ライフサイエンスコーパス: MTHFR

1 MTHFR 1298A>C and RFC1 intron 5A>G polymorphisms were as

2 MTHFR 677C>T genotype and folate status were generally n

3 MTHFR Ala222Val (C677T; rs 1801133) polymorphism has rep

4 MTHFR and TYMS genotypes were determined on 365 HCC case

5 MTHFR genotype was a determinant of vascular 5-MTHF (not

6 MTHFR genotype was an independent predictor of plasma an

7 MTHFR genotyping was performed to identify a C-->T mutat

8 MTHFR protein and mRNA were reduced in embryonic liver,

9 MTHFR protein levels were reduced in FASD pup livers, wi

10 MTHFR TT was associated with lower folate concentrations

11 MTHFR variants may be involved in SS non-MALT NHL develo

12 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF

13 1.46; 95% CI, 1.26-1.68; P = 2.5 x 10(-7)), MTHFR C677T and gastric cancer (OR, 1.52; 95% CI, 1.31-1

14 ckin mutant lines that effectively abolished MTHFR phosphorylation and compared them with the parenta

15 in S/P and RBC folate concentrations across MTHFR C677T genotypes.

16 ctions to a variety of pharmacologic agents (MTHFR) and an immunological transcription factor (IRF1)

17 were with a cluster of probes at the AGTRAP-MTHFR-NPPA/B gene locus on chromosome 1 (FDR = 1.3E-04),

18 endelian randomisation the association among MTHFR C677T, homocysteine levels and WMH, approached, bu

19 have further highlighted associations among MTHFR c.677C > T, tHcy, and aberrations in DNA methylati

20 evels are significantly elevated in CBS- and MTHFR-deficient patients.

21 stent with epistatic effects of the COMT and MTHFR polymorphisms on prefrontal dopamine signaling, an

22 tive synergistic effect between the CPS1 and MTHFR SNPs in the offspring (interaction P = 0.0046), th

23 the brain results from OCM dysfunction, and MTHFR mutations such as Mthfr 677C-->T, common in human

24 blood cell folate, plasma homocysteine, and MTHFR 677C>T genotype and colonic tissue biopsies for me

25 iations were found for IL2, CTLA4, HPSE, and MTHFR but were inconsistent with original publications.

26 ylation of only two studied genes, LTB4R and MTHFR, which were appreciably methylated even in control

27 ne and vitamin B12 levels were measured, and MTHFR C677T and A1298C genotyped.

28 10(-8) and 4.09 x 10(-8), respectively) and MTHFR in the African ancestry sample (P=1.72 x 10(-6)).

29 upplementation among different age, sex, and MTHFR genotype groups are required to provide evidence f

30 interactive effect of the MTHFR 677C-->T and MTHFR 1298A-->C polymorphisms on tHcy concentrations.

31 acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced in FASD-fed mice.

32 assess a causal relationship between WMH and MTHFR.

33 acid supplements, particularly those who are MTHFR deficient.

34 and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports

35 late status modifies the association between MTHFR 677C-->T and stroke in a genetic analysis and meta

36 e genetic studies of the association between MTHFR 677C-->T and stroke in low folate settings are nee

37 tudies have examined the association between MTHFR C677T (a proxy for high homocysteine concentration

38 there was no evidence of association between MTHFR C677T genotype and CHD risk (odds ratio [OR], 0.96

39 We assessed the association between MTHFR C677T genotypes and blood folate concentrations am

40 There was no significant association between MTHFR genotype and CHD risk in large studies from region

41 We investigated the associations between MTHFR 677C>T genotype, folate status, and DNA methylatio

42 We found a significant interaction between MTHFR 677C-->T and MTRR 66A-->G on serum homocysteine co

43 No interactions between MTHFR and child folate and homocysteine levels were obse

44 Both MTHFR genotype and vascular 5-MTHF were associated with

45 Phosphatidylcholine was modified by MTHFR genotype (P = 0.035; 677TT < 677CC).

46 s; 5,068 cases, 7,876 controls) of the C677T MTHFR polymorphism and CRC, with stratification by racia

47 ypes of interest and identify the candidates MTHFR, C10orf32, CSK, NOV, ULK4, SDCCAG8, SCAMP5, RPP25,

48 ort (TCN1, TCN2), or metabolism (BHMT2, CBS, MTHFR, MUT, SHMT1).

49 rders were diagnosed (mutations in PAH, CBS, MTHFR, CYP27A1, and HIBCH), and in 1 family, 2 disease-c

50 % CI, 6.5 to 26.4; P=0.002) lower than in CC MTHFR subjects.

51 ation was found in subjects with either [CC] MTHFR or [CT/TT] cSHMT genotypes.

52 e potential links between maternal and child MTHFR polymorphisms and child neurodevelopment in a lead

53 d with maternal MTHFR 1298 genotype or child MTHFR genotypes.

54 In both human and E. coli MTHFR, the A --> V mutation increases the rate of dissoc

55 gh Phe223 contacts each substrate in E. coli MTHFR, this residue is not invariant; for example, a leu

56 23 in the oxidative half-reaction of E. coli MTHFR.

57 lent Ala to Val mutation in Escherichia coli MTHFR, which is 30% identical to the catalytic domain of

58 synthesis is highly sensitive to the common MTHFR C677T polymorphism and that the effect of the poly

59 DNF, OXTR, RORA, GRM8, CHRNA4, IL-1A, CRHR1, MTHFR, DRD2, APOE) and loneliness were replicated (p>0.0

60 those with the 677TT genotype (50% decreased MTHFR activity) had both hyper- and hypomethylation in t

61 abolic studies revealed that the deregulated MTHFR cells undergo continuous transmethylation of homoc

62 Mexican American men (n = 60) with different MTHFR C677T genotypes (29 677TT, 31 677CC) consumed a di

63 nd Trypanosoma cruzi, contain genes encoding MTHFR and two distinct methionine synthases.

64 ymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756

65 Although 3 fetal MTHFR and DHFR genetic variants had no effect, the fetal

66 FR genetic variants had no effect, the fetal MTHFR 677TT genotype was associated with significantly l

67 ia and hypomethioninemia, reduced fibroblast MTHFR enzymatic activity (18%-52% of control participant

68 , mutagenic lesions, we suggest that, as for MTHFR C677T, the GGH -124 T>G SNP may modulate the risk

69 lementation with riboflavin-the cofactor for MTHFR.

70 d recycling and explaining the necessity for MTHFR to be regulated by SAM.

71 t to investigate the kinases responsible for MTHFR multisite phosphorylation and the physiological fu

72 Hence, this study demonstrates a role for MTHFR in lignin biosynthesis.

73 ten primary glaucoma cases were studied for MTHFR C677T polymorphism and compared with 280 controls

74 ntly potentiated in platelets harvested from MTHFR++ carriers, and it was reversed by the inhibition

75 ), the finding that bm2 encodes a functional MTHFR is consistent with its lignin phenotype.

76 show that the bm2 gene encodes a functional MTHFR.

77 Although the homocysteine remethylation gene MTHFR has emerged as a risk factor in some human populat

78 with a C677T polymorphism of the MTHFR gene (MTHFR++).

79 e methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Me

80 MTHFR phosphorylation in cells, we generated MTHFR CRISPR knockin mutant lines that effectively aboli

81 Seven polymorphisms in 6 genes (MTHFR, MTRR, FOLH1, CbetaS, RFC1, SHMT) involved in fola

82 ligand-free Phe223Leu and Phe223Leu/Glu28Gln MTHFR in complex with CH(3)-H(4)folate have been determi

83 MTHFR deficiency, methionine, homocysteine, MTHFR enzyme activity in fibroblasts, or mutations (in t

84 RD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally s

85 s demonstrated no significant differences in MTHFR Ala222Val genotype and allele distributions betwee

86 se A2 expression was significantly higher in MTHFR++ carriers compared with healthy volunteers.

87 ent treatment exacerbated hypomethylation in MTHFR 677TT men compared with 677CC.

88 The genetic mutations in MTHFR and TYMS genes may have influences on their respec

89 In children carrying C677T mutations in MTHFR, higher folate levels were associated with an incr

90 pport the role of the A1298C polymorphism in MTHFR as prognostic marker in female patients with metas

91 n that the common c.677C > T polymorphism in MTHFR influences global DNA methylation status through a

92 Polymorphisms in MTHFR may offer potential for treatment individualizatio

93 Similarly, in MTHFR++ carriers, the content of H2S was significantly h

94 We identified 5 SNPs in MTHFR that altered the slope of the intake-metabolite co

95 enetic variants had been measured, including MTHFR C677T.

96 tion coordinates with SAM binding to inhibit MTHFR activity in cells.

97 High folic acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced i

98 We investigated MTHFR C677T genotypes and alleles frequencies in primary

99 Leishmania MTHFR differed from those in other eukaryotes by the abs

100 posity (APOA5, APOB, APOE, GCKR, IRS-1, LPL, MTHFR, PCSK9, PNPLA3, PPARgamma2), gene-exercise (APOA1,

101 SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 x 10(-6

102 ay, six of the 55 examined gene loci (LTB4R, MTHFR, CDH13, PGR, CDH1, and IGSF4) were significantly h

103 Maternal MTHFR haplotype also predicted MDI-24 scores (mean +/- S

104 tion (chi(2) = 8.82, p = 0.003) and maternal MTHFR 677C>T genotype with IGF2 methylation (chi(2) = 2.

105 2) status, infant MTRR genotype and maternal MTHFR genotype, all of which may influence the supply of

106 ed to plasma folate concentrations, maternal MTHFR genotype did not explain the association of folate

107 acid supplement use or variation in maternal MTHFR genotype.

108 variate-adjusted regression models, maternal MTHFR 677 genotype predicted MDI-24 scores, in which eac

109 The maternal MTHFR 677T allele is an independent predictor of poorer

110 4 scores, in which each copy of the maternal MTHFR 677T variant allele was associated with lower MDI-

111 -24 scores were not associated with maternal MTHFR 1298 genotype or child MTHFR genotypes.

112 Mild MTHFR deficiency (677C > T polymorphism) increases risk

113 Neither CYP11B2 T(-344)C nor MTHFR C677T were significantly associated when tested in

114 choline between betaine and CDP-PC among NP (MTHFR rs1801133 and MTR rs1805087 WT) and lactating (MTH

115 h an interaction of tHcy and the activity of MTHFR enzyme on epigenetic regulation of the genome via

116 he frequency of the genotypes and alleles of MTHFR C677T differ significantly between cases and contr

117 Alteration of MTHFR function is expected to influence accumulation of

118 iod of follow-up, the inverse association of MTHFR with CVD mortality was significant only in the per

119 The inverse association of MTHFR with CVD mortality was unexpected and highlights t

120 The association of MTHFR, a gene consistently associated with homocysteine,

121 The objective was to examine associations of MTHFR C677T, a proxy for high homocysteine concentration

122 bjective: To investigate the associations of MTHFR polymorphisms and serum homocysteine levels with i

123 on prefrontal function within the context of MTHFR genotype.

124 dicates that the allele T and genotype CT of MTHFR C677T polymorphism are significantly associated wi

125 controls were genotyped for the detection of MTHFR polymorphisms.

126 authors assessed whether the distribution of MTHFR C677T genotypes was independent of potential confo

127 through the C-terminal SAM binding domain of MTHFR.

128 The effect of MTHFR 677C-->T on homocysteine concentrations was reduce

129 ndividual samples, we examined the effect of MTHFR genotype ([Formula: see text] 677CC, [Formula: see

130 n vitro, the multiply phosphorylated form of MTHFR is more sensitive to allosteric inhibition by SAM.

131 To understand the function of MTHFR phosphorylation in cells, we generated MTHFR CRISP

132 horylation and the physiological function of MTHFR phosphorylation in cells.

133 vity genotype, each low-activity genotype of MTHFR was associated with a statistically nonsignificant

134 measured confounders appeared independent of MTHFR genotype within the largest ethnically homogenous

135 mutant alleles in the 3 polymorphic loci of MTHFR/TYMS (range, 0-4), there was a monotonic decrease

136 s performed to explore a possible pathway of MTHFR polymorphisms via homocysteine levels to cortical

137 The functional polymorphism of MTHFR gene, C677T has been shown to impact various disea

138 udies are warranted to establish the role of MTHFR variants in these associations.

139 correlated with the phosphorylation state of MTHFR, with more severe mutations resulting in lower abu

140 Genetic polymorphism 677 C>T on MTHFR affects vascular 5-MTHF (but not homocysteine) and

141 ontrol participants), and 3 novel pathogenic MTHFR mutations, 2 as compound heterozygotes in one fami

142 GSK3A/B among the kinases that phosphorylate MTHFR.

143 lenetetrahydrofolate reductase polymorphism (MTHFR 677C>T) may influence risk by modifying DNA methyl

144 otein and activity levels, creating a pseudo-MTHFR deficiency.

145 late intake during pregnancy leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, e

146 s study supports the hypothesis that reduced MTHFR activity and enhanced TYMS activity, both of which

147 est that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTH

148 rphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with

149 The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural t

150 n 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamineN-

151 es 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C, methionine synthase reduc

152 ypes in methylenetetrahydrofolate reductase (MTHFR) 677TT, thymidylate synthase (TSER) *2/*2 (variabl

153 he 5,10-methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) genes were ass

154 Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known to play

155 m (SNP) methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) was used as proxy for homocyste

156 of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on choline status was also examine

157 he 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocystein

158 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-met

159 severe methylenetetrahydrofolate reductase (MTHFR) deficiency is presently unclear.

160 severe methylenetetrahydrofolate reductase (MTHFR) deficiency manifesting a complicated form of adul

161 he 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been associated with a lower risk of CRC

162 in the methylenetetrahydrofolate reductase (MTHFR) gene increases the requirement for folate and may

163 The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 co

164 CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to markedly elevated levels of circulat

165 utative methylenetetrahydrofolate reductase (MTHFR) gene, which is down-regulated in bm2 mutant plant

166 in the methylenetetrahydrofolate reductase (MTHFR) gene.

167 Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation

168 The methylenetetrahydrofolate reductase (MTHFR) genotype is associated with modification of disea

169 status, methylenetetrahydrofolate reductase (MTHFR) genotype, and exposures.

170 ith the methylenetetrahydrofolate reductase (MTHFR) genotype.

171 isms of methylenetetrahydrofolate reductase (MTHFR) have been associated with diastolic blood pressur

172 enzyme, methylenetetrahydrofolate reductase (MTHFR) in Mthfr(+/-) mice, exaggerated the ethanol effec

173 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of the tetrahydrofolate (THF)-med

174 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate l

175 Methylenetetrahydrofolate reductase (MTHFR) links the folate cycle to the methionine cycle in

176 rtance: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been shown to influence homocy

177 The methylenetetrahydrofolate reductase (MTHFR) protein and methylation potential [ratio of S-ade

178 Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (

179 bolism, methylenetetrahydrofolate reductase (MTHFR) rs1801133, methionine synthase (MTR) rs1805087 [w

180 dent of methylenetetrahydrofolate reductase (MTHFR) variants.

181 ncoding methylenetetrahydrofolate reductase (MTHFR) was responsive to supplementation with riboflavin

182 Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism is involv

183 enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the genome via DNA

184 nthase, methylenetetrahydrofolate reductase (MTHFR), and VEGF.

185 enzyme, methylenetetrahydrofolate reductase (MTHFR), from 564 individuals of diverse ethnicities.

186 genes: methylenetetrahydrofolate reductase (MTHFR), reduced folate carrier 1 (RFC1), and glutamate c

187 (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydroxymethyltransferase (SHMT), and cyst

188 of 5,10 methylenetetrahydrofolate reductase (MTHFR).

189 in the methylenetetrahydrofolate reductase (MTHFR)gene was associated with the risk ofAEin both tria

190 P 5,10-methylene tetrahydrofolate reductase (MTHFR) Ala222Val (dbSNP ID: rs1801133; P-value=1.27 x 10

191 of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is conten

192 used the methyl tetrahydrofolate reductase (MTHFR) gene polymorphism 677C>T as a model of chronic ex

193 of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and me

194 (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate

195 ulated methylene tetrahydrofolate reductase (MTHFR).

196 WMH to methylene tetrahydrofolate reductase (MTHFR).

197 (C677T methylenetetrahydrofolate reductase [MTHFR] and C1420T cytoplasmic serine hydroxymethyltransf

198 thway (methylene tetrahydrofolate reductase; MTHFR:C677T), and the vitamin D pathway (vitamin D recep

199 Data regarding MTHFR polymorphisms C677T and A1298C, peri- and postnata

200 Conclusions and Relevance: MTHFR polymorphism and elevated homocysteine levels cont

201 7C>T (rs1801133), MTHFR 1298A>C (rs1801131), MTHFR 1793G>A (rs2274976), MTR 2756A>G (rs1805087), and

202 olate-related SNPs-MTHFR 677C>T (rs1801133), MTHFR 1298A>C (rs1801131), MTHFR 1793G>A (rs2274976), MT

203 Severe MTHFR deficiency results in homocystinuria and neurologi

204 Although severe MTHFR deficiency is a rare cause of complicated spastic

205 To define severe MTHFR deficiency, methionine, homocysteine, MTHFR enzyme

206 betaine, or (2) single patients with severe MTHFR deficiency treated with betaine.

207 chomotor development in patients with severe MTHFR deficiency, highlighting the importance of timely

208 families with 2 or more patients with severe MTHFR deficiency, of whom at least 1 received betaine, o

209 Further, significant MTHFR x COMT genotype interactions were observed, which

210 We did not observe significant MTHFR genotype x lead interactions with respect to any o

211 Five folate-related SNPs-MTHFR 677C>T (rs1801133), MTHFR 1298A>C (rs1801131), MTH

212 The widely studied MTHFR C677T SNP (rs1801133) was also highly significant

213 or V Leiden, G20210A prothrombin, and 677C>T MTHFR polymorphisms.

214 ey folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del

215 -2000), and genetic variation (MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, SHMT1 1420C>T, TYMS 1494del6

216 hat manipulating tobacco (Nicotiana tabacum) MTHFR gene (NtMTHFR1) expression dramatically alters the

217 Our study demonstrated that MTHFR Ala222Val polymorphism and some clinical character

218 In addition, we found that MTHFR phosphorylation is maintained by adequate cellular

219 Herein, we tested the hypothesis that MTHFR variants contribute to pSS-related lymphomagenesis

220 Our observations indicate that MTHFR 677TT homozygous individuals are more likely to de

221 her logistic regression analysis showed that MTHFR Ala222Val genotype, psychopathological symptoms, n

222 Overall, our results suggest that MTHFR multisite phosphorylation coordinates with SAM bin

223 The MTHFR 1793G>A and MTRR 66A>G SNPs tended to be associate

224 The MTHFR 677C-->T polymorphism has been associated with rai

225 The MTHFR 677C-->T polymorphism was associated with signific

226 The MTHFR 677C-->T variant is associated with reduced enzyme

227 The MTHFR 677TT genotype was associated with a approximately

228 The MTHFR 677TT genotype was associated with increased plasm

229 The MTHFR 677TT polymorphism seems to be associated with a r

230 The MTHFR C677T polymorphism, which directly influences plas

231 The MTHFR C677T SNP was strongly associated with Hcy (P = 1.

232 The MTHFR gene was amplified using specific primers.

233 The MTHFR TT genotype was not associated with genomic or gen

234 eraction between plasma homocysteine and the MTHFR c.677C>T polymorphism is associated with site-spec

235 For unipolar depression and the MTHFR C677T polymorphism, the fixed-effects odds ratio f

236 potential gene regulatory mechanisms at the MTHFR and NOS3 loci.

237 The association between the MTHFR 677C>T SNP and breast-milk UMFA, albeit modest, hi

238 The inverse association between the MTHFR 677TT polymorphism and CRC was not significantly m

239 ysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and b

240 Individuals carrying the MTHFR 677T allele had a marked increase in risk of SCC (

241 the rise in plasma homocysteine, as did the MTHFR 677TT genotype (P < 0.001).

242 ethnic group and other CVD risk factors, the MTHFR C677T TT genotype was associated with significantl

243 s of European descent were genotyped for the MTHFR 677 C-->T polymorphism.

244 For the MTHFR A1298C (rs1801131) single nucleotide polymorphisms

245 , being ~12% higher in infants harboring the MTHFR A1298C (rs1801131) AC or CC genotypes and 10% lowe

246 However, the MTHFR 677C>T SNP was associated with breast-milk UMFA (R

247 We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal

248 ctivity in fibroblasts, or mutations (in the MTHFR gene) had to be described as well as the effect of

249 homozygous for a common polymorphism in the MTHFR gene.

250 ment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associ

251 leotide polymorphisms were identified in the MTHFR-CLCN6-NPPA-NPPB locus and were all replicated.

252 Whether genetic variants at or near the MTHFR and MUT genes influence SVS risk through pathways

253 ion was mainly driven by SNPs at or near the MTHFR and MUT genes.

254 variants previously reported at or near the MTHFR, MTR, CPS1, MUT, NOX4, DPEP1, and CBS genes.

255 There was no interactive effect of the MTHFR 677C-->T and MTHFR 1298A-->C polymorphisms on tHcy

256 f this study was to assess the effect of the MTHFR 677C-->T polymorphism on the current folate RDA fo

257 The effect of the MTHFR 677C-->T variant on homocysteine concentration was

258 toms of SCZ and compare the frequency of the MTHFR Ala222Val genotype in both suicide attempters and

259 Data on the association studies of the MTHFR and TYMS genetic polymorphisms and risk of hepatoc

260 to determine the differential effects of the MTHFR C677T genotype and the effect of various choline i

261 cysteinemia with a C677T polymorphism of the MTHFR gene (MTHFR++).

262 We propose that the effect of the MTHFR genotypes on increasing risk of adenoma recurrence

263 gest that the rs13306560 polymorphism of the MTHFR may be part of the observed hypertension process i

264 of CpGs reduced the promoter activity of the MTHFR regulatory region.

265 s, and Mexican Americans irrespective of the MTHFR TT genotype, and, from a population perspective, t

266 effect of the rs13306560 polymorphism on the MTHFR promoter region by means of luciferase reporter ge

267 suggest that in schizophrenia patients, the MTHFR 677T allele exacerbates prefrontal dopamine defici

268 ype, and, from a population perspective, the MTHFR 677C-->T variant does not warrant modifications to

269 vo PtdCho biosynthesis and indicate that the MTHFR 677TT genotype favors the use of choline as a meth

270 Computational simulations indicate that the MTHFR C677T polymorphism and folate deficiency interact

271 We conclude that the MTHFR C677T polymorphism increases the risk for POAG dev

272 d analysis of all samples confirmed that the MTHFR variant was more strongly associated with Hcy in t

273 entrations were significantly related to the MTHFR 677C-->T genotype but not to the other polymorphis

274 We sought to determine whether the MTHFR 677C-->T genotype modifies the response to folic a

275 randomized trials have examined whether the MTHFR genotype modifies the observed response.

276 steine concentrations between those with the MTHFR 677 CC and TT genotypes.

277 Persons with the MTHFR 677 TT genotype had a 22.1% (95% CI: 14.6%, 28.9%)

278 Men with the MTHFR 677TT genotype had a higher urinary enrichment rat

279 omocysteine concentrations in those with the MTHFR TT genotype.

280 riants (rs1801133 and rs13306560) within the MTHFR are associated with hypertension in Mexican-Mestiz

281 pidemiologic studies demonstrated that these MTHFR polymorphisms were associated with cancer risk in

282 fr null mice do not develop NTDs even though MTHFR mutations increase human NTD risk.

283 In carriers of [CT/TT] MTHFR genotypes, the SD of normal-to-normal intervals wa

284 In the same [CT/TT] MTHFR subjects, each 10-mug/m(3) increase in PM(2.5) in

285 Two MTHFR gene polymorphisms (C677T and A1298C) were tested

286 Two MTHFR gene polymorphisms, C677T and A1298C, are linked t

287 Two MTHFR polymorphisms, C677T (rs1801133) and A1298C (rs180

288 red to controls, individuals with one or two MTHFR 677T alleles were at 42% increased cancer risk (OR

289 Candidate genes (TYMS, MTHFR, ABCB1, BGLAP, ACP5, LRP5, ESR1, PAI-1, VDR, PTH,

290 necticut, 1997-2000), and genetic variation (MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, SHMT1 1420C>T,

291 When MTHFR C677T genotype frequencies in MSS CRC cases were c

292 While MTHFR has long been known to be allosterically inhibited

293 d with reduced DNA methylation levels, while MTHFR c. 1298A > C AC genotype with reduced DNA double-s

294 Although ethnicity was associated with MTHFR genotype distribution within the entire cohort (p

295 cysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, reg

296 No evidence of an association with MTHFR 677 was observed for ALL or AML, either in childre

297 was strongest for mothers and children with MTHFR 677 C>T variant genotypes.

298 As compared with MTHFR 677CC men, those with the 677TT genotype (50% decr

299 homozygous wild-type individuals, those with MTHFR 677TT genotype were more likely to have MSI than m

300 tretch within the regulatory region of yeast MTHFR to create a series of feedback-insensitive, deregu