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1 Mb (100 ug/mL) reduced the vascular contractility induce
3 ) in early prophase and extending to 1.5-2.0 Mb in late prophase as chromosomes compact and homologs
4 ways; some (chromosome 19; position 3.0-4.0 Mb) are associated with closely related taxa (Prevotella
5 RF16), some (chromosome 27; position 3.0-4.0 Mb) are associated with distantly related taxa (Prevotel
7 Among them, 273 QTLs were delimited to <=1.0-Mb intervals and 7 of them are either known genes (Rht-D
9 tes were identified within a conserved 40.09 Mb linkage-disequilibrium (LD) block on the X chromosome
10 his method to efficiently deliver large (1.1 Mb) synthetic yeast centromeric plasmids (YCps) to cultu
11 DB1-dependent loop formations bypassed 0.2-1 Mb of linear genome and radiated from the TAD(cPcdh) fri
14 iant, including four with a heterozygous 3.1 Mb 16p13 deletion encompassing XYLT1 and two with a hete
15 we sequenced and assembled approximately 3.1 Mb of the S(2) -haplotype of the S-locus in Petunia infl
16 meric satellite DNA array (approximately 3.1 Mb) and closed the 29 remaining gaps in the current refe
17 tosomes with sizes ranging from 12.4 to 33.1 Mb and a total size, in chromosomes, of 726 Mb, which ha
18 ne-mapped the classical MHC (chr6: 29.6-33.1 Mb), imputing 216 human leukocyte antigen (HLA) alleles
19 gies produced a draft nuclear genome of 36.1 Mb, organized into 321 scaffolds with L50 of 31 and N50
20 OH classes with different sizes (Small 0.5-1 Mb, Medium 1-5 Mb and Large >5 Mb), the numbers and tota
21 ssembly of C. salicifolius, comprising 820.1 Mb of genomic sequence with a contig N50 of 2.3 Mb and c
23 ed to a 35-kb region and was approximately 1 Mb away from Pl(17), flanked by SNP markers C4_6676629 a
24 one of the two genes in the approximately 1 Mb interval and the only gene disruption shared between
27 associations, and that long-range eQTMs (>1 Mb) are reduced when controlling for tissue/muscle fiber
30 ct with smoking were in close vicinity (</=1 Mb) to SNPs previously associated with IBD; many were lo
32 gains and losses of 17p11.2, occur up to ~1 Mb away from the breakpoint junctions, and favor C > G t
33 antly associated genes were located within 1 Mb of known GWAS-identified loci and were not significan
38 t of genetic variance accounted for by any 1-Mb window indicated that viral neutralization antibody l
43 ssociated with methylations of as much as 10 Mb from the promoters or more, and the long-range methyl
46 highly concordant with large-scale (order 10 Mb) features of previously reported genetic maps for mou
47 his genetic map enabled the anchoring of 100 Mb of WGS and 420 Mb of BAC sequences, an exploration of
48 s occupying 74 Mb of the A subgenome and 104 Mb of the D subgenome, and identified 19 candidate loci
49 ded to cover 50% of the genome [N50] = 18.11 Mb mainly on 8 pseudomolecules) and Trigoniulus corallin
53 e for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes
55 species with haploid genome assemblies ~150 Mb are among the largest in Agaricales, and we found tha
57 Like many draft genomes, however, the 158-Mb Spirodela genome sequence has not been resolved to ch
61 kage analysis identified an approximately 18 Mb disease-associated locus on chromosome 4 (maximal log
62 elicorthomorpha holstii (assembly size = 182 Mb; shortest scaffold/contig length needed to cover 50%
66 usly mapped to a gene cluster spanning a 3.2 Mb region at the upper end of sunflower chromosome 4.
68 is the identification of an inversion of 4.2 Mb among landraces and cultivars, which includes a gene
71 panded the C. elegans reference genome by >2 Mb due to a more accurate determination of repetitive se
73 ed for the study of mid-range (e.g., 20 kb-2 Mb for human genome) intra-chromosomal contacts; however
75 ormatics analysis, from a window frame of ~2 Mb containing 314 SNPs, we obtain imputation accuracy (r
77 cluding a large topologically associated 1.2-Mb domain conserved in humans and mice that encompasses
78 e 4727 deposited genomic trajectories of a 2-Mb-long chromatin interval from human chromosome 21.
81 that this cancer phenotype is linked to a 20 Mb region of 129P2 chromosome 15 harboring the Wnt7b gen
82 the presence and absence variants of over 20 Mb, one of which is a circum-basmati-specific deletion o
85 udes gapless assemblies of chromosome 3 (236 Mb) and chromosome 9 (162 Mb), and 53 Mb of the Ab10 mei
86 b of the estimated almond genome size of 238 Mb, of which 91% is anchored to eight pseudomolecules co
87 over 50% of the known genome (NG50) up to 25 Mb and phased ~99.5% of heterozygous sites at 98-99% acc
88 ng effect on maintenance of H3K27me3 in a 26 Mb region around the locus, demonstrating cell type-spec
89 s single fly genome assembly has a N50 of 26 Mb, a length that encompasses entire chromosome arms, co
92 e merged into 978 CNV regions, spanning ~262 Mb of total length and corresponding to ~8.96% of the go
93 e-scale A. paniculata genome sequence of 269 Mb that was assembled by Illumina short reads, PacBio lo
94 Despite possessing the smallest genome (0.27 Mb) of any organism not subsisting within a host cell, t
96 ciation study (GWAS), which identified a 1.3 Mb disease-associated region on canine chromosome 33, fo
97 -throughput STARR-seq to test the entire 1.3 Mb human and mouse TBX3 locus, including two cardiac con
99 of genomic sequence with a contig N50 of 2.3 Mb and containing 36 651 annotated protein-coding genes.
101 a mouse model of autism that duplicates 6.3 Mb region of chromosome 7 (Dp/+) corresponding to a regi
102 me assembly for P. dactylifera that is 772.3 Mb in length, with contig N50 of 897.2 Kb, and use this
103 g data from a single MinION flowcell, a 90.3 Mb nuclear genome was assembled into 202 contigs with an
104 rate that parents transmitting the de novo 3 Mb LCR22A-D 22q11.2 deletion, the reciprocal duplication
107 whether any of the other 29 genes in the 1.3-Mb M-locus are also needed for complete sex-conversion.
109 The assemblies show a contig N50 of 6.32 Mb and 10.53 Mb for Basmati 334 and Dom Sufid, respectiv
111 nd assembled the pomegranate genome with 328 Mb anchored into nine pseudo-chromosomes and annotated 2
112 e also identified coldspots encompassing 329 Mb, or [Formula: see text] of observable genome, in whic
113 dreae has a drastically smaller genome (1.34 Mb) than the symbiont's free-living relatives (4.29-4.97
115 tate, while the distal enhancer located 1.35 Mb from the promoter induces CCL5 expression in activate
118 the smallest genome size in the genus at 357 Mb and has a reduced set of predicted protein-coding gen
120 genome assembly with a total size of 695.36 Mb and a draft genome assembly of Calycanthus chinensis.
121 osome 11 modifier but instead harbors an ~37 Mb region containing non-B6-derived segments on chromoso
127 ological insights that emerge from this 17.4 Mb genome, we find an unexpected diploid structure for m
132 n this study, we report a high-quality 313.4-Mb genome sequence of a bottle gourd inbred line, USVL1V
134 says, targeting the BRCA1 gene, the entire 4-Mb major histocompatibility complex locus and 18 well-ch
137 abled the anchoring of 100 Mb of WGS and 420 Mb of BAC sequences, an exploration of genetic diversity
142 e assembled a total length of 1.536 Gbp, 444 Mb and 527 Mb of which were assigned to the canephora an
146 vated accession of white lupin (2n = 50, 451 Mb), as well as de novo assemblies of a landrace and a w
147 ome sequencing and analysis suggested a 9.47 Mb genome size with 42 predicted biosynthetic gene clust
149 different sizes (Small 0.5-1 Mb, Medium 1-5 Mb and Large >5 Mb), the numbers and total lengths of RO
150 ly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deleti
151 reciprocal duplication, and the smaller 1.5 Mb LCR22A-B 22q11.2 deletion carry inversions of LCR22B-
152 ng these previous findings, we sequenced 1.5 Mb of the PDE4D genomic locus in 20 families (consisting
154 ic distance range ( approximately 700 kb-1.5 Mb), while interactions involving actively marked DNase
156 14) and female (n = 938) carriers of 0.8-2.5 Mb duplications spanning STS, and non-carrier male (n =
159 embled Han Chinese genomes and detected 29.5 Mb novel genomic sequences and at least 188 novel protei
162 enced the genomes of T. cruzi Y strain (35.5 Mb) and three benznidazole-resistant clones derived from
163 rs the ability to visualize up to thirty 4.5 Mb DNA sequences simultaneously using one of five suppor
165 (Small 0.5-1 Mb, Medium 1-5 Mb and Large >5 Mb), the numbers and total lengths of ROH per individual
166 iated multi-megabase deletions of the Slx (5 Mb) and Slxl1 (2.3Mb) ampliconic regions result in post-
167 ing RNA (mencRNA) genes transcribed from 1.5-Mb intervals surrounding 139 breast cancer GWAS signals
168 oma, we find that T is associated with a 1.5-Mb region containing 'super-enhancers' and is the most h
169 Of these DMCs, 52% were located in one 15.5-Mb locus on chromosome 13, which encompassed the Bhmt ge
172 reorganization including the removal of ~50 Mb from thousands of loci called internal eliminated seq
177 a total length of 1.536 Gbp, 444 Mb and 527 Mb of which were assigned to the canephora and eugenioid
180 mbled a high-quality genome sequence of ~542 Mb and found that retrotransposon proliferation contribu
182 (Oncorhynchus mykiss) and characterize a 55-Mb double-inversion supergene that mediates sex-specific
184 Mb, and 14 contigs ranging from 0.35 to 4.58 Mb with an N50 of 2.86 Mb were assembled, including 4 co
185 210 kb region on chromosome 11 (50.37-50.58 Mb, mm10) containing two protein-coding genes (Hnrnph1,
186 riants, which overall account for nearly 580 Mb of DNA sequence not included in the reference genome
187 sorder caused by hemizygous deletion of ~1.6 Mb affecting 26 genes on chromosome 7 (7q11.23) and is c
188 inantly inverted and separated by up to ~1.6 Mb, an extraordinary distance for homology-based DNA rep
189 We obtained a genome assembly totaling 227.6 Mb of the estimated almond genome size of 238 Mb, of whi
191 several contigs, with combined length of 4.6 Mb and with 147 gene models, were identified as belongin
192 e constructed directed assemblies of the 4.6 Mb E. coli genome, 48.5 kb lambda genome, and a represen
194 ents involving up to 65 breakpoints and 60.6 Mb across four chromosomes, further defining rare catego
196 curvula have been obtained by sequencing 602 Mb of a diploid genotype using a strategy that combined
197 However, a novel region on BTA20 (55-63 Mb) for SCK2 was also identified, which was not reported
198 map was also successfully extended from 658 Mb to 969 Mb by assigning unplaced scaffolds to the pseu
202 Two combinatorial libraries totaling 0.7 Mb were constructed: An expression library of 6 partial
204 EMISH to human lymphoblastoid cells at a 1.7 Mb segment of the genome and visualize a large number of
208 Mb and a total size, in chromosomes, of 726 Mb, which has been corroborated by a high-resolution lin
209 scanned 93 domestication sweeps occupying 74 Mb of the A subgenome and 104 Mb of the D subgenome, and
210 plex gene family, the DNA sequence of a 1.75-Mb genomic region spanning the Gli-2 locus was analyzed
211 sis showed that these children shared a 4.76 Mb region of homozygosity on chromosome 1, with an ident
215 8% identity to N2 but with an additional 1.8 Mb including tandem repeat expansions and genome duplica
218 Recombination hotspots occur once per 23.8 Mb on average and account for ~9% of the physical map le
221 16), which depends on contraction of the 2.8-Mb-long immunoglobulin heavy chain (Igh) locus by Pax5(1
222 llowing, for example, the detection of a 7.8-Mb inversion on Chromosome 12 underlying ecological adap
223 ing from 0.35 to 4.58 Mb with an N50 of 2.86 Mb were assembled, including 4 contigs with telomeric se
226 oximately 1.2-Gb genome (scaffold N50 = 1.88 Mb) with at least 26 723 predicted genes for E. ulmoides
233 onsensus sequencing reads, an additional 8.9 Mb of DNA sequence was mappable, variant calling achieve
235 ng-by-sequencing analyses and identify a 3.9-Mb genomic interval where the lavender variant resides.
237 lso successfully extended from 658 Mb to 969 Mb by assigning unplaced scaffolds to the pseudo-chromos
238 symbiont's free-living relatives (4.29-4.97 Mb) but retains a versatile and energy-efficient metabol
239 le a high-quality genome (contig N50 of 6.99 Mb) of the apple anther-derived homozygous line HFTH1, i
241 g of alpha,beta-unsaturated aldehydes affect Mb oxidation and the onset of lipid oxidation are discus
243 to promote heme insertion into immature apo-Mb, and thus generate functional Mb during muscle myotub
244 on of C2C12 myoblasts into myotubes, the apo-Mb-hsp90 complex associates with 5 cell cochaperons, Hsp
246 es being separated by tens of million bases (Mb) along genomic sequence show a significantly higher t
247 ve a N50 contig length of 7.7 million bases (Mb) directly from long-read assembly, compared to those
251 and increase in BMI by 0.14 kg/m(2) for each Mb of total deletion burden (P = 2.5 x 10(-10), 6.0 x 10
258 ed a role for heat shock protein (hsp) 90 in Mb maturation in C2C12 skeletal muscle myoblasts and cel
263 of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have congenital heart disease
265 e genome with a contig N50 of >15 megabases (Mb) and concordance of 99.997%, substantially outperform
269 , < 1%, 47%) versus TMB of fewer than 10 mut/Mb (n = 50: PD-L1, >= 1%, 18%; PD-L1, < 1%, 5%), and pro
272 igher in patients with TMB of 10 or more mut/Mb (n = 48: PD-L1, >= 1%, 48%; PD-L1, < 1%, 47%) versus
273 onger in patients with TMB of 10 or more mut/Mb versus TMB of fewer than 10 mut/Mb (median, 7.1 v 2.6
276 ups based on TMB level: low (< 5.5 mutations/Mb), intermediate (5.5-19.5 mutations/Mb), and high (>=
284 ertensive effects and mechanism of action of Mb on N(G)-Nitro-L-arginine Methyl Ester (L-NAME) and De
292 despite sometimes being separated by tens of Mb along the genomic sequence than those belonging to di
293 nfer loops averaging 0.8-1.0 megabase pairs (Mb) in early prophase and extending to 1.5-2.0 Mb in lat
294 an genomes and recover 33-79 megabase pairs (Mb) of duplications in which approximately half of the l
295 proliferative fitness ( approximately 3% per Mb), slowed tumor growth, and reduced metastatic progres
296 64)Cu-NODAGA-PSMA-IgG and (64)Cu-NODAGA-PSMA-Mb retained the ability to bind cell surface PSMA, and b