ライフサイエンスコーパス: MRP2

1 r multidrug resistance-associated protein 2 (MRP2).

2 isoform of the multidrug resistance protein (Mrp2).

3 in human biopsies revealed up-regulation of MRP2.

4 tes, with some minor contribution from mouse Mrp2.

5 ]pyridine) is transported by BCRP, MDR1, and MRP2.

6 nd the multispecific organic anion exporter, mrp2.

7 at its canalicular transport did not require mrp2.

8 on was noted in TR- mutant rats deficient in mrp2.

9 ssociated proteins (MRP), including MRP1 and MRP2.

10 sphate (cAMP) increases plasma membrane (PM)-MRP2.

11 crease MARCKS phosphorylation or decrease PM-MRP2.

12 thout affecting cAMP-induced increases in PM-MRP2.

13 ug metabolism and drug transporters mdr1 and mrp2.

14 ction that required the PDZ-binding motif of Mrp2.

15 ition by the multidrug resistant transporter Mrp2.

16 se elements in the promoter regions of mouse Mrp2 [-185 base pairs (bp)], Mrp3 (-9919 bp), and Mrp4 (

17 The MRP2 5'-untranslated region (5'UTR) contains seven upstr

18 tion of an MRP2 polymorphism, -24C>T, in the MRP2 5'UTR, demonstrated no effect on mRNA expression or

19 We conclude that among the uORFs in the Mrp2 5'UTR, the uORF starting at nucleotide -109 probabl

20 We investigated MRP2 5'UTRs [-247 (-247 to -1), -204 (-204 to -1), or -9

21 In HepG2 cells transfected with SV40-MRP2-5'UTR-Luciferase cassettes, luciferase activities o

22 e multidrug resistance associated protein 2 (MRP2), a bilirubin-detoxifying transporter.

23 Multidrug resistance protein 2 (MRP2), a marker selectively transported to the apical (i

24 characterized using Tr(-) rats (deficient in mrp2, a canalicular transporter for organic anions), the

25 BSEP, MDR1, MDR2, and MRP2 ABC transporters are targeted to the apical (canali

26 o1a/1b(-/-)/(-/-)) or the efflux transporter Mrp2 (Abcc2(-/-)) were intravenously injected with (99m)

27 MRP2 (ABCC2), a member of the ATP binding cassette super

28 esistant-associated protein 1 (MRP1; ABCC1), MRP2 (ABCC2), and MRP4 (ABCC4).

29 gnificant reduction in hepatic expression of Mrp2 (Abcc2), the principal canalicular multispecific or

30 ts, deficient in the canalicular transporter Mrp2 (Abcc2).

31 drug-resistance associated transport protein Mrp2 (ABCC2).

32 ; multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp

33 Multidrug resistance-associated protein 2 (Mrp2, Abcc2) is an ATP-binding cassette transporter loca

34 Multidrug resistance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in th

35 e multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated

36 the immunoprecipitation-enriched samples of MRP2/ABCC2 following proteolysis with trypsin.

37 the absolute amount of MRP2/ABCC2 protein in MRP2/ABCC2 gene-transfected MDCK cells as well as the ba

38 ot able to detect the basal levels of canine Mrp2/Abcc2 in MDCK cells.

39 cells as well as the basal levels of canine Mrp2/Abcc2 protein in MDCK cells.

40 ccessfully determined the absolute amount of MRP2/ABCC2 protein in MRP2/ABCC2 gene-transfected MDCK c

41 le to many current research needs related to MRP2/ABCC2 protein.

42 thod was developed to quantitatively measure MRP2/ABCC2 using LC-MS/MS for detection of a selective t

43 Multidrug resistance-associated protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of orga

44 e multidrug resistance-associated protein 2 (MRP2/ABCC2) plays an important role in hepatobiliary eff

45 Multidrug resistance-associated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the

46 1/ABCC1), or multidrug resistance protein 2 (MRP2/ABCC2).

47 Mrp2 activity is regulated by insertion into the plasma

48 Thus, MRP1/MRP2 acts as an RNA matchmaker by stabilizing the RNA mo

49 Substrates of Mrp2 affect the ability of the protein to interact with

50 Finally, human MRP2 also transported As(GS)(3).

51 e sought to determine whether the absence of Mrp2 alters the accumulation and toxicity of platinum in

52 ned structures of Trypanosoma brucei apoMRP1/MRP2 and an MRP1/MRP2-gRNA complex.

53 MRP2 and BSEP were expressed with baculoviruses in insec

54 ment of PC12 cells with interfering RNAs for MRP2 and glycogen synthase kinase 3beta (GSK3beta) resul

55 itical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-de

56 ment: 1) PBOH-glucuronide is a substrate for Mrp2 and may compete with other organic anions for bilia

57 ch exhibit functional and properly localized Mrp2 and Mrp3 over time in culture.

58 uced, whereas the apical export transporters Mrp2 and Mrp4 are increased, resulting in a significant

59 uded that the efflux system for MTX includes MRP2 and MRP4, in addition to MRP1 and MRP3, and that MR

60 Mapping known mutations from MRP2 and MRP6 onto the Ycf1p structure explains how muta

61 Here we examine the interaction of Mrp2 and NHERF-1 and its physiological significance in H

62 iated with increased expression GST-Pi, Mrp1/Mrp2 and P-glycoprotein, which function together to redu

63 Mrp2 and RAR alpha:RXR alpha protein abundance and activ

64 eta treatment of primary hepatocytes reduced Mrp2 and RXR alpha expression.

65 e were reduced 4- to 6-fold in Bcrp1;Mdr1a/b;Mrp2(-/) (-) and Bcrp1;Mrp2;Mrp3(-/-) mice compared with

66 r multidrug resistance-associated protein 2 (Mrp2) and basolateral Mrp3 mediate the excretion of orga

67 f multidrug resistance-associated protein 2 (MRP2) and of bile salt export pump (BSEP) variants and m

68 r multidrug resistance-associated protein 2 (Mrp2) and the effect of pretreatment with dibutyryl-cycl

69 which encode for the efflux transporter Mrp1/Mrp2) and the multidrug resistance gene (MDR1, which enc

70 , multidrug resistance-associated protein 2 (Mrp2), and breast cancer resistance protein (BCRP) expre

71 r multidrug resistance-associated protein 2 (Mrp2), and the backflux transporter Mrp4, as determined

72 xpression (Western blots) of P-glycoprotein, Mrp2, and BCRP.

73 etermine expression of MRP3/Mrp3, CPF/Lrh-1, Mrp2, and Bsep.

74 We conclude that Bcrp1, Mdr1a/b, Mrp2, and Mrp3 significantly affect tissue disposition a

75 Three (MRP1, MRP2, and MRP3) of the four members that have this struc

76 dings strongly suggest that NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expre

77 profoundly up-regulates apical expression of MRP2, and that interfering with hepoxilin A(3) synthesis

78 with 80 mg/kg PB increased P-glycoprotein-, Mrp2-, and BCRP-mediated transport and protein expressio

79 MRP2 appeared to have no role.

80 Specific knockdown of Mrp2 (approximately 50% decrease in expression) resulted

81 tispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding cassette (ABC) transporters that co

82 specific organic anion transporter (cMOAT or MRP2) are ATP-binding cassette transporters that confer

83 ndocytic retrieval and decreased function of Mrp2 at 20 minutes and significantly accelerated the exo

84 he upregulation of P-glycoprotein, Bcrp, and Mrp2 at blood-CNS barriers.

85 d multidrug resistance-associated protein 2 (MRP2) at the BBB.

86 3, -132, and -98 nucleotides relative to the Mrp2 ATG) and contains potential upstream open reading f

87 Here we show that Arabidopsis MRP2 (AtMRP2) localizes to the vacuolar membrane fractio

88 The role of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion

89 Comparative structural analyzes of MRP2 bound to various substrates, as determined in this

90 , and sulfinpyrazone, inhibitors of MRP1 and MRP2, but was minimally affected by membrane potential o

91 ol increases the transport rates of BSEP and MRP2, but with the latter, may also modify the binding s

92 vation, implicating HNF1 in the induction of MRP2 by HCV.

93 In contrast, induction of MRP2 by phenobarbital, an activator of CAR, was comparab

94 d multidrug resistance-associated protein 2 (MRP2) by conventional PKCalpha (cPKCalpha), novel PKCdel

95 Prior in vitro studies suggest that Mrp2 can bind to Na(+)/H(+) exchanger regulatory factor

96 ransport of arsenic into bile depends on the MRP2/cMOAT transporter and that glutathione is obligator

97 Mrp2 co-precipitated with NHERF-1 in co-transfected HEK2

98 olites and in ABCC2 encoding the transporter MRP2 contributing to the biliary excretion of the reacti

99 Nonetheless, P-gp, Mrp2, Cyp3a, and Ces2a clearly restricted vinorelbine av

100 ls of PhIP metabolites were reduced in Bcrp1;Mrp2-deficient mice.

101 of 4MUG was also approximately 35% lower in Mrp2-deficient mouse livers.

102 (24 micromol) did not induce cholestasis in Mrp2-deficient TR(-) rats whereas 2 micromol of inverted

103 lated perfused livers (IPLs) from Wistar and Mrp2-deficient TR- rats.

104 The maximum transport rate of MRP2 ( Vmax,MRP2 ), derived from kinetic modeling of sodium fluoresc

105 Mrp2 down-regulation and IL-1 beta up-regulation were ob

106 mbranes suggested partial internalization of Mrp2 during the acute phase of cholestasis at 20 minutes

107 MRP2 dysfunction, in Dubin-Johnson syndrome or by off-ta

108 insertion of green fluorescent protein (GFP)-Mrp2 expressed in HepG2 cells was monitored by total int

109 Western blot studies indicated an absence of MRP2 expression in both blood-brain barrier preparations

110 ceptibility, we characterized Pgp, MRP1, and MRP2 expression in CD33+ cell lines and CD33+ AML sample

111 clear translocation of Nrf2, which activates MRP2 expression in macrophages upon infection by the par

112 Organ-specific regulation of Mrp2 expression in obstructive cholestasis is associated

113 Renal Mrp2 expression is preserved under these conditions.

114 In addition, we have shown that MRP2 expression is regulated by the pregnane X receptor

115 A significant decrease in MRP2 expression levels was observed following GSK3beta i

116 SK3beta overexpression was found to increase MRP2 expression levels.

117 Down-regulation of Mrp2 expression may explain impaired biliary excretion o

118 Preservation of renal Mrp2 expression may permit urinary excretion of toxic or

119 mice, suggesting that the down-regulation of Mrp2 expression was caused by post-transcriptional event

120 16alpha-carbonitrile-dependent induction of MRP2 expression was not evident in hepatocytes derived f

121 Renal RAR alpha:RXR alpha and Mrp2 expression were preserved under these conditions.

122 transport-deficient rats (TR(-)), which lack Mrp2 expression, showed none of these substrate effects.

123 ld be associated with suppression of hepatic Mrp2 expression.

124 ve polymerase chain reaction showed Mrp1 and Mrp2 expression.

125 MRP1, but not MRP2, expression correlated with MRP activity.

126 Finally, ATP increased GFP-Mrp2 fluorescence in the plasma membrane of HepG2 cells,

127 r of the Kelch-related protein family termed MRP2 (for Mayven-related protein 2) that is specifically

128 mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kineto

129 dies and demonstrated endocytic retrieval of Mrp2 from the canalicular membrane into pericanalicular

130 ay mediate cholestatic effects by retrieving MRP2 from the plasma membrane.

131 d multidrug resistance-associated protein 2 (Mrp2) from the canalicular membrane leading to cholestas

132 Mrp2 function is impaired in various experimental models

133 epoxilin A(3) synthesis and/or inhibition of MRP2 function results in a marked reduction in inflammat

134 n filaments, inhibits Nrf2 translocation and Mrp2 gene activation by pB(25)R infection.

135 ssays demonstrated that transcription of the Mrp2 gene at the various initiation sites was tissue-spe

136 d whether transgenic expression of the human MRP2 gene could protect against cisplatin injury in vivo

137 Transgenic expression of the human MRP2 gene in Mrp2-null mice reduced the accumulation and

138 Trypanosoma brucei apoMRP1/MRP2 and an MRP1/MRP2-gRNA complex.

139 While MRP2 has been shown to be expressed specifically in brai

140 We identified MRP2 in a screen designed to isolate genes that are regu

141 TLC increased PM-PKC and decreased PM-MRP2 in both HuH-NTCP cells and hepatocytes.

142 The measured half-lives of 14C-labeled Mrp2 in control, pregnant, and PCN-treated rats were 27,

143 plain the post-transcriptional regulation of Mrp2 in control, pregnant, and PCN-treated rats.

144 indings represent an alternative function of Mrp2 in hepatocytes.

145 first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-de

146 p3 may compensate for the down-regulation of Mrp2 in obstructive cholestasis.

147 cAMP did not affect PM-PKC and increased PM-MRP2 in these cells.

148 overlapping functions of Bcrp1, Mdr1a/b, and Mrp2 in vivo, we generated Bcrp1;Mdr1a/b;Mrp2(-/-) mice,

149 e multidrug resistance-associated protein-2 (Mrp2) in mediating cholestasis induced by estradiol-17be

150 d multidrug resistance associated protein-2 (Mrp2) in pregnancy and throughout lactation in rats.

151 f multidrug resistance-associated protein 2 (Mrp2) in the biliary excretion of PB and metabolites was

152 MRP2 interacted with GSK3beta through its NH2 terminus c

153 cantly accelerated the exocytic insertion of Mrp2 into the canalicular membrane and the recovery of b

154 The structures show that MRP1/MRP2 is a heterotetramer and, despite little sequence ho

155 MRP2 is a putative biomarker for the assessment of hepat

156 MRP2 is an actin-binding protein of the kelch-related pr

157 als in canalicular insertion and function of Mrp2 is not known.

158 These studies demonstrate that MRP2 is regulated by three distinct nuclear receptor sig

159 Multidrug resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organ

160 Multidrug resistance-associated protein 2 (MRP2) is an ATP-powered exporter important for maintaini

161 p multidrug resistance-associated protein 2 (Mrp2) is diminished in experimentally induced models of

162 n the process extension of rat OLGs, whereas MRP2/KLHL1 antisense reduced the process length of prima

163 MRP2/KLHL1 expression was abundant during the specific s

164 MRP2/KLHL1 is expressed in oligodendrocyte precursors an

165 Overexpression of MRP2/KLHL1 resulted in a significant increase in the pro

166 Furthermore, murine OLGs isolated from MRP2/KLHL1 transgenic mice showed a significant increase

167 MRP2/KLHL1 was localized in the cytoplasm and along the

168 Moreover, a direct endogenous association of MRP2/KLHL1 with actin was observed, which was significan

169 se studies provide insights into the role of MRP2/KLHL1, through its interaction with actin, in the p

170 g-resistance associated protein (MRP) 2, and Mrp2 knockout mice displayed increased vinorelbine plasm

171 e after oral administration, suggesting that Mrp2 limits the intestinal uptake of vinorelbine.

172 These data suggest that deficiency in Mrp2 lowers platinum excretion and increases susceptibil

173 g hepoxilin A(3) synthesis and/or inhibiting MRP2 may lead to the development of new therapeutic stra

174 closporins are potent inhibitors of OATP1B1, MRP2, MDR1, and other important drug transporters.

175 tion kinetics of sodium fluorescein reflects MRP2-mediated transport activity, providing a novel diag

176 These data indicate that the process of Mrp2-mediated transport of high concentrations of E(2)17

177 Mrp2 message was increased (2.3-fold) by PB pretreatment

178 and Mrp2 in vivo, we generated Bcrp1;Mdr1a/b;Mrp2(-/-) mice, which are viable and fertile.

179 cretion was reduced 41-fold in Bcrp1;Mdr1a/b;Mrp2(-/-) mice.

180 tes were excreted into bile predominantly by Mrp2, mouse Bcrp mediated the biliary excretion of sulfa

181 MRP2 mRNA and protein levels were up-regulated in PC12 c

182 no significant differences were observed in Mrp2 mRNA expression among these groups.

183 Transcription of rat hepatic Mrp2 mRNA is initiated at multiple sites (-213, -163, -1

184 Mrp2 mRNA levels diminished profoundly after endotoxin (

185 MRP2 mRNA levels were induced following treatment of hum

186 AR agonists results in a robust induction of MRP2 mRNA levels.

187 ndicate for the first time that the 5'UTR of MRP2 mRNA transcripts and the uORF at -105 markedly infl

188 Polysomal distribution analysis of Mrp2 mRNA was consistent with increased Mrp2 protein syn

189 Mrp2 mRNA was stable in pregnancy and postpartum, wherea

190 In NHERF-1(-/-) mouse liver, Mrp2 mRNA was unchanged but Mrp2 protein was reduced in

191 ult2a1, Ugt1a1), and Phase III transporters (Mrp2, Mrp3).

192 NAD(P)H:quinone oxidoreductase 1, as well as Mrp2, Mrp3, and Mrp4 expression.

193 xyanisole demonstrated that the induction of Mrp2, Mrp3, and Mrp4 is Nrf2-dependent.

194 decreased liver IL-10, FXR, CAR, VDR, BSEP, MRP2, MRP3, MRP4 was also observed in ANIT-induced chole

195 ubin metabolism and excretion (CYP2B, CYP3A, MRP2, MRP3, UGT1A, and glutathione S-transferase alpha),

196 fold in Bcrp1;Mdr1a/b;Mrp2(-/) (-) and Bcrp1;Mrp2;Mrp3(-/-) mice compared with wild-type mice.

197 These mice, together with Bcrp1;Mrp2;Mrp3(-/-) mice, were used to study the effects of t

198 In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice, the

199 d, to a much lesser extent, by MRP1, but not MRP2-MRP6 or BCRP/MXR.

200 as ATP-dependent but was neither mediated by MRP2 nor stimulated by cholesterol.

201 m were detected in the kidneys and livers of Mrp2-null mice compared with wild types.

202 nsive proximal tubule injury was observed in Mrp2-null mice compared with wild-type mice.

203 Kidneys from naive Mrp2-null mice had elevated glutathione S-transferase mR

204 nsgenic expression of the human MRP2 gene in Mrp2-null mice reduced the accumulation and nephrotoxici

205 vehicle- and cisplatin-treated wild-type and Mrp2-null mice were collected for quantification of plat

206 Enhanced platinum concentrations in Mrp2-null mice were observed in DNA and cytosolic fracti

207 r multidrug resistance associated protein 2 (Mrp2) on chloride channel activation and cell volume reg

208 ed in the membrane vesicles expressing human MRP2 or breast cancer resistance protein.

209 ey injury, which can be rescued by the human MRP2 ortholog.

210 ssociated with the expression of Oatp1a1 and Mrp2 (P < .001, r = 0.74 and P < .001, r = 0.70, respect

211 In conclusion, Mrp2 plays a role in regulation of chloride channel func

212 Characterization of an MRP2 polymorphism, -24C>T, in the MRP2 5'UTR, demonstrat

213 the putative HNF1 binding site of the human MRP2 promoter abrogated HCV-induced activation, implicat

214 otein and mRNA expression were increased and MRP2 promoter activity was increased 7-fold.

215 ha nuclear protein levels and binding to the Mrp2 promoter cis element.

216 Both the ntcp FpB element and the mrp2 promoter contain potential retinoid-response elemen

217 increased BLM and RAD54 corecruitment on the MRP2 promoter in camptothecin-resistant colon cancer cel

218 We have recently reported that the rat Mrp2 promoter is activated by RAR alpha:RXR alpha, and t

219 r gene constructs containing 1 kb of the rat MRP2 promoter were prepared and transiently transfected

220 leukin-1beta down-regulation of the ntcp and mrp2 promoters were mapped to RXRalpha:RARalpha-response

221 atic models resulted in a marked decrease in Mrp2 protein (P < 0.01) and its tissue localization at t

222 MRP2 protein and mRNA expression were increased and MRP2

223 Differences in the degradation of Mrp2 protein cannot explain the post-transcriptional reg

224 organic anions for biliary excretion and 2) Mrp2 protein expression and functional capacity is decre

225 stable in pregnancy and postpartum, whereas Mrp2 protein expression decreased significantly in pregn

226 plays an important role in the regulation of Mrp2 protein expression.

227 sis or degradation consistent with different Mrp2 protein expression.

228 s of Mrp2 mRNA was consistent with increased Mrp2 protein synthesis after PCN treatment.

229 We hypothesized that Mrp2 protein undergoes altered rates of protein synthesi

230 Mrp2 protein was increased slightly in PB-treated livers

231 /-) mouse liver, Mrp2 mRNA was unchanged but Mrp2 protein was reduced in whole cell lysates and membr

232 Mrp2 protein was significantly increased in rats treated

233 iol, and common bile duct ligation (CBDL) on Mrp2 protein, messenger RNA (mRNA) expression, and Mrp2

234 role for the translational regulation of rat Mrp2 protein.

235 s in contrast to the progressive decrease in Mrp2 protein.

236 In contrast to Mrp2, protein expression of ecto-ATPase and P-gp remaine

237 ermined in this study and others, reveal how MRP2 recognizes a diverse array of compounds, supporting

238 Mrp2 remained localized at the apical/canalicular membra

239 the expression and functional regulation of Mrp2 remains largely unknown.

240 that ABC transporters (ABCB1/MDR1 and ABCC2/MRP2, respectively) show dramatic overexpression, wherea

241 Ralpha:RARalpha heterodimers to the ntcp and mrp2 retinoid-response elements.

242 ated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cy

243 was to test the hypothesis that TLC-induced MRP2 retrieval involves PKC-mediated MARCKS phosphorylat

244 ults support the hypothesis that TLC-induced MRP2 retrieval involves TLC-mediated activation of PKC f

245 was impaired in parallel with the extent of Mrp2 retrieval.

246 NRP/B, MAYVEN, or MAYVEN-related protein 2 (MRP2), revealed that the NRF2-NRP/B complex is important

247 e, we determine the cryo-EM structure of rat Mrp2 (rMrp2) in an autoinhibited state and in complex wi

248 RAR alpha, RXR alpha, and Mrp2 RNA levels were determined by using ribonuclease pr

249 a critical role in the induction of hepatic MRP2 secondary to HCV subgenomic replication.

250 In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and

251 rane labeling for Mrp3 at a time when apical Mrp2 staining was significantly diminished.

252 120-min cumulative biliary excretion of the Mrp2 substrate 5-(and-6)-carboxy-2', 7'-dichlorofluoresc

253 In TR-hepatocytes the Mrp2 substrate had no effect on volume regulation.

254 ary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), wa

255 The MRP2 substrates CCK8 and vasopressin exhibited Michaelis

256 Two conjugated estrogens that are not Mrp2 substrates did not produce this effect.

257 with their ability to activate channels, the Mrp2 substrates increased the rate of volume regulatory

258 of multidrug-resistant associated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the can

259 We analyzed Mrp2 synthesis, expression, and degradation in control f

260 nctional homology between Ycf1p and MRP1 and MRP2, these data support the hypothesis that GSH efflux

261 rotein, messenger RNA (mRNA) expression, and Mrp2 tissue localization were determined in rat livers b

262 ganic anion secretion into bile by targeting Mrp2 to the canalicular membrane.

263 sP(3)R2-mediated Ca(2+) signals in targeting Mrp2 to the canalicular membrane.

264 Immunostaining localized P-glycoprotein and Mrp2 to the luminal surface of the capillary endothelium

265 utamylation similarly affects the ability of MRP2 to transport MTX.

266 nd multidrug resistant associated protein 2 (Mrp2) to the plasma membrane.

267 quence was identified 440 bp upstream of the MRP2 transcription initiation site that contains an ever

268 testine, and HepG2 cells identified multiple MRP2 transcription initiation sites.

269 The relative abundance of these Mrp2 transcripts expressed in tissues varied with age fr

270 ipts and the uORF at -105 markedly influence MRP2 translation.

271 ect of cAMP on PKCs, TC uptake, and Ntcp and Mrp2 translocation was studied in isolated rat hepatocyt

272 P and bistratene A on TC uptake and Ntcp and Mrp2 translocation were not additive.

273 esults suggest that cAMP stimulates Ntcp and Mrp2 translocation, at least in part, by activating nPKC

274 delta translocation, TC uptake, and Ntcp and Mrp2 translocation.

275 ion plays a role in cAMP-stimulated Ntcp and Mrp2 translocation.

276 delta translocation, TC uptake, and Ntcp and Mrp2 translocation.

277 lation method was used to determine Ntcp and Mrp2 translocation.

278 vels of GenX inhibited P-gp and BCRP but not MRP2 transport activities in male and female rat brain c

279 s to SFN increased P-glycoprotein, Bcrp, and Mrp2 transport activity and protein expression; SFN incr

280 We found that cholesterol stimulates MRP2 transport activity for substrates of different mole

281 urs in parallel with decreased bile flow and Mrp2 transport activity.

282 ion of endogenous kinases also reduces human MRP2 transport activity.

283 brane cholesterol content modulates BSEP and MRP2 transport kinetics differently.

284 mitant with the overexpression of macrophage MRP2 transporter.

285 e multidrug resistance-associated protein 2 (Mrp2) transporter may efflux cisplatin conjugates from c

286 In the liver, Mrp2 transports bilirubin-glucuronide, glutathione (GSH)

287 sion may induce adaptive responses involving MRP2 via HNF1 activation.

288 The maximum transport rate of MRP2 ( Vmax,MRP2 ), derived from kinetic modeling of sod

289 onal growth factor (NGF)-induced PC12 cells, MRP2 was expressed along the neurite processes and coloc

290 1 was expressed in 8 (50%) of 16 tumors, and MRP2 was expressed in 5 (31%) of 16 tumors.

291 The rate of incorporation of 35S into Mrp2 was highest in PCN-treated rats.

292 tp1a/1b) and multidrug resistance protein 2 (Mrp2) was investigated by small-animal SPECT.

293 ly synthesized mitochondrial matrix protein, MRP2, was also inhibited due to depletion of TbTim17, Tb

294 To assess whether changes were specific for Mrp2, we also examined the expression of canalicular ect

295 4, and for the apical bilirubin transporter, Mrp2, were all increased.

296 A coding for multidrug resistance protein 2 (MRP2), which transports GSH into bile, are half wild-typ

297 ug resistance-associated protein genes (MRP1/MRP2, which encode for the efflux transporter Mrp1/Mrp2)

298 E(2)17G induces endocytic internalization of Mrp2, which occurs in parallel with decreased bile flow

299 eased associations of MRP2 with GSK3beta and MRP2 with actin were observed in the NGF-treated PC12 ce

300 Additionally, increased associations of MRP2 with GSK3beta and MRP2 with actin were observed in

301 DN) PKC reversed TLC-induced decreases in PM-MRP2 without affecting cAMP-induced increases in PM-MRP2