ライフサイエンスコーパス: Leu-enkephalin

1 m Gly residue was proved by the synthesis of Leu-enkephalin.

2 the natively electroinactive peptide des-Tyr-Leu-enkephalin.

3 odel, the endogenous antinociceptive peptide Leu-enkephalin.

4 ubstrates smaller than hexapeptides, such as Leu-enkephalin.

5 ,129 prevented the cardiovascular effects of Leu-enkephalin.

6 bility to potentiate the agonist response of Leu-enkephalin.

7 y of sEVs detected endogenous opioid peptide leu-enkephalin.

8 synthesis of an azaphenylalanine analogue of Leu-enkephalin 40.

9 Extension to the syntheses of Leu-enkephalin (9) and amyloid-beta (34-42) (10) demonst

10 this study was to develop an immunoassay for Leu-enkephalin, a mammalian opioid peptide, using a C-te

11 be critical for the hydrolysis of exogenous Leu-enkephalin, a neuropeptide present in the CA3 region

12 ransfected HeLa cells did not accumulate [3H]Leu-enkephalin above background levels, demonstrating th

13 The delta-selective glycosylated Leu-enkephalin amide 2, H(2)N-Tyr-D-Thr-Gly-Phe-Leu-Ser(

14 retrometabolic drug design was applied to a Leu-enkephalin analogue, Try-D-Ala-Gly-Phe-D-Leu (DADLE)

15 The Leu-enkephalin analogues were tested in a panel of bindi

16 cation (LOQ) by analyzing targeted peptides, leu-enkephalin and angiotensin II, spiked in a BSA trypt

17 don) dramatically increased the potencies of Leu-enkephalin and dynorphin A to produce MOR-1 internal

18 teins, including PSD-95, and opioid peptides leu-enkephalin and dynorphin in the hippocampus of young

19 With age, females showed opposing changes in leu-enkephalin and dynorphin levels in the mossy fiber p

20 ion-phase- and gas-phase deuterium uptake of Leu-Enkephalin and Glu-Fibrinopeptide B, confirmed that

21 Fmoc-based solid-phase peptide synthesis of Leu-enkephalin and in microwave-assisted automated synth

22 ned effects on memory formation produced by [Leu]enkephalin and [Met]enkephalin administration in 2 r

23 Basal concentrations of endogenous [Leu]enkephalin and [Met]enkephalin were determined for 5

24 containing more neurons heavily labeled for leu-enkephalin, and the main olfactory bulb, where only

25 d simultaneous monitoring of Met-enkephalin, Leu-enkephalin, and unknown peptides.

26 to be processed by CPA6, including Met- and Leu-enkephalin, angiotensin I, and neurotensin.

27 ectron microscopy using substance P and Met-/Leu-enkephalin antibodies to label GABAergic terminals f

28 Leu-enkephalin-Arg and Leu-enkephalin-Arg-Arg were gener

29 Leu-enkephalin-Arg and Leu-enkephalin-Arg-Arg were generated from dynorphin A a

30 he endogenous peptide opioid receptor ligand Leu-enkephalin as a model compound.

31 ain the sequences of both Met-enkephalin and Leu-enkephalin as seen for mammalian proenkephalin.

32 halin, met-enkephalin was more abundant than leu-enkephalin both within individual cells (darker stai

33 of the Australian lungfish indicates that a Leu-enkephalin-coding gene, distinct from proenkephalin,

34 from naive female mice have higher levels of leu-enkephalin compared to male, matching the analgesic

35 Training had no effect on [Leu]enkephalin concentration in either the IMHV or the L

36 The results demonstrate that leu-enkephalin-containing terminals have a different ana

37 method was used to determine met-enkephalin, leu-enkephalin, dynorphin A(1-8), and beta-endorphin in

38 ntitative peroxidase immunohistochemistry of leu-enkephalin, dynorphin, synaptophysin, and PSD-95.

39 Des-tyrosyl-Leu-enkephalin elevated the apparent K(m) of L-proline t

40 Met/Leu-enkephalin expression was altered in pathological sk

41 phalin was then developed using the aequorin-Leu-enkephalin fusion protein as a labeled analyte in a

42 Des-Tyr-Leu-enkephalin (GGFL), a competitive peptide inhibitor o

43 y(3) and Phe(4)-Leu(5) dipeptide subunits in Leu-enkephalin (H(2)N-Tyr-Gly-Gly-Phe-Leu-OH), which is

44 The fact that Leu-enkephalin has been identified by radioimmunoassay a

45 r the accurate and precise quantification of Leu-enkephalin in a complex mixture using multiple-react

46 Levels of Leu-enkephalin in Cpefat/Cpefat mouse brain are approxim

47 red to male, matching the analgesic onset of leu-enkephalin in male recipient mice.

48 The previous detection of Met-enkephalin and Leu-enkephalin in the CNS of the Australian lungfish, Ne

49 The omission of any one inhibitor abolished Leu-enkephalin-induced internalization, indicating that

50 Microinjections of Leu-enkephalin into the dorsal vagal complex induced hyp

51 These results suggest that Leu-enkephalin is involved in cardiovascular regulation

52 sought to determine the relationship between leu-enkephalin (LE)-containing axon terminals and GABAer

53 Within the HF, leu-enkephalin (LENK) is most prominent in the mossy fib

54 ine acetyltransferase plus substance P-, and Leu-enkephalin (Leu-enk)-containing extrinsic afferents

55 adiol, with or without progesterone, altered leu-enkephalin levels in the dentate gyrus and synaptoph

56 Additionally, met- and leu-enkephalin localization patterns largely overlap.

57 high potency and specificity of des-tyrosyl-Leu-enkephalin make this compound a useful tool for eluc

58 eal-time, simultaneous detection of Met- and Leu-enkephalin (Met-Enk and Leu-Enk) in the mouse nucleu

59 will be presented for [(eta(6)-Cp*Rh-Tyr(1))-leu-enkephalin](OTf)(2) and [(eta(6)-Cp*Rh-Tyr(3))-octre

60 In situ Met/Leu-enkephalin peptides were expressed in differentiatin

61 Furthermore, the absence of a Leu-enkephalin sequence in lungfish and amphibian proenk

62 As seen for amphibians, no Leu-enkephalin sequence was detected in the Australian l

63 and/or efficacy of the orthosteric agonists leu-enkephalin, SNC80 and TAN67, as measured by receptor

64 approach, we have electroosmotically pulled Leu-enkephalin through OHSCs to identify ectopeptidase a

65 ith carboxypeptidase B restores the level of Leu-enkephalin to the level in control brain.

66 ee important GPCR peptides; namely, [Tyr(1)]-leu-enkephalin, [Tyr(4)]-neurotensin(8-13), and [Tyr(3)]

67 ormation of the two protonated pentapeptides Leu-enkephalin (Tyrosine-Glycine-Glycine-Phenylalanine-L

68 Quantitative determination of leu-enkephalin using external calibration was verified b

69 For that, the N-terminus of Leu-enkephalin was genetically fused to the C-terminus o

70 A standard curve of Leu-enkephalin was performed in the presence of a backgr

71 An immunoassay for Leu-enkephalin was then developed using the aequorin-Leu

72 of 125I-Tyr-MIF-1 to 84.4% of total, whereas Leu-enkephalin was without effect.

73 [Leu]enkephalin was amnestic when administered in the IMH

74 The opioid receptor agonist, leu-enkephalin, was predicted to have antisurvival effec

75 alin (met-enkephalin) or leucine enkephalin (leu-enkephalin), we observed enkephalin localization con

76 Basal dialysate levels of Met-enkephalin and Leu-enkephalin were 60 +/- 30 and 70 +/- 20 pM while K+-

77 In tyrosyl-glycine and Leu-enkephalin, which have N-terminal tyrosines, bicycli

78 hypothalamic levels of the endogenous opioid Leu-enkephalin, which is derived from the KOR agonist pr

79 oplets containing 1 muM propranolol or 5 muM leu-enkephalin with each droplet fully baseline-resolved