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1 MAR indices ranged from 0.2 to 1.
2 MAR lines had fewer nonexpressing cells than control lin
3 MAR measurement is a promising approach for directly ass
4 MAR measurement predicted drug response using samples as
5 MAR revealed heterogeneity in drug sensitivity not only
6 MAR versus SAR does not correlate with a difference in M
7 MAR was positively correlated and MER was negatively cor
8 MARs comprise one of the few classes of eukaryotic nonco
11 in hypoattenuating artifacts (CI/VMI(200keV)/MAR/VMI(MAR200keV), HU: -77.6 +/- 81.1/-65.1 +/- 103.2/-
14 such that constructs bearing both 5' and 3' MARs are passed to their offspring with greater frequenc
17 recognition sites for topoisomerase II and a MAR region were observed in the transgene integration ta
18 methyl-muconic acid to 2-methyl-adipic acid, MAR reduced only one double bond in 3-substituted muconi
19 The demonstration of a DMR and an active MAR in the 5' flank of opossum IGF2 mirrors the regulato
20 spectral-detector CT (SDCT) with additional MAR-reconstructions due to artifacts from coils or clips
22 MI) and metal artifact reduction algorithms (MAR) as well as the combination of both approaches (VMI(
31 as confirmed to be specific to TRPM1 because MAR serum did not stain these cells in a Trpm1(-/-) mous
34 s (MARs): an exceptionally intense computed 'MAR potential' and profound duplex destabilization and f
35 show that HPV18 promoter contains consensus MAR element in the LCR and E6 sequences where SMAR1 bind
36 transgene expression, a question arises: Do MARs increase transgene expression by increasing the per
37 nsport models for the fate of arsenic during MAR, and develop strategies to minimize arsenic release.
38 y and secondary precipitate formation during MAR, and in other systems where interactions between DOM
39 matter (DOM) on arsenic mobilization during MAR, this bench-scale study examined arsenic mobilizatio
41 causal mechanisms of arsenic release during MAR via injection in the Orange County Groundwater Basin
42 , geochemical and hydrological shifts during MAR can release toxic, geogenic contaminants from sedime
43 R1-HDAC1 repressor complex at the LCR and E6 MAR sequences, thereby decreasing histone acetylation at
44 ffered significantly (early AMR 79.6%, early MAR 54.7%, late AMR 23.4%, late MAR 21.1%, P < 0.001).
47 postrejection (early AMR 88.3% versus early MAR 77.8% versus late AMR 56.7% versus late MAR 54.9%, P
52 wever, differences were only significant for MAR in hypodense and VMI(MAR) in hypo- and hyperdense ar
53 Given our continued clinical suspicion for MAR, the patient's serum was sent for evaluation for TRP
54 nd assumed that the degree of departure from MAR varied according to an individual's self-reported HI
55 st assumed that the degree of departure from MAR was the same for all individuals with missing HIV se
56 sed to assess sensitivity to departures from MAR, both when estimating the prevalence of a partially
60 we show that the majority of PARPs generate MAR, not PAR, and demonstrate that the H-Y-E motif is no
62 ve deviants" were defined as having a higher MAR and a lower MER than the respective median values.
63 o quartile 4; 95% CI: 11.8, 14.3) and higher MAR (beta: 6.0; 95% CI: 3.5, 8.5) with minimal impact on
64 ated with higher nutritional quality (higher MAR, lower ED), regardless of whether costs were calcula
68 ify SARs and 2 m NaCl extraction to identify MARs revealed that approximately one-half of the sites w
69 mice, suggesting that the visual deficits in MAR are caused by the uptake of TRPM1 autoantibodies int
71 hould be developed alongside improvements in MAR and evaluated in "real-life" salinity-affected setti
72 I: 7.6, 9.1) and with a 4.1-unit increase in MAR (95% CI: 2.7, 5.5) with a minimal increase in diet c
73 primary target of autoantibodies produced in MAR patients with reduced b-wave is the TRPM1 cation cha
76 on with that of FBP and linear interpolation MAR, noise with IFS was similar close to and far from th
80 Anabolic load-induced periosteal lamellar MAR (0.58 +/- 0.14; Pkd1(Dmp1-cKO) vs. 1.68 +/- 0.34 mum
84 ed to the time before CXL for UCVA (0.01 log MAR; 95% confidence interval -0.14 to 0.15, P = .944), B
86 val -0.14 to 0.15, P = .944), BCVA (0.05 log MAR; 95% confidence interval -0.05 to 0.15, P = .310), a
91 4%, p = 0.047) and total VA improvement (log MAR 0.7 +/- 0.6 vs 1.6 +/- 0.9, p = 0.016) compared to t
92 tion at the base hospital which included log MAR visual acuity, refraction, applanation tonometry and
93 estrous female were noted in the adult male MAR-ASD animals, as well as reduced vocalizations emitte
97 we evaluated the expression from the E micro MAR element in mice 2 to 24 weeks posttransplant with tr
98 ceiving vectors with the E micro and E micro MAR elements upstream of the PGK promoter, there was a 2
101 ively in B cells transduced with the E micro MAR-containing vector and not other cells types or vecto
105 nt region (MAR) sequence compared with a non-MAR sequence and were similar in size to DNA loops extra
107 over the melt season, totaled just 37-75% of MAR, suggesting nontrivial subglacial water storage even
108 retinogram (ERG) phenotype characteristic of MAR resemble the congenital visual disease caused by mut
110 Intrigued by the substrate promiscuity of MAR, we probed its utility to produce branched chiral di
115 try could greatly simplify the evaluation of MARs or other sequence elements that affect transgene ex
117 ere analyzed extensively for the presence of MARs by in vitro matrix-binding assay, and for interacti
118 t genetic evidence that at least a subset of MARs performs an important biological function, possibly
126 ing intravitreal injection of TRPM1-positive MAR IgG into wild-type mouse eyes, and the appearance of
127 of live retinal neurons with TRPM1-positive MAR serum resulted in the selective accumulation of IgG
129 , we analyzed the co-occurrence of predicted MARs with highly conserved noncoding DNA regions in huma
131 Conversely, more than half of the predicted MARs co-occur with one or more independently identified
135 that the single-cell mass accumulation rate (MAR), profiled over many hours with a suspended microcha
137 gene dose, as were mineral apposition rate (MAR) and expression of Runx2-II, Osteocalcin, Dmp1, and
138 ion rate (BFR), and mineral apposition rate (MAR), improved the trabecular microarchitecture, and dec
139 The highest soot mass accumulation rates (MARs) occurred at the beginning of the Holocene as fuel
140 concentrations and mass accumulation rates (MARs) of soot have mainly occurred since ~1950, the esta
141 below the median, 2) a mean adequacy ratio (MAR) above the median, and 3) a mean excess ratio (MER,
144 average, cell lines transformed with the Rb7 MAR-containing vector expressed GFP at levels 2.0- to 3.
145 s to alternatives [managed aquifer recharge (MAR) and rainwater harvesting] that aimed to reduce sodi
148 ontaminants during managed aquifer recharge (MAR) poses a challenge to maintaining local groundwater
152 gate the impact of metal artifact reduction (MAR) algorithm of cone-beam computed tomography (CBCT) o
154 s VSD leads to multiple Andreev reflections (MAR), which in the limit of weak tunneling probability s
155 rent size regimes-motional averaging regime (MAR), static dephasing regime (SDR), and echo-limiting r
156 were enriched in a matrix attachment region (MAR) sequence compared with a non-MAR sequence and were
160 ions from the Modele Atmospherique Regional (MAR) regional climate model (0.056-0.112 km(3)d(-1) vs.
162 termining phenotype matrix attached regions (MARs) on human chromosomes 14-18 were identified as a fu
163 s have shown that matrix attachment regions (MARs) can increase expression of transgenes in whole org
165 flanking nuclear matrix attachment regions (MARs) encompassing the protamine domain were created.
166 nd to the nuclear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhance
171 istics of nuclear matrix attachment regions (MARs): an exceptionally intense computed 'MAR potential'
176 actor in the multiple adaptational response (MAR) family, regulates expression of the Yersinia type I
177 LcrF, a multiple adaptational response (MAR) transcription factor, regulates virulence in Yersin
180 ibose-protein hydrolase for mono-ADP-ribose (MAR) and poly(ADP-ribose) (PAR) chain removal (de-MARyla
181 either attached singly as mono(ADP-ribose) (MAR) or in polymeric chains as poly(ADP-ribose) (PAR).
182 r a segment of the North Mid-Atlantic Ridge (MAR) using sonar, corers, trawls, traps, and a remotely
183 The mean maximum acceptable annual risk (MAR) for each of the SAEs was calculated for various lev
184 ption cassettes CMV- Zif-VP64 and CMV-eGFP-S/MAR transfected a)K562 cells; b)murine beta-YAC bone mar
186 oth NP and uncompacted plasmid VMD2-hRPE65-S/MAR can mediate persistent, long-term improvement in an
187 t both plasmid and NP forms of VMD2-hRPE65-S/MAR improved the disease phenotypes in an rpe65(-/-) mod
188 and observe that NP or plasmid VMD2-hRPE65-S/MAR led to structural and functional improvements in the
191 Expression studies demonstrated that iBAC-S/MAR-LDLR completely restored LDLR function in CHO ldlr(-
192 lr(-/-) a7 clonal cell lines carrying iBAC-S/MAR-LDLR demonstrated low copy episomal stability of the
193 with a scaffold matrix attachment region (S/MAR) and vitelliform macular dystrophy 2 (VMD2) promoter
194 on the Scaffold/Matrix Attachment Region (S/MAR) for episomal retention and the beta-globin Replicat
201 nucleosome formation, and the majority of S/MARs contain at least one nucleosome-depleted region.
204 ern of distribution and genomic context of S/MARs is thought to be important for processes such as ch
210 fs and 6-mer enrichment patterns show that S/MARs are preferentially enriched in poly(dA:dT) tracts,
212 oci-specific studies, we have surveyed the S/MARs in HeLa S3 cells on human chromosomes 14-18 by arra
217 rchy for graft survival with ACR better than MAR better than AMR, which persisted for both early and
218 at cells preferentially uptook ctMA and that MAR efficiently reduced all muconic isomers to adipic ac
220 n sites on seven PARPs, and demonstrate that MAR and PAR generating PARPs modify similar amino acids,
222 ite-specific recombination demonstrated that MAR sequences were required for the establishment but no
234 Furthermore, the epitope targeted by the MAR autoantibodies was localized within the amino-termin
235 o test this possibility, we have deleted the MAR from a Chinese hamster ovary variant harboring a sin
236 mine whether the time to at least double the MAR was dependent on age at baseline or starting VA.
239 ation of segmental reference haplotypes, the MAR algorithm always calculates an exact form of transit
241 15 of 29 (52%, 33-71) participants in the MAR vaccine group had a T-cell response to the Marburg g
242 Nine of 29 (31%, 15-51) participants in the MAR vaccine groups had an antibody response to the Marbu
243 s contains multiple enhancers, including the MAR/intronic (iE(kappa)) and 3' enhancers (3'E(kappa)).
244 ty, the applicability and performance of the MAR analysis utilizing (13)C and (19)F cross-polarizatio
245 l replicon mapping shows that removal of the MAR has no significant effect either on the frequency or
246 lkaline conditions show that deletion of the MAR interferes with local separation of daughter chromat
247 l flat plain at 3500 m depth in place of the MAR would contain 85.6 kt C, implying an increase of 173
250 Primary production and export flux over the MAR were not enhanced compared with a nearby reference s
251 ancement of biological productivity over the MAR; oceanic bathypelagic species are replaced by benthi
255 fference of VA was determined by whether the MAR between the two eyes differed by less than a factor
256 lar to staining for TRPM1, staining with the MAR sera was strong in dendritic tips and somas and was
257 -binding assay, and for interaction with the MAR-binding proteins cut-like protein x/CCAAT-displaceme
264 om moderate daily symptoms to remission, the MARs ranged from 0.69% to 0.81% and from 0.39% to 0.55%,
266 M1 gene, and Western blots probed with these MAR sera showed the expected band size ( approximately 1
267 ding 5' ends of genes, suggesting that these MARs are primarily involved in transcriptional control.
269 direct lines of evidence suggested that this MAR might be required for origin activation in early S p
271 and structural constraints limiting PARPs to MAR synthesis do not limit their ability to modify canon
274 become evident: the enzyme used to transform MAR/PAR into phosphoribose must be purified from the rat
276 nd-drinking subjects (SAD), marijuana users (MAR), smoking-and-marijuana users (SAM), marijuana-and-d
277 at the potential long-term benefits of using MAR in CABG patients with renal insufficiency may be off
278 del to estimate each subject's unblurred VA (MAR(0) in minutes of arc) and equivalent intrinsic blur
279 n the propensity to have received SAR versus MAR, within groups with preoperative glomerular filtrati
285 Compared to CI, VMI >= 100 keV, MAR and VMI(MAR) between 100-200 keV increased attenuation in hypoat
287 l as the combination of both approaches (VMI(MAR)) compared to conventional CT images (CI) as standar
289 associated with transcript presence whereas MARs contained within a gene are associated with silence
290 en insufficiently powered to address whether MAR confers long-term benefit over SAR in patients with
291 ts expressing mini-white transgenes in which MAR sequences from the human apoB gene were arranged in
292 e potential of a tag-based pipeline in which MAR/PAR is hydrolyzed down to phosphoribose, leaving a 2
293 nd in pretreated lignin, we found that while MAR fully reduced 2-methyl-muconic acid to 2-methyl-adip
294 at the vision of at least some patients with MAR is compromised due to autoantibody-mediated inactiva
295 sensitivity loss shown by the patients with MAR is consistent with the dysfunction at the level of t
297 ntrast sensitivity deficits of patients with MAR under photopic conditions are not specific to the MC
300 Staining of mouse and primate retina with MAR sera revealed immunoreactivity in all types of ON bi