (OH > LLE > YE; P < 0.05) in normalized power among OH (16.7 6

82 mization effort using 9, we further improved LLE as exemplified by a much more druglike analog 26.

83 rough biodegradation of oil, are detected in LLE extracts (up to C(30) and double-bond equivalents, D

84 was confirmed in positive ionisation mode in LLE extract, whereas in the SPE extract they were not pr

85 re, we introduce a new fully automated micro-LLE technique based on gas-pressure assisted mixing foll

86 have been made in automated and miniaturized LLE procedures, fully automated LLE techniques allowing

87 id-liquid extraction (LLE), termed miniscale-LLE (msLLE), with automated full evaporation dynamic hea

88 Results showed that the modified LLE was robust to a range of salinity, Fe, and DOC conce

89 -amide (LLVY-MCA) and LLE-beta-nitroanilide (LLE-betaNA) more than REGalpha or REGbeta alone.

90 ositional selectivity and analytical bias of LLE versus SPE for HOPs using combined EEM-PARAFAC and U

91 solubility, and the composite parameters of LLE and pIC50-pSolubility were used to assess compound q

92 Here we investigated the performance of LLE and LELP on multiple data sets representing differen

93 limitations and compositional selectivity of LLE and SPE using groundwater samples from the Bemidji,

94 mparable or better than conventional offline LLE, in which the handling of small volumes remains chal

95 In the optimized LLE method, a formate buffer solution was first loaded i

96 In the optimized LLE method, crude combinatorial library samples were dis

97 Overall, 96% of drugs have LE or LLE values, or both, greater than the median values of t

98 y modestly activates cleavage of LLVY-MCA or LLE-betaNA by the proteasome.

99 acted by XAD (<30%) was lower than by SPE or LLE (30-60%).

100 d safety profiles; however, LELP outperforms LLE in risk assessment at least on the present data set.

101 Pd and Au-Pd LLE studies yielded the first K(+)-charge balanced and K

102 ifelong exercise intensity into performance (LLE-P) (n = 14) and fitness (LLE-F) (n = 7).

103 local symmetries of linear reconstructions, LLE is able to learn the global structure of nonlinear m

104 methods for local dimensionality reduction, LLE maps its inputs into a single global coordinate syst

105 steps involved in a manual or semiautomated LLE method, leading to significantly reduced sample prep

106 gas chromatography-tandem mass spectrometry (LLE-GC-MS/MS) method with the first analysis by tandem g

107 e profiles with MHC I power driven by speed (LLE-P) or force (LLE-F), suggesting exercise intensity i

108 DBPs, XAD resulted in lower recoveries than LLE and SPE at both 1- and 10-L scales.

109 Conclusions indicate that LLE gives better recoveries for highly polar, non-polar,

110 ion mass spectrometry (UHR-MS) revealed that LLE selectively recovered aliphatic-like compounds but u

111 sequentially added to the LLE plate so that LLE would occur in the interface between the two liquid

112 This suggests that LLE and SPE-PPL retain different water-soluble oil speci

113 The LLE extracts of the plasma samples of the two compounds

114 The LLE method was automated using 96-well-format plates and

115 The LLE-P and LLE-F had similar single fibre profiles with M

116 A nonorganic fraction obtained during the LLE step was used to analyze small polar metabolites.

117 iazole) to 6.4 ng/mL (benzothiazole) for the LLE method.

118 Overall, the LLE was less precise and less representative of polar HO

119 ethyl ketone, were sequentially added to the LLE plate so that LLE would occur in the interface betwe

120 application of the automated high-throughput LLE method should greatly reduce the labor, time, and co

121 gher O/C ratio and carbon number compared to LLE extracted compounds.

122 limits of quantification (LOQs) compared to LLE-GC-MS using selected ion monitoring (SIM).

123 and reduced matrix interference compared to LLE.

124 probe assisted liquid-liquid extraction (US-LLE) combined with a freeze-based fat precipitation clea

125 ration of biological samples using a 96-well LLE plate and a 96-channel robotic liquid handling works

126 The 96-well LLE plate is made of a 96-well filter plate filled with

127 icians with LLE (26%), and 7 clinicians with LLE (18%).

128 Eligible experts with LLE self-identified as meeting diagnostic criteria for s

129 hout LLE of SUD (55%), 10 nonclinicians with LLE (26%), and 7 clinicians with LLE (18%).

130 rate, 44%), including 21 clinicians without LLE of SUD (55%), 10 nonclinicians with LLE (26%), and 7