ライフサイエンスコーパス: Merkel cell

1 type I (SAI) neurons innervate skin-derived Merkel cells.

2 regions where Bdnf was deleted in embryonic Merkel cells.

3 seen during postnatal development of normal Merkel cells.

4 ratinocytes in juxtaposition with innervated Merkel cells.

5 er Atoh1 was sufficient to create additional Merkel cells.

6 ly activated cation channel, is expressed in Merkel cells.

7 e- or pre-B cell rather than the postmitotic Merkel cells.

8 rhans cells, while CK20 did not identify any Merkel cells.

9 cerebellum, hair cells of the inner ear, and Merkel cells.

10 (+) CD200(-) epidermis does not give rise to Merkel cells.

11 e rise to the epidermis, hair follicles, and Merkel cells.

12 s express several markers detected in normal Merkel cells, a nonproliferative population of neuroendo

13 increase in the number of lineage-committed Merkel cells, a specialized subtype of skin cells involv

14 Merkel cell ablation also decreased downstream TrkB sign

15 Here we show that Merkel cells actively participate in touch reception in

16 Together, these findings indicate that Merkel cells actively tune mechanosensory responses to f

17 cts of touch sensation remain intact without Merkel cell activity.

18 nd signaling pathways required for targeting Merkel-cell afferents to discrete mechanosensory compart

19 Surprisingly, Merkel cells also mediate allodynia, providing a new cel

20 ed stem cell niches and that might relate to Merkel cell and melanocyte ontogeny and tumorigenesis.

21 l discs are tactile end organs consisting of Merkel cells and Abeta-afferent nerve endings and are lo

22 Synapse-like junctions are observed between Merkel cells and associated afferents, and yet it is unc

23 for a two-receptor-site model, in which both Merkel cells and innervating afferents act together as m

24 l as diverse nonneuronal cell types, such as Merkel cells and intestinal secretory lineages.

25 .5 (E16.5), touch domes emerge as patches of Merkel cells and keratinocytes clustered with a previous

26 cent parallel studies clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel

27 anding controversy regarding the function of Merkel cells and their afferent nerve fiber partners.

28 onal epidermal barrier, formation of ectopic Merkel cells, and defective postnatal development of hai

29 onal epidermal barrier, formation of ectopic Merkel cells, and defective postnatal hair follicle deve

30 es: sebaceous glands, arrector pili muscles, Merkel cells, and sensory nerve endings.

31 Merkel cells are absent from these areas in Atoh1(CKO) a

32 ogenetic approaches in intact skin show that Merkel cells are both necessary and sufficient for susta

33 Thus, mammalian Merkel cells are derived from the skin lineage.

34 Merkel cells are essential for these tactile discriminat

35 ted afferents, and yet it is unclear whether Merkel cells are inherently mechanosensitive or whether

36 Merkel cells are mechanosensitive skin cells whose produ

37 that Piezo2 and Ca(2+)-action potentials in Merkel cells are required for behavioral tactile respons

38 We show that Merkel cells are required for the molecular and function

39 Merkel cells are specialized cells in the skin that are

40 Merkel cells are, therefore, required for the proper enc

41 Ikeda et al. now implicate Merkel cells as the primary sites of tactile transductio

42 Merkel-cell associated afferents are thought to play a m

43 via K14Cre resulted in a decreased number of Merkel cells but had no effect on other epithelial compa

44 gina and vulva need to be distinguished from Merkel cell cancers.

45 ients, with minor regressions in gastric and Merkel cell cancers.

46 eins such as MCV sT, which may contribute to Merkel cell carcinogenesis.

47 were found after Kaposi sarcoma (685.68) and Merkel cell carcinoma (117.23).

48 nts), squamous cell carcinoma (26 patients), Merkel cell carcinoma (6 patients), pigmented epithelioi

49 therapy-refractory, histologically confirmed Merkel cell carcinoma (aged >/=18 years) were enrolled f

50 cinoma (SCC) and rare skin tumors, including Merkel cell carcinoma (MCC) and dermatofibrosarcoma prot

51 ator of Merkel cell development, its role in Merkel cell carcinoma (MCC) carcinogenesis remains contr

52 le has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumo

53 ous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs recei

54 Merkel cell carcinoma (MCC) is a cutaneous neuroendocrin

55 Merkel cell carcinoma (MCC) is a highly aggressive neuro

56 Merkel cell carcinoma (MCC) is a highly aggressive neuro

57 Merkel cell carcinoma (MCC) is a highly malignant neuroe

58 Merkel cell carcinoma (MCC) is a lethal skin cancer that

59 Merkel cell carcinoma (MCC) is a malignant neuroendocrin

60 Merkel cell carcinoma (MCC) is a neoplasm thought to ori

61 Merkel cell carcinoma (MCC) is a polyomavirus-associated

62 Merkel cell carcinoma (MCC) is a rare and aggressive cut

63 Merkel cell carcinoma (MCC) is a rare and aggressive for

64 Merkel cell carcinoma (MCC) is a rare and aggressive, ye

65 Merkel cell carcinoma (MCC) is a rare and deadly neuroen

66 Merkel cell carcinoma (MCC) is a rare and highly aggress

67 Merkel cell carcinoma (MCC) is a rare but aggressive ski

68 Merkel cell carcinoma (MCC) is a rare but highly aggress

69 Merkel cell carcinoma (MCC) is a rare, aggressive skin c

70 Merkel cell carcinoma (MCC) is a rare, aggressive, neuro

71 Merkel cell carcinoma (MCC) is a rare, highly aggressive

72 Merkel cell carcinoma (MCC) is a relatively rare, potent

73 Merkel cell carcinoma (MCC) is an aggressive cutaneous m

74 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

75 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

76 Merkel cell carcinoma (MCC) is an aggressive skin cancer

77 Merkel cell carcinoma (MCC) is an aggressive skin cancer

78 Merkel cell carcinoma (MCC) is an aggressive, polyomavir

79 Merkel cell carcinoma (MCC) is an uncommon but highly in

80 Merkel cell carcinoma (MCC) is an uncommon, but highly m

81 adiation therapy (RT) to the primary site in Merkel cell carcinoma (MCC) is not uncommon.

82 targeted therapeutic intervention.IMPORTANCE Merkel cell carcinoma (MCC) is the most aggressive cutan

83 Merkel cell carcinoma (MCC) is the most aggressive skin

84 The literature on Merkel cell carcinoma (MCC) of the eyelid remains scarce

85 uman polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens.

86 Merkel cell carcinoma (MCC) tumor cells express several

87 avirus (MCPyV) is frequently associated with Merkel cell carcinoma (MCC), a highly aggressive neuroen

88 Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a lethal form of skin cance

89 n polyomavirus etiologically associated with Merkel cell carcinoma (MCC), a rare and aggressive form

90 Merkel cell carcinoma (MCC), a rare but aggressive cutan

91 to be clonally integrated in 80% of cases of Merkel cell carcinoma (MCC), a rare but aggressive form

92 or clinical applications of such pathways in Merkel cell carcinoma (MCC), a rare but lethal cutaneous

93 irus (MCPyV) causes the majority of cases of Merkel cell carcinoma (MCC), an aggressive skin cancer w

94 ed to support the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extremely lethal form of

95 l polyomavirus (MCPyV) in the development of Merkel cell carcinoma (MCC), making MCPyV the first poly

96 skin tumors, basal cell carcinoma (BCC) and Merkel cell carcinoma (MCC), with overlapping histologic

97 he biophysical properties of piezo2 in human Merkel cell carcinoma (MCC)-13 cells; piezo2 is a low-th

98 Merkel cell carcinoma (MCC)-a neuroendocrine cancer of t

99 yomavirus (MCPyV) plays an important role in Merkel cell carcinoma (MCC).

100 ients who underwent definitive treatment for Merkel cell carcinoma (MCC).

101 genome has been observed in at least 80% of Merkel cell carcinoma (MCC).

102 the main oncoprotein for the development of Merkel cell carcinoma (MCC).

103 to explain many of the enigmatic features of Merkel cell carcinoma (MCC).

104 rade neuroendocrine neoplasm consistent with Merkel cell carcinoma (MCC).

105 e development of an aggressive human cancer, Merkel cell carcinoma (MCC).

106 ated with an aggressive form of skin cancer, Merkel cell carcinoma (MCC).

107 iltrate informs patient prognosis in primary Merkel cell carcinoma beyond the T-cell density.

108 to the host genome correlate with 80% of all Merkel cell carcinoma cases.

109 proliferation of Merkel cell polyomavirus(+) Merkel cell carcinoma cell lines.

110 We conclude that MCV sT is required for Merkel cell carcinoma growth, but its in vitro transform

111 es of melanoma, squamous cell carcinoma, and Merkel cell carcinoma in this high-risk population.

112 Merkel cell carcinoma is a highly aggressive form of ski

113 In contrast, Merkel cell carcinoma is a rare and aggressive malignanc

114 Merkel cell carcinoma is a rare cutaneous neoplasm.

115 Merkel cell carcinoma is a rare skin cancer associated w

116 Merkel cell carcinoma is a rare, aggressive skin cancer

117 vances, and areas of controversy in NMSC and Merkel cell carcinoma of the head and neck.

118 e recently been discovered: MCV was found in Merkel cell carcinoma samples, while Karolinska Institut

119 noclonal antibody, in patients with stage IV Merkel cell carcinoma that had progressed after cytotoxi

120 that the 81% of patients with virus-positive Merkel cell carcinoma tumors had earlier stage disease a

121 Prior studies associating Merkel cell carcinoma viral status with prognosis have i

122 ons; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomaviru

123 yV-induced cellular proliferation.IMPORTANCE Merkel cell carcinoma was first described in 1972 as a n

124 The majority of Merkel cell carcinoma, a highly aggressive neuroendocrin

125 avirus Merkel cell polyomavirus (MCV) causes Merkel cell carcinoma, an aggressive but rare human skin

126 Seven cancers (non-Hodgkin lymphoma, Merkel cell carcinoma, gastric adenocarcinoma, hepatocel

127 d in the USA for the treatment of metastatic Merkel cell carcinoma, has shown antitumour activity and

128 progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic rash or trichodysplasia

129 MCV) causes an aggressive human skin cancer, Merkel cell carcinoma, through expression of small T (sT

130 made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-B

131 -associated T cells correlates with improved Merkel cell carcinoma-specific survival, but the prognos

132 esents a new therapeutic option for advanced Merkel cell carcinoma.

133 tient for prostate cancer, and 1 patient for Merkel cell carcinoma.

134 either melanoma, squamous cell carcinoma, or Merkel cell carcinoma.

135 squamous cell carcinoma, Kaposi sarcoma, and Merkel cell carcinoma.

136 es implicates MCV as an etiological agent of Merkel cell carcinoma.

137 tal risk factor and prognostic biomarker for Merkel cell carcinoma.

138 epresent a potential therapeutic approach in Merkel cell carcinoma.

139 Merkel-cell carcinoma is an aggressive skin cancer that

140 Advanced Merkel-cell carcinoma often responds to chemotherapy, bu

141 with pembrolizumab in patients with advanced Merkel-cell carcinoma was associated with an objective r

142 lled study, we assigned adults with advanced Merkel-cell carcinoma who had received no previous syste

143 patients with trunk/limb sarcomas, melanoma, Merkel-cell carcinoma, and colorectal/lung cancer.

144 t is likely involved in the etiology of most Merkel cell carcinomas (MCC).

145 Merkel cell carcinomas (MCCs) are rare but highly malign

146 ting conclusions regarding the proportion of Merkel cell carcinomas (MCCs) that contain the Merkel ce

147 Human Merkel cell carcinomas (MCCs) that harbor a clonally int

148 ered in 2008, drives the development of most Merkel cell carcinomas (MCCs) through several canonical

149 MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuro

150 CV) is the recently discovered cause of most Merkel cell carcinomas (MCCs), an aggressive form of non

151 ceptor repertoire associated with 72 primary Merkel cell carcinomas and correlated metrics of the T-c

152 Examination of Merkel cell carcinomas confirmed nuclear SOX2 expression

153 viral T antigens is a common feature of most Merkel cell carcinomas, a primary neuroendocrine skin tu

154 mavirus (MCPyV), the causative agent of most Merkel cell carcinomas.

155 cently described as the cause for most human Merkel cell carcinomas.

156 Merkel cell clusters appear to have direct access to Fz6

157 erents lacking Merkel cells demonstrate that Merkel cells confer high-frequency responses to dynamic

158 We found that mice devoid of Merkel cells could not detect textured surfaces with the

159 Recordings from touch-dome afferents lacking Merkel cells demonstrate that Merkel cells confer high-f

160 iption factor ATOH1 is a master regulator of Merkel cell development, its role in Merkel cell carcino

161 The reduced number of Merkel cells did not affect the number or patterning of

162 The subsequent maturation steps of Merkel cell differentiation are controlled by cooperativ

163 In this study, we analyzed Merkel cell differentiation during development and found

164 y activates Atoh1, the obligate regulator of Merkel cell differentiation.

165 Merkel cells display fast, touch-evoked mechanotransduct

166 Epidermal Merkel cells display features of sensory receptor cells

167 We conclude that BDNF produced by Merkel cells during a precise embryonic period guides SA

168 sed TUBB3(+) and protein gene product 9.5(+) Merkel cells during in vivo repair, after ES.

169 vertebrate touch receptors, which innervate Merkel cells, encode shape and texture.

170 ing Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation.

171 Transgenic mice lacking Merkel cells had normal dorsal root ganglion (DRG) neuro

172 It has been demonstrated that Merkel cells have a role in vertebrate mechanosensation

173 rnover of large T (LT) proteins from BK, JC, Merkel cell, HPyV7 and trichodysplasia spinulosa polyoma

174 s acquired several characteristics of mature Merkel cells in a time frame similar to that seen during

175 nn cells form nerve-like bundles that target Merkel cells in organoid hair follicles, mimicking the n

176 toh1 expression is sufficient to produce new Merkel cells in the epidermis, that epidermal cell compe

177 auchene hair follicles and by mechanosensory Merkel cells in the touch domes of guard hairs.

178 lation of Sox2 results in a dramatic loss of Merkel cells, indicating that Sox2 is a critical regulat

179 r of differentiated cells in the case of the Merkel cell lineage and hair follicle type in the case o

180 ene expression and reduced expression of key Merkel cell lineage/MCC marker genes, including HES6, SO

181 d that NDRG1 exerts its biological effect in Merkel cell lines by regulating the expression of the cy

182 1 expression drove ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epiderm

183 main type of tactile end organ consisting of Merkel cells (MCs) and Abeta-afferent endings, are highl

184 n and identify the Piezo2 ion channel as the Merkel cell mechanical transducer.

185 Recently, Merkel cell mechanoreceptors were identified as a fourth

186 n, but not in sensory neurons, and show that Merkel-cell mechanosensitivity completely depends on Pie

187 Our results indicate that Piezo2 is the Merkel-cell mechanotransduction channel and provide the

188 expansion of touch dome keratinocytes but no Merkel cell neoplasia.

189 The Merkel cell-neurite complex is a gentle touch receptor i

190 Thus, the Merkel cell-neurite complex is an unique sensory structu

191 y adapting responses in vivo mediated by the Merkel cell-neurite complex show reduced static firing r

192 How the Merkel cell-neurite complex transduces and encodes touch

193 er myelinated mechanoreceptors that form the Merkel cell-neurite complex.

194 results indicate a division of labour in the Merkel cell-neurite complex: Merkel cells signal static

195 se touch domes, which contain mechanosensory Merkel cell-neurite complexes and abut primary hair foll

196 Merkel cell-neurite complexes are located in touch-sensi

197 hanoreceptors that form Meissner corpuscles, Merkel cell-neurite complexes, and circumferential hair

198 We studied this question in Merkel cell-neurite complexes, where slowly adapting typ

199 n and in cutaneous mechanoreceptors known as Merkel-cell-neurite complexes.

200 However, whether Merkel cell/neurite complex function is required for the

201 implicate one of these mechanoreceptors, the Merkel cell/neurite complex, in two-point discrimination

202 These findings suggest that Merkel cell/neurite complexes are essential for texture

203 l cells to directly test the hypothesis that Merkel cell/neurite complexes are necessary to perform t

204 ry afferents can functionally substitute for Merkel cell/neurite complexes in this sensory organ.

205 in stratified squamous epithelial cells and Merkel cells of the skin epidermis.

206 thought to originate from the neuroendocrine Merkel cells of the skin.

207 However, whether Merkel cells or afferent fibres themselves sense mechani

208 -expressing precursors along neuroendocrine (Merkel cell) or melanocytic lines, respectively.

209 It has been shown that Merkel cells originate from epidermal stem cells, but th

210 development and reveal a novel way in which Merkel cells participate in mechanosensation.

211 led 3 (Fz3) can rescue the hair follicle and Merkel cell polarity defects in frizzled 6-null (Fz6(-/-

212 ma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV).

213 Merkel cell polyoma virus (MCV) has been implicated in a

214 hat we believe to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomaviru

215 rkel cell carcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV) and the clinical signif

216 Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell

217 Merkel cell polyomavirus (MCPyV) causes the majority of

218 Merkel cell polyomavirus (MCPyV) causes the majority of

219 ex Virus (HSV), Influenza A Virus (IAV), and Merkel Cell Polyomavirus (MCPyV) could be targeted.

220 MCCs frequently contain Merkel cell polyomavirus (MCPyV) DNA and express viral t

221 In at least 80% of all MCC, Merkel cell polyomavirus (MCPyV) DNA has undergone clona

222 Merkel cell polyomavirus (MCPyV) expressing viral T anti

223 The Merkel cell polyomavirus (MCPyV) genome undergoes clonal

224 Accumulating evidence indicates a role for Merkel cell polyomavirus (MCPyV) in the development of M

225 Merkel cell polyomavirus (MCPyV) is a common infectious

226 Merkel cell polyomavirus (MCPyV) is a human double-stran

227 Merkel cell polyomavirus (MCPyV) is a small, nonenvelope

228 Merkel cell polyomavirus (MCPyV) is frequently associate

229 Merkel cell polyomavirus (MCPyV) is the first human poly

230 Merkel cell polyomavirus (MCPyV) is the newest member of

231 lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage.

232 Merkel cell polyomavirus (MCPyV) may contribute to tumor

233 Merkel cell polyomavirus (MCPyV) plays an important role

234 Mutations, copy number alterations, and Merkel cell polyomavirus (MCPyV) sequence were analyzed

235 d with clonal integration of a polyomavirus, Merkel cell polyomavirus (MCPyV), and MCC tumor cells ex

236 The Merkel cell polyomavirus (MCPyV), discovered in 2008, dr

237 Merkel cell polyomavirus (MCPyV), identified in the majo

238 reading frame (ALTO) in the early region of Merkel cell polyomavirus (MCPyV), the causative agent of

239 reported in 2008 to be caused by a PyV named Merkel cell polyomavirus (MCPyV), the first PyV linked t

240 Notably, ectopic expression of different Merkel cell polyomavirus (MCPyV)-derived truncated large

241 een discovered in the last decade, including Merkel cell polyomavirus (MCPyV).

242 ggressive skin cancer commonly driven by the Merkel cell polyomavirus (MCPyV).

243 Merkel cell polyomavirus (MCV) causes an aggressive huma

244 Merkel cell polyomavirus (MCV) causes an aggressive skin

245 The double-stranded DNA polyomavirus Merkel cell polyomavirus (MCV) causes Merkel cell carcin

246 Merkel cell polyomavirus (MCV) contributes to approximat

247 Clonal integration of Merkel cell polyomavirus (MCV) DNA into the host genome

248 mas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genome have low mutation

249 Merkel cell polyomavirus (MCV) has been recently describ

250 Merkel cell polyomavirus (MCV) infection and DNA integra

251 Merkel cell polyomavirus (MCV) is a newly discovered hum

252 Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in

253 Merkel cell polyomavirus (MCV) is the first polyomavirus

254 Merkel cell polyomavirus (MCV) is the recently discovere

255 Merkel cell polyomavirus (MCV) small T (sT) oncoprotein

256 Merkel cell polyomavirus (MCV) small T antigen (sT) is t

257 Torque teno virus (TTV) and Merkel cell polyomavirus (MCV) were detected by qPCR in

258 y aggressive skin cancer associated with the Merkel cell polyomavirus (MCV).

259 of the skin-is caused by the integration of Merkel cell polyomavirus and persistent expression of la

260 Merkel cell polyomavirus could contribute to the origin

261 cinoma is a rare skin cancer associated with Merkel cell polyomavirus in most cases.

262 crine cancer of the skin, is associated with Merkel cell polyomavirus infection.

263 Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ultraviolet-rad

264 Merkel cell polyomavirus is a newly discovered human can

265 ing mitosis revealed by a viral oncoprotein, Merkel cell polyomavirus small T (MCV sT).

266 verses rodent cell transformation induced by Merkel cell polyomavirus small T antigen viral oncoprote

267 lection was not based on PD-L1 expression or Merkel cell polyomavirus status.

268 Merkel cell polyomavirus was detected in 32 of 38 specim

269 Merkel cell polyomavirus(+) and Merkel cell polyomavirus

270 an option to interfere with proliferation of Merkel cell polyomavirus(+) Merkel cell carcinoma cell l

271 Merkel cell polyomavirus(+) and Merkel cell polyomavirus(-) cells express serine palmito

272 s malignancy linked to a contributory virus (Merkel cell polyomavirus).

273 Merkel cell polyomavirus, trichodysplasia spinulosa poly

274 awi polyomavirus are shed from the skin, and Merkel cell polyomavirus, trichodysplasia spinulosa poly

275 Induced expression of Merkel cell polyomavirus-large tumor antigen in human lu

276 se correlations were mostly preserved in the Merkel cell polyomavirus-negative subgroup.

277 , the median age was 70.5 years, and 64% had Merkel cell polyomavirus-positive tumors.

278 s of Bcl-2 family profile or the presence of Merkel cell polyomavirus.

279 n aggressive skin cancer often caused by the Merkel cell polyomavirus.

280 ne skin tumor frequently associated with the Merkel cell polyomavirus.

281 ked to exposure to ultraviolet light and the Merkel-cell polyomavirus (MCPyV).

282 irus or pseudovirions derived from the BK or Merkel cell polyomaviruses.

283 innervation, and expansion of melanocyte and Merkel cell pool during repair.

284 Here we show that Merkel cells produce touch-sensitive currents in vitro.

285 ding simian virus 40 (SV40), murine PyV, and Merkel cell PyV, are found integrated in the host genome

286 ing rat whisker hair follicles, we show that Merkel cells rather than Abeta-afferent nerve endings ar

287 ion of the stem or progenitor population for Merkel cells remains unknown.

288 Merkel cells sense mechanical stimuli (through Piezo2),

289 f labour in the Merkel cell-neurite complex: Merkel cells signal static stimuli, such as pressure, wh

290 Skin- and Merkel cell-specific deletion of Bdnf during embryogenes

291 characterized by a sequential activation of Merkel cell-specific genes.

292 ription factor Atoh1 is required for initial Merkel cell specification.

293 icating that Sox2 is a critical regulator of Merkel cell specification.

294 ional network required to produce functional Merkel cells that are required for tactile discriminatio

295 We genetically engineered mice that lack Merkel cells to directly test the hypothesis that Merkel

296 eleted Sox2 in DP cells via Blimp1Cre and in Merkel cells via K14Cre.

297 aviruses (KI virus (KIV), WU virus (WUV) and Merkel cell virus (MCV)) to a class that previously had

298 Keratin-17-expressing keratinocytes but not Merkel cells were necessary to establish innervation pat

299 ile stimuli into Ca(2+)-action potentials in Merkel cells, which drive Abeta-afferent nerve endings t

300 enforced by the juxtaposition of TDPCs with Merkel cells within the touch dome niche.