ライフサイエンスコーパス: Legionella pneumophila

1 se (Thi5) was necessary for HMP synthesis in Legionella pneumophila.

2 racellular iron acquisition strategy used by Legionella pneumophila.

3 ubsequent infection with Escherichia coli or Legionella pneumophila.

4 e ubiquitination and promotes infectivity of Legionella pneumophila.

5 ed with the Gram-negative bacterial pathogen Legionella pneumophila.

6 cteria, including the opportunistic pathogen Legionella pneumophila.

7 tor protein SidM from the bacterial pathogen Legionella pneumophila.

8 LC4 is induced by the intracellular pathogen Legionella pneumophila.

9 n is critical to the growth and virulence of Legionella pneumophila.

10 respectively, from the pathogenic bacterium Legionella pneumophila.

11 R amplicons derived from genomic DNA of live Legionella pneumophila.

12 core components of an orthologous system in Legionella pneumophila.

13 for assembly of macromolecular structures in Legionella pneumophila.

14 competence in the freshwater living pathogen Legionella pneumophila.

15 of five F-box-domain-containing proteins of Legionella pneumophila.

16 d by caspase-1 after macrophage infection by Legionella pneumophila.

17 S) with homology to the Dot/Icm apparatus of Legionella pneumophila.

18 sponsive to heat-killed Escherichia coli and Legionella pneumophila.

19 ne in the facultative intracellular pathogen Legionella pneumophila.

20 eviously identified competence regulators in Legionella pneumophila.

21 intracellular respiratory bacterial pathogen Legionella pneumophila.

22 ella burnetii, Agrobacterium tumefaciens and Legionella pneumophila.

23 intact T2SS imaged within the human pathogen Legionella pneumophila.

24 on with the intracellular bacterial pathogen Legionella pneumophila.

25 re form of pneumonia caused by the bacterium Legionella pneumophila.

26 s of 9 different serogroups of the bacterium Legionella pneumophila, a common human pathogen responsi

27 Legionella pneumophila, a motile opportunistic pathogen

28 e ubiquitination and promotes infectivity of Legionella pneumophila, a pathogenic bacteria that cause

29 Legionella pneumophila actively modulates host vesicle t

30 Typhimurium, Pectobacterium carotovorum and Legionella pneumophila, also include global regulators t

31 During its life cycle, Legionella pneumophila alternates between a replicative

32 During its life cycle, Legionella pneumophila alternates between at least two p

33 The enzymes DrrA/SidM and AnkX from Legionella pneumophila AMPylate and phosphocholinate Rab

34 Legionella pneumophila, an intracellular pathogen respon

35 Legionella pneumophila, an intracellular pathogen that c

36 We show here that Legionella pneumophila, an intravacuolar pathogen that r

37 We characterized a DGR in Legionella pneumophila, an opportunistic human pathogen

38 ctivation of caspase-1 cleared unmanipulated Legionella pneumophila and Burkholderia thailandensis by

39 We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type

40 ases in the intracellular bacterial pathogen Legionella pneumophila and identified the type 4 secreti

41 inhibits axenic and intracellular growth of Legionella pneumophila and of 27 strains of wild-type an

42 eta induction by the intracellular bacterium Legionella pneumophila and promotes the bacterial growth

43 ay is necessary for thiamine biosynthesis in Legionella pneumophila and provide biochemical data to e

44 ssecting the interaction between a pathogen (Legionella pneumophila) and its host (cultured Drosophil

45 etecting and discriminating Legionella spp., Legionella pneumophila, and Legionella pneumophila serog

46 ctivity toward B. cereus 11778, B. subtilis, Legionella pneumophila, and Salmonella Typhimurium has d

47 Coxiella burnetii and Legionella pneumophila are evolutionarily related pathog

48 hough most Dot/Icm-translocated effectors of Legionella pneumophila are not required for intracellula

49 ave been identified using bioinformatics and Legionella pneumophila as a surrogate type IV delivery s

50 The intracellular pathogen Legionella pneumophila avoids fusion with lysosomes and

51 onfronted with metabolic stress, replicative Legionella pneumophila bacteria convert to resilient, in

52 l role in forming the replication vacuole of Legionella pneumophila bacteria, which requires ERGIC-de

53 uring infection of macrophages, the pathogen Legionella pneumophila bypasses the microbicidal endosom

54 femtomole levels of 16s rRNA from pathogenic Legionella pneumophila can be timely and effectively det

55 at a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubi

56 Legionella pneumophila causes a potentially fatal form o

57 tion, the intracellular pathogenic bacterium Legionella pneumophila causes an extensive remodeling of

58 Legionella pneumophila causes Legionnaires' disease, a s

59 Legionella pneumophila causes life-threatening pneumonia

60 The quantification of RNA from Legionella pneumophila cellular lysates was successfully

61 cleotides (oligos) generate mutations on the Legionella pneumophila chromosome by a mechanism that re

62 causative agent of Legionnaires' pneumonia, Legionella pneumophila, colonizes diverse environmental

63 he intracellularly replicating lung pathogen Legionella pneumophila consists of an extraordinary vari

64 The Legionella pneumophila-containing phagosome evades endoc

65 The intracellular pathogen Legionella pneumophila converts from a noninfectious rep

66 one B are active against bacteria, including Legionella pneumophila Corby, algae, and fungi.

67 Here, we found that SidM from Legionella pneumophila could act as both GEF and GDI-dis

68 re, we found that the intracellular pathogen Legionella pneumophila could interfere with autophagy by

69 Many intracellular pathogens like Legionella pneumophila, Coxiella burnetii, Listeria mono

70 The gram-negative bacterial pathogen Legionella pneumophila creates a novel organelle inside

71 The bacterial pathogen Legionella pneumophila creates an intracellular niche pe

72 The structure of Legionella pneumophila Cu(+)-ATPase shows that a kinked

73 Importantly, Legionella spp. and Legionella pneumophila decreased after switching back to

74 Legionella pneumophila directs the formation of a specia

75 The Legionella pneumophila Dot/Icm T4SS injects approximatel

76 VceC could also be translocated by the Legionella pneumophila Dot/Icm T4SS into host cells.

77 egions, were secreted by the closely related Legionella pneumophila Dot/Icm T4SS.

78 Effectors delivered into host cells by the Legionella pneumophila Dot/Icm type IV transporter are e

79 The Legionella pneumophila Dot/Icm type IVB secretion system

80 f the Dot/Icm type IV protein transporter of Legionella pneumophila during infection.

81 The Legionella pneumophila effector MavC induces ubiquitinat

82 Here, we report the crystal structure of the Legionella pneumophila effector protein, SidJ, in comple

83 -ATPase through its interaction with SidK, a Legionella pneumophila effector protein.

84 The Legionella pneumophila effector vacuolar protein sorting

85 Therefore, we screened the Legionella pneumophila effectors to probe virus-host int

86 biquitination mediated by the SidE family of Legionella pneumophila effectors, such as SdeA, that cat

87 Legionella pneumophila encodes a family of phosphoribosy

88 The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host s

89 cm-translocated ankyrin B (AnkB) effector of Legionella pneumophila exhibits molecular mimicry of euk

90 Legionella pneumophila exhibits surface translocation wh

91 The bacterial pathogen Legionella pneumophila exploits host cell vesicle transp

92 wed the phagocytosis of both viable and dead Legionella pneumophila filaments.

93 ria monocytogenes that ectopically expresses Legionella pneumophila flagellin, a potent activator of

94 he transition state mimetic structure of the Legionella pneumophila GAP LepB in complex with Rab1 and

95 Using transposon sequencing, we identify Legionella pneumophila genes required for growth in four

96 When Legionella pneumophila grows on agar plates, it secretes

97 el of isolates of the opportunistic pathogen Legionella pneumophila GWAS revealed that the absence of

98 er domain of a guanidine III riboswitch from Legionella pneumophila has a different effect, stabilizi

99 irulence factors from the bacterial pathogen Legionella pneumophila has been discovered to modify hum

100 Legionella pneumophila has been shown to secrete a prote

101 Legionella pneumophila has co-evolved with amoebae, thei

102 igation of legionellosis outbreaks caused by Legionella pneumophila However, as common sequence types

103 the PmrA/PmrB two-component system (TCS) of Legionella pneumophila in global gene regulation and in

104 le and non-viable Legionella spp. as well as Legionella pneumophila in one hour.

105 at2, effectively suppress the replication of Legionella pneumophila in primary murine macrophages.

106 Based on the crystal structure of LapG of Legionella pneumophila in the accompanying report by Cha

107 es intracellular infection of macrophages by Legionella pneumophila In the present study, we identifi

108 infection mouse model of influenza virus and Legionella pneumophila in which we can separate resistan

109 s well as proof-of-concept measurements with Legionella pneumophila including cell cultivation and pl

110 Legionella pneumophila infection blocked xenophagic targ

111 The progression of Legionella pneumophila infection in macrophages is contr

112 Upon Legionella pneumophila infection of macrophages, the cyt

113 the present study, we examined the effect of Legionella pneumophila infection on the expression of th

114 5 amino acids of flagellin or in response to Legionella pneumophila infection.

115 s of inflammation induced by oral cancer and Legionella pneumophila infection.

116 Legionella pneumophila infects human alveolar macrophage

117 Legionella pneumophila infects lung macrophages and inje

118 cultured in broth to the transmissive phase, Legionella pneumophila infects macrophages by inhibiting

119 The intracellular bacterium Legionella pneumophila inhibits host translation, thereb

120 The Dot/Icm type IV secretion system of Legionella pneumophila injects into host cells the F-box

121 The intracellular pathogen Legionella pneumophila interferes with autophagy by deli

122 Upon entry of Legionella pneumophila into amoebas and macrophages, hos

123 ave the unique ability to restrict or permit Legionella pneumophila intracellular growth.

124 Legionella pneumophila is a bacterial pathogen of amoeba

125 Legionella pneumophila is a bacterial pathogen that thri

126 Legionella pneumophila is a bacterial pathogen that util

127 AnkB effector of the intravacuolar pathogen Legionella pneumophila is a bona fide F-box protein, whi

128 Legionella pneumophila is a causative agent of a severe

129 Legionella pneumophila is a causative agent of severe pn

130 Legionella pneumophila is a facultative intracellular hu

131 Legionella pneumophila is a gram-negative facultative in

132 Legionella pneumophila is a Gram-negative opportunistic

133 Legionella comprises 65 species, among which Legionella pneumophila is a human pathogen causing sever

134 The Gram-negative bacterium Legionella pneumophila is a parasite of eukaryotic cells

135 Legionella pneumophila is a water-borne bacterium that c

136 Legionella pneumophila is an environmental bacterium and

137 Legionella pneumophila is an intracellular bacterial pat

138 Legionella pneumophila is an intracellular bacterial pat

139 Legionella pneumophila is an intracellular bacterial pat

140 Legionella pneumophila is an intracellular bacterium tha

141 Legionella pneumophila is an intracellular pathogen of f

142 Legionella pneumophila is an intracellular pathogen that

143 Legionella pneumophila is an intravacuolar pathogen that

144 Legionella pneumophila is an opportunistic intracellular

145 Legionella pneumophila is an opportunistic pathogen that

146 Legionella pneumophila is auxotrophic for several amino

147 evious studies established that the pathogen Legionella pneumophila is capable of hijacking Rab1 func

148 e Dot/Icm type IV secretion system (T4SS) of Legionella pneumophila is crucial for the pathogen to su

149 Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide

150 The virulence of Legionella pneumophila is dependent upon its capacity to

151 After the pathogenic bacterium Legionella pneumophila is phagocytosed, it injects more

152 owth of Chlamydia psittaci, trachomatis, and Legionella pneumophila is regulated by the levels of int

153 Type II protein secretion (T2S) by Legionella pneumophila is required for intracellular inf

154 The type II secretion (T2S) system of Legionella pneumophila is required for the ability of th

155 Legionella pneumophila is the causative agent of a sever

156 Bacterial pathogen Legionella pneumophila is the causative agent of Legionn

157 Legionella pneumophila is the causative agent of the sev

158 Legionella pneumophila is the causative agent of the sev

159 One effector of Legionella pneumophila is the glucosyltransferase Lgt1,

160 Legionella pneumophila is the only prokaryote found, thu

161 Legionella pneumophila is the predominant cause of Legio

162 le genome sequence analysis was performed on Legionella pneumophila isolates from the infected patien

163 he performance of laboratories in genotyping Legionella pneumophila isolates using the standard Europ

164 rsistence and associated risks of pathogenic Legionella pneumophila (L. pneumophila), thus raising hu

165 Legionella pneumophila (L.p.), the microbe responsible f

166 Previously, we reported that mutants of Legionella pneumophila lacking a type II secretion (T2S)

167 experimental validation of 20 effectors from Legionella pneumophila, Legionella longbeachae, and Coxi

168 plasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, Legionella micdadei, Bordetella

169 Legionella pneumophila (Lp), an important cause of morbi

170 model for Mtb), Pseudomonas aeruginosa (Pa), Legionella pneumophila (Lp), and Enterococcus faecalis (

171 (UATs) for Streptococcus pneumoniae (SP) and Legionella pneumophila (LP).

172 from Escherichia coli (EcFAAL) and FAAL from Legionella pneumophila (LpFAAL) bound to acyl adenylate,

173 The L-serine dehydratase from Legionella pneumophila (lpLSD) has recently been shown t

174 s from Bacillus subtilis (bsLSD, type 1) and Legionella pneumophila (lpLSD, type 2).

175 Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumon

176 During infection, the bacterial pathogen Legionella pneumophila manipulates a variety of host cel

177 The intracellular bacterial pathogen Legionella pneumophila modulates a number of host proces

178 The bacterial pathogen Legionella pneumophila modulates host immunity using eff

179 The intracellular pathogen Legionella pneumophila modulates the activity of host GT

180 icrobial communities, the bacterial pathogen Legionella pneumophila must withstand competition from n

181 dentify amoeba isolates, and the presence of Legionella pneumophila , Mycobacterium spp., Pseudomonas

182 Legionella pneumophila, Mycobacterium avium, and Pseudom

183 ersistence of three opportunistic pathogens (Legionella pneumophila, Mycobacterium avium, and Pseudom

184 tive for at least one OPPP (Legionella spp., Legionella pneumophila, Mycobacterium avium, Mycobacteri

185 atypical and anaerobic pathogens, including Legionella pneumophila, Mycoplasma spp., Ureaplasma spp.

186 Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, s

187 Intracellular growth of Legionella pneumophila occurs in a replication vacuole c

188 opportunists via a cultivation-based assay (Legionella pneumophila only) and quantitative PCR.

189 rulent strain of the intracellular bacterium Legionella pneumophila or a nonpathogenic mutant of L. p

190 Bartonella henselae, Listeria monocytogenes, Legionella pneumophila, or adenovirus type 5, promoted a

191 mon lung pathogens Streptococcus pneumoniae, Legionella pneumophila, or Mycobacterium tuberculosis-in

192 nnaires' disease in a clinical setting where Legionella pneumophila PCR had been introduced.

193 in strains, in H. pylori 26695 strain and in Legionella pneumophila Philadelphia 1 strain.

194 Gram-negative Legionella pneumophila produces a siderophore (legiobact

195 Legionella pneumophila proliferates in environmental amo

196 Legionella pneumophila proliferates within various proti

197 The type II secretion system of Legionella pneumophila promotes pathogenesis.

198 lination of Rab35, which is catalyzed by the Legionella pneumophila protein AnkX, interferes with the

199 study provides detailed understanding of the Legionella pneumophila protein DrrA and of AMP-transfer

200 resses translation of the hupA mRNA, and the Legionella pneumophila protein RocC binds the RocR sRNA,

201 gen testing for Streptococcus pneumoniae and Legionella pneumophila provide direction for the clinici

202 sional structure of the protein lpg2210 from Legionella pneumophila provides the first structural inf

203 her lethal (Yersinia pestis) and non-lethal (Legionella pneumophila, Pseudomonas aeruginosa) pulmonar

204 lytes of three pathogenic bacterial strains: Legionella pneumophila, Pseudomonas aeruginosa, and Salm

205 uctures of three Gammaproteobacteria motors: Legionella pneumophila, Pseudomonas aeruginosa, and Shew

206 ography and sub-tomogram averaging of intact Legionella pneumophila, Pseudomonas aeruginosa, and Shew

207 is, Escherichia coli, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa, Stenotro

208 Infection by the human pathogen Legionella pneumophila relies on the translocation of ap

209 Many bacteria, including Legionella pneumophila, rely on the type IV secretion sy

210 Legionella pneumophila remains an important opportunisti

211 se-11 was dispensable for the restriction of Legionella pneumophila replication in macrophages and in

212 es of the host cell cycle are permissive for Legionella pneumophila replication, whereas S phase prov

213 Members of the SidE effector family from Legionella pneumophila represent a new paradigm in the u

214 erologous expression of homologous lbtA from Legionella pneumophila, required for rhizoferrin biosynt

215 The intracellular pathogen Legionella pneumophila resides in a vacuole that is ubiq

216 ) and 26GUmicroL(-1) for Legionella spp. and Legionella pneumophila, respectively, were achieved.

217 oazide (PMA) to simultaneously detect viable Legionella pneumophila, Salmonella typhimurium, and Stap

218 /phosphodiesterase 1, Escherichia coli RppH, Legionella pneumophila Sde and Homo sapiens NudT16 (HsNu

219 When cultured in a low-iron medium, Legionella pneumophila secretes a siderophore (legiobact

220 ion of macrophages, the pathogenic bacterium Legionella pneumophila secretes effector proteins that i

221 phages, the intracellular bacterial pathogen Legionella pneumophila secretes effector proteins that m

222 Under iron stress, Legionella pneumophila secretes legiobactin, a nonclassi

223 The intracellular pathogen, Legionella pneumophila, secretes approximately 300 effec

224 ted that 84% are caused by the microorganism Legionella pneumophila Serogroup (Sg) 1.

225 Legionella spp., Legionella pneumophila, and Legionella pneumophila serogroup 1 in primary specimens.

226 Because Legionella pneumophila serogroup 1 is responsible for >8

227 bacteria belonging to the genus Legionella; Legionella pneumophila serogroup 1 is the causative agen

228 Legionella pneumophila serogroup 1 isolates were culture

229 mately 84% of legionellosis cases are due to Legionella pneumophila serogroup 1.

230 t the genomic sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H (ATC

231 Legionella pneumophila serogroup 3 was recovered in neon

232 In this report, we found that members of the Legionella pneumophila SidE effector family harbor a DUB

233 m type IV secretion system (T4SS) of several Legionella pneumophila strains.

234 Proteases from Mycoplasma hyorhinis, Legionella pneumophila, Streptococcus pneumonia and Cand

235 The intracellular bacterial pathogen Legionella pneumophila subverts host membrane transport

236 The intracellular pathogen Legionella pneumophila subverts Rab1 function to create

237 Enzymes secreted by Legionella pneumophila, such as phospholipases A (PLAs)

238 Legionella pneumophila survives and replicates inside ho

239 Legionella pneumophila survives and replicates within a

240 for translocation using the well-established Legionella pneumophila T4SS secretion model.

241 stem (T4SS) highly similar to the Dot/Icm of Legionella pneumophila that is believed to be essential

242 o independently identify relevant sources of Legionella pneumophila that likely resulted in the outbr

243 In some instances, such as infection with Legionella pneumophila, the activation of the NLRC4 infl

244 Legionella pneumophila, the agent of Legionnaires' disea

245 For Legionella pneumophila, the bacterium translocates prote

246 cal protection from pulmonary infection with Legionella pneumophila, the causative agent of a severe

247 Legionella pneumophila, the causative agent of a severe

248 fer protection from secondary infection with Legionella pneumophila, the causative agent of a severe

249 thal infection by the intracellular pathogen Legionella pneumophila, the causative agent of a severe

250 ip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe

251 is a previously uncharacterized effector of Legionella pneumophila, the causative agent of Legionnai

252 mune response to bacterial pathogens such as Legionella pneumophila, the causative agent of Legionnai

253 The facultative intracellular pathogen Legionella pneumophila, the causative agent of Legionnai

254 Legionella pneumophila, the causative agent of Legionnai

255 When the bacterium Legionella pneumophila, the causative agent of Legionnai

256 Legionella pneumophila, the causative agent of Legionnai

257 Legionella pneumophila, the causative agent of Legionnai

258 Legionella pneumophila, the causative agent of Legionnai

259 Legionella pneumophila, the causative agent of Legionnai

260 The genome of the Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legion

261 The Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legion

262 Legionella pneumophila, the etiological agent of Legionn

263 Legionella pneumophila, the etiological agent of Legionn

264 Legionella pneumophila, the Gram-negative pathogen causi

265 as the gold standard for DNA-based typing of Legionella pneumophila, the Legionella laboratory at the

266 scovery protocol by targeting this enzyme in Legionella pneumophila, the major causative agent of Leg

267 Legionella pneumophila, the most commonly identified cau

268 Legionella pneumophila, the primary agent of Legionnaire

269 In Legionella pneumophila, the two-component system (TCS) P

270 The ability of Legionella pneumophila to cause pneumonia is determined

271 ls by the Dot/Icm injection apparatus allows Legionella pneumophila to establish a niche called the L

272 retion system (T2SS) promotes the ability of Legionella pneumophila to grow in coculture with amoebae

273 etwork of proteins secreted by the bacterium Legionella pneumophila to promote intracellular growth,

274 Here, we used the bacterial pathogen Legionella pneumophila to understand how the immune syst

275 To transit between hosts, intracellular Legionella pneumophila transform into a motile, infectio

276 vacuole that supports bacterial replication, Legionella pneumophila translocates a large number of ba

277 The intracellular human pathogen Legionella pneumophila translocates multiple proteins in

278 The Dot/Icm type IV secretion system of Legionella pneumophila translocates numerous bacterial e

279 During infection, Legionella pneumophila translocates over 300 effector pr

280 The Dot/Icm system of Legionella pneumophila triggers activation of caspase-3

281 The noninvasive Legionella pneumophila triggers an identical response th

282 al host organism Acanthamoeba castellanii to Legionella pneumophila under in vivo (LCV) conditions.

283 igated the role of RNase R in the biology of Legionella pneumophila under various conditions and perf

284 Legionella pneumophila uses a single homodimeric disulfi

285 Legionella pneumophila uses a type IVB secretion system

286 Legionella pneumophila uses the Icm/Dot type 4B secretio

287 The bacterial pathogen Legionella pneumophila utilizes approximately 300 effect

288 Legionella pneumophila utilizes the Dot/Icm type IV tran

289 this list are the sialylated human pathogens Legionella pneumophila, Vibrio parahemeolyticus, Pseudom

290 inic acid from the lipopolysaccharide of the Legionella pneumophila virulence factor.

291 Legionella pneumophila was found in the sedimentation po

292 Label-free detection of Legionella pneumophila was performed using a PC platform

293 the DNA uptake system in the human pathogen Legionella pneumophila We found that a repressor of this

294 ddition, during coinfection experiments with Legionella pneumophila, we found that defective intracel

295 g homogenates from guinea pigs infected with Legionella pneumophila were plated monthly onto differen

296 ologs encoded by the Philadelphia isolate of Legionella pneumophila were toxic to yeast, and SidJ sup

297 These findings contrasted with those for Legionella pneumophila, where chemical inhibition of the

298 rucella melitensis, Bartonella henselae, and Legionella pneumophila, which are also able to persist w

299 In this study, we used Legionella pneumophila, which triggers membrane-bound an

300 n, and infection in mouse models compared to Legionella pneumophila, yet these two species have indis