ライフサイエンスコーパス: LVM

1 LVM and relative wall thickness increased, whereas preva

2 LVM determined by micro-CT was higher in HCM than normal

3 LVM indexed to body surface area (LVMI) and MWT were sig

4 LVM regressed in both groups but with no significant dif

5 LVM was calculated on the basis of an echocardiography.

6 LVM was indexed to body surface area, and the LVM-to-vol

7 LVM was measured by echocardiography, and measurements o

8 LVM was obtained by determining myocardial volume.

9 LVM was obtained with 2D M-mode echocardiography in a co

10 LVM was quantified by AS and MP in 126 consecutive patie

11 LVM was similar in individuals predisposed to hypertensi

12 LVM-AI predicted LV mass correlated with CMR-derived LV

13 LVM-AI-predicted LVH was associated with incident atrial

14 0.001) and electrocardiographic (p < 0.001) LVM remained associated with development of depressed LV

15 n LVM (13.1 g; 95% CI, 5.0-21.3 g; P=0.002), LVM index (6.9 g/m(2); 95% CI, 2.4-11.3 g/m(2); P=0.003)

16 In regression models, year 25 LVM or relative wall thickness was the dependent variabl

17 Significant determinants of year 25 LVM/m(2.7) were year 5 LVM, year 5 and change in body ma

18 terminants of year 25 LVM/m(2.7) were year 5 LVM, year 5 and change in body mass index, year 5 and ch

19 We prove that, despite the challenges above, LVM-based estimators of causal queries are accurate if t

20 Allopurinol significantly reduced absolute LVM (-2.65 +/- 5.91 g vs. placebo group +1.21 +/- 5.10 g

21 st correlation was found between RI and age, LVM, LVMI, and plasma parathormone concentration and was

22 vs. placebo -1.3 +/- 4.48 g; p = 0.007) and LVM index (LVMI) (allopurinol -2.2 +/- 2.78 g/m(2) vs. p

23 cebo group +1.21 +/- 5.10 g [p = 0.012]) and LVM indexed to body surface area (-1.32 +/- 2.84 g/m(2)

24 ]; two studies, 70 patients, I(2) = 88%) and LVM indexed (mean difference, -1 g/m(2) [95% CI: -6, 3];

25 ion existed between sympathetic activity and LVM index in the LVH[-] and LVH[+] groups (at least r=0.

26 Comparable hemodynamics and LVM regression can be achieved using a second-generation

27 e velocity, left ventricular mass (LVM), and LVM index (LVMI) increased in subsequent RI quartile sub

28 ons between cardiometabolic risk markers and LVM indexed for the body height (g/m(2.7)).

29 rmined LVM was indexed to body surface area (LVM index); in the LVH[-] group, LVM index was 67+/-2.1

30 of 50 patients, MRI was also used to assess LVM regression, and again there was no significant diffe

31 cardiovascular magnetic resonance to assess LVM, and positron emission tomography to quantify restin

32 ular wall mass (LVM), measured in grams; (b) LVM indexed to body mass index, measured in grams per me

33 <55%, was analyzed by quartiles of baseline LVM.

34 coronary artery bypass surgery, or baseline LVM.

35 n=28 612), we assessed associations between LVM-AI predicted LVH and incident cardiovascular outcome

36 B, n=1371]), we assessed correlation between LVM-AI predicted and CMR-derived LV mass and compared LV

37 imilar LVH discrimination in the UK Biobank (LVM-AI c-statistic 0.653 [95% CI, 0.608 -0.698] versus a

38 significantly higher CVI compared with both LVM (P = 0.001) and SDD subgroups (P < 0.001).

39 The study compared patients affected by LVM with cohorts displaying a similar phenotypic spectru

40 t, and sex has a strong correlation with CMR LVM in large cohort of normal individuals in the United

41 The following measures minimally decreased: LVM (mean difference, -18 g [95% CI: -33, -3]; seven stu

42 LVM was considerably higher than CMR-derived LVM (mean+/-SD of 138.8+/-28.9 g versus 86.3+/-20.9 g).

43 sional echocardiograms obtained to determine LVM.

44 ardiac magnetic resonance imaging-determined LVM was indexed to body surface area (LVM index); in the

45 Baseline quartile of echocardiographic LVM indexed to body surface area was associated with dev

46 Elevated LVM index, concentric LVH, altered diastolic function, a

47 protein expression associated with elevated LVM.

48 propose a general and practical approach for LVM-based estimation of causal queries.

49 cardiometabolic biomarkers associations for LVM have not been clarified in physically active young a

50 rtial voxels, but this has not been used for LVM quantification.

51 or LVIDd and at age 26, 43, and 53 years for LVM.

52 s the only metabolic risk marker for greater LVM in both men and women.

53 Compared with whites, blacks had greater LVM (indexed to height(2.7); P<0.05).

54 20 years onwards was associated with greater LVM and LVIDd independent of confounders.

55 exercise performance associated with greater LVM was noted only in men, while greater WC was the only

56 rface area (LVM index); in the LVH[-] group, LVM index was 67+/-2.1 g/m2, a value between those of th

57 patients were included, of which 20 eyes had LVM, 20 eyes had AVLs, and the remaining had SDDs.

58 were on dialysis had greater cIMT and higher LVM index than those with CRI (P < 0.001) and greater ar

59 and dialysis groups had greater cIMT, higher LVM index, and poorer diastolic function than the contro

60 Both groups had higher LVM index compared with controls (22.2+/-6.1 g/m(2.7), P

61 The dialysis group had higher LVM index than the group with CRI (42.9+/-10.3 versus 29

62 al voxel segmentation, AS(PV) yielded higher LVM (159+/-38 g) than MP (Delta=20+/-10 g) and AS(FV) (D

63 0th percentile), and concentric hypertrophy (LVM and RWT >or=80th percentile).

64 >or=80th percentile), eccentric hypertrophy (LVM >or=80th percentile but RWT <80th percentile), and c

65 In patients without baseline hypertrophy, LVM index and MFS remained stable.

66 mean difference between groups for change in LVM and LVMI was -3.89 g (95% confidence interval: -1.1

67 Change in LVM index (54 +/- 13 g/m(2.7) to 42 +/- 10 g/m(2.7), p <

68 The primary outcome measure was change in LVM, assessed by cardiac magnetic resonance imaging (CMR

69 main cardiac secondary outcome was change in LVM.

70 Changes in LVM were associated with changes in blood pressure (conv

71 l partial voxels yields a 14-17% increase in LVM versus full voxel segmentation, with increased diffe

72 lysis resulted in a significant reduction in LVM (13.1 g; 95% CI, 5.0-21.3 g; P=0.002), LVM index (6.

73 The primary outcome was reduction in LVM as calculated by cardiac magnetic resonance imaging

74 Increased LVM as assessed by electrocardiography or echocardiograp

75 Increased LVM is associated with an increased risk for stroke.

76 Increased LVM is associated with an increased risk of stroke, espe

77 d undergoing chronic dialysis have increased LVM, LV performance, and contractility at rest.

78 thyroid hormone was a predictor of increased LVM index and poor diastolic function.

79 ltivariate analysis, the effect of increased LVM on the risk of stroke was significantly decreased by

80 Prior studies have shown that increased LVM is a risk factor for heart failure but not whether i

81 Thus, increased LVM was defined by the highest quartile of LVM.

82 n in Endog that is associated with increased LVM and impaired cardiac function.

83 redict cardiovascular events, with increased LVM predictive in male participants, while LVM-to-volume

84 fect was stronger in subjects with increased LVM than among those without increased LVM (p = 0.033).

85 risk of stroke among patients with increased LVM to a level comparable to that of patients without in

86 sk, especially among patients with increased LVM.

87 eased LVM than among those without increased LVM (p = 0.033).

88 arable to that of patients without increased LVM.

89 ighly replicated, blood-pressure-independent LVM locus on rat chromosome 3p.

90 ft ventricular mass-artificial intelligence [LVM-AI]).

91 Patients with LVH (LVM/body surface area >/=116 and >/=96 g/m(2) in men and

92 Adjusted mean values of LV mass (LVM), LVM index, relative wall thickness, CAC, and cIMT were i

93 sively abnormal adjusted mean values of LVM, LVM index, relative wall thickness, and ankle-brachial i

94 Adjusted mean values of LVM, LVM index, relative wall thickness, CAC, ankle-brachial

95 While hypertrophy/mass (LVM) can be objectively measured, fibrosis and myocyte d

96 nd CV risk factors and trabeculated LV mass (LVM) and (b) establish normal reference ranges in a sele

97 is of sex-specific distributions of LV mass (LVM) and relative wall thickness (RWT): normal (LVM and

98 esonance (CMR) typically quantifies LV mass (LVM) by means of manual planimetry (MP), but this approa

99 between sympathetic activation and LV mass (LVM) has not been clearly defined across a range of arte

100 meter, LV posterior wall thickness, LV mass (LVM), and LV mass index (LVMI), compared to participants

101 Adjusted mean values of LV mass (LVM), LVM index, relative wall thickness, CAC, and cIMT

102 relationship between LV structure [LV mass (LVM), relative wall thickness, and LV internal diameter

103 0-year change in left ventricular (LV) mass (LVM) and LV geometry in black and white young adults in

104 Left ventricular mass (LVM) and cardiac gene expression are complex traits regu

105 ies such as increased left ventricular mass (LVM) and diastolic dysfunction develop at the time of mi

106 s may lead to greater left ventricular mass (LVM) and reduce the effect of cardiometabolic risk facto

107 ied the correlates of left ventricular mass (LVM) in 84 healthy young adults aged 16 to 24 years from

108 quation for predicted left ventricular mass (LVM) in a cohort of normal individuals in the United Kin

109 relationship between left ventricular mass (LVM) in adults and longitudinal measurements of CV risk

110 allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD).

111 causes regression of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM).

112 ustained reduction in left ventricular mass (LVM) index after 5 years (from 71.4 [SD 22.5] g/m(2.7) t

113 Left ventricular mass (LVM) is a highly heritable trait and an independent risk

114 ine whether increased left ventricular mass (LVM) is a risk factor for the development of a reduced l

115 Increased left ventricular mass (LVM) is a strong independent predictor for adverse cardi

116 Background Left ventricular mass (LVM) is an established marker of cardiovascular risk; ho

117 An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular mor

118 Left ventricular mass (LVM) is correlated with body composition and central hem

119 ciated with increased left ventricular mass (LVM) is modified by physical activity (PA).

120 We assessed left ventricular mass (LVM) regression with transthoracic echocardiography (TTE

121 ative contribution of left ventricular mass (LVM) regression, change in aortic valve area (AVA), and

122 pulse wave velocity, left ventricular mass (LVM), and LVM index (LVMI) increased in subsequent RI qu

123 resonance to measure left ventricular mass (LVM), and PET to quantify resting and hyperemic (dipyrid

124 Left ventricular mass (LVM), left ventricular (LV) geometry, systolic and diast

125 parameters: (a) left ventricular wall mass (LVM), measured in grams; (b) LVM indexed to body mass in

126 ventricular hypertrophy (LVH; high LV mass [LVM]) is traditionally classified as concentric or eccen

127 y, 939 hypertensive patients with measurable LVM at baseline were randomized to a mean of 4.8 years o

128 nil at this time, lunar vertical migration (LVM) may facilitate monthly pulses of carbon remineraliz

129 n 29%, concentric dilated in 14%, and normal LVM in 25%.

130 roups to 23%, 4%, 5%, and 7%; 62% had normal LVM after 4 years.

131 ts because hypertensive patients with normal LVM seem to be a low-risk group.

132 e-varying Cox analyses, compared with normal LVM, those with eccentric dilated and both concentric no

133 EDV)-and compared with patients with normal LVM.

134 ) and relative wall thickness (RWT): normal (LVM and RWT <80th percentile), concentric remodeling (LV

135 baseline a normal LVEF and an assessment of LVM (either by electrocardiogram or echocardiogram), and

136 se To assess the sex-specific association of LVM measured with cardiac MRI with cardiovascular outcom

137 To dissect the major determinants of LVM, we combined expression quantitative trait locus1 an

138 The extent of LVM during the winter suggests that the behavior is high

139 curves were applied to assess the impact of LVM.

140 03), and percent change in geometric mean of LVM (7.0%; 95% CI, 1.0%-12.6; P=0.02).

141 ment (LGE) extent, measured in percentage of LVM; and (e) native T1 mapping, measured in milliseconds

142 ng in childhood is a consistent predictor of LVM in young adults, underscore the importance of obesit

143 to adulthood were significant predictors of LVM index in young adults.

144 The presence of LVM correlated with a fourfold increase in the likelihoo

145 uence of partial voxels on quantification of LVM.

146 c stroke was seen in the highest quartile of LVM (odds ratio [OR]: 6.14 [95% confidence interval [CI]

147 d LVM was defined by the highest quartile of LVM.

148 Allopurinol causes regression of LVM in patients with T2DM and LVH.

149 Regression of LVM occurred in all patients (from 129+/-30 to 94+/-24 g

150 Regression of LVM was linearly related to change in resting total LV b

151 are not directly dependent on regression of LVM.

152 a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice.

153 ese data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modif

154 therapy was associated with stabilization of LVM, MLVWT, and T1 mapping values, whereas LGE extent mi

155 rdiography (echo) and an ex vivo standard of LVM at necropsy.

156 ogressively abnormal adjusted mean values of LVM, LVM index, relative wall thickness, and ankle-brach

157 Adjusted mean values of LVM, LVM index, relative wall thickness, CAC, ankle-brac

158 k of stroke and may have variable effects on LVM.

159 he effect of cardiometabolic risk factors on LVM.

160 The benefit of frequent hemodialysis on LVM may be mediated by salutary effects on blood pressur

161 ronounced effect of frequent hemodialysis on LVM was evident among patients with left ventricular hyp

162 enced the effect of frequent hemodialysis on LVM.

163 l blood pressure and sympathetic activity or LVM index.

164 TTE overestimates LVM and MWT and has lower reproducibility compared with

165 In female participants, LVM was associated with age, blood pressure, smoking sta

166 olesterol level, while in male participants, LVM was associated with age and blood pressure.

167 Predicted LVM calculated using a CMR-derived equation that incorpo

168 Predicted LVM was calculated based on participants' sex, height, a

169 Predicted LVM was considerably higher than CMR-derived LVM (mean+/

170 nalyses were performed between the predicted LVM and the LVM obtained from manual contouring of CMR c

171 AS quantified LVM in all patients, yielding a 12-fold decrease in proc

172 tic resonance imaging to accurately quantify LVM, in hypertensive patients with and without LVH and i

173 (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated wi

174 o placebo, allopurinol significantly reduced LVM (allopurinol -5.2 +/- 5.8 g vs. placebo -1.3 +/- 4.4

175 Frequent in-center hemodialysis reduces LVM.

176 WT <80th percentile), concentric remodeling (LVM <80th percentile but RWT >or=80th percentile), eccen

177 When compared with any ECG rule, LVM-AI demonstrated similar LVH discrimination in the UK

178 al hour of sleep was associated with smaller LVM (beta: -3.483, P < 0.0001) and LVMI (beta: -0.815, P

179 analysis of the combined groups showed that LVM correlated closely with body size, particularly lean

180 performed between the predicted LVM and the LVM obtained from manual contouring of CMR cine images.

181 VM was indexed to body surface area, and the LVM-to-volume ratio was calculated.

182 with a median survival of 3.9 years for the LVM group and 7.1 years for controls.

183 In male participants, the LVM was associated with cardiovascular events (HR, 3.2 [

184 In female participants, the LVM-to-volume ratio was associated with cardiovascular e

185 quartile vs the lowest quartile), while the LVM was not.

186 quartile vs the lowest quartile), while the LVM-to-volume ratio was not.

187 total LV blood flow was linearly related to LVM, whereas CVR was not.

188 osed, and diastolic perfusion rather than to LVM.

189 V chamber volume (r=0.28, P=0.002) and total LVM (r=0.19, P=0.03).

190 ristics and CV risk factors and trabeculated LVM.

191 Conclusion Higher trabeculated LVM was observed with hypertension, higher BMI, and high

192 01) were associated with higher trabeculated LVM.

193 Median trabeculated LVM decreased with age for men from 6.5 g (IQR, 4.8-8.7

194 the reference group, the median trabeculated LVM was 6.3 g (IQR, 4.7-8.5 g) for men and 4.6 g (IQR, 3

195 ex-specific reference ranges of trabeculated LVM in a healthy middle-aged White population were estab

196 identified the genetic factors that underlie LVM variation, and the regulatory mechanisms for blood-p

197 Unfortunately, LVM-based estimation of causal queries can be inaccurate

198 V mass and compared LVH discrimination using LVM-AI versus traditional ECG-based rules (ie, Sokolow-L

199 MR agreement with echo and necropsy-verified LVM.

200 Multivariable regression determined whether LVM was independently associated with the development of

201 d LVM predictive in male participants, while LVM-to-volume ratio is predictive in female participants

202 Methods were independently compared with LVM quantified on echocardiography (echo) and an ex vivo

203 nsidered to be more strongly correlated with LVM in comparison to other descriptors of fatness.

204 aist circumference (WC) were correlated with LVM index (beta = 0.07, 0.10, - 0.01, 0.01, 0.24 and 0.2

205 omen, SBP, HDL-C and WC were correlated with LVM index in the univariate analysis (beta = 0.07, - 0.0

206 , P<.05) showed significant correlation with LVM.

207 t abundance had the highest correlation with LVM.

208 elded small but significant differences with LVM at necropsy.

209 Eyes with LVM presented the greatest proportion of complications (

210 iations of cardiometabolic risk markers with LVM might vary by sex.