ライフサイエンスコーパス: LRR

1 LRR cumulative incidence at 2 years: Lap 5.4%; Open 3.1%

2 LRR genes can be sorted into 3 different age groups.

3 LRR occurred in 5% within the target volume, in 2% in th

4 LRR-RKs can sense small molecule, peptide, or protein li

5 LRR-RLK subgroups harbor extremely contrasting rates of

6 LRR-RLKs have diversified to hundreds of genes in many p

7 LRR-specific mAbs recognized LGI1 docked to its interact

8 he leucine-rich transmembrane receptor DMA-1/LRR-TM expressed on PVD neurons [8, 9].

9 DMA-1/LRR-TM interacts through a PDZ ligand motif with the gua

10 gest that HPO-30/Claudin localizes the DMA-1/LRR-TM receptor on PVD dendrites, which in turn can cont

11 X-7/L1CAM, but not on MNR-1/Menorin or DMA-1/LRR-TM, suggesting that LECT-2 functions as part of the

12 mbrane localization and trafficking of DMA-1/LRR-TM.

13 ve of more than 30% of the approximately 223 LRR RLKs in Arabidopsis thaliana.

14 Based on the phylogeny of 7,554 LRR-RLK genes from 31 fully sequenced flowering plant ge

15 268 sites) or Thr (229 sites) residues in 68 LRR RLKs.

16 otal of 592 phosphorylation events across 73 LRR RLKs, with 497 sites uniquely assigned to specific S

17 rs, including the CLV1 receptor kinase and a LRR receptor-like protein, CLV2.

18 were significantly more likely to develop a LRR than were those with margins >=2 mm (10-yr LRR rate,

19 patterns of 30 genes including LEC1-2, AGL9, LRR, PKL and ARF8-1 were validated by qRT-PCR.

20 ajectories have independently occurred among LRR genes in the different Tetrahymena species.

21 rning the interaction between the NB-ARC and LRR in the highly homologous plant immune receptors Gpa2

22 transcription factors, such as MYB, ARF, and LRR.

23 782 that lacks the 3' end encoding F-box and LRR.

24 domain closely related to Rpg1r with CC and LRR domains from a more distantly related CC-NB-LRR gene

25 polymorphic surfaces within both the CC and LRR domains.

26 target of siR109944 is the F-Box domain and LRR-containing protein 55 (FBL55), which encode the tran

27 ogated long-term potentiation induction, and LRR-directed antibodies with higher binding strengths in

28 lf-oligomerization by disrupting the PYD and LRR domains, which are essential in maintaining NLRP1 as

29 onalities and differences between LRR-RK and LRR-RP signaling.

30 ers like beads on a string, with the RRM and LRR domains binding RNAs and the NTF2-like and UBA domai

31 The association between margin width and LRR differed by adjuvant RT status (interaction P = 0.02

32 lationship between negative margin width and LRR with or without adjuvant radiation therapy (RT).

33 functions as an extra sensor and the NB-ARC-LRR as an activator, and that Sw-5b NLR adopts a two-ste

34 he nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only w

35 the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only when NSm and NSm(21) levels are hi

36 y effect of coiled-coil domain on the NB-ARC-LRR region.

37 nificantly enhance the ability of the NB-ARC-LRR to detect low levels of NSm effector and facilitate

38 failed to enhance the ability of the NB-ARC-LRR to sense low levels of NSm and NSm(21).

39 ition, to create the unique 90-bp exon array LRR genes.

40 and followed for a minimum 2 years to assess LRR, DFS, and overall survival (OS).

41 ion of commonalities and differences between LRR-RK and LRR-RP signaling.

42 38) were not significantly different between LRR and ORR.

43 eventing interaction with the ligand-binding LRR-RLK FLS2.

44 ) that interacts with several ligand-binding LRR-RLKs to positively regulate their functions.

45 ary 1, 1995, to June 30, 2016, that compared LRR with ORR for histologically proven rectal cancer in

46 randomized clinical trials (RCTs) comparing LRR vs ORR.

47 eat proteins were built from self-compatible LRRs that are designed to interact to form highly curved

48 ntified any plant CCR4 proteins that contain LRR motifs.

49 selection footprints on LSE and single-copy LRR-RLK genes.

50 tures reveal coupled dilation of cytoplasmic LRRs and the channel pore, suggesting a mechanism for ch

51 plasmic kinase domains of the SERK-dependent LRR-RKs BRASSINOSTEROID INSENSITIVE1, HAESA and ERECTA f

52 o the concave surface of the membrane-distal LRR domain, in contrast to the flanking ligand interacti

53 ssess conserved leucine rich repeat domains (LRR) as proposed sites of molecular recognition, though

54 h extracellular leucine-rich repeat domains (LRR-RKs) form the largest group of membrane signaling pr

55 Donor LRR cassettes were classifiable into five basic structur

56 Biased and repetitive use of certain donor LRR cassettes was demonstrable in mature VLRCs.

57 s well as women with a particularly elevated LRR risk in whom whole-breast RT was not sufficiently ef

58 ts, several defense response genes (encoding LRR-containing, NBARC-containing, pathogenesis-related,

59 The youngest 90-bp exon LRR genes in T. thermophila are concentrated in pericent

60 igin and successive expansions of 90-bp-exon LRR genes.

61 g RPP1 homologs and possess greatly expanded LRR domains.

62 receptor chimera in which the extracellular LRR domain of BIR3 is fused to the cytoplasmic kinase do

63 orts, then independently validated ARTIC for LRR in 748 patients in SweBCG91-RT.

64 GmCLV1A and GmNARK encode for LRR receptor kinases, and share 92% of protein sequence.

65 ARTIC was highly prognostic for LRR in patients treated with RT (hazard ratio [HR], 3.4;

66 Freedom from LRR at 5 years ranged from 86% to 97% by clinical stage,

67 uctural changes, including central GPIbalpha LRR-A1 contact, contribute to VWF affinity regulation.

68 Finally, a soluble Gpr124(LRR-Ig) probe binds to cells expressing Frizzled, Wnt7a

69 n and novel CIFs suggest that the homologous LRR-RKs GSO1/SGN3 and GSO2 have evolved unique peptide b

70 her, our results suggest that the identified LRR protein is an AtPNP-A receptor essential for the PNP

71 Our method may be used to identify LRR-type RKs and RLPs required for PAMP perception/respo

72 Identifying LRR gene age groups allowed us to document a Tetrahymena

73 n overall seroprevalence by region: 26.2% in LRR and 17.1% in URR (p < 0.0001).

74 en 1-9 years old, seroprevalence was 4.4% in LRR and 3.9% in URR.

75 was no statistical significant difference in LRR between patients with <2 mm and >=2 mm negative marg

76 Further, the interactive LRR spectrum panel within ShinyCNV can facilitate the pr

77 protein localizes to the cell wall, and its LRR-domain (which likely mediates protein-protein intera

78 iral DNA and other nucleic acids through its LRR domain.

79 lar pattern flagellin peptide 22 through its LRR RLK, FLS2, and co-receptor BAK1.

80 he leucine-rich repeat receptor-like kinase (LRR-RLK) family, is also involved in this pathway.

81 a leucine-rich repeat receptor-like kinase (LRR-RLK) identified as a virulence target of the begomov

82 by the leucine-rich repeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA.

83 Leucine-rich repeat receptor-like kinases (LRR RLKs) form a large family of plant signaling protein

84 t leucine-rich repeat receptor-like kinases (LRR RLKs), not GPCRs, provide this discrimination throug

85 d leucine-rich repeat receptor-like kinases (LRR-RLK) constitute the largest receptor-like kinases fa

86 y leucine-rich repeat receptor-like kinases (LRR-RLKs) are essential for plant growth, development, a

87 e leucine-rich repeat receptor-like kinases (LRR-RLKs) are signal receptors critical in development a

88 d leucine-rich repeat receptor-like kinases (LRR-RLKs).

89 The leucine-rich repeat receptor kinases (LRR-RK) FLS2 and EFR, and the LRR receptor protein (LRR-

90 ts use leucine-rich repeat receptor kinases (LRR-RKs) to sense sequence diverse peptide hormones at t

91 ing the pathologic outcomes of laparoscopic (LRR) vs open (ORR) rectal resection for rectal cancer.

92 Predictive modeling indicates that Lrch4 LRRs conform to the horseshoe-shaped structure typical o

93 The EMS1 (EXCESS MICROSPOROCYTES1) LRR-RLK and its small protein ligand TPD1 (TAPETUM DETER

94 NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one

95 and Staphylococcus infection activate NACHT, LRR and PYD domains-containing protein (NLRP)3 inflammas

96 endent of the inflammasome components NACHT, LRR, and PYD domains-containing protein 3, apoptosis-ass

97 lar sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-containing protein 3) forms a macro

98 els of interleukin (IL)-1beta, NLPR3 (NACHT, LRR, and PYD domain-containing protein 3), ASC (apoptosi

99 main-containing protein 8) and NLRP1 (NACHT, LRR and PYD domain-containing protein 1) from the FIIND

100 First the role of NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome

101 -dependent protein kinase-II), NLRP3 (NACHT, LRR, and PYD domains-containing protein-3), and transcri

102 of activated components of the NLRP3 (NACHT, LRR, and PYD domains-containing protein-3)-inflammasome

103 Activation of NACHT, LRR and PYD domains-containing proteins (NALPs) may cont

104 The Nod-like receptor NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) and Bru

105 d renal necroinflammation include the NACHT, LRR and PYD domains-containing protein-3 (NLRP3) inflamm

106 by bacteria, which then activates the Nacht, LRR, and PYD domains-containing protein 3 (NALP3) inflam

107 to infection and tissue damage is the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflam

108 The NACHT, LRR, and PYD domains-containing protein 3 inflammasome i

109 The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) infla

110 honuclear leukocytes (PMNs), and the Nacht-, LRR-, and PYD-domains-containing protein 3 (NLRP3) infla

111 RenSeq is a NB-LRR (nucleotide binding-site leucine-rich repeat) gene-t

112 rms a receptor complex with RPS4, another NB-LRR protein.

113 sponses induced by both TIR-NB-LRR and CC-NB-LRR classes of immune receptors are compromised.

114 domains from a more distantly related CC-NB-LRR gene.

115 ucleotide-binding leucine-rich repeat (CC-NB-LRR) protein.

116 ation of the switch and sensor domains in NB-LRR proteins.

117 on of pathogen effectors by intracellular NB-LRR immune receptors encoded by Resistance (R) genes.

118 ted genes encoding receptor-like kinases, NB-LRR resistance proteins, transcription factors, RNA sile

119 Ectopic expression of Medicago NB-LRR-targeting miRNAs in Arabidopsis showed that only a f

120 ants have evolved a limited repertoire of NB-LRR disease resistance (R) genes to protect themselves a

121 These data show the versatility of NB-LRR genes to generate resistance to unrelated pathogens

122 counterbalanced by the rapid evolution of NB-LRR proteins, as only a few sequence changes have been s

123 little is known about the flexibility of NB-LRR R genes to switch resistance specificities between p

124 The Arabidopsis RRS1-R NB-LRR protein carries a C-terminal WRKY DNA binding domain

125 cleotide-binding and leucine-rich repeat (NB-LRR) domain-containing resistance proteins, which recogn

126 nucleotide-binding, leucine-rich repeat (NB-LRR) immune receptors carry fusions with other protein d

127 Nucleotide-binding leucine-rich repeat (NB-LRR, or NLR) receptors mediate pathogen recognition.

128 We propose that NB-LRR receptor pairs, one member of which carries an addit

129 So although the NB-LRR receptors involved in ETI are well studied, how they

130 fer of the effector binding signal to the NB-LRR regulatory unit (consisting of a central nucleotide

131 utants, ETI responses induced by both TIR-NB-LRR and CC-NB-LRR classes of immune receptors are compro

132 Arabidopsis thaliana TIR-NB-LRR proteins RRS1-R and RPS4 together recognize two bact

133 (208 or 41% of the total) corresponded to NB-LRR genes; some of these small RNAs preferentially accum

134 NAs in Arabidopsis showed that only a few NB-LRRs are capable of phasiRNA production; our data indica

135 Our survey reveals that 48.5% of the 132 NBS-LRR loci tested contain functional rice blast R genes, w

136 Here, we survey 332 NBS-LRR genes cloned from five resistant Oryza sativa (rice)

137 26753327 (-)}, a NBS-LRR resistance protein (R) with homology to the Arabidop

138 In addition, NBS-LRR pathogen recognition genes were found to be involved

139 The chitinase gene clusters and NBS-LRR disease resistance genes in this region suggest the

140 inases, strictosidine synthase-like, and NBS-LRR proteins.

141 is true for other pathogens, many extant NBS-LRR genes retain functionality.

142 eotide binding site-leucine rich repeat (NBS-LRR) resistance proteins of plants (R-proteins) and the

143 be more duplication of genes within the NBS-LRR and the SAUR-like auxin superfamilies compared with

144 It remains unclear whether the NBS-LRR architectures were innovations of plants and animals

145 zed the phylogenetic distribution of the NBS-LRR domain architecture, used maximum-likelihood methods

146 It was then incorporated into the NBS-LRR protein to create a main sub-class of RPW8-encoding

147 y RIL 46, a constitutively expressed TIR-NBS-LRR gene was identified as the candidate for nematode re

148 QTL on A02 is rich in genes encoding TIR-NBS-LRR protein domains that are involved in plant defenses.

149 -binding site leucine-rich repeat genes (NBS-LRRs), 290 receptor-like protein kinase genes (RLKs), an

150 The NLRs or NBS-LRRs (nucleotide-binding, leucine-rich-repeat) form the

151 Lrch4 is a membrane protein with nine LRRs in its predicted ectodomain.

152 de induced a programmed death ligand 1/NOD-, LRR-, and pyrin domain-containing protein 3 (PD-L1/NLRP3

153 NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intrac

154 y of specific inhibition of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasom

155 utsugamushi reduces cellular levels of NOD-, LRR-, and CARD-containing 5 (NLRC5), a recently identifi

156 lammasome with a specific inhibitor of NOD-, LRR-, and pyrin domain-containing protein 3.

157 ngoing structural evolution generating novel LRR-RLK genes.

158 In this dimer, the linkers between the NXF1 LRR and NTF2-like domains interact with NXT1, generating

159 We provide evidence for AS of LRR domain within several Nod-like receptors, most promi

160 llow-up of 49 months, the crude incidence of LRR was 6.5%.

161 2], P = .23; 10-year cumulative incidence of LRR, 25% v 32%).

162 ], P < .001; 10-year cumulative incidence of LRR, 6% v 21%), whereas those with high ARTIC scores ben

163 adiation therapy decreases the likelihood of LRR after mastectomy.

164 Here we report strict exonic modularity of LRR domains of several human gene families, which is a p

165 EPTP) domains of LGI1, with stable ratios of LRR:EPTP antibody levels over time.

166 ceptor pseudokinases, negative regulators of LRR-RK signaling.

167 imately required for a full understanding of LRR RLK biology and function, bacterial expression of re

168 mains) family NTPase followed by a series of LRRs, suggesting inheritance from a common ancestor with

169 to the horseshoe-shaped structure typical of LRRs in pathogen-recognition receptors and that the best

170 es of AS through differential utilization of LRRs modules in vertebrate innate immunity.

171 cidate the physiological functions of orphan LRR-RKs and to identify their receptor activation mechan

172 ilies interact with a single common "orphan" LRR protein.

173 Using a benchmark of other LRR protein complexes, we further demonstrated that the

174 Multiple autophosphorylation sites per LRR RLK were the norm, with an average of seven sites pe

175 PK-LRR and SA mediated disease resistance are well known to

176 nd protein kinase leucine-rich receptors (PK-LRR).

177 BAK1 is a plant LRR-receptor-like kinase (RLK) that interacts with sever

178 FLS2 and EFR, and the LRR receptor protein (LRR-RP) receptors RLP23 and RLP42, respectively, represe

179 alized SNP data, which includes log R ratio (LRR) and B allele frequency, can be plotted against the

180 extract coverage, representing log R ratio (LRR) of signal intensity, and B allele frequency (BAF).

181 lgorithm, manual inspection of log R ratios (LRR) and qPCR probes.

182 Therefore, LIMYB links immune receptor LRR-RLK activation to global translation suppression as

183 unction, bacterial expression of recombinant LRR RLK cytoplasmic catalytic domains for identification

184 or rectal cancer on locoregional recurrence (LRR) and disease-free survival (DFS) at 2 years.

185 erative CRT reduced locoregional recurrence (LRR) from 34% to 14% (P < .001) and peritoneal carcinoma

186 ry (BCS) to prevent locoregional recurrence (LRR).

187 s with respect to local-regional recurrence (LRR).

188 T in patients with esophageal cancer reduced LRR and peritoneal carcinomatosis.

189 cipants of all ages from Lower River Region (LRR) (N = 1028) and Upper River Region (URR) (N = 840) u

190 int mutations, that the leucine-rich repeat (LRR) 5 region comprises an important functional domain f

191 recently identified the leucine-rich repeat (LRR) adhesion protein, trophoblast glycoprotein (TPBG),

192 ns containing an N-terminal Leu-rich repeat (LRR) and a C-terminal extensin domain.

193 in of Reck binds to the leucine-rich repeat (LRR) and immunoglobulin (Ig) domains of Gpr124, and weak

194 /11 CSFs bound both the leucine-rich repeat (LRR) and the epitempin repeat (EPTP) domains of LGI1, wi

195 ) within the C-terminal leucine rich repeat (LRR) domain is responsible for the gain of powdery milde

196 t homology to the short leucine-rich repeat (LRR) domain of SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINAS

197 re, the properties of a leucine-rich repeat (LRR) domain protein, designated AdpF, are described.

198 In addition to its leucine-rich repeat (LRR) domain that has been previously reported, the N-ter

199 nking substrate-binding leucine-rich repeat (LRR) domain when substrate is absent.

200 amples of proteins with Leucine Rich Repeat (LRR) domains and other solenoids like proteins, we show

201 Leucine-rich repeat (LRR) domains are evolutionarily conserved in proteins th

202 ECD is divided into two leucine-rich repeat (LRR) domains, each of which is capped by cysteine-rich d

203 (LLG) complexes, or by leucine-rich repeat (LRR) extensin proteins (LRXs).

204 In particular, leucine-rich repeat (LRR) genes make the largest contribution to the high lev

205 ansmembrane protein with leucin-rich repeat (LRR) motifs and bears three CS sugar chain attachment si

206 CR4s contain N-terminal leucine-rich repeat (LRR) motifs that interact with CAF1s in yeast, fruit fly

207 f-of-concept, we used a leucine-rich repeat (LRR) protein binder, called a repebody (Rb), that specif

208 entification of a novel Leucine-Rich Repeat (LRR) protein that directly interacts with A. thaliana PN

209 nucleotide-binding (NB)-leucine-rich repeat (LRR) protein.

210 nucleotide-binding (NB) leucine-rich repeat (LRR) receptor (NLR) proteins function as intracellular i

211 Transmembrane leucine-rich repeat (LRR) receptors are commonly used innate immune receptors

212 ception by cell surface leucine-rich repeat (LRR) receptors, including the CLV1 receptor kinase and a

213 ceptor lacking a single leucine-rich repeat (LRR) within its N-terminus.

214 inding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3

215 inding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome family that has been

216 sed gene that encodes a leucine-rich repeat (LRR)-containing protein detected at higher levels on the

217 ied LRRC25, a member of leucine-rich repeat (LRR)-containing protein family, as a negative regulator

218 e-binding domain (NBD), leucine-rich repeat (LRR)-containing proteins (NLRs) attenuate innate immunit

219 ligand perception, many leucine-rich repeat (LRR)-containing PRRs interact with the LRR-RK BRI1-ASSOC

220 ansgenic plants for all leucine-rich repeat (LRR)-RLKs in Arabidopsis and analyzed their expression p

221 omain, and a C-terminal leucine-rich repeat (LRR).

222 protein that contains a leucine-rich-repeat (LRR), which binds R-ras and may regulate cdc42.

223 nucleotide-binding [NB] leucine-rich repeat [LRR] receptor) proteins are critical for inducing immune

224 de-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in i

225 nding domain [NBD]- and leucine-rich repeat [LRR]-containing) proteins mediate innate immune sensing

226 Herein, we introduce leucine-rich repeats (LRRs) and calponin homology containing 4 (Lrch4) as a no

227 sed almost entirely by leucine-rich repeats (LRRs) and having an N-terminal region enriched in altern

228 that contains multiple leucine-rich repeats (LRRs) and interacts with integrin-dependent adhesion com

229 oding proteins bearing leucine-rich repeats (LRRs) and nucleotide-binding domains.

230 mbrane protein with 17 leucine-rich repeats (LRRs) at its C-terminal end and is an essential componen

231 MYC via its C-terminal leucine-rich repeats (LRRs) domain.

232 tructures, we designed leucine-rich repeats (LRRs) from the ribonuclease inhibitor (RI) family that a

233 een A1 and the central leucine-rich repeats (LRRs) of GPIbalpha, previously shown to be important at

234 lthough intensively studied, a well-resolved LRR-RLK gene tree has remained elusive.

235 of the endogenous promoter of the respective LRR-RK leads to strong gain-of-function brassinosteroid,

236 In the retina, LRR proteins have been implicated in the development and

237 etric platform in which the RNA-binding RRM, LRR and NTF2-like domains are arranged on one face.

238 protein constructed from four domains (RRM, LRR, NTF2-like and UBA domains).

239 protein constructed from four domains (RRM, LRR, NTF2-like and UBA) that have been thought to be joi

240 lysed the structural organization of SHOC2's LRR motifs, and determined the impact of SHOC2 mislocali

241 BRYOGENESIS RECEPTOR-LIKE KINASE1) and SERK2 LRR-RLKs act redundantly as coregulatory and physical pa

242 often critical for the activation of several LRR RLK family members with proven functional roles in p

243 sification, led to misclassification of some LRR-RLK variants as members of other gene families.

244 g two antibodies, one against the N-terminal LRR domain and the other against the C-terminal PDZ-inte

245 d to the plasma membrane with the N-terminal LRR domain facing the extracellular space.

246 R4 can interact with CAF1 via its N-terminal LRR domain.

247 wever, no CCR4 protein containing N-terminal LRR motifs have been found in plants.

248 ion in Lrrc8a that truncates the 15 terminal LRRs of LRRC8A.

249 tion in LRRC8A that truncates the 2 terminal LRRs was reported in a patient with agammaglobulinemia a

250 s through direct association with C-terminal LRRs.

251 We show that LRRs 1 to 13 constitute a structurally recognizable doma

252 We found that both the F-box domain and the LRR domain are important for FBXL16-mediated C-MYC stabi

253 ith a PYD core surrounded by the NBD and the LRR domain.

254 which is dependent on its CS chains and the LRR motifs.

255 eptor kinases (LRR-RK) FLS2 and EFR, and the LRR receptor protein (LRR-RP) receptors RLP23 and RLP42,

256 lfide bond-stabilized proteins that bind the LRR domain of LRX proteins with low nanomolar affinity.

257 The conformation assumed by the LRR and NTF2-like domains results in clusters of positiv

258 , ligand specificity was mediated not by the LRR domain, but by an internal region encompassing sever

259 the recognition specificities defined by the LRR domain, either aboveground or belowground.

260 ved from both patients recognized either the LRR or EPTP domain.

261 ukin-1 receptor (TIR) domain and L816 in the LRR domain were also important for effector recognition.

262 hat exchanging the recognition moiety in the LRR is sufficient to convert extreme virus resistance in

263 In cells transfected with FliI mutants, the LRR of FliI, but not its gelsolin-like domains, mediated

264 ally specified by a C-terminal region of the LRR domain.

265 determined by the C-terminal portion of the LRR domain.

266 how the ARC2, NB, and N-terminal half of the LRR form a clamp, which regulates the dissociation and r

267 A 3.0- angstrom crystal structure of the LRR-RK GSO1/SGN3 regulating Casparian strip formation in

268 to infer complete gene trees for each of the LRR-RLK subclades and reconstructed the deepest nodes of

269 *To resolve the LRR-RLK gene tree, we developed an improved gene discove

270 le X-ray scattering data, indicated that the LRR domain has a defined spatial relationship to the Mex

271 Further study demonstrated that the LRR domain of LRRC25 interacted with the Rel Homology do

272 *We discovered that the LRR-RLK gene family is even larger than previously thoug

273 PFL9 acting from the carpel wall through the LRR-receptor kinases ER, ERL1, and ERL2 promotes fruit g

274 rabidopsis AtPNP-A binds specifically to the LRR protein, termed AtPNP-R1, and the active region of A

275 ippocampal injection, and by contrast to the LRR-directed mAbs, the EPTP-directed mAbs showed far les

276 by a short-circuiting mechanism wherein the LRR domain selectively blocks productive aminolysis, but

277 mains, and their proximity-together with the LRR domain-to the kinase domain suggest an intramolecula

278 utive, ligand-independent complexes with the LRR ectodomains of BAK1-INTERACTING RECEPTOR-LIKE KINASE

279 tic fusion of the CC-NB-ARC of Gpa2 with the LRR of Rx1 (Gpa2CN/Rx1L) results in autoactivity, but lo

280 peat (LRR)-containing PRRs interact with the LRR-RK BRI1-ASSOCIATED KINASE 1 (BAK1).

281 ls unique recognition mechanisms between the LRRs.

282 n phenotype, but exchange of the first three LRRs of Gpa2 by the corresponding region of Rx1 was suff

283 iversified their recognition spectra through LRR expansion and sequence variation, allowing them to d

284 m better stratifies patients with respect to LRR after neoadjuvant chemotherapy than presenting clini

285 a RNAi screen, they identify a transmembrane LRR protein-Lapsyn-that plays a critical role in this pr

286 eam of the DMA-1 leucine-rich transmembrane (LRR-TM) receptor.

287 We found the expression of two LRR-RLKs, MUSTACHES (MUS) and MUSTACHES-LIKE (MUL), are

288 ability and folding cooperativity in RI-type LRR proteins.

289 interactors and a previously uncharacterized LRR-RLP that we termed RECEPTOR-LIKE PROTEIN REQUIRED FO

290 d in 179 (13.2%) of 1354 patients undergoing LRR and 104 (10.4%) of 998 patients undergoing ORR (RR,

291 nd in 135 (7.9%) of 1697 patients undergoing LRR and 79 (6.1%) of 1292 patients undergoing ORR (RR, 1

292 significantly higher in patients undergoing LRR compared with ORR.

293 ecular bait to identify a previously unknown LRR-RLP required for the recognition of the csp22 peptid

294 gery type were independently associated with LRR, with increased risk among patients with CPS+EG scor

295 mm (n = 120; P = 0.005) were associated with LRR.

296 s performed to evaluate for association with LRR.

297 Thousands of young LRR genes contain tandem arrays of exactly 90-bp exons.

298 -bp exon/intron repeat units of the youngest LRR genes.

299 R than were those with margins >=2 mm (10-yr LRR rate, 30.9% vs 5.4%, respectively; hazard ratio, 5.5

300 mm negative margins who underwent RT (10-yr LRR rate, 4.8% vs 3.3%, respectively; hazard ratio, 0.8;