ライフサイエンスコーパス: Lyme disease spirochete

1 xpression in physiological adaptation by the Lyme disease spirochete.

2 biological and pathogenic properties of the Lyme disease spirochete.

3 ular adaptation by Borrelia burgdorferi, the Lyme disease spirochete.

4 tion suggests a role in transmission of this Lyme disease spirochete.

5 CsrA in differential gene expression in the Lyme disease spirochete.

6 the RpoS-dependent adaptive response of the Lyme disease spirochete.

7 y that is essential to the life cycle of the Lyme disease spirochete.

8 gene deletion during murine infection by the Lyme disease spirochete.

9 tro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete.

10 s OspC and OspA in Borrelia burgdorferi, the Lyme disease spirochete.

11 tinct roles in cell type-specific binding by Lyme disease spirochetes.

12 ty in relapsing-fever spirochetes but not in Lyme disease spirochetes.

13 higher cell densities in blood than those of Lyme disease spirochetes.

14 tative lipoprotein genes was used to examine Lyme disease spirochetes.

15 rrelates with the loss of infectivity of the Lyme disease spirochetes.

16 ctions essential to both relapsing fever and Lyme disease spirochetes.

17 amily in the biology and pathogenesis of the Lyme disease spirochetes.

18 with the rep+ and ORF-E gene families of the Lyme disease spirochetes.

19 n of the cp32 circular plasmids found in the Lyme disease spirochetes.

20 logous sequences in the three genospecies of Lyme disease spirochetes.

21 ar mechanism for selective C1s inhibition by Lyme disease spirochetes.

22 ticated complement evasion system present in Lyme disease spirochetes.

23 nto the genetic regulatory mechanisms of the Lyme disease spirochetes.

24 izes to defend itself against infection with Lyme disease spirochetes.

25 r the outer surface protein C (OspC) gene in Lyme disease spirochetes.

26 se to this important virulence factor of the Lyme disease spirochetes.

27 Summary Borrelia burgdorferi, the Lyme disease spirochete, adapts as it moves between the

28 able surface Ag of Borrelia burgdorferi, the Lyme disease spirochete, also contains both variable and

29 MMPs may play a role in dissemination of the Lyme disease spirochete and in the pathogenesis of Borre

30 gnificant role in mammalian infection by the Lyme disease spirochete and is an important antigen for

31 binding preference varies with the strain of Lyme disease spirochete and that this variation influenc

32 Deer tick-transmitted pathogens such as Lyme disease spirochetes and babesiae appear to require

33 nces are present consistently in low-passage Lyme disease spirochetes and indicate that both highly c

34 e current landscape of complement evasion by Lyme disease spirochetes and provide an update on recent

35 robial immune evasion strategies focusing on Lyme disease spirochetes and rickettsial or tularemia ag

36 as reservoirs for ehrlichiae as well as for Lyme disease spirochetes and the piroplasm that causes h

37 frastructure in both Borrelia burgdorferi (a Lyme disease spirochete) and B. turicatae (a relapsing f

38 revA genes are widely distributed among Lyme disease spirochetes, and the present studies determ

39 ubjects, 97 (8.4%) were seroreactive against Lyme disease spirochete antigen, of whom 14 (14%) also w

40 ins that are differentially expressed by the Lyme disease spirochete at various stages of its life cy

41 g cascades and limits the acquisition of the Lyme disease spirochete B. burgdorferi.

42 urface proteins and antigens shared with the Lyme disease spirochete (B. burgdorferi), may cause both

43 ified as a receptor for all three species of Lyme disease spirochetes (B. burgdorferi sensu stricto,

44 homologous to the cp32 plasmid family of the Lyme disease spirochete, B. burgdorferi.

45 The three major species of Lyme disease spirochete--B. burgdorferi sensu stricto, B

46 investigate the polymorphic CspZ protein of Lyme disease spirochete bacteria to assess the role of m

47 tebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi.

48 BBA68 (BbCRASP-1) of the Lyme disease spirochetes binds human factor H (FH) and F

49 Borrelia burgdorferi, the Lyme disease spirochete, binds the host complement inhib

50 rine infectivity and tick persistence of the Lyme disease spirochete Borrelia (Borreliella) burgdorfe

51 Using the Lyme disease spirochete Borrelia burgdorferi (Bb) as a m

52 The Lyme disease spirochete Borrelia burgdorferi alters the

53 th either laboratory or field strains of the Lyme disease spirochete Borrelia burgdorferi and field s

54 tting several human pathogens, including the Lyme disease spirochete Borrelia burgdorferi and the obl

55 tion by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the ric

56 sion increased microbial colonization by the Lyme disease spirochete Borrelia burgdorferi and the ric

57 orin-binding proteins (DbpA and DbpB) of the Lyme disease spirochete Borrelia burgdorferi bind decori

58 Infection of C57BL/6 (B6) mice with the Lyme disease spirochete Borrelia burgdorferi can result

59 the natural mammal-tick infection cycle, the Lyme disease spirochete Borrelia burgdorferi comes into

60 The genome of the Lyme disease spirochete Borrelia burgdorferi contains mu

61 Here we show that the Lyme disease spirochete Borrelia burgdorferi depends on

62 lycan cell-wall synthesis, we found that the Lyme disease spirochete Borrelia burgdorferi displays a

63 quirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a un

64 Outer surface protein A (OspA) from the Lyme disease spirochete Borrelia burgdorferi elicits pro

65 The Lyme disease spirochete Borrelia burgdorferi exhibits dr

66 The Lyme disease spirochete Borrelia burgdorferi exists in n

67 The Lyme disease spirochete Borrelia burgdorferi expresses a

68 The Lyme disease spirochete Borrelia burgdorferi expresses d

69 aphy revealed that the chemoreceptors of the Lyme disease spirochete Borrelia burgdorferi form long,

70 As an obligate pathogen, the Lyme disease spirochete Borrelia burgdorferi has a strea

71 Outer surface protein A (OspA) from the Lyme disease spirochete Borrelia burgdorferi has been a

72 The Lyme disease spirochete Borrelia burgdorferi has bundles

73 The Lyme disease spirochete Borrelia burgdorferi has two pla

74 ogens, promotes vascular interactions of the Lyme disease spirochete Borrelia burgdorferi Here, we in

75 etect heterogeneity of ospC genotypes of the Lyme disease spirochete Borrelia burgdorferi in the tick

76 The Lyme disease spirochete Borrelia burgdorferi is dependen

77 The Lyme disease spirochete Borrelia burgdorferi is the only

78 is paper, we show that the morphology of the Lyme disease spirochete Borrelia burgdorferi is the resu

79 The Lyme disease spirochete Borrelia burgdorferi lacks endog

80 The Lyme disease spirochete Borrelia burgdorferi lacks the t

81 s upon feeding and infection with either the Lyme disease spirochete Borrelia burgdorferi or the rick

82 The Lyme disease spirochete Borrelia burgdorferi possesses 1

83 The Lyme disease spirochete Borrelia burgdorferi reduces the

84 The Lyme disease spirochete Borrelia burgdorferi sensu stric

85 acterized an elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promot

86 The Lyme disease spirochete Borrelia burgdorferi undergoes s

87 In this report, the Lyme disease spirochete Borrelia burgdorferi was used as

88 of the antigenic variation vlsE gene of the Lyme disease spirochete Borrelia burgdorferi were analyz

89 Two motility genes (fliH and fliI) of the Lyme disease spirochete Borrelia burgdorferi were cloned

90 arial parasite Plasmodium falciparum and the Lyme disease spirochete Borrelia burgdorferi, among othe

91 cell depletion on the immune response to the Lyme disease spirochete Borrelia burgdorferi, an extrace

92 iota of I. scapularis, a major vector of the Lyme disease spirochete Borrelia burgdorferi, influence

93 To enhance genetic manipulation of the Lyme disease spirochete Borrelia burgdorferi, we assayed

94 markable case of displacement is seen in the Lyme disease spirochete Borrelia burgdorferi, which does

95 dified lipoproteins, including OspA from the Lyme disease spirochete Borrelia burgdorferi.

96 ever agent Borrelia hermsii, and OspC of the Lyme disease spirochete Borrelia burgdorferi.

97 ding protein with an HU-like activity in the Lyme disease spirochete Borrelia burgdorferi.

98 s an abundant immunogenic lipoprotein of the Lyme disease spirochete Borrelia burgdorferi.

99 , motility, and infectious life cycle of the Lyme disease spirochete Borrelia burgdorferi.

100 ssed elements of the segmented genome of the Lyme disease spirochete Borrelia burgdorferi.

101 n FlgJ homolog (FlgJ(Bb)) was studied in the Lyme disease spirochete Borrelia burgdorferi.

102 d for gene regulation and infectivity in the Lyme disease spirochete Borrelia burgdorferi.

103 t a number of human pathogens, including the Lyme disease spirochete Borrelia burgdorferi.

104 ility and flagellar filament assembly in the Lyme disease spirochete Borrelia burgdorferi.

105 abolism and salvage compared to those in the Lyme disease spirochete Borrelia burgdorferi.

106 s crucial for the pathogenic strategy of the Lyme disease spirochete Borrelia burgdorferi.

107 amino acid sequences that were absent in the Lyme disease spirochete Borrelia burgdorferi.

108 The genetic structure of the Lyme disease spirochete (Borrelia burgdorferi) and its m

109 Outer surface proteins (Osp) A and C of the Lyme disease spirochete (Borrelia burgdorferi) are selec

110 A prime example is the Lyme disease spirochete, Borrelia burgdorferi (B. burgdo

111 of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an o

112 After transmission by an infected tick, the Lyme disease spirochete, Borrelia burgdorferi sensu lato

113 The Lyme disease spirochete, Borrelia burgdorferi, causes a

114 The Lyme disease spirochete, Borrelia burgdorferi, causes pe

115 VlsE, the variable surface antigen of the Lyme disease spirochete, Borrelia burgdorferi, contains

116 The Lyme disease spirochete, Borrelia burgdorferi, controls

117 The Lyme disease spirochete, Borrelia burgdorferi, encodes a

118 The Lyme disease spirochete, Borrelia burgdorferi, encounter

119 ed glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited

120 The Lyme disease spirochete, Borrelia burgdorferi, exists in

121 The Lyme disease spirochete, Borrelia burgdorferi, exists in

122 ous immunological studies indicated that the Lyme disease spirochete, Borrelia burgdorferi, expresses

123 The Lyme disease spirochete, Borrelia burgdorferi, expresses

124 Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have stro

125 protein B (OspB), a major lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi, have the

126 Persistence of the Lyme disease spirochete, Borrelia burgdorferi, in the pr

127 surface protein loci (ospA and ospC) of the Lyme disease spirochete, Borrelia burgdorferi, infecting

128 The Lyme disease spirochete, Borrelia burgdorferi, infects m

129 The Lyme disease spirochete, Borrelia burgdorferi, inhabits

130 Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi, is a dumb

131 The Lyme disease spirochete, Borrelia burgdorferi, is an ext

132 The Lyme disease spirochete, Borrelia burgdorferi, is capabl

133 The Lyme disease spirochete, Borrelia burgdorferi, is ingest

134 The Lyme disease spirochete, Borrelia burgdorferi, is introd

135 The Lyme disease spirochete, Borrelia burgdorferi, is largel

136 ponses and disease during infection with the Lyme disease spirochete, Borrelia burgdorferi, is not we

137 All examined isolates of the Lyme disease spirochete, Borrelia burgdorferi, naturally

138 The Lyme disease spirochete, Borrelia burgdorferi, occupies

139 A Lyme disease spirochete, Borrelia burgdorferi, that was

140 ion between arthropod and mammals forces the Lyme disease spirochete, Borrelia burgdorferi, to adapt

141 When the Lyme disease spirochete, Borrelia burgdorferi, transfers

142 pC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it i

143 n the critical host-adaptive response of the Lyme disease spirochete, Borrelia burgdorferi.

144 visualize the intact flagellar motor in the Lyme disease spirochete, Borrelia burgdorferi.

145 phy was used to analyze the structure of the Lyme disease spirochete, Borrelia burgdorferi.

146 s crucial for the pathogenic strategy of the Lyme disease spirochete, Borrelia burgdorferi.

147 The Lyme disease spirochetes, Borrelia burgdorferi (sensu la

148 In the Lyme disease spirochetes, both the ospE and vlsE gene fa

149 Infection with Lyme disease spirochetes can be chronic.

150 The Lyme disease spirochetes, comprised of at least three cl

151 s been postulated that the vls system of the Lyme disease spirochetes contributes to immune evasion t

152 The Lyme disease spirochete controls production of its OspC

153 investigations into mechanisms by which the Lyme disease spirochete controls synthesis of its Erp su

154 Borrelia burgdorferi, the Lyme disease spirochete, couples environmental sensing a

155 Southern blot analyses of Lyme disease spirochetes cultured from 16 of the patient

156 ies (>10(8)/ml) in their host's blood, while Lyme disease spirochetes do not (<10(5)/ml).

157 Taken together, our data demonstrate the Lyme disease spirochete encodes a manganese-dependent SO

158 The ospE gene family of the Lyme disease spirochetes encodes a polymorphic group of

159 The genome of Borrelia burgdorferi, the Lyme disease spirochete, encodes a homolog (the bb0184 g

160 Lyme disease spirochetes express nearly a dozen outer su

161 The Lyme disease spirochete expresses several plasminogen-bi

162 e borrelial lipoprotein, BBK32, protects the Lyme disease spirochete from complement-mediated attack

163 the first report and characterization of the Lyme disease spirochete from that state.

164 to immunological pressures suggests that the Lyme disease spirochete has exploited recombinatorial pr

165 Borrelia burgdorferi, the Lyme disease spirochete, has a genome comprised of a lin

166 oglycans (GAGs) by Borrelia burgdorferi, the Lyme disease spirochete, has the potential to promote th

167 ltiple FH-binding mechanisms evolved through Lyme disease spirochete-host interactions.

168 lants represents a novel system for studying Lyme disease spirochetes in a mammalian host-adapted sta

169 expressed dbpA alleles derived from diverse Lyme disease spirochetes in B. burgdorferi strain B314,

170 nce of large-scale genetic exchanges between Lyme disease spirochetes in nature, including the appare

171 us genes are important to the maintenance of Lyme disease spirochetes in one or more of their hosts.

172 ification of several mammalian receptors for Lyme disease spirochetes, including glycosaminoglycans,

173 omologic index based on density estimates of Lyme disease spirochete-infected nymphal deer ticks (lxo

174 Lyme disease spirochetes interfere with complement by pr

175 Outer surface protein A (OspA) of the Lyme disease spirochete is primarily produced in the tic

176 Outer surface protein C (OspC) of the Lyme disease spirochetes is an important virulence facto

177 Some Lyme disease spirochete isolates can bind complement reg

178 basis of how Borrelia burgdorferi (Bb), the Lyme disease spirochete, maintains itself in nature via

179 Through this mechanism, a population of Lyme disease spirochetes may synchronize production of s

180 ces in our ability to genetically manipulate Lyme disease spirochetes, particularly B. burgdorferi, a

181 Borrelia burgdorferi, the Lyme disease spirochete, persistently infects mammalian

182 Lyme disease spirochetes possess a single HtrA protease

183 Borrelia burgdorferi, the Lyme disease spirochete, possesses a surface protein, Vl

184 The Lyme disease spirochetes produce several factor H bindin

185 ent functional investigations uncovered that Lyme disease spirochetes recognize epidermal growth fact

186 borrelial isolates in order to elucidate the Lyme disease spirochete's complex parasitic strategies.

187 In human Lyme disease, spirochetes spread from the site of a tick

188 None of the Lyme disease spirochetes tested possessed catalase or pe

189 ortant in the pathogenesis or biology of the Lyme disease spirochetes, then a wide distribution among

190 at additional mechanisms are employed by the Lyme disease spirochete to evade complement-mediated kil

191 hat multiple integrins mediate attachment of Lyme disease spirochetes to host cells.

192 Borrelia burgdorferi, the Lyme disease spirochete, undergoes dramatic changes in a

193 tial evidence that Borrelia burgdorferi, the Lyme disease spirochete, undergoes major alterations in

194 y the ability to bind to target tissues, and Lyme disease spirochetes utilize multiple adhesive molec

195 Plasmin stabilized on the surface of the Lyme disease spirochete was shown to activate pro-MMP-9

196 proteins (Hsps) by Borrelia burgdorferi, the Lyme disease spirochete, was investigated by radiolabeli

197 microbes including Borrelia burgdorferi, the Lyme disease spirochete, was manufactured and evaluated.

198 Three representatives of each species of Lyme disease spirochete were tested for the ability to b

199 Lyme disease spirochetes were previously shown to bind g

200 ponses of Borrelia burgdorferi (Bb) B31, the Lyme disease spirochete, when grown under conditions ana

201 variable metabolic requirements of different Lyme disease spirochetes within tick vectors could poten