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1 n of exogenous cAMP and dominant active FST7 MEK kinase.
2 activation of PI3K/Akt and p38 MAPK, but not MEK kinase.
3 hat is independent of both Mcs4 and the Wak1 MEK kinase.
4                           Raf is a candidate MEK kinase.
5 ctors and, in turn, activates its substrate, MEK kinase.
6 ulates Ras GTP-loading and activates Raf and MEK kinases.
7 m components of the MAPK pathway, B-Raf, and MEK kinases.
8  TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/
9 e we show that nuclear c-Abl associates with MEK kinase 1 (MEKK-1), an upstream effector of the SEK1-
10                                              MEK kinase 1 (MEKK1) activates the c-Jun NH2-terminal ki
11        Aggregation of FcepsilonRI stimulated MEK kinase 1 (MEKK1) activity, which activates JNK kinas
12 d to inhibition of ANF expression induced by MEK kinase 1 (MEKK1) and the hypertrophic agonists.
13 o activate this pathway; a dominant-negative MEK kinase 1 (MEKK1) blocks activation of SAPK by NIK.
14                   The coding sequence of rat MEK kinase 1 (MEKK1) has been determined from multiple,
15        We examined the function of the MAP3K MEK kinase 1 (MEKK1) in proinflammatory signaling.
16                                              MEK kinase 1 (MEKK1) induces apoptosis through the activ
17                   Recombinant forms of MAP3K MEK kinase 1 (MEKK1) interact in vivo and in vitro with
18                                              MEK kinase 1 (MEKK1) is a 196-kDa enzyme that is involve
19                                              MEK kinase 1 (MEKK1) is a 196-kDa protein that, in respo
20                                              MEK kinase 1 (MEKK1) is highly expressed in the growing
21                                              MEK kinase 1 (MEKK1) which activates the JNK activator,
22     Targeted disruption of the gene encoding MEK kinase 1 (MEKK1), a mitogen-activated protein kinase
23      We show that both JNK isoforms transmit MEK kinase 1 (MEKK1)-mediated morphogenetic signals duri
24 -GTPase activating protein, RAB35), kinases (MEK kinase 1 and 4, PKC, MLCK, cyclin G-associated kinas
25  activation by expression of kinase-inactive MEK kinase 1(MEKK1) or dominant-negative IkappaB (DeltaI
26 aspase 3 are inhibited in cells deficient in MEK kinase 1, an upstream activator of JNK in reovirus-i
27 The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals require
28 production is required for activation of the MEK kinase-1 (MEKK-1)--> SAPK pathway.
29  to an extent comparable to that achieved by MEK kinase-1.
30                                              MEK kinase 2 (MEKK2) is a 70-kDa protein serine/threonin
31 fluorescence imaging demonstrate that T cell MEK kinase 2 (MEKK2) is translocated to the T cell/antig
32                                 We show that MEK kinase 2 (MEKK2), a MAPK kinase kinase (MAP3K) that
33 domain-containing adaptor protein that binds MEK kinase 2 (MEKK2), a mitogen-activated protein kinase
34                   Targeted disruption of the MEK kinase 2 gene had no effect on activation of the JNK
35 s activation is inhibited by MAP/ERK kinase (MEK) kinase 2 (MEKK2) gene disruption.
36 rgeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 pr
37            These results strongly argue that MEK kinase activity of Raf-1 is not essential for normal
38       Here we purified and characterized the MEK kinase activity present in Xenopus M phase-arrested
39 e hyperphosphorylation of Raf-1 inhibits its MEK kinase activity.
40  and Akt kinases, while partially inhibiting MEK kinase activity.
41 itogen-activated protein kinase kinase (MAPK/MEK) kinase and phosphatidylinositol-3 (PI3) kinase, res
42    Spa2p interacts with Ste11p (MAPK kinase [MEK] kinase) and Ste7p (MEK) of the mating signaling pat
43              A dominant-negative form of the MEK kinase B-Raf also blocks circadian and cAMP modulati
44 only partially impaired in cells lacking the MEK kinase Bck1.
45 ernative pathways, e.g. Janus kinase/STAT or MEK kinase/c-Jun NH2-terminal protein kinase.
46 otentiated by signalling through the Ras-Raf-MEK kinase cascade and inhibited by a direct interaction
47 Raf-mitogen-activated protein kinase kinase (MEK) kinase cascade.
48 on of Ras activation, negative regulation of MEK kinase (e.g. Raf) activities, and up-regulation of d
49  interactions in addition to its established MEK kinase function.
50                      Inhibitors of B-Raf and MEK kinases hold promise for the management of cutaneous
51                Pharmacological inhibition of MEK kinase in iPSC-derived JMML cells reduced their GM-C
52  activated alleles of Ras or calcineurin, or MEK kinase, in the case of AP-1.
53              Transfection with PKA, MEK, and MEK kinase induced NF-kappaB-dependent transcription by
54 , demonstrating that beta2AR stimulation and Mek kinase inhibition are required for ARA-211 antitumor
55         Notably, Ets-1 is induced by BRAF or MEK kinase inhibition, resulting in increased NRAS expre
56                       On the other hand, the MEK kinase inhibitor PD098059 had no effects, further de
57                        CK2alpha-mediated RAF-MEK kinase inhibitor resistance was tightly linked to it
58 on this pathway was determined using a known MEK kinase inhibitor, SL327.
59 ated protein kinase (MAP kinase)/ERK kinase (MEK) kinase inhibitor SL327, but not with the nonblood-b
60                                         BRAF/MEK kinase inhibitors have transformed the outlook and t
61 n (MAP)/extracellular signal-regulated (ERK; MEK) kinase inhibitors, respectively.
62                                    The TPL-2 MEK kinase is essential for activation of the Erk MAP ki
63 ude a MAPK kinase (MAPKK or MEK) and a MAPKK/MEK kinase (MAPKKK/MEKK).
64 In this study, we cloned a full-length human MEK kinase (MEKK) 2 cDNA from Jurkat T-cells and demonst
65 le dominant negative forms of Ras, RacI, and MEK kinase (MEKK) inhibited EGF induction.
66 mammalian p65PAK protein kinases), Ste11 [an MEK kinase (MEKK) or MAPK kinase (MEK) kinase], Ste7 (ME
67           The first kinase in the cascade, a MEK kinase (MEKK), is characterized by its ability to ac
68 ted protein kinase (ERK) kinase (MEK), and a MEK kinase (MEKK).
69 MAP/ERK kinase (MEK), in turn activated by a MEK kinase (MEKK).
70 ich is itself activated by Wik1/Wak1/Wis4, a MEK kinase (MEKK).
71 K occurs through a pathway requiring Ras and MEK kinase (MEKK).
72 activation of MAP kinase/ERK kinase (MEK) by MEK kinase (MEKK).
73  this study, we investigated the role of the MEK kinase (MEKK)1/ERK/p90 ribosomal S6 kinase (RSK)1-de
74 ivated/extracellular response kinase kinase (MEK) kinase (MEKK) is a serine-threonine kinase that reg
75  with a dominant-negative MAP kinase kinase (MEK kinase, MEKK-1), confirming that HBx stimulates the
76 Nck-interacting kinase, acts upstream of the MEK kinase MEKK1 to activate the c-Jun N-terminal kinase
77 cascade, activates NHE1 through a Cdc42- and MEK kinase (MEKK1)-dependent mechanism that is independe
78              Endothelial cells that lack the MEK kinase MEKK3 cannot form vessels.
79 wo cDNAs encoding splice variants of a novel MEK kinase, MEKK4.
80 tified a developmentally regulated, putative MEK kinase (MEKKalpha) that contains an F-box and WD40 r
81                                              MEK kinases (MEKKs) 1, 2, 3 and 4 are members of sequent
82                                              MEK kinases (MEKKs) are serine-threonine kinases that re
83 t PTP3, suppressed growth defects due to the MEK kinase mutation, BCK1-20, and the MEK mutation, MKK1
84                Although it is known that the MEK kinase of the pathway, Ste11, associates with Ste5,
85              Here, we show that one of three MEK kinases of the HOG pathway, Ssk2p, is specialized to
86 s fully compensated by other Raf proteins or MEK kinases or that its role in MEK/ERK activation is hi
87 af-MEK-MAPK pathway with PD98059, or the Ras-MEK kinase-p38 pathway with SB203580 had no effect on ra
88 tivity also was observed between the LPS and MEK kinase pathways, indicating that mutual antagonism c
89                                Inhibitors of MEK kinase, PD98059, or overexpression of dominant negat
90 turn are phosphorylated and activated by MKK/MEK kinases (Raf and MKKK/MEKKs).
91 mains (in order): leucine-rich repeats, Ras, MEK kinase, Ras guanine nucleotide exchange factor N-ter
92 an unidentified protein kinase A-insensitive MEK kinase, rather than Raf-1, to regulate ERK activity.
93 Our results show that B-Raf was the critical MEK kinase required for M phase activation of the MAPK p
94 In addition, U0126 (a selective inhibitor of MEK kinase responsible for ERK phosphorylation) blocked
95  Ste11 [an MEK kinase (MEKK) or MAPK kinase (MEK) kinase], Ste7 (MEK or MAPK kinase), and the transcr
96 aused by deletion of BCK1, a gene encoding a MEK kinase that functions in a mitogen-activated protein
97 bition of ERK2 or chemical inhibition of the MEK kinase that phosphorylates ERK2 led to chromosome al
98  that the mixed lineage kinases (MLK1-4) are MEK kinases that reactivate the MEK/ERK pathway in the p
99 eam of Wak1, a homolog of the SSK2 and SSK22 MEK kinases, which transmits the stress signal to the Wi