ライフサイエンスコーパス: Marburg virus

1 -based inhibitors are also effective against Marburg virus.

2 responses than Zaire Ebola virus (ZEBOV) or Marburg virus.

3 entified in Ebola virus GP1 are conserved in Marburg virus.

4 r period, particularly in feces, compared to Marburg virus.

5 effective therapeutics and vaccines against Marburg virus.

6 se caused by the filoviruses Ebola virus and Marburg virus.

7 osure of rhesus macaques to a lethal dose of Marburg virus.

8 ected primates respond following exposure to Marburg virus.

9 tact virus-like particles, and within intact Marburg viruses.

10 strategies against infections with Ebola and Marburg viruses.

11 urrently no approved countermeasures against Marburg viruses.

12 sing replication-competent Ebola, Sudan, and Marburg viruses.

13 for the largest outbreak ever documented for Marburg viruses.

14 Marburg virus, a cousin of Ebola virus, causes severe he

15 Here, bats previously infected with either Marburg virus alone or with both Kasokero and Marburg vi

16 completely protect nonhuman primates against Marburg virus and 3 different species of Ebola virus.

17 t virus, Bundibugyo virus, Reston virus, and Marburg virus and differentiated between the genera Ebol

18 The filoviruses Marburg virus and Ebola virus cause severe hemorrhagic f

19 typed with Marburg virus GP(1,2), as well as Marburg virus and Ebola virus infection in a dose-depend

20 sembled using filovirus matrix proteins from Marburg virus and Ebola virus is also sensitive to inhib

21 The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic

22 ope glycoproteins (GPs) from the filoviruses Marburg virus and Ebola virus.

23 re likely induced in response to exposure to Marburg virus and further suggested that the early immun

24 ndibugyo virus (BDBV), Sudan virus, and even Marburg virus and Lloviu virus, which belong to the hete

25 ctor encoding GP from EBOV, Sudan virus, and Marburg virus and nucleoprotein from Tai Forest virus (M

26 VP24 is only 30% identical between Marburg virus and the ebolaviruses.

27 Filoviruses, which include Marburg viruses and Ebola viruses, are zoonotic pathogen

28 n, Tai Forest, Bundibugyo, Zaire, Sudan, and Marburg viruses and found two antibodies that showed pan

29 ae contains three genera, Ebolavirus (EBOV), Marburg virus, and Cuevavirus.

30 dengue virus, West Nile virus, Ebola virus, Marburg virus, and Zika virus.

31 In addition, we showed that Marburg virus Angola and Ebola virus Makona-WPGC07 effic

32 (cAd3)-vectored vaccine encoding a wild-type Marburg virus Angola glycoprotein (cAd3-Marburg) in heal

33 la virus/Kikwit, Ebola virus/Makona-C05, and Marburg virus/Angola in the rhesus macaque model.

34 The filoviruses Ebola Zaire virus and Marburg virus are believed to infect target cells throug

35 uctures and visual images of the proteins of Marburg virus are essential for the development of antiv

36 while the ebolaviruses Sudan and Reston and Marburg virus are not.

37 onstrate that the VP35s from Ebola virus and Marburg virus are the major suppressors of DC maturation

38 Ebola and Marburg viruses are believed to enter host cells by rece

39 Ebola and Marburg viruses are filoviruses: filamentous, enveloped

40 The filoviruses, Ebola virus and Marburg virus, are zoonotic pathogens that cause severe

41 WHO has identified Marburg virus as an emerging virus requiring urgent vacc

42 Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped vi

43 re resistant to infection by Ebola virus and Marburg virus, but remain fully susceptible to a suite o

44 Marburg virus can cause severe disease, with up to 90% h

45 Infection of Ebola virus and Marburg virus can cause severe illness in humans with a

46 Infection by Ebola virus and Marburg virus can cause severe illness in humans, with a

47 Ebola and Marburg viruses can cause hemorrhagic fever (HF) outbrea

48 the family Filoviridae, including Ebola and Marburg viruses, can cause severe disease and high morta

49 Ebola virus and Marburg virus cause serious disease outbreaks with high

50 Filoviruses, including the Ebola and Marburg viruses, cause hemorrhagic fevers with up to 90%

51 Filoviruses, including Ebola and Marburg viruses, cause rapidly fatal diseases in humans

52 Marburg virus causes a severe infection that is associat

53 VV and MARV.IMPORTANCERavn virus, along with Marburg virus, causes severe viral disease in humans wit

54 To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic a

55 the Ravn strain (RAVV VP40)-from a distinct Marburg virus clade-is demonstrated to also inhibit IFN

56 1 x 10(7) PFU of a VSV-based vaccine against Marburg virus (control; five NHPs).

57 virus (MARV), a filovirus that causes deadly Marburg virus disease (MVD) in humans.

58 Marburg virus disease (MVD) is a severe viral infection

59 Human case fatality rates of Marburg virus disease (MVD) outbreaks range from 20% to

60 ber 27, 2024, Rwanda reported an outbreak of Marburg virus disease (MVD), after a cluster of cases of

61 s (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD).

62 ganda and was confirmed to be an outbreak of Marburg virus disease (MVD).

63 ssessment of remdesivir for the treatment of Marburg virus disease in humans.

64 of BCX4430 protects against Ebola virus and Marburg virus disease in rodent models.

65 The ongoing outbreak of Marburg virus disease in Rwanda marks the third largest

66 mdesivir showed therapeutic efficacy in this Marburg virus disease model with treatment initiation 5

67 family Filoviridae), are causative agents of Marburg virus disease, a severe viral disease that typic

68 d MARV vaccine (FILORAB3) to protect against Marburg virus disease.

69 fever, Ebola virus disease, Lassa fever, and Marburg virus disease.

70 ILORAB3 is a promising vaccine candidate for Marburg virus disease.IMPORTANCE Marburg virus (MARV) is

71 iral activity against filoviruses, including Marburg virus, Ebola virus, and Sudan virus (SUDV).

72 experimentally primed or prime-boosted with Marburg virus, Ebola virus, or Sosuga virus for the pres

73 ignificantly to the control and clearance of Marburg virus, Ebola virus, or Sosuga virus infection in

74 he trafficking and subsequent release of the Marburg virus from infected cells.

75 y responses and T-cell responses against the Marburg virus glycoprotein insert, and assessment of neu

76 d Sudan glycoproteins and one (MAR) encoding Marburg virus glycoprotein.

77 e, we present the 3.6 A crystal structure of Marburg virus GP in complex with a cross-reactive antibo

78 bited entry of retroviruses pseudotyped with Marburg virus GP(1,2), as well as Marburg virus and Ebol

79 tro potency of CV-N to inhibit EboZV GP- and Marburg virus GP-pseudotyped viruses (EC50 approximately

80 animal that developed the highest titers of Marburg virus GP-specific neutralizing antibodies, we so

81 s highly similar to those of Ebola virus and Marburg virus GP2 despite CASV genome homology to arenav

82 ructure has been observed in Ebola virus and Marburg virus GP2, as well as other viruses that enter v

83 uring mouse adaptation of the Ravn strain of Marburg virus have impacted the budding function of the

84 filoviruses including Sudan, Bundibugyo, and Marburg viruses have caused human outbreaks with mortali

85 herapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are

86 omologous protection against Ebola virus and Marburg virus in a prophylactic setting against in macaq

87 EV) demonstrated protective efficacy against Marburg virus in nonhuman primates.

88 were permissive to infection with Ebola and Marburg viruses in vitro.

89 are currently no approved interventions for Marburg virus, in part because a small-animal model that

90 ar requirements of nucleocapsid transport in Marburg virus-infected cells under biosafety level 4 con

91 nes whose disruption allowed the survival of Marburg virus-infected cells, suggesting that Rab9 is ut

92 ngs demonstrate very early host responses to Marburg virus infection and provide a rich data set for

93 were tested for evidence of acute or recent Marburg virus infection by reverse transcription-polymer

94 Marburg virus infection in humans is associated with cas

95 study, we carefully analyzed the timeline of Marburg virus infection in nonhuman primates in order to

96 We evaluated the susceptibility to Ebola and Marburg virus infection of mice that cannot respond to i

97 completely protects cynomolgus macaques from Marburg virus infection when administered as late as 48

98 rus infection followed a similar timeline to Marburg virus infection, with virus detected in blood, s

99 significantly increased survival time after Marburg virus infection.

100 own to protect macaques from Ebola virus and Marburg virus infections, both prophylactically and post

101 development of life-saving measures against Marburg virus infections.

102 showing their utility in combating Ebola and Marburg virus infections.

103 The findings imply that reservoir hosts of Marburg virus inhabit caves, mines, or similar habitats.

104 Marburg virus is a genetically simple RNA virus that cau

105 In contrast, the ecology of the related Marburg virus is much better understood; with experiment

106 aviruses is immunosuppressive, while that of Marburg virus is not.

107 One key protein in the Marburg virus life cycle is VP40, which both assembles t

108 ve different viruses, including Ebola virus, Marburg virus, lymphocytic choriomeningitis virus (LCMV)

109 hieved 92% protection against murine-adapted Marburg virus (ma-MARV).

110 Ebola virus (EboV) and Marburg virus (MarV) (filoviruses) are the causative age

111 Marburg virus (MARV) and Ebola virus (EBOV) belong to th

112 Infections with Marburg virus (MARV) and Ebola virus (EBOV) cause severe

113 Marburg virus (MARV) and Ebola virus (EBOV), members of

114 rousettes) are a natural reservoir host for Marburg virus (MARV) and Ravn virus (RAVV), as well as a

115 members of the Marburgvirus genus, including Marburg virus (MARV) and Ravn virus (RAVV), is difficult

116 Marburg virus (MARV) and Ravn virus (RAVV), the only two

117 Marburg virus (MARV) and the ebolaviruses belong to the

118 Ebola virus (EBOV) and Marburg virus (MARV) are among the deadliest human patho

119 sms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known.

120 The filoviruses Ebola virus (EBOV) and Marburg virus (MARV) are responsible for devastating hem

121 Ebola virus (EBOV) and Marburg virus (MARV) are zoonotic filoviruses that cause

122 Ebola virus (EBOV) and Marburg virus (MARV) belong to the Filoviridae family an

123 Ebola virus (EBOV) and Marburg virus (MARV) cause rapidly progressive hemorrhag

124 Marburg virus (MARV) causes a hemorrhagic fever disease

125 Marburg virus (MARV) causes a severe hemorrhagic fever d

126 Marburg virus (MARV) causes sporadic outbreaks of severe

127 Ebola virus (EBOV) and Marburg virus (MARV) continue to emerge and cause severe

128 Marburg virus (MARV) disease is lethal, with fatality ra

129 d remdesivir in a non-human primate model of Marburg virus (MARV) disease.

130 V) causes lethal disease in ferrets, whereas Marburg virus (MARV) does not.

131 Here we report rescue of a recombinant Marburg virus (MARV) expressing EGFP from an additional

132 In the seven protein-coding genes in the Marburg virus (MARV) genome, the synonymous nucleotide d

133 ll as the addition of Sudan virus (SUDV) and Marburg virus (MARV) GP containing virions.

134 Marburg virus (MARV) has been associated with sporadic e

135 Marburg virus (MARV) has caused numerous sporadic outbre

136 Marburg virus (MARV) has caused outbreaks of filoviral h

137 n virus (SUDV), Bundibugyo virus (BDBV), and Marburg virus (MARV) have also caused sizeable human out

138 dated as an inhibitor of infectious EBOV and Marburg virus (MARV) in cell-based assays, with 50% inhi

139 The recent outbreak of Marburg virus (MARV) in Rwanda underscores the need for

140 lonal antibody responses generated following Marburg virus (MARV) infection and its evolution in surv

141 Marburg virus (MARV) infection causes a severe and often

142 Marburg virus (MARV) infection causes severe morbidity a

143 The 2005 outbreak of Marburg virus (MARV) infection in Angola was the most le

144 Marburg virus (MARV) infection is a lethal hemorrhagic f

145 Marburg virus (MARV) infection results in severe viral h

146 of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection.

147 Marburg virus (MARV) is a filovirus related to Ebola vir

148 Marburg virus (MARV) is a filovirus that causes severe a

149 Marburg virus (MARV) is a filovirus with documented huma

150 Marburg virus (MARV) is a highly pathogenic filovirus th

151 Marburg virus (MARV) is a lipid-enveloped filamentous vi

152 Marburg virus (MARV) is a lipid-enveloped virus from the

153 Marburg virus (MARV) is a lipid-enveloped virus harborin

154 ndidate for Marburg virus disease.IMPORTANCE Marburg virus (MARV) is a virus similar to Ebola virus a

155 Marburg virus (MARV) is among the most virulent pathogen

156 Marburg virus (MARV) is an emerging zoonotic pathogen th

157 Ebola virus (EBOV) and Marburg virus (MARV) made headlines in the past decade,

158 cause the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) modulate host innate immunity, MLAV

159 targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein.

160 The first-ever recent Marburg virus (MARV) outbreak in Tanzania and recent eme

161 e particles (VLPs) of Ebola virus (EBOV) and Marburg virus (MARV) produced in human 293T embryonic ki

162 2 closely related plaque-derived variants of Marburg virus (MARV) species Lake Victoria marburgvirus,

163 Phylogenetic comparisons of known Marburg virus (MARV) strains reveal 2 distinct genetic l

164 that the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) suppress DC maturation in vitro Bot

165 s, we delivered an antigen-capture assay for Marburg virus (MARV) that was based on llama single-doma

166 Marburg virus (MARV), a close relative of Ebola virus, i

167 sette bats (ERBs) are the known reservoir of Marburg virus (MARV), a filovirus that causes deadly Mar

168 Marburg virus (MARV), a member of the Filoviridae family

169 Marburg virus (MARV), a member of the filovirus family,

170 iruses, consisting of Ebola virus (EBOV) and Marburg virus (MARV), are among the most lethal infectio

171 ruses, including both Ebola virus (EBOV) and Marburg virus (MARV), can infect humans and other animal

172 BV) viruses, as well as multiple variants of Marburg virus (MARV), have also caused high fatality epi

173 Immune responses to Marburg virus (MARV), however, remain almost entirely un

174 y lethal filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), in humans.

175 ilable to prevent or treat disease caused by Marburg virus (MARV), potently neutralizing monoclonal a

176 Among these, Ebola virus (EBOV), Marburg virus (MARV), Sudan virus (SUDV), and Bundibugyo

177 re highly conserved among filoviruses except Marburg virus (MARV), suggesting that MARV may not bind

178 oding the glycoprotein (GP) gene from Angola Marburg virus (MARV), were compared for their ability to

179 Marburg virus (MARV), which belongs to the virus family

180 In the first study, Marburg virus (MARV)-infected NHPs were treated 15 to 30

181 iRNAs from both EBOV and the closely related Marburg virus (MARV).

182 hogenic and biological threat agents such as Marburg virus (MARV).

183 natural reservoir for the highly pathogenic Marburg virus (MARV).

184 dly pathogens such as Ebola virus (EBOV) and Marburg virus (MARV).

185 ) infected with EBOV, Sudan virus (SUDV), or Marburg virus (MARV).

186 ette bat (ERB) is a known reservoir host for Marburg virus (MARV).

187 were inoculated subcutaneously (n = 22) with Marburg virus (MARV).

188 te bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which M

189 ents against the filoviruses Ebola virus and Marburg virus (MARV); however, the mechanisms that drive

190 f lethal infection with the Angola strain of Marburg virus (MARV-Ang) in rhesus macaques and tested t

191 The Angola strain of Marburg virus (MARV/Ang) was responsible for the largest

192 ) and nucleoprotein (NP) of Ebola (EBOV) and Marburg viruses (MARV) play key roles during virion asse

193 PORTANCE Filoviruses (Ebola virus [EBOV] and Marburg virus [MARV]) are zoonotic, emerging pathogens t

194 Marburg viruses (MARVs) cause highly lethal infections i

195 Recombinant Ebola and Marburg virus matrix VP40 and glycoprotein (GP) antigens

196 We had previously shown that three anti-Marburg virus nanobodies (VHH or single-domain antibody

197 r hosts of highly virulent pathogens such as Marburg virus, Nipah virus, and SARS coronavirus.

198 ars, several viruses, including Ebola virus, Marburg virus, Nipah virus, Hendra virus, severe acute r

199 d Marburg viruses were later challenged with Marburg virus or the related Ravn virus.

200 he putative matrix protein of both Ebola and Marburg viruses, possesses a conserved proline-rich moti

201 luding validation experiments with Sudan and Marburg virus, presents a rich resource for host regulat

202 ]R downward arrow), and one is predicted for Marburg viruses (R[R/K]KR downward arrow), although in a

203 that the VP40 protein of the Ravn strain of Marburg virus (Ravn virus [RAVV]) failed to block IFN si

204 lecular automaton able to diagnose Ebola and Marburg virus sequences.

205 A comparison with the closely related Marburg virus shows that the N-terminal region of nucleo

206 e ZEBOV and Sudan Ebolavirus and 4 different Marburg virus strains produced severe, but more slowly p

207 y, a deterministic model for the dynamics of Marburg virus transmission that incorporates the impact

208 ds, both critical target sites for Ebola and Marburg virus tropism.

209 roup received the same dose of the VSV-based Marburg virus vaccine at both time points; another group

210 cluding the group treated with the VSV-based Marburg virus vaccine.

211 The crystal structure of Marburg virus VP24, presented here, reveals that althoug

212 ays, including Ebola virus VP35 and VP24 and Marburg virus VP35, VP40, and VP24, on DC maturation and

213 the corresponding (84)LPLGIM(89) sequence of Marburg virus VP40 (mVP40) are critical for efficient re

214 The Marburg virus VP40 protein is a viral matrix protein tha

215 Here we provide the molecular structure of Marburg virus VP40, illustrate differences from VP40 of

216 The host response to aerosolized Marburg virus was evident at 1 day postexposure.

217 using in vitro affinity reagent selection on Marburg virus we rapidly established monoclonal affinity

218 arburg virus alone or with both Kasokero and Marburg viruses were later challenged with Marburg virus

219 Marburg viruses were the first filoviruses characterized

220 an completely protect rhesus monkeys against Marburg virus when administered after exposure and can p

221 virus, Lassa virus, LCMV, rabies virus, and Marburg virus, which was substituted for the VSV glycopr