ライフサイエンスコーパス: MTOC

1 MTOC reorientation was closely preceded first by product

2 MTOC repositioning allows the release of proteases and t

3 ls early in their cell cycle, an acentriolar MTOC reassembled, and, prior to NEB, a functional amphia

4 Formation of such acentriolar MTOCs could be phenocopied by overexpression of Sas-4 in

5 res loss of microtubule-organizing activity (MTOC) at the centrosome, but the mechanisms regulating t

6 whether blocking DGAT1 in PCa cells altered MTOC and lipid signaling.

7 ls, the centrosome is often attenuated as an MTOC and MTOC function is reassigned to non-centrosomal

8 Our results suggest that Cep55 may act as an MTOC-associated protein regulating spindle organization,

9 bout how the centrosome is inactivated as an MTOC.

10 in C. elegans embryonic intestinal cells and MTOC function is reassigned to the apical membrane.

11 However, whether duplication and MTOC organization reflect innate activities of centriole

12 thways is required for cytotoxic granule and MTOC polarization and for cytotoxicity of human NK cells

13 ulating the clustering of lytic granules and MTOC repositioning during the development of NK cell-med

14 mulate at the immunological synapse (IS) and MTOC translocation was inhibited.

15 entrosome is often attenuated as an MTOC and MTOC function is reassigned to non-centrosomal sites suc

16 tep in gamma-tubulin complex recruitment and MTOC formation, but how Mto1 localizes to such sites has

17 H 3T3 fibroblasts where MT stabilization and MTOC reorientation are triggered by lysophosphatidic aci

18 to1/2[bonsai], that does not localize to any MTOC sites.

19 R-antigen microcluster gathering, as well as MTOC polarization and lysosome exocytosis, at the synaps

20 more, AurA-coated magnetic beads function as MTOCs in the presence of RanGTP in Xenopus egg extracts

21 rA is essential for the beads to function as MTOCs.

22 tial for the function of these organelles as MTOCs.

23 ane (eMTOCs) and nuclear-envelope associated MTOCs in interphase cells (iMTOCs).

24 o (self-organize) without nuclear-associated MTOCs, but require the microtubule nucleator mod20-mbo1-

25 persist independently of nuclear-associated MTOCs, including the spindle pole body (SPB)--the centro

26 ergillus nidulans SPBs and septum-associated MTOCs were described.

27 uced pPKCdelta(Thr505) protein expression at MTOCs and leads to a significant (P < 0.05) disruption o

28 gamma-tubulin and pericentrin expression at MTOCs were decreased in pPKCdelta(Thr505)-depleted oocyt

29 ammaTuSC are highly conserved and present at MTOCs in diverse eukaryotes, similar regulatory mechanis

30 s associated with decreased gamma-tubulin at MTOCs in NEDD1-depleted oocytes, as well as a high frequ

31 Because MTOC polarization to the synapse is required for polariz

32 nt on dynein motor function, occurred before MTOC polarization, and did not require a commitment to c

33 n requires tight mechanical coupling between MTOC and nucleus, which is mediated by lamin A/C.

34 t divide after differentiation, the cellular MTOC state switches between the membrane and the centros

35 antation development, the number of cellular MTOCs progressively decreased, the spindle pole graduall

36 ized in the microtubule organization center (MTOC) and, in contrast to other survivin isoforms (i.e.

37 ocuses to the microtubule organizing center (MTOC) after NK cell activation, when it is able to assoc

38 on leading to microtubule-organizing center (MTOC) amplification.

39 zation of the microtubule organizing center (MTOC) and cytolytic granules to the NK cell immune synap

40 , whereas the microtubule organizing center (MTOC) and cytosolic granules follow the nucleus across t

41 usion) to the microtubule-organizing center (MTOC) and promotes its fusion with lysosomes, which is n

42 ome acts as a microtubule organizing center (MTOC) and remains stationary, forming one pole of the fu

43 tion near the microtubule-organizing center (MTOC) and subsequent delivery by the polarized MTOC dire

44 es toward the microtubule organizing center (MTOC) and translocation of the MTOC to the target contac

45 rgence to the microtubule-organizing center (MTOC) as an early, prerequisite step in NK cell cytotoxi

46 n a discrete posterior MT organizing center (MTOC) capable of supporting ectopic posterior localizati

47 e acts as the microtubule-organizing center (MTOC) during mitosis in animal cells.

48 preading, and microtubule organizing center (MTOC) formation in NK cells.

49 ration of the microtubule organizing center (MTOC) from the nuclear envelope.

50 s the primary microtubule-organizing center (MTOC) in animal cells.

51 is the major microtubule organizing center (MTOC) in dividing cells and in many postmitotic, differe

52 itment of the microtubule organizing center (MTOC) in HIV-1-infected cells.

53 from the microtubule (MT)-organizing center (MTOC) in IQGAP1-deficient cells.

54 s is the main microtubule-organizing center (MTOC) in muscle cells due to the accumulation of centros

55 The microtubule-organizing center (MTOC) is reoriented between the nucleus and the leading

56 elease of the microtubule organizing center (MTOC) linker protein, C-NAP1, and the failure to recruit

57 centrosome, the major MT organizing center (MTOC) of the cell.

58 away from the microtubule-organizing center (MTOC) on microtubules.

59 ion preceding microtubule-organizing center (MTOC) polarization to the synapse.

60 calcium flux, microtubule organizing center (MTOC) polarization, phosphorylation of ZAP-70, and T-cel

61 through its effects on MT organizing center (MTOC) polarization.

62 he centrosome/microtubule organizing center (MTOC) relative to the cell nucleus and the body axes, as

63 MTs emanating from the MT-organizing center (MTOC) shortly after viral entry and more pronounced and

64 ains a unique microtubule-organizing center (MTOC) that organizes the cytoskeleton.

65 and a movement of the MT organizing center (MTOC) to a position that is just underneath the plasma m

66 zation of the microtubule-organizing center (MTOC) to the immunological synapse enables the direction

67 cation of the microtubule-organizing center (MTOC) to the synapse, and focused secretion of effector

68 zation of the microtubule organizing center (MTOC) together with cytolytic granules to the synapse wi

69 of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven

70 of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell enables the dir

71 tation of the microtubule-organizing center (MTOC) toward the APC.

72 cation of the microtubule organizing center (MTOC) toward the contact zone, which necessitates a prop

73 ration of the microtubule-organizing center (MTOC) well before nuclear envelope breakdown (NEB).

74 vement of the microtubule organizing center (MTOC), granzyme B (a component of cytotoxic granules), a

75 acentrosomal microtubule-organizing center (MTOC), nucleating new microtubules at distances far from

76 zation at the microtubule-organizing center (MTOC), Nuf is present at the MTOC only during the phases

77 ome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spind

78 with two key microtubule organizing center (MTOC)-associated proteins, pericentrin and gamma-tubulin

79 zation of the microtubule-organizing center (MTOC).

80 occur at the microtubule-organizing center (MTOC).

81 tation of the microtubule organizing center (MTOC).

82 s as an unconventional MT-organizing center (MTOC).

83 the daughter microtubule organizing center (MTOC).

84 es toward the microtubule-organizing center (MTOC).

85 near the host microtubule-organizing center (MTOC).

86 known as the microtubule organizing center (MTOC).

87 e reorientation of the MT organizing center (MTOC).

88 rently at the microtubule-organizing center (MTOC).

89 acentrosomal microtubule-organizing center (MTOC).

90 ation and mislocalized MT organizing center (MTOC)/Golgi and myosin IIB cell rear enrichment.

91 centrosome- [microtubule organizing center (MTOC)] associated protein that regulates nucleokinesis v

92 Moreover, the microtubule-organizing center (MTOC, or centrosome), which rapidly reorients to the imm

93 formation of microtubule organizing centers (MTOC) on its own.

94 gamma-TuC to microtubule-organizing centers (MTOCs) [14, 20-22], and analysis of Mto1[bonsai], a trun

95 rse types of microtubule organizing centers (MTOCs) also exist, especially in differentiated cells.

96 s located at microtubule-organizing centers (MTOCs) and coimmunoprecipitates with gamma-tubulin Gtb1

97 ically to cytoplasmic MT organizing centers (MTOCs) and interphase MTs.

98 alescence of microtubule organizing centers (MTOCs) and MI spindle assembly are further supported by

99 cifically at microtubule-organizing centers (MTOCs) and not more broadly throughout the cytoplasm.

100 hundreds of microtubule-organizing centers (MTOCs) are assembled completely from maternal components

101 Microtubule-organizing centers (MTOCs) are large, multi-subunit protein complexes.

102 -centrosomal microtubule organizing centers (MTOCs) direct microtubule (MT) organization to exert div

103 Microtubule-organizing centers (MTOCs) form, anchor, and stabilize the polarized network

104 sociate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and

105 ricentrin at microtubule-organizing centers (MTOCs) in mouse oocytes arrested at prophase-I.

106 sitioning of microtubule-organizing centers (MTOCs) incorporates biochemical and mechanical cues for

107 n persist as microtubule organizing centers (MTOCs) into interphase.

108 iginate from microtubule-organizing centers (MTOCs) located at either pole.

109 Microtubule-organizing centers (MTOCs) nucleate microtubules that can grow autonomously

110 es, the main microtubule organizing centers (MTOCs) of metazoan cells, contain an older "mother" and

111 egulation of microtubule organizing centers (MTOCs) orchestrates the reorganization of the microtubul

112 leation from microtubule organizing centers (MTOCs) such as the animal centrosome and fungal spindle

113 ttachment of microtubule-organizing centers (MTOCs) to intermediate filaments (IFs) enables their loc

114 centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation i

115 granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lym

116 distributed microtubule-organizing centers (MTOCs) without centrioles, because of the concerted acti

117 st prominent microtubule organizing centers (MTOCs), disappeared during plant evolution as angiosperm

118 Microtubule-organizing centers (MTOCs), known as centrosomes in animals and spindle pole

119 s, and other microtubule organizing centers (MTOCs), whether by direct filiation or symbiogenesis, ha

120 exes to microtubule (MT) organizing centers (MTOCs).

121 ntrosomes or microtubule-organizing centers (MTOCs).

122 primary microtubule (MT)-organizing centers (MTOCs).

123 of multiple microtubule-organizing centers (MTOCs).

124 at specific microtubule organizing centers (MTOCs).

125 bulin within microtubule organizing centers (MTOCs).

126 g cells, the microtubule-organizing centers (MTOCs; mammalian centrosome and yeast spindle pole body

127 The central MTOC is the centrosome that duplicates during the cell c

128 le to promote microtubule organizing centre (MTOC) formation in both embryos and oocytes.

129 me, the major microtubule organizing centre (MTOC).

130 acentriolar microtubule-organizing centres (MTOCs) into a high number of small MTOCs to be able to t

131 Although hyperactive centrosomal MTOC activity is a hallmark of some cancers, little is k

132 Depletion of the non-centrosomal MTOC protein GM130 reduced PCa cell proliferation and mi

133 Here, we use the robust loss of centrosomal MTOC activity in the epidermis to identify two pools of

134 f these complexes drives loss of centrosomal MTOC activity.

135 rganizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood.

136 mitochondrial MTOC and other non-centrosomal MTOCs has not been discerned.

137 assembly and organization of non-centrosomal MTOCs.

138 in live embryos, we find that the centrosome MTOC state is dominant and that the inactive MTOC state

139 ults in rapid reactivation of the centrosome MTOC.

140 cell before being activated as a centrosome/MTOC.

141 xes, providing a mechanistic link connecting MTOC activity and differentiation.

142 processes, including cell motility, coupled MTOC and nucleus dynamics, and cell polarization, depend

143 it to several different types of cytoplasmic MTOC sites.

144 As mto1Delta mutants lack cytoplasmic MTOCs, cytoplasmic MTs arise from spindle or other intra

145 yces pombe has multiple types of cytoplasmic MTOCs, and these vary through the cell cycle.

146 from stathmin(-/-) mice displayed defective MTOC polarization and defective target cell cytolysis.

147 subregions of MASC target Mto1 to different MTOCs, and multimerization of MASC is important for effi

148 tant for targeting Mto1 to multiple distinct MTOCs.

149 r proteins that function downstream to drive MTOC movement.

150 Lipid droplets, MTOCs, and microtubule-regulating proteins were reduced

151 in the microtubule arrays generated by each MTOC, which we demonstrate with in vivo measurements, an

152 accumulation and Cdc42 activation to enable MTOC polarization and NK cell cytotoxicity.

153 rmation and activity of the nuclear envelope MTOC in human osteoclasts.

154 AP6 as key component of the nuclear envelope MTOC.

155 ion, microtubule release from the equatorial MTOC (eMTOC), and the dynamic fusion and splitting of mi

156 and during late anaphase from the equatorial MTOC (EMTOC).

157 luding the SPB and interphase and equatorial MTOCs.

158 Both Golgi and nuclear envelope exhibit MTOC activity utilizing either AKAP9, or Pcnt-AKAP9, res

159 ed the organizing principle of the flagellar MTOC.

160 Instead, flexible MTOCs may emerge on the plasma membrane, the nuclear env

161 MT nucleation sites or flexible MTOCs in plant cells V.

162 eta, yet these components were essential for MTOC reorientation, as they maintained the MTOC at the c

163 showing that ERK activation is important for MTOC polarization.

164 ot and immunofluorescence were performed for MTOC and triglyceride mediators.

165 und that compared with the time required for MTOC polarization, lytic granules converged to the MTOC

166 ts indicated that PKC-theta was required for MTOC reorientation and that PKC-varepsilon and PKC-eta o

167 defines a minimal molecular requirement for MTOC generation and implicates the potent role of Cnn (o

168 ner and is required for conjugate formation, MTOC (microtubule organizing center) polarization, and N

169 Failure to fragment MTOCs leads to defects in spindle assembly, which delay

170 Mechanisms generating MTOC diversity are poorly understood.

171 suppressing PCa growth by regulating GM130, MTOC number and disrupting microtubule integrity.

172 multimolecular complexes that maintain Golgi/MTOC orientation, differ from those that might contain a

173 l migration and initial orientation of Golgi/MTOC toward the leading edge, which was not mimicked by

174 Schizosaccharomyces pombe harbors MTOCs at spindle pole bodies, transient MTOCs in the div

175 Here, we analyze how MTOC function is reassigned to the apical membrane of C.

176 In other cell types, however, MTOC function is reassigned from the centrosome to nonce

177 Hyperactive MTOC function at the centrosome is associated with epith

178 disrupting the localization of DAG impaired MTOC recruitment.

179 iated antigen 1, leads to a severe defect in MTOC polarization at the immunological synapse.

180 to the centrosome, culminating in a peak in MTOC function in metaphase.

181 ical pulling forces, ultimately inactivating MTOC function at the centrosome.

182 MTOC state is dominant and that the inactive MTOC state of the centrosome is malleable; fusion of a m

183 How signals emanating from the TCR induce MTOC polarization is not known.

184 Furthermore, blocking LFA-1-induced MTOC polarization through ZAP70 inhibition prevented int

185 t-negative form of Par1b blocked TCR-induced MTOC polarization, our data suggest that Par1b functions

186 t cells or primary mouse CTLs also inhibited MTOC translocation and CTL-mediated killing.

187 ed LPA-induced stable MTs without inhibiting MTOC reorientation.

188 ing small interfering RNA similarly inhibits MTOC polarization and cytotoxic activity but does not im

189 symmetry in mitosis primes biased interphase MTOC activity, necessary for correct spindle orientation

190 entrosome cycle produces a single interphase MTOC, coarsely aligning the spindle, and spindle-cortex

191 orces are at work to maintain the interphase MTOC position in wild-type cells.

192 iginate from poorly characterized interphase MTOCs and spindle pole body (SPB), and during late anaph

193 tle is known about the mechanisms that limit MTOC activation at the centrosome.

194 is union and block normal CIP4 localization, MTOC polarization to the IS, and cytotoxicity.

195 s in attachment of this complex to the major MTOC site.

196 ential for functional centrosomes, the major MTOCs in animal cells.

197 ecular characterization of the mitochondrial MTOC defines a minimal molecular requirement for MTOC ge

198 , the molecular basis for this mitochondrial MTOC and other non-centrosomal MTOCs has not been discer

199 al to specify the apical membrane as the new MTOC.

200 anism for the organization of noncentrosomal MTOCs in eukaryotic cells.

201 induced the formation of stable MTs, but not MTOC reorientation, in starved fibroblasts.

202 We show that conversion of MTOC state involves the conserved centrosome protein SPD

203 ctions about the spatiotemporal evolution of MTOC position and MT cytoskeleton morphology with experi

204 K cells, similar to Arl8b, led to failure of MTOC-lytic granule polarization to the immune synapse, s

205 rosome position and that the reassignment of MTOC function from centrosomes to the apical membrane is

206 view recent advances in our understanding of MTOC reorientation in T cells, focusing first on the imp

207 ctivity generally correlates with the age of MTOCs and contributes to orienting the mitotic spindle w

208 that GCP6 participates in the attachment of MTOCs to IFs in epithelial cells and is among the factor

209 in, Spa10, as anchor for a specific class of MTOCs.

210 n hubs in controlling biological networks of MTOCs in early-branching protozoan parasites.

211 The intracellular position of MTOCs was polarized, perpendicular to the plane of the g

212 e in cell biology, the physical structure of MTOCs is poorly understood.

213 could be attributed to a defect in not only MTOC polarity, but also impaired clustering of lytic gra

214 an essential component of acentriolar oocyte MTOCs, which functions in the regulation of meiotic spin

215 ate formation, lytic granule convergence, or MTOC polarization to the cytotoxic synapse (CS).

216 or can be self-organized, relying on its own MTOC activity.

217 Here we report a perinuclear MTOC in Drosophila fat body cells that is anchored by th

218 cell surface with respect to the perinuclear MTOC.

219 f migrating neurons with correctly polarized MTOC location was significantly reduced while nuclear-ce

220 OC) and subsequent delivery by the polarized MTOC directly to the secretory domain-the shortest path.

221 Golgi compartment proximal to the polarized MTOC.

222 ated Jurkat cells, and loss of ADAP prevents MTOC translocation and the specific recruitment of dynei

223 /CD3 clustering, which subsequently prevents MTOC reorientation, cell cycle progression, and mitosis.

224 not microfilaments, are required for proper MTOC localization of Nuf and Rab11.

225 Localization of Mto1 to prospective MTOC sites has been proposed as a key step in gamma-tubu

226 This defines a novel paradigm for rapid MTOC-directed transport as a prerequisite for directed s

227 am signals that promote actin rearrangement, MTOC polarization, and calcium mobilization are not.

228 hermore, analysis of partially reconstituted MTOC asters in cells that escape complete repolymerizati

229 protein, C-NAP1, and the failure to recruit MTOC components and liquid-like spindle domain (LISD) fa

230 allel microtubules originating from a single MTOC, the growth of multiple microtubules needs to coord

231 centres (MTOCs) into a high number of small MTOCs to be able to then regroup and merge them into two

232 proteins are associated with plant-specific MTOCs and how plant cells activate or inactivate MT nucl

233 lems with establishing predetermined spindle MTOC inheritance patterns during stem cell division have

234 After duplication, spindle MTOCs can be differentially inherited during asymmetric

235 cruitment of two key determinants of spindle MTOCs distribution, that is the gamma-tubulin complex re

236 ntrosomes, making it an ideal model to study MTOC assembly.

237 Such MTOCs had pericentriolar material and the centriolar pro

238 ium in a uropod during chemokine-driven TEM, MTOC reorientation to the contact region between the T c

239 Here, we find that MTOC function at the centrosome is completely inactivate

240 Our data reveal the novel finding that MTOC separation and amphiaster formation does not absolu

241 of the T cell antigen receptor, we show that MTOC polarization is driven by localized accumulation of

242 We show that MTOCs are fragmented in a three-step process.

243 The MTOC function of AurA-coated beads require both MT nucle

244 The MTOC localization of Nuf also relies on Dynein.

245 The MTOC-directed movement of lytic granules was independent

246 nd that the positions of the nucleus and the MTOC are established by separate regulatory pathways.

247 ired clustering of lytic granules around the MTOC.

248 pletely overlapped with gamma-tubulin at the MTOC in cells inspected by confocal microscopy.

249 anizing center (MTOC), Nuf is present at the MTOC only during the phases of the cell cycle in which f

250 l amounts always remained, apparently at the MTOC.

251 necessitates a proper connection between the MTOC and the IS via dynamic microtubules (MTs).

252 Collectively, we decipher the MTOC at the nuclear envelope as a bi-layered structure g

253 f Jurkat cells microtubules project from the MTOC to a ring of the scaffolding protein ADAP, localize

254 les of concentration and dispersion from the MTOC.

255 rough an interaction with ADAP, reels in the MTOC, allowing for directed secretion along the polarize

256 r MTOC reorientation, as they maintained the MTOC at the cell centroid.

257 e aberrant particles still assemble near the MTOC but do not produce infectious virus.

258 nduce MT thickening and acetylation near the MTOC, potentially aiding in the delivery viral genomes t

259 However, both polarization of the MTOC and cytolytic granules to the synaptic region and N

260 Both are required for polarization of the MTOC and cytolytic granules, a prerequisite for killing

261 cused secretion, namely translocation of the MTOC and lytic granules to the IS, respectively.

262 gagement triggers active polarization of the MTOC and the associated Env-containing secretory apparat

263 number of searching MTs and distance of the MTOC from the nuclear surface.

264 tion, neurite outgrowth, and function of the MTOC in a dose-dependent manner.

265 First, PLK1 triggers a decondensation of the MTOC structure.

266 izing center (MTOC) and translocation of the MTOC to the target contact site.

267 the T cell receptor to translocation of the MTOC, in which the minus end-directed motor cytoplasmic

268 cells, a CD28 signal is used to polarize the MTOC and cytolytic granules to the NK cell immune synaps

269 d away from the leading edge to reorient the MTOC, while the MTOC remained stationary.

270 In the final stages of TCR-driven TEM, the MTOC precedes, rather than follows, the nucleus across t

271 Models suggest that the MTOC is moved to its position during reorientation.

272 The mechanisms that couple DAG to the MTOC are not known.

273 ubiquitinated pathological aggregates to the MTOC for aggresome formation and autophagosomal degradat

274 ts suggest that Mzt1/Tam4 contributes to the MTOC function through regulation of GCP3(Alp6).

275 , Dynein-dependent recruitment of Nuf to the MTOC influences the timing of RE-based vesicle delivery

276 trachomatis bacteria fail to traffic to the MTOC or to switch into the conventional persistent state

277 olarization, lytic granules converged to the MTOC rapidly.

278 Nucleic acids endogenous to the MTOC would support evolutionary origin by symbiogenesis.

279 is responsible for targeting assembly to the MTOC.

280 ich promoted granule polarization toward the MTOC in CD8(+) T cells.

281 over the cortical sliding mechanism when the MTOC and IS are initially diametrically opposed.

282 leading edge to reorient the MTOC, while the MTOC remained stationary.

283 etry with Alp4/GCP2 and localizes to all the MTOCs, including the SPB and interphase and equatorial M

284 Third, KIF11 further fragments the MTOCs following nuclear envelope breakdown so that they

285 origin and polarity of forces acting on the MTOCs.

286 Second, BicD2-anchored dynein stretches the MTOCs into fragmented ribbons along the nuclear envelope

287 These MTOCs appear to be canonical centrosomes because they co

288 Strikingly, the center of these MTOCs did not contain centrioles, as described previousl

289 Two of these MTOCs join the female pronucleus to set up the first mit

290 l for gamma-TuC function and localization to MTOCs [11, 12].

291 ated version of Mto1 that cannot localize to MTOCs, has shown that Mto1 also has a role in gamma-TuC

292 s Mto1 and Mto2 (Mto1/2), which localizes to MTOCs and interacts with the gamma-tubulin complex.

293 and is sufficient to convert mitochondria to MTOCs independent of core pericentriolar proteins that r

294 s in social microwells were polarized toward MTOC.

295 bors MTOCs at spindle pole bodies, transient MTOCs in the division plane (eMTOCs) and nuclear-envelop

296 g of wound-edge fibroblasts after triggering MTOC reorientation with soluble factors, we found instea

297 The asymmetry might result from the two MTOCs being in distinctive maturation states.

298 ng intracellular vesicles at the IS, whereas MTOC translocation was not affected.

299 dicate that pPKCdelta(Thr505) interacts with MTOC-associated proteins and plays a role in meiotic spi

300 hase-II, the protein remains associated with MTOCs, in a pericentrin dependent manner.