ライフサイエンスコーパス: MC1R

1 MC1R agonist- but not MC1R antagonist-conjugated nanopar

2 MC1R and MC3R mRNA and protein were both expressed in th

3 MC1R and TYR are associated with pigmentation, freckling

4 MC1R antagonists human beta-defensin 3 and agouti signal

5 MC1R encodes a cyclic AMP-stimulating G-protein-coupled

6 MC1R is a candidate gene involved in alternative male mo

7 MC1R nucleotide diversity, pi, was much higher (10.1 x 1

8 MC1R overexpression, treatment with the MC1R ligand, or

9 MC1R palmitoylation, primarily mediated by the protein-a

10 MC1R SNP R163Q was also significantly (P<0.001) associat

11 MC1R variants may influence orofacial pain perception an

12 MC1R was positively associated with BRAF V600E cases but

13 MC1R's associations with BRAF V600E cases limited to ind

14 MC1R, number of moles, skin reaction to first summer sun

15 MC1R- and VLA-4-targeting peptides and peptide-conjugate

16 MC1R-cAMP signaling promotes PKA-mediated phosphorylatio

17 ic loci: IRF4 (rs12203592, P=1.8 x 10(-27)), MC1R (compound heterozygosity score, P=2.3 x 10(-24)), a

18 mes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genome-wide significance with

19 y targeted expression of ZDHHC13 in C57BL/6J-MC1R(RHC) mice and subsequently inhibit melanomagenesis.

20 curve (AUC) for a model by Han et al. with 7 MC1R variants was 0.72 (95% confidence interval (CI): 0.

21 d to rate their itching, and genotyped for 8 MC1R SNPs.

22 ude OCA2-HERC2 (combined P = 3.80 x 10(-8)), MC1R (P = 1.82 x 10(-13)), a region near TYR (P = 1.57 x

23 d in 94% of uveal melanoma metastases, and a MC1R-specific ligand (MC1RL) with high affinity and sele

24 riants for therapeutic benefit by activating MC1R protein palmitoylation.

25 sferase ZDHHC13, is essential for activating MC1R signalling, which triggers increased pigmentation,

26 sulfide bond) is essential for high-affinity MC1R binding and inverse agonism.

27 exhibited excellent MC4R selectivity against MC1R whereas those with an amino acid had moderate MC4R/

28 ating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by p

29 less MC1R model containing Mc1r(-/-) albino, MC1R(+)Mc1r(-/-) albino, Mc1r(-/-) pigmented, and MC1R(+

30 dy design with complete determination of all MC1R coding region variants.

31 a-melanocyte stimulating hormone (alphaMSH), MC1R function can be antagonized by a secreted factor, a

32 Although MC1R signaling is critically dependent on its palmitoyla

33 ecific interaction between MC1R antigens and MC1R-Abs when the target melanoma cells are present in t

34 ficant negative association between BRAF and MC1R mutations for head/neck melanomas.

35 All host characteristics and MC1R were more strongly associated with multiple BCC cas

36 n, inferring a steroidogenic-independent and MC1R-dispensable anti-proteinuric effect of melanocortin

37 stics (freckles, nevi, phenotypic index) and MC1R status with incident amelanotic melanomas were eval

38 r probe for small-animal PET of melanoma and MC1R expression in melanoma xenografted mouse models.

39 gmentation genes: MATP, IRF4, TYR, OCA2, and MC1R.

40 n to their functional relationship, OPN3 and MC1R colocalize at both the plasma membrane and in intra

41 +)Mc1r(-/-) albino, Mc1r(-/-) pigmented, and MC1R(+)Mc1r(-/-) pigmented mice was generated.

42 ssociations between self-identified race and MC1R single-nucleotide polymorphisms (SNPs) with severit

43 door tanning, burns from indoor tanning, and MC1R (AUC = 0.77, 95% CI: 0.74, 0.81).

44 anocortin 1 receptor (MC1R) antigen and anti-MC1R antibody (MC1R-Ab).

45 arker melanocortin 1 receptor (MC1R) to anti-MC1R antibody.

46 eptor (MC1R) antigen and anti-MC1R antibody (MC1R-Ab).

47 had significantly higher frequencies of any MC1R variants.

48 The above analogs are MC1R agonists, as their effects were abrogated by an ana

49 with wild-type (WT), but not RHC-associated MC1R variants, which protects PTEN from WWP2-mediated de

50 We also found no association between MC1R status and any somatic mutations in this community

51 est study to date on the association between MC1R variants and BRAF mutant melanoma.

52 lar basis underlying the association between MC1R variants and melanomagenesis.

53 Associations between MC1R genetic risk groups and some pigmentation character

54 sing due to the specific interaction between MC1R antigens and MC1R-Abs when the target melanoma cell

55 , fear of pain mediated the relation between MC1R variant status and dental fear (B = 1.60, 95% confi

56 Results: High biostability, MC1R-specific cytotoxicity, and high binding affinity we

57 BCC risk conferred by MC1R tended to be stronger among those with darker pigme

58 sine monophosphate (cAMP) response evoked by MC1R via activation of the Galphai subunit of G proteins

59 Over half of participants carried MC1R variants known to increase risk of skin cancer, and

60 Individuals carrying MC1R variants, especially those associated with red hair

61 and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1.54, 95% CI

62 ans, the proportion of participants carrying MC1R variants imparting elevated skin cancer risk was co

63 s melanoma with an emphasis on CDKN2A, CDK4, MC1R, and MAPK pathway targets (e.g., RAS and BRAF), apo

64 n expression from MC1R in favour of chimeric MC1R-TUBB3 isoforms in cultured melanocytes.

65 VR susceptibility as a result of compromised MC1R function are unclear, but hypotheses include reduce

66 signaling, possibly due to high constitutive MC1R activity.

67 By contrast, MC1R responds primarily to those chimeras with a sequenc

68 In contrast, MC1R antagonists agouti signaling protein (ASIP) or huma

69 seful biomarker for the DNA repair-deficient MC1R phenotype.

70 We observed 85 different MC1R variants, 10 of which occurred at a frequency >1%.

71 ese loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10(-27) for rs258322), 11q14-q

72 However, the endogenous MC1R agonists lack selectivity for the MC1R and thus can

73 57BL/6J-Mc1r(e/e)J mice, in which endogenous MC1R is prematurely terminated, expressing Mc1r RHC vari

74 bearing uveal melanoma tumors or engineered MC1R-positive and -negative tumors were studied for biod

75 <15 min), renal and hepatobillary excretion, MC1R-specific tumor uptake, and minimal retention in oth

76 entally tested signal processing in the FGFR/MC1R/B-Raf/C-Raf/MAPK1,2 network in human melanoma cells

77 CTH are endogenous nonselective agonists for MC1R, MC3R, MC4R, and MC5R.

78 was tested in vitro for biostability and for MC1R-specific cytotoxicity in uveal melanoma cells, and

79 defensin 3 (HBD3) acted as an antagonist for MC1R, inhibiting the alpha-melanocortin (alpha-melanocyt

80 compound heterozygosity and homozygosity for MC1R variants.

81 On the basis of our theoretical model for MC1R, using mutagenesis, we have examined 19 transmembra

82 ignificantly elevated when this was null for MC1R.

83 ader effects on growth, revealing a role for MC1R in normal fetal development.

84 affected families, and considered a role for MC1R in this condition.

85 Hence, a role for MC1R in youthful looks independent of its known melanin

86 The results highlight a central role for MC1R palmitoylation in pigmentation and protection again

87 C1RL) with high affinity and selectivity for MC1R was previously developed.

88 on equally in primary podocytes derived from MC1R-null and wild-type mice.

89 anning, result in a shift in expression from MC1R in favour of chimeric MC1R-TUBB3 isoforms in cultur

90 ctivation of MAPK1,2, whereas signaling from MC1R results in transient activation of MAPK1,2.

91 strategy in mice to rescue loss-of-function MC1R in MC1R RHC variants for therapeutic benefit by act

92 The contribution of other loss-of-function MC1R variants (in particular rs1805005, rs2228479 and rs

93 t in melanocytes expressing loss-of-function MC1R.

94 te pigmentation in the absence of functional MC1R in red/blonde-haired Mc1r(e/e) mice.

95 Furthermore, in the absence of functional MC1R, fewer p53 clones were observed in pigmented than i

96 available despite the absence of functional MC1R.

97 onstructed from four pre-selected functional MC1R SNPs (p = 2.69 x 10(-12)), which was replicated in

98 d gene expression of IL-7, IL-7R, IFN-gamma, MC1R, NF-kappaB, phosphorylated NF-kappaB (p-NF-kappaB),

99 Consistent with this hypothesis, the gene MC1R exhibits reduced diversity in African populations f

100 The melanocortin 1 receptor gene (MC1R) is responsible for normal pigment variation in hum

101 ariants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescen

102 phenotypes and melanocortin 1 receptor gene (MC1R) variants in relation to early-onset BCC.

103 lymorphisms in melanocortin-1 receptor gene (MC1R).

104 anning and the melanocortin 1 receptor gene, MC1R.

105 The effect of germline MC1R genotype on development and severity of CMN led us

106 ined the role of Phe(7) in ACTH on human (h) MC1R, MC3R, and MC4R binding and signaling.

107 how MC1R photoprotects, an in vivo hairless MC1R model containing Mc1r(-/-) albino, MC1R(+)Mc1r(-/-)

108 uptake in the B16F10 murine model, with high MC1R expression, but much lower uptake in the A375M huma

109 lly achieved in preclinical models with high MC1R expression.

110 Individuals carrying the homozygote MC1R risk haplotype looked on average up to 2 years olde

111 r (FGFR) and melanocyte stimulating hormone (MC1R) receptors stimulates B-Raf and C-Raf isoforms that

112 To determine how MC1R photoprotects, an in vivo hairless MC1R model conta

113 However, how MC1R activity is modulated by ultraviolet irradiation, w

114 However, MC1R diversity in non-African populations that have evol

115 Human MC1R variants with reduced or absent function are associ

116 oat pigmentation is mediated solely by human MC1R.

117 gnalling protein, blocks activation of human MC1R, its action is unlike that on the mouse receptor in

118 o detectable chimeric mRNA could be found in MC1R expressing mouse melanocytes.

119 y in mice to rescue loss-of-function MC1R in MC1R RHC variants for therapeutic benefit by activating

120 cological rescue to reduce UV mutagenesis in MC1R-defective, melanoma-susceptible individuals.

121 on may be present in European populations in MC1R.

122 ed podocytopathy was completely preserved in MC1R-null mice, marked by reduced albuminuria and dimini

123 Brief treatment with alpha-MSH resulted in MC1R desensitization, whereas continuous treatment up to

124 in IRF4 (Phet = 3.94 x 10(-4)), rs1805007 in MC1R (Phet = 7.71 x 10(-3)), and two SNPs in DEF8 (rs426

125 ere indicate little regional substructure in MC1R.

126 we investigated whether genetic variants in MC1R modulate the risk of PD by sequencing the entire ge

127 Germline variants in MC1R, the gene encoding the melanocortin-1 receptor, and

128 served in a mouse colony bearing an inactive MC1R.

129 nset BCC risk prediction model incorporating MC1R and indoor tanning extends the work of other skin c

130 ibitor ML349 treatment efficiently increases MC1R signaling and represses UVB-induced melanomagenesis

131 llow pheomelanin pigment, whereas increasing MC1R activity stimulates the production of black/brown e

132 protein-acyl transferase, whether increasing MC1R palmitoylation represents a viable therapeutic targ

133 irm that ASIP diminishes agonist-independent MC1R basal signaling whereas HBD3 is a neutral MC1R anta

134 fic and efficient in vivo strategy to induce MC1R palmitoylation for therapeutic benefit.

135 We conclude that genetic variations in IRF4, MC1R, RALY/ASIP, and BNC2 contribute to the acquired amo

136 lternative splicing of the classically known MC1R (MC1R317).

137 ism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface.

138 Along with two known pigmentation loci, MC1R and OCA2, the IRF4 rs12203592 T allele was associat

139 viously confirmed pigmentation-related loci: MC1R, ASIP, TYR, SLC45A2, OCA2, IRF4 and BNC2.

140 melanoma xenografted in mice, indicating low MC1R expression.

141 s those with an amino acid had moderate MC4R/MC1R selectivity.

142 s in the exons of six genes, comprising MHC, MC1R and four others.

143 Individuals with two or more MC1R non-synonymous variants were 3.59 times (95% CI=2.3

144 as assayed for agonist activity at the mouse MC1R, MC3R, MC4R, and MC5R.

145 The activation of p53-POMC/MSH-MC1R signaling is required for the UV-induced melanogeni

146 ling pathway interacts with the p53-POMC/MSH-MC1R signaling pathway, and both are crucial in melanoge

147 well as melanoma risk, including in or near MC1R, MX2, and TERT/CLPTM1L (P < 1 x 10(-10)).

148 by gene sequencing to bear dominant-negative MC1R mutations.

149 1R basal signaling whereas HBD3 is a neutral MC1R antagonist that blocks activation by melanocortins.

150 yellow (e/e) mouse, bearing a nonfunctional MC1R, thereby incrementing our knowledge on this topic.

151 MC1R agonist- but not MC1R antagonist-conjugated nanoparticles exhibit signifi

152 coefficient 1.32; 95% CI: 0.23-2.40) but not MC1R SNP genotype was associated with increased itch sco

153 s study identifies and characterizes a novel MC1R isoform (MC1R350) generated by alternative splicing

154 Activation of MC1R in melanocytes by alpha-melanocyte-stimulating horm

155 e photoprotective eumelanin on activation of MC1R, a melanoma susceptibility gene.

156 This review highlights the advances of MC1R- and VLA-4-targeted radiolabeled peptides and pepti

157 Diminished function alleles of MC1R are associated with decreased tanning and increased

158 ree of penetrance for red hair of alleles of MC1R.

159 mber of red hair/low pigmentation alleles of MC1R; we found that together these MC1R alleles explaine

160 he sensor performance, such as the amount of MC1R-Abs loaded, incubation time with the target melanom

161 Our pooled analysis of MC1R genetic data of young patients with melanoma showed

162 Association of MC1R variants and melanoma risk independent from sun exp

163 We assessed the association of MC1R variants with childhood and adolescent melanoma in

164 We determined associations of MC1R genetic risk categories and phenotypic variables an

165 Associations of MC1R with BRAF mutations in melanoma have been inconsist

166 Carriage of MC1R variants was associated with amelanotic melanoma bu

167 ther phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are as

168 ompared with wild-type carriers, carriers of MC1R variants were at higher melanoma risk after statist

169 Carriers of MC1R variants were at increased melanoma risk independen

170 We investigated the effect of MC1R variants on melanoma using a large, international p

171 ts into the pleiotropic molecular effects of MC1R signaling that may function during development and

172 We studied the expression of MC1R under UVR and alpha-MSH stimulation in skin of diff

173 he biological consequences of the failure of MC1R variants to suppress PI3K/AKT signaling are highly

174 or retrieved from biobanks for genotyping of MC1R variants and ancestry informative markers.

175 but limited evidence exists on the impact of MC1R variants in Hispanic populations.

176 nk cohort to capture a comprehensive list of MC1R variants contributing to red hair colour.

177 contact with the first extracellular loop of MC1R through a series of key hydrophobic interactions.

178 75M melanoma with a relatively low number of MC1R receptors.

179 lopment of an (18)F-labeled probe for PET of MC1R-positive malignant melanoma.

180 -1 is a promising molecular probe for PET of MC1R-positive tumors.

181 Presence of MC1R variant alleles predicted higher levels of dental f

182 in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melan

183 addition to the MC1R genotype, regulation of MC1R expression and activity is expected to affect human

184 teristics may not modify the relationship of MC1R variants and melanoma risk, and suggest that associ

185 Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility

186 ally derived characterization of the role of MC1R variants in red hair colour and offer a powerful, e

187 in production by modulating the signaling of MC1R.

188 facilitated by a distinguishing structure of MC1R, in which loss-of-function variants are never found

189 /F10 melanoma tumors with high expression of MC1Rs and Fox Chase Scid mice bearing human A375M melano

190 rt a model of strong selective constraint on MC1R in Northern Island Melanesia This absence of strong

191 typed for single-nucleotide polymorphisms on MC1R and completed self-report measures of fear of pain

192 operating characteristic of 0.96 using only MC1R variants.

193 rastrand cisplatin-adducts in melanocytes or MC1R-transfected HEK293 cells.

194 were 2387 patients with data for phenotypes, MC1R genotype, and primary melanomas scored for histopat

195 agouti signaling protein, the physiological MC1R antagonist, and were absent in melanocytes expressi

196 ty, and lower protection by "non-pigmentary" MC1R effects.

197 Here we demonstrate a potential MC1R-targeted intervention strategy in mice to rescue lo

198 use of noncanonical amino acids in previous MC1R ligand development raises safety concerns.

199 iant and one r variant (defined as any non-R MC1R variant; OR, 1.6; 95% CI, 1.3-2.2) and among those

200 H) that function as melanocortin 1 receptor (MC1R) agonists.

201 Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin alpha(4)b

202 etween cell surface melanocortin 1 receptor (MC1R) antigen and anti-MC1R antibody (MC1R-Ab).

203 oding region of the melanocortin-1 receptor (MC1R) gene is associated with constitutive pigmentation

204 hat variants of the melanocortin 1 receptor (MC1R) gene may predict greater levels of dental fear.

205 lanoma and germline melanocortin-1 receptor (MC1R) gene status.

206 show that the human melanocortin 1 receptor (MC1R) gene, a critical component of the facultative skin

207 1 that includes the Melanocortin-1 receptor (MC1R) gene, which regulates colour polymorphisms in nume

208 (R alleles) in the melanocortin 1 receptor (MC1R) gene.

209 olymorphisms in the melanocortin 1 receptor (MC1R) gene.

210 ve, but the role of melanocortin 1 receptor (MC1R) has been implicated and was examined here.

211 The melanocortin-1 receptor (MC1R) is a key regulator of pigmentation in mammals and

212 enetic variation in melanocortin-1 receptor (MC1R) is a known contributor to disease-free red hair in

213 The melanocortin 1 receptor (MC1R) is expressed in 94% of uveal melanoma metastases,

214 Variation at the melanocortin 1 receptor (MC1R) is very common in most non-African world populatio

215 tion alleles of the melanocortin 1 receptor (MC1R) lead to red hair, freckling, and sun sensitivity.

216 S) are unknown, and melanocortin 1 receptor (MC1R) loss-of-function leads to fibrogenesis in experime

217 The melanocortin 1 receptor (MC1R) mediates the tanning response through induction of

218 design of specific melanocortin-1 receptor (MC1R) targeted imaging probes, we report on the effect o

219 l surface biomarker melanocortin 1 receptor (MC1R) to anti-MC1R antibody.

220 nformation based on melanocortin-1 receptor (MC1R) variants could inform prevention and screening rec

221 Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC

222 ndividuals carrying melanocortin-1 receptor (MC1R) variants, especially those associated with red hai

223 The melanocortin 1 receptor (MC1R), a G(s) protein-coupled receptor, has an important

224 The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role

225 Loss-of-function in melanocortin 1 receptor (MC1R), a GS protein-coupled receptor that regulates sign

226 The melanocortin 1 receptor (MC1R), a GS-coupled receptor that signals through cAMP a

227 Melanocortin type 1 receptor (MC1R), also known as alpha-melanocyte-stimulating hormon

228 is regulated by the melanocortin 1 receptor (MC1R), is an effective protection against melanoma.

229 lls expressing melanocortin type-1 receptor (MC1R), that the nature of targeting ligands, i.e., wheth

230 tor, but not to the melanocortin 1 receptor (MC1R), whereas ASIP binds with high affinity to all thre

231 ific ligand for the melanocortin 1 receptor (MC1R), which has been evaluated as a cell-surface marker

232 The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic tran

233 g downstream of the melanocortin-1 receptor (MC1R).

234 the Galphas-coupled melanocortin 1 receptor (MC1R).

235 ne, melanocyte stimulating hormone receptor (MC1R), is strongly associated with distinct differences

236 MSH) receptor (melanocortin type 1 receptor [MC1R]) is overexpressed in most murine and human melanom

237 The melanocortin receptor, MC1R, is a key regulator of pigmentation in mammals, and

238 fects on the melanocortin 1 and 4 receptors (MC1R and MC4R) in the skin and the brain, respectively,

239 d, whereas exposure to UV radiation reduced, MC1R gene and membrane protein expression.

240 We report MC1R-mediated or pharmacologically-induced cAMP signalin

241 in Hispanics and that carriage of high risk MC1R alleles occurs even among Hispanics with stronger A

242 Some MC1R variants have been associated with skin cancer risk

243 g peptide conjugates displaying subnanomolar MC1R binding affinity.

244 that these Gd-Tx micelles are able to target MC1R-expressing xenograft tumors in vitro and in vivo mo

245 times more selective over this receptor than MC1R or MC5R, respectively, and had no detectable bindin

246 We conclude that MC1R genotype may influence post-burn scarring.

247 Our results confirm that MC1R is a low-penetrance susceptibility locus for melano

248 These findings demonstrate that MC1R variants are important for pigmentation characteris

249 is study aimed to replicate the finding that MC1R variant status predicts dental fear and to determin

250 We have found that MC1R or cAMP signaling also directly decreases prolifera

251 In order to test the hypothesis that MC1R variation has been constrained in Melanesians the c

252 viduals with darker phenotypes indicate that MC1R genotypes specifically provide information about BR

253 The results indicate that MC1R protects by a combination of pigmentary and non-pig

254 These results show that MC1R and cAMP signaling can directly inhibit melanoma gr

255 ependent Caucasian populations, we show that MC1R variants are strongly associated with BRAF mutation

256 of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and ado

257 Our results suggest that MC1R genetic variants modulate the risk of PD disease in

258 tion and demonstrate for the first time that MC1R isoform-specific expression is closely related to s

259 The MC1R gene also may be etiologically important for fear o

260 The MC1R-Abs were immobilized in amino-functionalized silica

261 Considering that mRNA for MC2R and the MC1R variants are present in head kidney cells, we hypot

262 By identifying APT2 as the MC1R depalmitoylation enzyme, we are able to demonstrate

263 These studies establish the MC1R-PTEN axis as a central regulator for melanocytes' r

264 rast agent payloads to tumors expressing the MC1R.

265 enous MC1R agonists lack selectivity for the MC1R and thus can have side effects.

266 been successfully developed for imaging the MC1R.

267 s' variants do not substantially improve the MC1R red hair colour predictive model.

268 Common genetic variants in the MC1R (melanocortin 1 receptor) gene, which determines sk

269 cial age were found for multiple SNPs in the MC1R gene (p < 1 x 10(-7)).

270 A non-synonymous SNP in the MC1R gene (rs1805007 encoding Arg151Cys substitution), a

271 ns unclear whether pigmentary effects of the MC1R can account for all of the increase in cancer risk.

272 ined in Melanesians the coding region of the MC1R gene was sequenced in 188 individuals from Northern

273 regulation of expression and activity of the MC1R in primary human melanocyte cultures.

274 part by different binding affinities of the MC1R variants for MRAP.

275 18)F-FB-NAPamide specifically recognizes the MC1R in living mice.

276 of mouse transgenics to demonstrate that the MC1R signaling pathway influences cancer risk via mechan

277 We found that the MC1R variant p.R160W (rs1805008) is marginally associate

278 ategies in ruffs and other species, thus the MC1R gene is a strong candidate to play a role in altern

279 Therefore, in addition to the MC1R genotype, regulation of MC1R expression and activit

280 Significantly, treatment with the MC1R agonist alpha-MSH or activation of the stress respo

281 MC1R overexpression, treatment with the MC1R ligand, or treatment with small-molecule activators

282 lleles of MC1R; we found that together these MC1R alleles explained 4.1% of variance in skin pattern

283 rize the molecular effects elicited by those MC1R ligands.

284 has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-targeting profiles w

285 dividuals with red hair and fair skin due to MC1R gene variants are at higher risk of cutaneous neopl

286 We validate the importance of ZDHHC13 to MC1R signaling in vivo by targeted expression of ZDHHC13

287 that trout MRAP interacts with the two trout MC1R variants and MC2R, but failed to detect regulation

288 MC2R function, binds differently to the two MC1R variants.

289 senescence; in the presence of BRAF(V600E), MC1R deficiency-induced elevated PI3K/AKT signaling driv

290 e effect in proteinuric glomerulopathies via MC1R-independent mechanisms.

291 non-pigmentary effects in vivo and that when MC1R function is compromised the melanin type in skin is

292 alized upon ligand-receptor binding, whereas MC1R antagonist-conjugated HAuNS remain attached on the

293 nvironment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/N

294 nd to determine, for the first time, whether MC1R variant status predicts fear of pain.

295 0.66, 0.78), while that by Smith et al. with MC1R and indoor tanning had an AUC of 0.69 (95% CI: 0.63

296 btype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanom

297 hood and adolescent melanoma associated with MC1R variants by multivariable logistic regression.

298 ospheres (HAuNS, diameter=40 nm) coated with MC1R agonist are internalized upon ligand-receptor bindi

299 risk of cutaneous neoplasia, consistent with MC1R having a role in photoprotection.

300 jects underwent pigmentary phenotyping, with MC1R genotyping in 113.