ライフサイエンスコーパス: MCM6

1 , DNA primase (PRIM1), and minichromosome 6 (MCM6).

2 n autoinhibitory domain in the C terminus of Mcm6.

3 ubs of connectivity: CDC2, CHEK1, CDC45L and MCM6.

4 of lactase in an intron of the adjacent gene MCM6.

5 osome maintenance (MCM) complex of proteins, MCM6.

6 ing point allows phosphorylation of Mcm2 and Mcm6.

7 se at the N-terminal tails of Mcm2, Mcm4 and Mcm6.

8 M5 at the 3'-end of the DNA spiral, but only MCM6, 4, 7 and 3 make a full set of interactions.

9 f the pre-replicative complex proteins ORC2, MCM6 and Cdc6 to telomeric DNA.

10 2 for systolic and diastolic blood pressure, MCM6 and DARS for total cholesterol, and TRIB1 for trigl

11 tified DDK phosphorylation sites on Mcm4 and Mcm6 and found that phosphorylation of either subunit su

12 mutational analysis in the Walker A motif of MCM6 and MCM7 of MCM2-7, we show that ATP binding and/or

13 mily, co-isolates through several steps with MCM6 and MCM7, and MCM8 co-immunoprecipitates with MCM4,

14 7, and MCM8 co-immunoprecipitates with MCM4, MCM6 and MCM7, proteins reportedly forming a helicase co

15 with numerous replication factors, including MCM6 and RPA, the latter of which limits the hypoxia-ind

16 g coimmunoprecipitation, we find that Mis5p (MCM6) and Cdc21p (MCM4) are tightly associated with one

17 sequence in an intron of a neighboring gene (MCM6) and modulate lactase transcription in vitro.

18 es associated with FDG uptake (LY6E, RNF149, MCM6, and FAP) were also associated with survival.

19 N-terminal domains (NTDs) of subunits Mcm2, Mcm6, and Mcm4.

20 sideways by OB hairpin-loops of Mcm3, Mcm4, Mcm6, and Mcm7.

21 With the exception of Mcm4, Mcm6, and Psf1, knockdown of individual CMG genes inhibi

22 alysis suggests that CDC2, CHEK1, CDC45L and MCM6 are key players in mediating the biological activit

23 Remarkably, ORC and Mcm6 associated with just the ARS1-A replicator in G(1)

24 We find that MCM6 associates with other MCM subunits during amplifica

25 ncompassing the LANA aa 1104 to 1123 reduced MCM6 association with LANA and TR replication.

26 reover, phosphomimicking mutants in Mcm4 and Mcm6 bind Sld3 without DDK and facilitate DDK-independen

27 -phase, with a third site playing a role for Mcm6 binding after DNA damage.

28 n the carboxyl-terminal domain identified an MCM6 binding domain, and overexpression of that domain (

29 Disruption of Mcm6-binding to BLM in S-phase leads to supra-normal DNA

30 ly bound to the amino-terminal domain, while MCM6 bound to both the amino- and carboxyl-terminal doma

31 ichromosome maintenance complex component 6 (MCM6) contribute to DNA replication and tumor pathogenes

32 echanism by which these missense SNPs of the MCM6 gene alter the structural integrity and functional

33 the regulatory sequence in intron 13 of the MCM6 gene associated with lactase persistence (i.e. the

34 2 containing the regulatory sequence in the MCM6 gene associated with lactase persistence, a human t

35 ositively regulates the transcription of the MCM6 gene that is involved in DNA replication by directl

36 the dbSNP database, among 15,009 SNPs in the MCM6 gene, 642 missense SNPs (4.28%), 291 synonymous SNP

37 BLM interacts with the N-terminal domain of Mcm6 in G1 phase and switches to the C-terminal Cdt1-bin

38 hes to the C-terminal Cdt1-binding domain of Mcm6 in S-phase, with a third site playing a role for Mc

39 Upon disruption of BLM/Mcm6 interaction, repair of replication-dependent DNA do

40 the Mcm4(Chaos3) allele, which disrupts MCM4:MCM6 interaction, triggers a Dicer1 and Drosha-dependent

41 evolutionary history in Africa, we sequenced MCM6 introns 9 and 13 and ~2 kb of the LCT promoter regi

42 ress, but that its physical interaction with Mcm6 is required in unperturbed cells, most notably in S

43 ted in 8,790 independent EA individuals, and MCM6/LCT and SLC5A10 were also associated among AA.

44 ted signal of association between rs4988235 (MCM6/LCT) and Bifidobacterium.

45 Seven loci in/near EFNA1/SLC50A1, MCM6/LCT, SI, MGAM, MGAM2, SLC5A10, and SLC5A1 showed ge

46 reflect the host-microbe interactions at LCT/MCM6 locus and represent an adaptive microbial response

47 Here, we report that MCM2, MCM3, MCM4, and MCM6 (MCM2/3/4/6) are elevated in human NEPC and high le

48 n that MCM2 interacts directly with MCM5 and MCM6; MCM5 with MCM3 and MCM2; and MCM6 with MCM2 and MC

49 We studied the mechanism of the Mcm4-Mcm6-Mcm7 complex, a useful model system because this co

50 The Mcm4/Mcm7 and Mcm4/Mcm6/Mcm7 assemblies can open to load onto circular DNA

51 7 results in the formation of an active Mcm4/Mcm6/Mcm7 helicase assembly.

52 steric exclusion mechanism, similar to Mcm4/Mcm6/Mcm7.

53 into MCM complexes and differs from maternal MCM6 (mMCM6) in having a carboxy-terminal extension and

54 rmine how mutations affect the corresponding MCM6 protein.

55 Lethal alleles of MCM6 reveal it is essential for mitotic cycles and endoc

56 The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly ass

57 Although MCM6-rs3754686 is a good milk intake proxy in these popu

58 The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) w

59 ichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy i

60 ified a direct physical interaction with the Mcm6 subunit of the minichromosome maintenance (MCM) com

61 site for Mcm10 on MCM includes the Mcm2 and Mcm6 subunits and overlaps that for the loading factor C

62 es dephosphorylation, and the Mcm2, Mcm3, or Mcm6 subunits are then actively phosphorylated by kinase

63 The addition of Mcm6 to Mcm4/Mcm7 results in the formation of an active

64 the C-terminal winged-helix-domain (WHD) of Mcm6 to slow down the loading reaction, thereby capturin

65 was capable of abrogating the association of MCM6 with LANA and blocking DNA replication.

66 MCM5 and MCM6; MCM5 with MCM3 and MCM2; and MCM6 with MCM2 and MCM4.

67 developmentally regulated mcm gene, zygotic mcm6 (zmcm6), expressed only after gastrulation when the