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1 coordinate both processes for the Gq-coupled M1 muscarinic receptor.
2 s transiently transfected with TRPC5 and the M1 muscarinic receptor.
3  are conserved, including suppression by the M1 muscarinic receptor.
4 tivation through cAMP-responsive element via M1 muscarinic receptor.
5  from the beta(2)-adrenergic receptor or the m1 muscarinic receptor.
6 omes that contain both heterotrimeric Gq and m1 muscarinic receptor.
7 cells is mediated by the genetically defined m1 muscarinic receptor.
8 activation in response to stimulation of the m1 muscarinic receptor.
9 y cells after activation of the metabotropic m1-muscarinic receptor.
10 pruning was prevented by genetic deletion of M1 muscarinic receptors.
11 alpha subunits to the endothelin B (ETB) and M1 muscarinic receptors.
12 d PG cell subtype via synaptic activation of M1 muscarinic receptors.
13 cted acetylcholine release via activation of M1 muscarinic receptors.
14 ation of mouse eggs overexpressing the human m1 muscarinic receptor, a G protein-coupled receptor.
15                            We tested whether M1 muscarinic receptor activation enhances glutamatergic
16                                              M1 muscarinic receptor activation of IP production was n
17 d by TRPV1 activation but not that evoked by M1 muscarinic receptor activation.
18 cent development of new and highly selective M1 muscarinic receptor agonists with disease-modifying p
19 y carbachol in Xenopus oocytes co-expressing M1 muscarinic receptors also causes inhibition of the ch
20  to phospholipid vesicles that contain m2 or m1 muscarinic receptor and G(i), G(z), or G(q), GAP acti
21 phaq-protein coupled receptors (GqPCRs) (the M1 muscarinic receptor and the mGluR1 metabotropic gluta
22 re, we demonstrate the colocalization of the m1 muscarinic receptor and the NR1a NMDA receptor subuni
23         GABAA-LTP requires the activation of M1-muscarinic receptors and an increase in cytosolic Ca(
24  current that develops during stimulation of M1 muscarinic receptors, and the currents activated by a
25                                          The M1 muscarinic receptor antagonist pirenzepine dose depen
26                                      Because M1 muscarinic receptors are typically coupled with G-alp
27 ents in these cells were potently reduced by M1 muscarinic receptors, because the effects of carbacho
28                                Activation of M1 muscarinic receptors, but not nicotinic receptors, si
29                                Activation of m1 muscarinic receptors by carbachol relaxed this inhibi
30 oupled receptors (GPCRs), represented by the m1 muscarinic receptor, can initiate intracellular signa
31 en added to proteoliposomes containing M2 or M1 muscarinic receptor-coupled G-protein heterotrimers.
32        These data suggest that activation of M1 muscarinic receptors during an ischemic event may con
33 of either the human P2Y2 (P2U-purinergic) or M1 muscarinic receptor expressed in oocytes resulted in
34 us orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations i
35 ospholipase Cbeta1 (PLCbeta1) signaling, the m1 muscarinic receptor, Galphaq, and PLCbeta1 were expre
36              This work demonstrates that the m1-muscarinic receptor gene product modulates excitatory
37             After transfection with IRK1 and m1 muscarinic receptor genes, tsA cells expressed a cesi
38 ase and establish PYK2 as an effector of the m1 muscarinic receptor in the regulation of multiple cel
39 haX, inhibited the activation of transfected m1 muscarinic receptor in these cells.
40            This indicates involvement of the M1 muscarinic receptor in this response.
41 els is potently reduced by signaling through M1 muscarinic receptors in striatopallidal neurons, but
42 ad weak affinity (Ki 22 microM) for central (M1) muscarinic receptors in a [3H]quinuclidinyl benzilat
43 e that the small GTPase, Rho, transduces the m1 muscarinic receptor-induced inhibition of Kir2.1 via
44 e second messengers were not involved in the m1 muscarinic receptor-induced response.
45                           Stimulation of the m1 muscarinic receptor inhibited Kir2.1, when both recep
46        Therefore, the data indicate that the m1 muscarinic receptor inhibits IRK1, presumably via sti
47                                          The M1 muscarinic receptor is excitatory, and facilitates ne
48 n in the striatum as a result of stimulating m1 muscarinic receptors located within this structure an
49 ffect the PM localization or function of the M1 muscarinic receptor (M1R)/Gq signaling cascade.
50 ma mutants, however, showed little effect on m1-muscarinic receptor-mediated PLC activation, which is
51     Most striatal projection neurons express m1 muscarinic receptor mRNA with m4 mRNA found in 40-50%
52                                Activation of M1 muscarinic receptors occurs through orthosteric and a
53 sing through the thalamic radiation activate M1 muscarinic receptors on TC projections and sustain gl
54 lation in RBL2H3 cells stably expressing the M1 muscarinic receptor (RBL-2H3-M1 cells).
55                                              M1 muscarinic receptors regulate the phosphorylation of
56 ng M current inhibition by B2 bradykinin and M1 muscarinic receptors respond very differently to inhi
57             We show that D2 dopaminergic and M1 muscarinic receptors selectively modulate a biophysic
58                                   Disrupting M1 muscarinic receptor signaling specifically in indirec
59 ing; and (c) a requirement for hVPS34 during M1 muscarinic receptor signaling.
60 otein kinase c (PKC), mimicked the effect of m1 muscarinic receptor stimulation by inhibiting the IRK
61 lts delineate molecular events attending the m1 muscarinic receptor stimulation of this tyrosine kina
62 l, fully prevented the inhibition of IRK1 by m1 muscarinic receptor stimulation.
63 aM kinase II inhibitors, KN-93 and KN-62, on M1-muscarinic receptor stimulation of inositol phosphate
64                       CaM inhibitors reduced M1-muscarinic receptor stimulation of inositol phospholi
65               First, we used cell lines with M1 (muscarinic) receptors that couple to phospholipase C
66 platelet-derived growth factor receptors and m1 muscarinic receptors that selectively stimulate the E
67                  We expressed in COS-7 cells m1 muscarinic receptors that were mutated at Asp122 and
68 e Gq family couple ligand stimulation of the m1 muscarinic receptor to activation of phospholipase C,
69  beta1 gamma2HF dimers supported coupling of M1 muscarinic receptors to the Gq alpha subunit.
70                                           In m1 muscarinic receptor transfected HEK-293 cells, carbac
71 (M,ng)) by acetylcholine was investigated in m1 muscarinic receptor-transformed mouse neuroblastoma-r
72 rivatives display functional selectivity for m1 muscarinic receptors, warranting further evaluation a
73 y rectifying potassium channel (IRK1) by the m1 muscarinic receptor was studied with the whole-cell p
74 eceptors were found in goblet cells, whereas M1-muscarinic receptors were in stratified squamous cell
75 N-desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC50 of 55 nM and was a