ライフサイエンスコーパス: MALDI

1 MALDI imaging mass spectrometry (IMS) of low molecular w

2 MALDI mass spectrometry imaging (MSI) enables label-free

3 MALDI TIMS-MS separation of lipid isomer standards, incl

4 MALDI TOF-TOF analysis suggested covalent (ester bond) a

5 MALDI-FTICR mass spectrometry, immunohistochemistry, 3D

6 MALDI-HiTES is a broadly applicable tool for the discove

7 MALDI-ISD MS protein analysis involves only minimal samp

8 MALDI-MSI experiments on spleen tissues from intravenous

9 MALDI-MSI methods were developed to enhance the detectio

10 MALDI-TOF enzymatic fingerprinting and NMR experiments r

11 MALDI-TOF mass spectrometry analyses revealed the oxidat

12 MALDI-TOF MS data combined with multivariate analysis, s

13 MALDI-TOF MS has shown great utility for rapidly identif

14 MALDI-TOF MS is becoming more commonplace for the genus-

15 MALDI-TOF MS-based structural analysis of the mutant CWP

16 MALDI-TOF profiles demonstrated that Burkholderia lipid

17 itivity, and dynamic range combined in a 21T MALDI FT-ICR MSI experiment enable researchers to visual

18 In a MALDI-TOF DUB assay, we quantitate the amount of mono-ub

19 method for arriving at a classification of a MALDI-ToF sample, provided the collagen sequences for ea

20 port use of 2-AA for labeling N-glycans on a MALDI target through nonreductive amination, while simul

21 Here, we demonstrate that a MALDI quadrupole time-of-flight (Q-TOF) mass spectromete

22 cted 37 cerebrosides in a single run using a MALDI-TOF instrument.

23 In addition, MALDI FT-ICR MS of IdeS-digested mAbs allowed isotopic-l

24 on and antigen epitope preservation to allow MALDI MSI to be performed and directly followed by IHC a

25 ofluidic capillary electrophoresis (CE), and MALDI-MS were adopted to resolve positional isomers of s

26 tudy, we have evaluated by HPLC-DAD, DLS and MALDI-TOF a synergic effect of the coexistence of two sa

27 were characterized by SDS-page, RP-HPLC and MALDI-TOF-MS.

28 ate registration of the cell-identifying and MALDI-MS images.

29 s method that combines microarrays, MEF, and MALDI-MS presents an effective platform for lipidomic st

30 the predominant clone identified by MLST and MALDI-TOF, and CR-KP infection was associated with incre

31 ity of compound identification for LC-MS and MALDI imaging lipidomics.

32 xhibiting a high agreement between LC-MS and MALDI-Q-MSI (Pearson correlation r = 0.87).

33 dual-polarity high-resolution MALDI-MSI and MALDI MS(2)I studies.

34 ity in lipid coverages between the NAPA- and MALDI-MSI platforms presents the possibility of selectiv

35 ure was also characterized by FTIR, NMR, and MALDI-TOF.

36 eight <15 kDa) as determined by SDS-PAGE and MALDI-TOF/MS analyses.

37 Simulations and MALDI spectra of a stroke-damaged rat brain show MS sign

38 ds as well as in vivo, EPR spectroscopy, and MALDI measurements, we show that several MoFe protein sp

39 alternative to conventional targets for any MALDI MS analysis.

40 ctive method for simple postionization in AP-MALDI MSI.

41 rix-assisted laser desorption/ionization (AP-MALDI) setup for high-throughput large-scale sample anal

42 re matrix assisted desorption/ionization (AP-MALDI), several ion sources, operating in a range of geo

43 However, the ultimate limits of liquid AP-MALDI in sample throughput can be conservatively estimat

44 n also be used in combination with liquid AP-MALDI MS.

45 second-generation transmission mode (TM) AP-MALDI imaging platform with in-line plasma postionizatio

46 erformed using a mass spectrometry approach (MALDI-ToF-MS), and the potential bioactivity evaluated b

47 r weight ions is particularly challenging as MALDI matrix clusters are often nominally isobaric with

48 In this study, we developed a cell-based MALDI MS workflow for investigation of OATP2B1 cellular

49 d non-fermented bovine milk were analysed by MALDI-TOF mass spectrometry, and their tryptic digestion

50 43 were isolated, and structural analysis by MALDI-TOF-MS, GC-MS, and 2D NMR revealed that both were

51 The resulting materials are analyzed by MALDI-imaging mass spectrometry (MALDI-IMS) to verify th

52 collected from the capillary and analyzed by MALDI-TOF MS.

53 ulting in a bottom-up proteomics approach by MALDI-TOF mass spectrometry (MS).

54 ccessfully identified directly from broth by MALDI-TOF.

55 The improved chemical coverage by MALDI-2 can also help to improve our understanding of th

56 by NAPA-MS and 62 were uniquely detected by MALDI-MS.

57 incubation, washing, and elution followed by MALDI-MS analysis.

58 imple dilution of milks in water followed by MALDI-TOF MS analyses in the positive linear ion mode an

59 Results given by MALDI-TOF were compared with the reference methods used

60 Bacteria were identified by MALDI-TOF, antimicrobial susceptibility testing followed

61 glycoblotting-protocol then investigated by MALDI-TOF/MS.

62 However, robust and accurate quantitation by MALDI-MSI still remains a challenge.

63 oteins observed in infected kidney tissue by MALDI FT-ICR IMS through accurate mass matching.

64 postionisation coupled with MALDI (so-called MALDI-2) to the analysis and imaging of pharmaceutical c

65 We present a protocol that combines MALDI-MS with immunocytochemistry to assay over a thousa

66 mple images corresponding to the most common MALDI matrix (2,5-dihydroxybenzoic acid, DHB) and charac

67 mpared to that of MALDI-MSI using two common MALDI matrices.

68 designed to produce reliable and comparable MALDI-MSI data from single sections and tissue microarra

69 that culturing can be avoided by conducting MALDI-TOF MS on individual bacterial cells.

70 In particular, TOF-SIMS and confirmatory MALDI FT-ICR MS (/MS) analysis permitted the mapping of

71 e detected without the use of a conventional MALDI matrix.

72 orders of magnitude compared to conventional MALDI analysis.

73 from tissue was obtained using conventional MALDI.

74 -steel targets and may be used for different MALDI-TOF MS applications.

75 distributions of z' ions in protein top-down MALDI-ISD FT-ICR mass spectra and show why these distrib

76 tained from kinetic investigations and DSC-, MALDI-TOF-MS-, (1)H NMR-studies of linear polymers prepa

77 on zone produced by P. cichorii, we employed MALDI imaging mass spectrometry (MALDI IMS) and MS/MS mo

78 makes a substantial step toward establishing MALDI-MSI as a fully quantitative validated method.

79 nced lipid ionization through thin-gold-film MALDI-MS.

80 me-of-flight mass spectrometer (timsTOF fleX MALDI-2, Bruker Daltonics).

81 laser desorption ionization-time of flight (MALDI-TOF) analyses following trypsin digestion of the t

82 laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry.

83 laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry.

84 laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications in dual polari

85 laser desorption/ionization time-of-flight (MALDI-TOF) MS analysis of microbial proteins.

86 laser desorption/ionization time-of-flight (MALDI-ToF) spectra.

87 laser desorption ionization/time-of-flight (MALDI/ToF) mass spectrometry and (1)H NMR were used for

88 re, on-tissue derivatization was applied for MALDI-MSI of N-glycans from human laryngeal cancer and o

89 ree sulfhydryl groups in tissue is known for MALDI MSI.

90 hiol-containing metabolites with CHC-Mal for MALDI MSI was also possible when using aged tissue in th

91 d was successfully applied as the matrix for MALDI-TOF mass spectrometry imaging (MSI) for studying t

92 rs the highest mass spectral performance for MALDI MSI experiments, and often reveals molecular featu

93 es were subcultured on blood agar plates for MALDI-TOF analysis.

94 ctrospray ionization (ESI) source, while for MALDI imaging, the exchange was performed in the ion fun

95 to achieve a trustworthy identification from MALDI-TOF MS data, a significant amount of biomass shoul

96 d by extraction of EYFP's molecular ion from MALDI-MS images, automated, whole-image assignment of ce

97 we accomplish by using the heme signals from MALDI-MSI and iron signals from LA-ICP-MSI to overlay th

98 an external control for peptide and N-glycan MALDI-MSI throughout the experiment.

99 Here, MALDI MSI at 21T is demonstrated for the first time: mas

100 -transform ion cyclotron resonance (FT-ICR), MALDI mass spectrometry imaging (MSI) to image the distr

101 storage containers and obtained identifiable MALDI-TOF MS collagen fingerprints, all indicative of th

102 rption/ionization mass spectrometry imaging (MALDI MSI) and laser scanning confocal microscopy (LSCM)

103 rption/ionization mass spectrometry imaging (MALDI MSI) is a powerful technique for spatially resolve

104 rption/ionization mass spectrometry imaging (MALDI MSI) is an established tool for the investigation

105 rption ionization mass spectrometry imaging (MALDI MSI) technologies offers a high promise to deeper

106 rption/ionization mass spectrometry imaging (MALDI MSI) workflows with antibody slide arrays is descr

107 rption/ionization mass spectrometry imaging (MALDI MSI)-based study was designed in order to selectiv

108 rption/ionization mass spectrometry imaging (MALDI-MSI) and laser ablation inductively coupled plasma

109 rption/ionization mass spectrometry imaging (MALDI-MSI) experiments were performed on whole brains fr

110 rption/ionization mass spectrometry imaging (MALDI-MSI) has been widely applied to the discovery of p

111 rption/ionization mass spectrometry imaging (MALDI-MSI) is an established tool in drug development, w

112 rption ionization mass spectrometry imaging (MALDI-MSI) is widely used to visualize and analyze the d

113 rption/ionization mass spectrometry imaging (MALDI-MSI) was developed for analysis of N-glycans from

114 rption/ionization-mass spectrometry imaging (MALDI-MSI) within pharmaceutical research.

115 rption/ionization mass spectrometry imaging (MALDI-MSI).

116 Although our PTEN immuno-MRM and immuno-MALDI assays can be considered to be orthogonal as they

117 N in Colo-205 cells by immuno-MRM and immuno-MALDI using 2-PIC and external calibration yielded very

118 total protein) between immuno-MRM and immuno-MALDI.

119 ration: 4.9% for immuno-MRM; 1.1% for immuno-MALDI), without the need for a surrogate matrix or addit

120 nic acids facilitating their anionization in MALDI source).

121 ntly up-regulated in 5-FU-resistant cells in MALDI-TOF analysis.

122 rate and confident assignments of z' ions in MALDI-ISD FT-ICR mass spectra.

123 le simultaneously functioning as a matrix in MALDI-MS glycan analysis.

124 seful for the identification of pathology in MALDI biological samples.

125 ser desorption ionization (MALDI), including MALDI-MS imaging and ion mobility, particularly high-fie

126 spectrometric analysis techniques, including MALDI and various ambient ionization methods.

127 With increasing MALDI-TOF MS use, CLs are well-advised to adhere strictl

128 the combination of negative and positive ion MALDI FT-ICR MS is a useful tool to improve the characte

129 matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) for both spatia

130 matrix-assisted laser desorption ionization (MALDI) and other IMS methods through direct IMS analyses

131 matrix-assisted laser desorption ionization (MALDI) imaging and infrared (IR) laser ablation sampling

132 Matrix Assisted Laser Desorption Ionization (MALDI) Imaging and Laser Ablation - Inductively Coupled

133 matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) combined with tim

134 matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS).

135 matrix-assisted laser desorption ionization (MALDI) is the method of choice for the molecular imaging

136 matrix-assisted laser desorption ionization (MALDI) techniques.

137 matrix-assisted laser desorption ionization (MALDI), desorption electrospray ionization (DESI) and se

138 matrix assisted laser desorption ionization (MALDI), including MALDI-MS imaging and ion mobility, par

139 matrix-assisted laser desorption ionization (MALDI)-like scenario, leading to the desorption/ionizati

140 matrix-assisted laser desorption ionization (MALDI)] enables the development of highly sensitive and

141 matrix-assisted laser desorption/ionization (MALDI) analyses, and heterologous enzyme production iden

142 matrix-assisted laser desorption/ionization (MALDI) combined with in-source decay (ISD) fragmentation

143 Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) allows for direct

144 matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) of bacterial micr

145 matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry in positive ionization

146 Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) provides a unique

147 matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrume

148 matrix-assisted laser desorption/ionization (MALDI) matrix for spatially resolved lipidomics investig

149 matrix-assisted laser desorption/ionization (MALDI) MS can measure the chemical contents of individua

150 matrix-assisted laser desorption/ionization (MALDI) with 1,4-phenylenedipropionic acid (PDPA) reagent

151 matrix-assisted laser desorption/ionization (MALDI), combined with in-source decay (ISD) fragmentatio

152 matrix-assisted laser desorption/ionization (MALDI).

153 lem by use of laser-induced post-ionization (MALDI-2) and by adapting a t-MALDI-2 ion source to an Or

154 riments revealed that laser post-ionization (MALDI-2) has great potential to overwrite changes in sig

155 Upon use of a 1 kHz postionization laser, MALDI-2 produces a sizable increase in the number of det

156 gher spatial resolution than most metabolite MALDI IMS experiments (20 mum) while maintaining broad c

157 In particular, with current microbial MALDI-MSI methods chemical coverage is strongly limited

158 The use of negative ion mode MALDI-2-MSI could constitute a valuable tool in glycobio

159 visited the application of negative ion mode MALDI-ISD and found good coverage of the peptide chain t

160 evaluation of positive and negative ion mode MALDI-ISD FT-ICR MS in the m/z range 46-13 500 showed an

161 Moreover, MALDI-TOF MSI results were obtained for lipid distributi

162 LC, combined with highly sensitive LC-MS/MS, MALDI-TOF-MS, and exoglycosidase treatments.

163 -assisted laser desorption/ionization-Q-MSI (MALDI-Q-MSI), using a mixture of three isotopically labe

164 al capabilities of BzPy as a multifunctional MALDI-MSI matrix are demonstrated by imaging endogenous

165 lts demonstrate the promising application of MALDI-TOF MS in evaluating the photodynamic effect of ea

166 Collision-induced dissociation (CID) of MALDI-generated ozonide ions (with yields in the several

167 e Classifier, to bacterial classification of MALDI-TOF MS data.

168 tis tissue sections, that the combination of MALDI-2 with the trapped ion mobility spectrometry (TIMS

169 Comparison of MALDI-TOF-MS spectra of all obtained extracts clearly in

170 The 3D printing allows easy manufacturing of MALDI targets with different dimensions and spot geometr

171 ssues begins within the normal time scale of MALDI MSI sample preparation.

172 ombination with the increased sensitivity of MALDI-2 available in one instrument, the described metho

173 we compare the utility of NAPA-MS to that of MALDI-MS using two common matrices for the analysis of m

174 afforded by NAPA-MSI is compared to that of MALDI-MSI using two common MALDI matrices.

175 By use of MALDI-MS imaging (MSI) in combination with PNGase F trea

176 This work demonstrates the utility of MALDI imaging for spatial localization of fungicide in f

177 rk will contribute towards the validation of MALDI MS based methods and deployment in violent crimes

178 structural characterization of mAbs based on MALDI in-source decay (ISD) fragmentation, coupled with

179 that is specifically designed to operate on MALDI peptide imaging data.

180 This 2-AA on-MALDI-target glycan derivatization eliminates tedious sa

181 The on-MALDI-target sample preparation is a single-step protoco

182 we coupled laser-induced postionization, or MALDI-2, to a trapped ion mobility quadrupole time-of-fl

183 ization-mass spectrometry imaging with PBCs (MALDI-MSI-PBC) as a drug screening platform.

184 ulation of CD11b/CD18 function, we performed MALDI TOF Mass Spectrometry (MS) analyses on CD11b/CD18

185 In conclusion, performing MALDI-TOF mass spectrometry analyses in oxidizing condit

186 resulting beneficial effects on phospholipid MALDI IMS.

187 er, due to ion suppression by phospholipids, MALDI has limited ability to efficiently ionize and imag

188 combined with laser-induced postionization (MALDI-2) is a recently introduced method for enhanced ma

189 combined with laser-induced postionization (MALDI-2-MSI) to simultaneously visualize the distributio

190 ass spectrometers with laser-postionization (MALDI-2) modules to increase the analytical sensitivity

191 ple preparation with subatmospheric pressure MALDI, we demonstrate that chemical output from groups o

192 The results indicate that 3D printed MALDI targets are comparable to standard MBT BioTargets

193 Moreover, the 3D printed MALDI targets are disposable, cheap, and easy to produce

194 The 3D printed MALDI targets were validated by analysis of different ty

195 lide mounting, a nine-step washing protocol, MALDI matrix sublimation and recrystallization.

196 This prototype MALDI timsTOF instrument is capable of 10 mum spatial re

197 he HT adaptation of the previously published MALDI-TOF-based DUB assay method.

198 We present a quantitative MALDI-MSI method using two instruments with different ty

199 report on a sensitive and fast quantitative MALDI-MS/MS method used to assess saffron authenticity b

200 described previously for low repetition rate MALDI-2 systems, but now enables substantially enhanced

201 For the isophthalic/maleic acid ratio, MALDI results yielded constantly lower values than (1)H

202 mpared to the previously introduced reactive MALDI matrix benzophenone, 2-benzoylpyridine (BzPy) is i

203 ing the capabilities of BPh as a PB-reactive MALDI matrix to potentially unveil the impact of DB-posi

204 Recently, MALDI-TOF MS-based methodologies for bacteria detection/

205 Furthermore, two reducing MALDI matrices, namely 1,5-diaminonaphthalene and N-phen

206 ent and allows dual-polarity high-resolution MALDI-MSI and MALDI MS(2)I studies.

207 icantly, five micron high-spatial resolution MALDI-MSI revealed that Arabidopsides are localized to t

208 The resulting MALDI-ISD MS data is complementary to electrospray ioniz

209 Our results indicate that fast and robust MALDI MS cellular assays could emerge as a high-throughp

210 milks based on lipids fingerprint by routine MALDI-TOF mass spectrometry (MS).

211 of the MALDIxin test adapted for the routine MALDI Biotyper Sirius system provides an unbiased, fast,

212 Second, MALDI-MSI of kidney tissues was performed to study the s

213 er many spectra are acquired during a single MALDI-MSI experiment or data from independent experiment

214 MALDIxin test for the MALDI Biotyper Sirius MALDI-TOF MS system (Bruker Daltonics).

215 we employed MALDI imaging mass spectrometry (MALDI IMS) and MS/MS molecular networking.

216 ser desorption/ionization mass spectrometry (MALDI MS) is limited for complex mixtures of carbohydrat

217 ser Desorption Ionisation Mass Spectrometry (MALDI MS)-proteomics based method for the reliable detec

218 analyzed by MALDI-imaging mass spectrometry (MALDI-IMS) to verify their identity.

219 ser desorption/ionization mass spectrometry (MALDI-MS) for the rapid identification of cryptic peptid

220 ser desorption/ionization mass spectrometry (MALDI-MS) is an important tool for high-throughput N-gly

221 ser desorption/ionization mass spectrometry (MALDI-MS) to monitor the multistep conversion of the nat

222 ser desorption/ionization mass spectrometry (MALDI-MS), and capillary liquid chromatography-tandem ma

223 ser desorption/ionization-mass spectrometry (MALDI-MS).

224 ionization time of flight mass spectrometry (MALDI-TOF MS) analysis allowing in minutes the identific

225 ionization-time of flight mass spectrometry (MALDI-TOF MS) and automated identification systems as we

226 ionization-time-of-flight mass spectrometry (MALDI-TOF MS) can be applied for the identification of p

227 ionization-time of flight mass spectrometry (MALDI-TOF MS) for yeast isolate identification, real-tim

228 ionization-time of flight mass spectrometry (MALDI-TOF MS) identification and broth microdilution phe

229 ionization-time of flight mass spectrometry (MALDI-TOF MS) in less than 15 min but is not optimized f

230 ionization time-of-flight mass spectrometry (MALDI-TOF MS) is described in this study.

231 ionization-time of flight mass spectrometry (MALDI-TOF MS) or gene sequencing.

232 ionization time-of-flight mass spectrometry (MALDI-TOF MS) plates, termed fast lipid analysis techniq

233 ionization-time of flight mass spectrometry (MALDI-TOF MS) system was able to identify S. delphini to

234 ionization time-of-flight mass spectrometry (MALDI-TOF MS) target plates printed by FDM technology us

235 ionization time of flight mass spectrometry (MALDI-TOF MS) with only 1 muL of sample in a fast (less

236 ionization-time of flight mass spectrometry (MALDI-TOF MS), and 16S rRNA partial genome sequence anal

237 ionization-time of flight mass spectrometry (MALDI-TOF MS), gas chromatography (GC), SDS-PAGE, Toll-l

238 ionization-time of flight mass spectrometry (MALDI-TOF MS), which has a limited capacity to identify

239 ionization-time of flight mass spectrometry (MALDI-TOF MS).

240 ionization time-of-flight mass spectrometry (MALDI-TOF MS).

241 Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS).

242 ionization time-of-flight mass spectrometry (MALDI-TOF MS).

243 ionization-time of flight mass spectrometry (MALDI-TOF) in Central China.

244 ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is the preferred instrumental platform for

245 ionization time-of-flight mass spectrometry (MALDI-TOF-MS).

246 -diamine-6-ethyl moiety by NMR spectroscopy, MALDI-TOF mass spectroscopy, UV-Vis spectroscopy, and ti

247 g different GPL classes observed in standard MALDI-MSI.

248 ding electrospray ionization and solid state MALDI, as well as MS methods using multiplexing by label

249 luding the observation of cyclic structures (MALDI), E/Z isomerism from maleic to fumaric acid, and t

250 d sequence by database search and subsequent MALDI-TOF/TOF analysis.

251 ost-ionization (MALDI-2) and by adapting a t-MALDI-2 ion source to an Orbitrap mass analyzer.

252 try imaging in transmission-mode geometry (t-MALDI-MSI) can provide molecular information with a pixe

253 l studies of fucosylated N-glycans by tandem MALDI mass spectrometry (MS) in the positive ion mode.

254 y (13)C NMR and multidimensional techniques, MALDI/ToF MS provides a straightforward technique that c

255 ates were identified by biochemical testing, MALDI-TOF MS, and 16S rRNA sequence analysis (179 isolat

256 We demonstrate that MALDI-2 increased the signal intensities for 7 out of th

257 Taken together, these results indicate that MALDI-IMS can readily visualize metabolites made by very

258 Results suggest that MALDI-TOF MS and multivariate analysis are useful in det

259 lphini to the species level, suggesting that MALDI-TOF MS is the best option for distinguishing membe

260 This suggests that MALDI/ToF MS is a suitable tool for the semiquantitative

261 The MALDI MSI protocol was optimized in terms of fiducial co

262 The MALDI source utilizes a Bruker SmartBeam 3-D laser syste

263 eening technologies currently available, the MALDI-TOF DUB assay combines the use of physiological su

264 d by sample preparation, particularly by the MALDI (matrix-assisted laser desorption/ionization) matr

265 ctionalization of unsaturated PLs during the MALDI process via a laser-light driven Paterno-Buchi (PB

266 tion of available charge carriers during the MALDI process.

267 study, we adapted the MALDIxin test for the MALDI Biotyper Sirius MALDI-TOF MS system (Bruker Dalton

268 ure, the beads are directly dispensed on the MALDI-TOF MS target enabling the identification and sens

269 We have shown that the MALDI timsTOF platform can maintain reasonable data acqu

270 Intra-assay reproducibility of this MALDI MS method was high (CV < 10%), and results agreed

271 ll-associated polysaccharides (CWPS) through MALDI-TOF MS and methylation analysis, we report on thre

272 consistent with bactericidal rates and thus MALDI-TOF MS might be able to replace the LB agar colony

273 re plasma probe from our developmental AP-TM-MALDI stage.

274 achine learning techniques can be applied to MALDI-TOF mass spectral data of drug-treated cells to ob

275 latform offers better uniformity compared to MALDI, and the wider dynamic range offered by NAPA promi

276 ve alkali metal cation adduction relative to MALDI-MS, with the [M + 2Na/K - H](+) species accounting

277 ution between different classes of GPL under MALDI-MSI conditions.

278 Here, we use MALDI timsTOF IMS to image low molecular weight metaboli

279 stored in a plastic bag, provided no useful MALDI-TOF MS spectra.

280 Using MALDI-2 and StxB-based immunofluorescence microscopy, Gb

281 sitive (DLD-1) colorectal cancer cells using MALDI-MS and LC-MRM-MS.

282 slow-growing organisms in BSCs and not using MALDI-TOF MS for identification until BTAs have been rul

283 -shaped crystals in their solid state, using MALDI-TOF and Raman spectroscopy.

284 for selective detection of free thiols using MALDI MSI.

285 and dog liver tissue to be visualized using MALDI-2, whereas little-to-no signal from tissue was obt

286 identification, that is, NMR, FT-IR, UV-vis, MALDI-TOF spectral data, single crystal X-ray diffractio

287 ned in the mass region above m/z 1000, while MALDI matrix ions generally hamper the detection of smal

288 Data were acquired with MALDI-MS by rastering each hair individually.

289 f the analyte molecules, suggesting, as with MALDI, the occurrence of complex and yet to be elucidate

290 urified with RP HPLC, and characterized with MALDI-TOF MS and enzyme digestion essays.

291 and chemical treatments in combination with MALDI-TOF MS and MS/MS.

292 tion, WGS showed 99 and 93% concordance with MALDI-TOF MS at the genus and species levels, respective

293 ication of laser-postionisation coupled with MALDI (so-called MALDI-2) to the analysis and imaging of

294 the on-tissue labeling strategy coupled with MALDI-MSI shows great potential to spatially characteriz

295 eferential formation of [M + H](+) ions with MALDI-2 has no obvious correlation with the gas-phase pr

296 uming complex titrations, were measured with MALDI and (1)H NMR and were in good agreement.

297 or drugs, indicating that coupling PBCs with MALDI-MSI has the potential to develop rapid, large-scal

298 We demonstrate that with MALDI-2 the sensitivity for the detection of molecular [

299 specific GPL classes and analyzed them with MALDI-MSI in positive- and negative-ion modes.

300 f as few as ~50 cells can be visualized with MALDI-IMS.