1 MCTD-like lung disease also developed in 50% of immunize
2 of a cohort of patients with MCTD and in
an MCTD-like mouse model.
3 a closer link between anti-70K immunity
and MCTD-like lung disease.
4 cells in autoantibody production in SLE
and MCTD.
5 However, TLR-3(-/-) mice failed to
develop MCTD-like lung disease when treated with 70K and U1 RNA.
6 Mixed connective tissue
disease (
MCTD) is a rare and complex autoimmune disease that pres
7 Mixed connective tissue
disease (
MCTD) is a systemic autoimmune disease with significant
8 feature of mixed connective tissue
disease (
MCTD) is the presence of antibodies against the U1-ribon
9 s [SSc]) or mixed connective tissue
disease (
MCTD).
10 atient with mixed connective tissue
disease (
MCTD).
11 our had 4 mixed connective tissue
disorders (
MCTD).
12 that are homologous to T cells isolated
from MCTD patients.
13 atients, 82 (92.1%) had SSc and 7 (7.9%)
had MCTD.
14 n (RNP) complex, but other autoantibodies
in MCTD have recently been described.
15 en the immunologic and clinical phenomena
in MCTD are emerging.
16 Autoreactive IgE raised against the
main MCTD autoantigen U1 small nuclear ribonucleoprotein 70k
17 The typical core clinical features
of MCTD tended to develop over time; features of inflammati
18 genetic, clinical, and serologic findings
of MCTD, and the condition rarely evolved into systemic lup
19 en-specific T cells in a new murine model
of MCTD.
20 /or infectious agents in the pathogenesis
of MCTD have been advanced.
21 The pathophysiology
of MCTD is not well understood, and no specific treatment i
22 basophils and IgE in the pathophysiology
of MCTD.
23 A significant number of patients with SSc
or MCTD (13.3%) followed up in a community rheumatology pra
24 evelopment of SLE-like nephritis rather
than MCTD-like lung disease.
25 onucleoprotein 70k were also observed in
the MCTD-like mouse model along with basophil accumulation i
26 Basophils and IgE contribute
to MCTD pathophysiology and represent new candidate therape
27 nity and target organ injury consistent
with MCTD.
28 eripheral blood of a cohort of patients
with MCTD and in an MCTD-like mouse model.
29 Patients
with MCTD have a peripheral basopenia and activated blood bas
30 Longitudinal study of patients
with MCTD highlights the impact of pulmonary hypertension on
31 Similar to patients
with MCTD, CD4(+) T cells can be readily identified from 70-k
32 didate therapeutic targets for patients
with MCTD.