ライフサイエンスコーパス: MED

1 MED is a milder disease with radiographic features often

2 MED-assigned patients who underwent CABG had lower 5-yea

3 MED-FASP offers efficient exploration of previously unus

4 y apparent over a narrow dose range around 1 MED.

5 The results show that after exposure to 1 MED of UV, the skin of subjects from all groups suffered

6 respectively, in skin types I/II, whereas 1 MED only suppressed CHS by 40% in skin types III/IV.

7 particles (n = 811) were fibres (ATL: 77.1% MED: 85.3% PAC: 64.8%) with blue and black being the dom

8 erate sunburn (two minimal erythema doses [2 MED]) was sufficient to suppress CHS in all volunteers b

9 Overall, 2 MED caused 17%-20% suppression of elicitation responses

10 nerated cellulosic fibres (SRCF; ATL: 63.2%: MED: 5.8% PAC: 68.9%).

11 ng groups: 1) healthy dietary guidelines, 2) MED diet, or 3) green-MED diet, high in polyphenols, and

12 llow 1) healthy dietary guidelines (HDG), 2) MED, or 3) Green-MED diet.

13 Compared with the AAD, all 3 MED diets decreased LDL cholesterol (MED0.5: -10.3 mg/dL

14 posed buttock skin was exposed to 1, 2 and 3 MED of each spectrum.

15 the applied stimuli after exposure to 2 or 3 MED.

16 d apoB (P < 0.01) were lower following the 3 MED diets; there were no differences between the MED die

17 7%), and de-escalating dose (from 20 to <3mg MED, 9.4%).

18 suberythemal exposure of either 0.25 or 0.5 MED suppressed CHS responses by 50 and 80%, respectively

19 on the cohort of 151 patients (STN-DBS n=67, MED n=84) resulted in a well-balanced sub-cohort includi

20 .2%; PAC: 3.4%), thermoplastics (ATL: 36.8%: MED: 20.7% PAC: 27.7%) and synthetic regenerated cellulo

21 esser quantities were fragments (ATL: 22.9%: MED: 14.7% PAC: 20.2%) and microbeads (4.8%; PAC only; t

22 CCAAT box, a CF1, a HIP1 binding motif and a MED-1 element; (d) modulated weakly by a positive-acting

23 provides significant genetic evidence for a MED locus on the short arm of chromosome 2 (2p24-p23), a

24 pathway, while reduction of Med15 levels, a MED subunit in the tail domain, suppressed the Nodal sig

25 We find that a transcriptional activator, MED-1, associates in vivo with the end-1 and end-3 targe

26 All MED diets elicited similar reductions in total LDL parti

27 randomly assigned to medical therapy alone (MED) or to MED and coronary artery bypass graft (CABG) s

28 We found that although MED accurately rebuilds gene expression levels from deco

29 tual and academic achievement deficits among MED survivors.

30 Enrichment using Droplet Pre-Amplification (MED-Amp) method, which combines single-molecule emulsifi

31 vity in U87MG mouse xenografts, achieving an MED of 1.5 mg/kg, following weekly intravenous dosing.

32 two expansion mut-ations in this repeat: an MED patient carrying a (GAC)6allele and a PSACH patient

33 (27+/-17 and 27%, respectively; P<0.03) and MED (58+/-42 and 33%; P<0.05) versus CTRL (88+/-52 and 7

34 of endoderm differentiation by the SKN-1 and MED-1/2 transcription factors.

35 nt GATA-type transcription factors MED-1 and MED-2 are encoded by an unlinked, redundant pair of intr

36 actor gene tbx-35, a target of the MED-1 and MED-2 divergent GATA factors, was previously found to re

37 nefit from the inclusion of colorimetric and MED measurements along with traditional risk factors to

38 ical characteristics between the STN-DBS and MED groups.

39 In contrast, GBM and MED contained progressively fewer infiltrating leukocyte

40 tes with decreased enrichment of H3K27ac and MED (Mediator complex subunit)-1, and reduced recruitmen

41 ence of phenotypic overlap between PSACH and MED.

42 sequences in combination with nearby Sp1 and MED-1 sites together account for virtually all promoter

43 vator for nuclear receptors, and an SRB- and MED-containing cofactor complex (SMCC) that mediates act

44 MYC oncogene, we predict interaction between MED and FBP1 might also have implications for cancer ini

45 te GATA TF interface and suggest that binary MED subunit-TF partnerships are probably oversimplified

46 Both MED groups consumed 28 g walnuts/d (+440 mg/d polyphenol

47 mesendodermal progenitors are controlled by MED-1 and -2, members of the GATA factor family.

48 ly shown that the binding site recognized by MED-1 is a noncanonical RAGTATAC site that is not expect

49 Impairment of viral replication by MED subunits was at a post-integration step.

50 e MED sites, we have identified 19 candidate MED targets.

51 e compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equa

52 c low-fat or Mediterranean/low-carbohydrate (MED/LC) diet+28 g walnuts/day with/without added moderat

53 o Rituxan-induced apoptosis than Myc(ON)CD20(MED).

54 In the E cell, MED-1,2 activate transcription of the endoderm-promoting

55 Biochemical analysis of CKM-MED showed that the CKM blocks binding of the RNA Pol II

56 mers and wet winters (Mediterranean climate; MED) are especially vulnerable to climate change.

57 This 3-cluster solution was replicated in CO-MED and was similar for the HAM-D scale.

58 < 0.0001), and 0.26 (0.04, p < 0.0001) in CO-MED, EMBARC, and SAMS respectively.

59 < 0.0001), and -0.12 (0.05, p = 0.024) in CO-MED, EMBARC, and SAMS, respectively.

60 dications to Enhance Depression Outcomes (CO-MED) trial (n = 640).

61 dications to Enhance Depression Outcomes (CO-MED) trial (N=664).

62 dications to Enhance Depression Outcomes (CO-MED, n = 665), Establishing Moderators and Biosignatures

63 with logistic regression analyses in the CO-MED trial using participants with complete data (N=431)

64 d no meaningful benefit (AUC=0.76) in the CO-MED trial were used to predict remission (AUC=0.80) and

65 In the CO-MED trial, irritability was significantly reduced (effec

66 The human Mediator complex (MED) is composed of 28 elements and represents a fundame

67 ily conserved multiprotein Mediator complex (MED) serves as an interface between DNA-bound transcript

68 -dependent genes, in unperturbed conditions, MED is detected at both the UASs and promoters.

69 s a hypomorphic allele of Med10, a conserved MED middle domain subunit.

70 ciaries with a prescription yielding a daily MED of more than 120 mg did not decline after adoption o

71 ibers; 5% had prescriptions yielding a daily MED of more than 120 mg in any calendar quarter; and 0.3

72 data through minimum entropy decomposition (MED).

73 Motif expression decomposition (MED) was recently introduced to describe the expression

74 osed that each TF interacts with a dedicated MED subunit to induce specific transcriptional responses

75 i) metal-enhanced electrochemical detection (MED) and (ii) label-free surface plasmon resonance (SPR)

76 a metal-enhanced electrochemical detection (MED) sensor, which relied on the redox properties of a s

77 nts the concept of metal-enhanced detection (MED) for the determination of DNA-DNA reactions and pres

78 information in molecular electronic devices (MEDs).

79 ems (NEMS) and molecular electronic devices (MEDs).

80 FASP and the related multienzyme digestion (MED) FASP method.

81 using multiple enzymes for sample digestion (MED), primarily an increase of sequence coverage, have b

82 s were maintained on multi-electrode dishes (MED) with an 8x8 array of electrodes and examined for ph

83 At present, the role of distinct MED subunits in general transcription versus transcripti

84 s specified by the activity of the divergent MED-1,2 GATA factors.

85 We studied a family with autosomal dominant MED affecting predominantly the knee joints and a mild p

86 ide screen of family with autosomal-dominant MED not linked to the EDM1-3 genes provides significant

87 utcome was daily morphine-equivalent dosage (MED) of opioids dispensed from 60 days before to up to 7

88 ced hyperlocomotion (minimum effective dose (MED) = 3 mg/kg, p.o.) and MK-801 induced disruptions of

89 he ratio between the minimum effective dose (MED) for significant impairment in rotarod performance a

90 digm (X-maze) with a minimum effective dose (MED) of 0.1 microgram/kg.

91 s yielding a daily morphine-equivalent dose (MED) of more than 120 mg, and treatment for nonfatal pre

92 ectories of opioid morphine equivalent dose (MED) prescribed during the 12-month period before the di

93 Minimal erythema dose (MED) and melanin index were determined using a cutometer

94 ols were exposed to 1 minimum erythema dose (MED) of UVR delivered from Waldmann UV-6 bulbs to the up

95 The minimal erythema dose (MED) was established for each subject exposed to UVA/UVB

96 start with 70% of the minimal erythema dose (MED) with 20% increments at each treatment thereafter.

97 ed by colorimetry and minimal erythema dose (MED), respectively.

98 Individual minimal erythema doses (MED) for each source were determined and previously unex

99 xposed to 0.75 and 2 minimum erythema doses (MED) of SSR on the upper inner arm.

100 ither 0, 0.6, 1 or 2 minimal erythema doses (MED).

101 GSK931145 had lower minimum effective doses (MEDs) in the MEST test than other GlyT1 inhibitors.

102 in vitro IC(50) at minimum effective doses (MEDs) of 3 mg/kg in preclinical anxiety models.

103 nd determination of minimum eliciting doses (MEDs).

104 scription initiation window and a downstream MED-1 element (GCTCCC/G).

105 an Inr-like sequence as well as a downstream MED-1 element.

106 ent, multiple start site element downstream (MED-1), decreased transcription in drug-resistant cells

107 the treatment of male erectile dysfunction (MED) with a lower incidence of PDE-associated adverse ef

108 potential use in male erectile dysfunction (MED).

109 sponsible for multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH).

110 a (PSACH) and multiple epiphyseal dysplasia (MED) are autosomal dominant osteochondrodysplasias that

111 a (PSACH) and multiple epiphyseal dysplasia (MED) are relatively common skeletal dysplasias belonging

112 a (PSACH) and multiple epiphyseal dysplasia (MED) are two human autosomal dominant skeletal dysplasia

113 Multiple epiphyseal dysplasia (MED) is a degenerative cartilage condition shown in some

114 Multiple epiphyseal dysplasia (MED) is a relatively mild and clinically variable osteoc

115 can result in multiple epiphyseal dysplasia (MED), a disease characterized by delayed and irregular b

116 uch disorder, multiple epiphyseal dysplasia (MED), is characterized by mild dwarfism and early-onset

117 a (PSACH) and multiple epiphyseal dysplasia (MED/EDM1).

118 e of synthetic materials such as elastomers (MED: 61.2%; PAC: 3.4%), thermoplastics (ATL: 36.8%: MED:

119 21st century replacement of the equatorward MED margins by the arid climate type.

120 drier in both the old and newly established MED zones.

121 As an example, MED results are used to demonstrate that motifs generall

122 he divergent GATA-type transcription factors MED-1 and MED-2 are encoded by an unlinked, redundant pa

123 were selected as development candidates for MED and other indications.

124 ve recently been shown to be responsible for MED and PSACH.

125 We identified a role for MED in KC proliferation and differentiation in cultured

126 Patients treated for MED had significantly less NWM (p < 0.01) and significan

127 the hypotheses that (1) patients treated for MED in childhood have reduced volumes of normal white ma

128 en pediatric patients previously treated for MED were matched on the basis of age at the time of eval

129 Full-Scale IQ among the patients treated for MED.

130 Common reasons for crossover from MED to CABG were progressive symptoms or acute decompens

131 yeloid and lymphoid cells compared with GBM, MED, or NT.

132 dietary guidelines, 2) MED diet, or 3) green-MED diet, high in polyphenols, and low in red meat.

133 ietary guidelines (HDG), 2) MED, or 3) Green-MED diet.

134 ell-characterized endoderm-promoting SKN-1-->MED regulatory cascade.

135 specification in the absence of the SKN-1-->MED transcriptional input, accounting for the impenetran

136 nts with high skin types tended to have high MEDs (P<0.001).

137 Knockdown of 9 out of 28 human MED proteins significantly impaired viral replication wi

138 tory pain (CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg, p.o.).

139 omonas) was first confirmed to be present in MED B. tabaci using Hiseq2500 and FISH technologies.

140 rature standard 1 (CP154526-1) was inactive (MED > 30 mg/kg (po)).

141 blish a direct correlation between increased MED and bacterial abundance.

142 Strikingly, the lipid ligand MED (myristoylated alanine-rich C kinase substrate effec

143 benefit by clinical severity score (median [MED] and interquartile range [IQR] 10 [5.5-30] vs. 7 [2.

144 ing two central players, TFIID and Mediator (MED), in potentiating activated transcription.

145 ranscriptional coactivator complex Mediator (MED) facilitates transcription of nuclear hormone recept

146 The MEDIATOR (MED) complex plays diverse functions in plant developmen

147 The role of the MEDIATOR (MED) transcriptional co-activator, through its MED16 sub

148 etween Psi and the transcriptional mediator (MED) complex, a known sensor of signaling inputs.

149 The transcriptional Mediator (MED) is a multiprotein complex that transmits informatio

150 s guideline-based antidepressant medication (MED) and were randomly assigned to add-on therapy with c

151 region for 2 hours 3 times a day), medicine (MED; carvedilol therapy at 12.5 mg PO BID), or control (

152 stent transmission of CCYV by Mediterranean (MED) cryptic species of B. tabaci complex.

153 [ATL]: n = 30, four species; Mediterranean (MED): n = 56, two species; Pacific (PAC): n = 16, five s

154 N), 5 glioblastoma (GBM), 6 medulloblastoma (MED), and 5 nontumor brain (NT) control samples obtained

155 ter treatment for childhood medulloblastoma (MED), the pathophysiology underlying this process is poo

156 100 mg MED), low (<50 mg MED), or none (0 mg MED).

157 rge (>/=100 mg MED), moderate (50 to <100 mg MED), low (<50 mg MED), or none (0 mg MED).

158 We categorized dosages as large (>/=100 mg MED), moderate (50 to <100 mg MED), low (<50 mg MED), or

159 mg MED, 27.3%), consistent high dose (150 mg MED, 15.0%), escalating dose (from <3 to 20 mg MED, 13.7

160 D, 15.0%), escalating dose (from <3 to 20 mg MED, 13.7%), and de-escalating dose (from 20 to <3mg MED

161 MED, 34.6%), consistent moderate dose (20 mg MED, 27.3%), consistent high dose (150 mg MED, 15.0%), e

162 iagnosis emerged: consistent low dose (<3 mg MED, 34.6%), consistent moderate dose (20 mg MED, 27.3%)

163 ), moderate (50 to <100 mg MED), low (<50 mg MED), or none (0 mg MED).

164 ere prescribed a mean daily dose below 90 mg MED before diagnosis.

165 ioid doses below the risk threshold of 90 mg MED.

166 tivity in the rat situational anxiety model (MED = 3 mg/kg (po)), whereas a literature standard 1 (CP

167 es, a newly developed 1D water column model (MED) successfully reproduced the MeHg species distributi

168 mg/kg), and a large therapeutic window (MTD/MED > 50) in mice, CN016 might have great potential to b

169 To date, no MED-like zinc fingers have been described outside of C.

170 Nonetheless, MED provides accurate estimates of relative binding stre

171 (STR), hippocampus (HC), medulla oblongata (MED) and anterior cingulate (ACNG) and five peripheral t

172 nce interval: 1.07, 1.43) per 10 mJ/cm(2) of MED.

173 mputer simulation to examine the accuracy of MED.

174 erns, these define three distinct classes of MED-regulated genes: MS-specific, E-specific, and E plus

175 s how and why the geographic distribution of MED will change based on the latest-available climate pr

176 northward and eastward future expansions of MED over both the Euro-Mediterranean and western North A

177 A recessive form of MED (EDM4) has also been reported; it is caused by a mut

178 ith mild PSACH and the second with a form of MED, we identified different substitutions for a residue

179 These dominant forms of MED (EDM1-3) are caused by mutations in the genes encodi

180 PSACH and some forms of MED result from mutations in cartilage oligomeric matrix

181 PSACH and some forms of MED result from mutations in the gene for cartilage olig

182 ously been shown to cause different forms of MED.

183 Moreover, genetic manipulation of MED activity modified Psi-dependent growth, which sugges

184 was previously observed in a murine model of MED caused by a Matn3 V194D mutation, some mutant protei

185 hanisms that underpin the pathophysiology of MED we generated a murine model of epiphyseal dysplasia

186 The novel phenotype of MED and mild myopathy is likely caused by a dominant-neg

187 erythema was approximately 60% regardless of MED.

188 Here, we investigated the in vivo role of MED by generating a conditional null mice model in which

189 enes, implying shared or differential use of MED subunits by GATAs depending on the target gene.

190 With these understandings, judicious use of MED will likely provide useful information about eukaryo

191 rmation of food allergy and determination of MEDs in adults and children with body weight >28.8 kg (a

192 In the quest for the next generation of MEDs, it is likely that monolayers of bistable MIMs will

193 spectroscopic and other means in support of MEDs that store information through switching collection

194 g a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the ef

195 INTERPRETATION: Results from SPYRAL HTN-OFF MED provide biological proof of principle for the blood-

196 SPYRAL HTN-OFF MED was a multicentre, international, single-blind, rand

197 the impenetrance of mutants lacking SKN-1 or MED-1,2 activity.

198 amenable to CABG were randomized to CABG or MED in the STICH trial (Surgical Treatment for Ischemic

199 s in an additional 14 families with PSACH or MED phenotypes.

200 Differences in skin type or MED are not associated with clinically important differe

201 pes I-IV patients regardless of skin type or MED.

202 of 65 medically managed transplant patients (MED), 30 patients supported with an LVAD, and 5 nonfaili

203 largely mitigated by the outcomes of the PD MED and Levodopa in Early Parkinson's Disease (LEAP) stu

204 tion in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like ac

205 his domain a missense mutation that produced MED Fairbank.

206 into their molecular electronic properties, MEDs incorporating hundreds to thousands of molecules tr

207 PSACH-MED patients often have a mild myopathy characterized by

208 We hypothesize that the myopathy in PSACH-MED originates from an underlying tendon and ligament pa

209 on of the musculoskeletal phenotype of PSACH-MED and is directly relevant to the clinical management

210 however, the myopathy associated with PSACH-MED has not previously been studied.

211 Our data suggest the key target of the Psi/MED network in controlling developmentally regulated tis

212 cursor cells (GNP) and a MB cell line, PZp53(MED).

213 ing igf2 signaling inhibited growth of PZp53(MED) cells, implicating igf2 as a potential clinical tar

214 duced by complete Freund's adjuvant in rats (MED = 1 mg/kg, p.o).

215 10 patients (9.0%) assigned to CABG received MED only.

216 wer 5-year mortality than those who received MED only (25% vs 42%; hazard ratio, 0.50; 95% confidence

217 ced disruptions of novel object recognition (MED = 10 mg/kg p.o.), thus providing efficacy in preclin

218 ablation or medical therapy with riociguat (MED group; n = 25).

219 Knockdown of the selected MED factors compromised HIV transcription induced by Tat

220 asured erythemal UV sensitivity of the skin (MED) is a more useful predictor of DNA photodamage than

221 Some MED targets encode transcription factors related to thos

222 Biochemical analysis of the SRB-MED complex from the sin4 suppressor strain revealed a s

223 aled a structurally distinct form of the SRB-MED complex that lacks a subset of mediator subunits.

224 e, whose product is also a member of the SRB-MED complex, failed to suppress ydr1(cs) and bur6(cs) mu

225 4 gene, which encodes a component of the SRB-MED complex.

226 ion is not due to general defects in the SRB-MED complex.

227 nd RSC in addition to SAGA, SWI/SNF, and SRB/MED.

228 equires SAGA, SWI/SNF, and SRB mediator (SRB/MED) and identify key nonessential subunits of these com

229 eriments show that Mbf1p, SAGA, SWI/SNF, SRB/MED, RSC, CCR4-NOT, and the Paf1 complex all are recruit

230 identified polypeptides, but none of the SRB/MED proteins or other factors found associated with the

231 Mammalian counterparts of the yeast SRB/MED transcriptional 'mediator' complex have recently bee

232 (2) deficits in NWM among patients surviving MED can at least partially explain deficits in their int

233 stent transmission mode of CCYV by B. tabaci MED.

234 ession data from only 30 conditions and that MED results are robust to the existence of unknown occur

235 Intriguingly, we find that MED and TFIID interact functionally to modulate transcri

236 We report that MED-1 binds invariant noncanonical sites in the end gene

237 We show that MED FASP in combination with the total protein approach

238 The MED concept has been tested for voltammetric detection o

239 The MED concept relies on the idea that metallic films depos

240 The MED was significantly increased in the PomX and PomJ gro

241 The MED-Amp assay increased mutant signal by over 50-fold wi

242 The MED-Amp assay successfully detected KRAS mutant ctDNA in

243 The MED/LC diet mobilizes specific ectopic fat depots, and e

244 The MED/LC diet was superior to the low-fat diet in decreasi

245 nt impairment in rotarod performance and the MED for significant neuroprotection.

246 sus -11.5% for the MED/LC; P<0.001), and the MED/LC group decreased reported carbohydrates intake (-3

247 diets; there were no differences between the MED diets.

248 ted fat intake (-21.0% versus -11.5% for the MED/LC; P<0.001), and the MED/LC group decreased reporte

249 Baseline mean (SD) BPI scores in the MED and CBT groups were 6.45 (1.79) and 6.49 (1.67), res

250 he PADN group as compared to distance in the MED group (470 +/- 84 m vs. 399 +/- 116 m, respectively;

251 different across the spectrum of age in the MED group (53% versus 49% for quartiles 4 and 1, respect

252 ollow-up, PDQ-8 and ADL worsened only in the MED group (PDQ-8 change, -10.9; 95% CI, -19.0 to -2.7; P

253 In the MED group, a sham procedure with mapping but no ablation

254 In the MED group, left ventricular ejection fraction was 61+/-4

255 group versus 149 +/- 73 dyn s cm(-5) in the MED group, mean between-group difference was 109 dyn s c

256 CBT-arm, 40% in the ECT-arm, and 44% in the MED-arm.

257 CBT-arm, 28% in the ECT-arm, and 33% in the MED-arm.

258 ion in waist circumference was higher in the MED/LC group (-6.9 +/- 6.6 cm) than in the LF diet group

259 IPF volume had reduced twice as much in the MED/LC group compared with the LF group [-37 +/- 26.2 mL

260 ence rebound with the greatest effect in the MED/LC(PA+) group (P<0.05).

261 We have previously isolated the MED complex from primary keratinocytes (KCs) as the vita

262 Here, we provide an evaluation of the MED activity on HIV replication.

263 cells to selectively deplete subunits of the MED and TFIID complexes to dissect the contribution of e

264 ice model in which a critical subunit of the MED complex, MED1, is deleted from their KCs.

265 bsequently activated upon recruitment of the MED complex.

266 d contacts between these two subunits of the MED middle module.

267 he T-box factor gene tbx-35, a target of the MED-1 and MED-2 divergent GATA factors, was previously f

268 We report that the MED-1 and -2 GATA factors specify the entire fate of EMS

269 We have previously shown that the MED-1,2 divergent GATA factors act apparently zygoticall

270 We report that the MED-1,2 target gene tbx-35, which encodes a T-box transc

271 ers lack a TATA box, and Pint belongs to the MED-1 class of promoters, which initiate transcription a

272 cantly improved in the SCS compared with the MED and CTRL groups (P<0.001 for both).

273 onal regulatory inputs, including SKN-1, the MEDs, PAL-1, and the Wnt/MAPK-activated form of POP-1, a

274 l sites in the end genes, revealing that the MEDs are atypical members of the GATA factor family that

275 icacy of CABG compared with medical therapy (MED) in patients with heart failure caused by ischemic c

276 ive therapy (ECT-arm), or no add-on therapy (MED-arm).

277 y searching the genome for clusters of these MED sites, we have identified 19 candidate MED targets.

278 STJs) associated with the crossbars of these MEDs, have a profound influence on device operation and

279 CABG added to MED has a consistent beneficial effect on cardiovascular

280 CABG added to MED has a more substantial benefit on all-cause mortalit

281 Adherence to MED correlated with a microbial cluster of commensals an

282 Adherence to MED is associated with beneficial clinical outcomes and

283 Adherence to MED was associated with a noncomplicated CD course, and

284 r compared with younger patients assigned to MED (79% versus 60% for quartiles 4 and 1, respectively;

285 ormed in 65/602 patients (10.8%) assigned to MED, and 55/610 patients (9.0%) assigned to CABG receive

286 ).The main reason for crossover from CABG to MED was patient/family decision.

287 They were deemed crossover to MED.

288 ssigned to medical therapy alone (MED) or to MED and coronary artery bypass graft (CABG) surgery in t

289 The CABG-to-MED crossover population had higher 5-year mortality com

290 10, reduction of Med12 and Med13 levels, two MED subunits in the regulatory domain, led to an enhance

291 Thus, Med10 appears to be a unique MED subunit that differentially transduces information f

292 diovascular hospitalization with CABG versus MED in younger compared with older patients (Pinteractio

293 The effect of CABG versus MED on all-cause mortality tended to diminish with incre

294 d to be economically favorable compared with MED in 87% of microsimulations.

295 ssociated with lower mortality compared with MED in per-protocol and several time-dependent analyses

296 Compared with MED patients, diastolic pulmonary pressures trended lowe

297 of matrilin-3 in two unrelated families with MED (EDM5).

298 nt growth, which suggests Psi interacts with MED to integrate developmental growth signals.

299 s no impact on disease severity in mice with MED.

300 Patients with MED and a waddling gait but minimal radiographic hip inv