ライフサイエンスコーパス: Merkel cell carcinoma

1 es implicates MCV as an etiological agent of Merkel cell carcinoma.

2 eted neurological disorder in the setting of Merkel cell carcinoma.

3 squamous cell carcinoma, Kaposi sarcoma, and Merkel cell carcinoma.

4 e for unresectable, recurrent, or metastatic Merkel cell carcinoma.

5 2016 was conducted among 3720 patients with Merkel cell carcinoma.

6 Incidence rates of Merkel cell carcinoma.

7 tal risk factor and prognostic biomarker for Merkel cell carcinoma.

8 rcinoma, basal cell carcinoma, melanoma, and Merkel cell carcinoma.

9 and salvage therapeutic option for advanced Merkel cell carcinoma.

10 ephalopathy (PML), BK virus nephropathy, and Merkel cell carcinoma.

11 nitors are and whether they can give rise to Merkel cell carcinoma.

12 epresent a potential therapeutic approach in Merkel cell carcinoma.

13 esents a new therapeutic option for advanced Merkel cell carcinoma.

14 tient for prostate cancer, and 1 patient for Merkel cell carcinoma.

15 either melanoma, squamous cell carcinoma, or Merkel cell carcinoma.

16 n polyomavirus causing the majority of human Merkel cell carcinomas.

17 mavirus (MCPyV), the causative agent of most Merkel cell carcinomas.

18 cently described as the cause for most human Merkel cell carcinomas.

19 were found after Kaposi sarcoma (685.68) and Merkel cell carcinoma (117.23).

20 n cancer, including melanoma (3419 [89.1%]), Merkel cell carcinoma (121 [3.2%]), hemangiosarcoma (104

21 st common cancer (1471 [61.8%]), followed by Merkel cell carcinoma (334 [14.0%]), Kaposi sarcoma (186

22 nts), squamous cell carcinoma (26 patients), Merkel cell carcinoma (6 patients), pigmented epithelioi

23 The majority of Merkel cell carcinoma, a highly aggressive neuroendocrin

24 stage (unresectable, recurrent, or stage IV) Merkel cell carcinoma, a minimum of two tumour lesions m

25 regeneration is of interest to the study of Merkel cell carcinoma, a rare neuroendocrine skin cancer

26 viral T antigens is a common feature of most Merkel cell carcinomas, a primary neuroendocrine skin tu

27 therapy-refractory, histologically confirmed Merkel cell carcinoma (aged >/=18 years) were enrolled f

28 avirus Merkel cell polyomavirus (MCV) causes Merkel cell carcinoma, an aggressive but rare human skin

29 We report a case of Merkel cell carcinoma, an uncommon cutaneous malignancy

30 rus (MCPyV) was identified recently in human Merkel cell carcinomas, an aggressive neuroendocrine ski

31 DG PET may be a useful technique for staging Merkel cell carcinoma and for assessing the tumor respon

32 Unlike Merkel cell carcinoma and melanoma, satellitosis or in-t

33 e outcomes are similar to those observed for Merkel cell carcinoma and melanoma.

34 ceptor repertoire associated with 72 primary Merkel cell carcinomas and correlated metrics of the T-c

35 patients with trunk/limb sarcomas, melanoma, Merkel-cell carcinoma, and colorectal/lung cancer.

36 Melanoma and Merkel cell carcinoma arose disproportionately on sun-ex

37 adiotherapy (SBRT) in patients with advanced Merkel cell carcinoma as a first-line therapy or followi

38 ons resembling clonally expanded variants in Merkel cell carcinomas, as well as novel junctions betwe

39 made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-B

40 iltrate informs patient prognosis in primary Merkel cell carcinoma beyond the T-cell density.

41 to the host genome correlate with 80% of all Merkel cell carcinoma cases.

42 le and female mouse sensory neurons, a human Merkel cell carcinoma cell line and female human iPSC-de

43 proliferation of Merkel cell polyomavirus(+) Merkel cell carcinoma cell lines.

44 Examination of Merkel cell carcinomas confirmed nuclear SOX2 expression

45 We suggest that Merkel cell carcinoma could have an increased incidence

46 Seven cancers (non-Hodgkin lymphoma, Merkel cell carcinoma, gastric adenocarcinoma, hepatocel

47 We conclude that MCV sT is required for Merkel cell carcinoma growth, but its in vitro transform

48 d in the USA for the treatment of metastatic Merkel cell carcinoma, has shown antitumour activity and

49 aneous squamous cell carcinoma, melanoma, or Merkel cell carcinoma if surgery and/or radiotherapy hav

50 ojected that there will be 3023 new cases of Merkel cell carcinoma in 2020 and 5130 new cases in 2030

51 es of melanoma, squamous cell carcinoma, and Merkel cell carcinoma in this high-risk population.

52 e period from 2012 to 2016, the age-adjusted Merkel cell carcinoma incidence rate was 0.66 per 100 00

53 The incidence of Merkel cell carcinoma increased with patient age across

54 Merkel cell carcinoma is a highly aggressive form of ski

55 In contrast, Merkel cell carcinoma is a rare and aggressive malignanc

56 Merkel cell carcinoma is a rare cutaneous neoplasm.

57 Merkel cell carcinoma is a rare neuroendocrine carcinoma

58 Merkel cell carcinoma is a rare skin cancer associated w

59 Merkel cell carcinoma is a rare, aggressive skin cancer

60 Merkel cell carcinoma is among the most aggressive and l

61 IMPORTANCE Merkel cell carcinoma is an aggressive skin cancer that

62 Merkel cell carcinoma is an aggressive, cutaneous, neuro

63 Understanding why the incidence of Merkel cell carcinoma is increasing through underlying f

64 lthough the causative link between MCPyV and Merkel cell carcinoma is well established, the molecular

65 Merkel-cell carcinoma is an aggressive skin cancer that

66 cinoma (SCC) and rare skin tumors, including Merkel cell carcinoma (MCC) and dermatofibrosarcoma prot

67 Merkel cell carcinoma (MCC) and melanoma are important c

68 ator of Merkel cell development, its role in Merkel cell carcinoma (MCC) carcinogenesis remains contr

69 The pathogenesis of 80% of Merkel cell carcinoma (MCC) cases is associated with Mer

70 le has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumo

71 ncoprotein that drives the transformation of Merkel cell carcinoma (MCC) cells by activating transcri

72 the size of local excision (LE) margins for Merkel cell carcinoma (MCC) have not been well establish

73 ous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs recei

74 Merkel cell carcinoma (MCC) is a cutaneous neuroendocrin

75 Merkel cell carcinoma (MCC) is a highly aggressive neuro

76 Merkel cell carcinoma (MCC) is a highly aggressive neuro

77 Merkel cell carcinoma (MCC) is a highly immunogenic skin

78 Merkel cell carcinoma (MCC) is a highly malignant neuroe

79 Merkel cell carcinoma (MCC) is a lethal skin cancer that

80 Merkel cell carcinoma (MCC) is a malignant neuroendocrin

81 Merkel cell carcinoma (MCC) is a neoplasm thought to ori

82 Merkel cell carcinoma (MCC) is a neuroendocrine skin can

83 Merkel cell carcinoma (MCC) is a neuroendocrine tumor ei

84 Merkel cell carcinoma (MCC) is a polyomavirus-associated

85 Merkel cell carcinoma (MCC) is a rare and aggressive cut

86 Merkel cell carcinoma (MCC) is a rare and aggressive for

87 Merkel cell carcinoma (MCC) is a rare and aggressive ski

88 Merkel cell carcinoma (MCC) is a rare and aggressive, ye

89 Merkel cell carcinoma (MCC) is a rare and deadly neuroen

90 Merkel cell carcinoma (MCC) is a rare and highly aggress

91 Merkel cell carcinoma (MCC) is a rare and highly aggress

92 Merkel cell carcinoma (MCC) is a rare but aggressive hum

93 Merkel cell carcinoma (MCC) is a rare but aggressive ski

94 Merkel cell carcinoma (MCC) is a rare but aggressive ski

95 Merkel cell carcinoma (MCC) is a rare but highly aggress

96 Merkel cell carcinoma (MCC) is a rare cutaneous malignan

97 Merkel cell carcinoma (MCC) is a rare cutaneous malignan

98 Merkel cell carcinoma (MCC) is a rare neuroendocrine cut

99 Merkel cell carcinoma (MCC) is a rare skin malignancy th

100 Merkel cell carcinoma (MCC) is a rare, aggressive neuroe

101 Merkel cell carcinoma (MCC) is a rare, aggressive neuroe

102 Merkel cell carcinoma (MCC) is a rare, aggressive skin c

103 Merkel cell carcinoma (MCC) is a rare, aggressive skin c

104 Merkel cell carcinoma (MCC) is a rare, aggressive, neuro

105 Merkel cell carcinoma (MCC) is a rare, but aggressive sk

106 Merkel cell carcinoma (MCC) is a rare, highly aggressive

107 Merkel cell carcinoma (MCC) is a relatively rare, potent

108 Merkel cell carcinoma (MCC) is an aggressive cutaneous m

109 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

110 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

111 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

112 Merkel cell carcinoma (MCC) is an aggressive malignancy

113 Merkel cell carcinoma (MCC) is an aggressive neuroendocr

114 Merkel cell carcinoma (MCC) is an aggressive neuroendocr

115 Merkel cell carcinoma (MCC) is an aggressive skin cancer

116 Merkel cell carcinoma (MCC) is an aggressive skin cancer

117 Merkel cell carcinoma (MCC) is an aggressive skin cancer

118 Merkel cell carcinoma (MCC) is an aggressive skin cancer

119 Merkel cell carcinoma (MCC) is an aggressive, fast-growi

120 Merkel cell carcinoma (MCC) is an aggressive, HLA-I-low,

121 Merkel cell carcinoma (MCC) is an aggressive, polyomavir

122 Merkel cell carcinoma (MCC) is an immunogenic but aggres

123 Merkel cell carcinoma (MCC) is an uncommon but highly in

124 Merkel cell carcinoma (MCC) is an uncommon, but highly m

125 Although virus-negative Merkel cell carcinoma (MCC) is characterized by a high f

126 Delineating these differences in Merkel cell carcinoma (MCC) is needed to better understa

127 adiation therapy (RT) to the primary site in Merkel cell carcinoma (MCC) is not uncommon.

128 imary cancers after a diagnosis of cutaneous Merkel cell carcinoma (MCC) is not well established.

129 targeted therapeutic intervention.IMPORTANCE Merkel cell carcinoma (MCC) is the most aggressive cutan

130 Merkel cell carcinoma (MCC) is the most aggressive skin

131 Merkel cell carcinoma (MCC) is typically caused by the M

132 The literature on Merkel cell carcinoma (MCC) of the eyelid remains scarce

133 Merkel cell carcinoma (MCC) often behaves aggressively;

134 uman polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens.

135 Merkel cell carcinoma (MCC) tumor cells express several

136 For patients with Merkel cell carcinoma (MCC) who are refractory to immune

137 avirus (MCPyV) is frequently associated with Merkel cell carcinoma (MCC), a highly aggressive neuroen

138 Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a lethal form of skin cance

139 study, we investigated the susceptibility of Merkel cell carcinoma (MCC), a neuroendocrine carcinoma

140 rkel cell polyomavirus (MCPyV), was found in Merkel cell carcinoma (MCC), a rare aggressive skin canc

141 n polyomavirus etiologically associated with Merkel cell carcinoma (MCC), a rare and aggressive form

142 Merkel cell carcinoma (MCC), a rare but aggressive cutan

143 to be clonally integrated in 80% of cases of Merkel cell carcinoma (MCC), a rare but aggressive form

144 or clinical applications of such pathways in Merkel cell carcinoma (MCC), a rare but lethal cutaneous

145 ncy is perturbed, the virus can give rise to Merkel cell carcinoma (MCC), an aggressive and difficult

146 as been associated with approximately 80% of Merkel cell carcinoma (MCC), an aggressive and increasin

147 irus (MCPyV) causes the majority of cases of Merkel cell carcinoma (MCC), an aggressive skin cancer w

148 ed to support the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extremely lethal form of

149 l polyomavirus (MCPyV) in the development of Merkel cell carcinoma (MCC), making MCPyV the first poly

150 skin tumors, basal cell carcinoma (BCC) and Merkel cell carcinoma (MCC), with overlapping histologic

151 he biophysical properties of piezo2 in human Merkel cell carcinoma (MCC)-13 cells; piezo2 is a low-th

152 Merkel cell carcinoma (MCC)-a neuroendocrine cancer of t

153 cts as a tumor suppressor and is silenced in Merkel cell carcinoma (MCC).

154 the main oncoprotein for the development of Merkel cell carcinoma (MCC).

155 ds to a highly aggressive skin cancer called Merkel cell carcinoma (MCC).

156 ce imaging in patients treated for stage III Merkel cell carcinoma (MCC).

157 rade neuroendocrine neoplasm consistent with Merkel cell carcinoma (MCC).

158 e development of an aggressive human cancer, Merkel cell carcinoma (MCC).

159 ated with an aggressive form of skin cancer, Merkel cell carcinoma (MCC).

160 yomavirus (MCPyV) plays an important role in Merkel cell carcinoma (MCC).

161 ients who underwent definitive treatment for Merkel cell carcinoma (MCC).

162 genome has been observed in at least 80% of Merkel cell carcinoma (MCC).

163 to explain many of the enigmatic features of Merkel cell carcinoma (MCC).

164 t is likely involved in the etiology of most Merkel cell carcinomas (MCC).

165 Merkel cell carcinomas (MCCs) are rare but highly malign

166 ting conclusions regarding the proportion of Merkel cell carcinomas (MCCs) that contain the Merkel ce

167 Human Merkel cell carcinomas (MCCs) that harbor a clonally int

168 ered in 2008, drives the development of most Merkel cell carcinomas (MCCs) through several canonical

169 MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuro

170 CV) is the recently discovered cause of most Merkel cell carcinomas (MCCs), an aggressive form of non

171 nto the genome of approximately 80% of human Merkel cell carcinomas (MCCs).

172 vances, and areas of controversy in NMSC and Merkel cell carcinoma of the head and neck.

173 Advanced Merkel-cell carcinoma often responds to chemotherapy, bu

174 progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic rash or trichodysplasia

175 e recently been discovered: MCV was found in Merkel cell carcinoma samples, while Karolinska Institut

176 ring CosMx fields of vision from a cohort of Merkel cell carcinoma samples.

177 mab and ipilimumab in patients with advanced Merkel cell carcinoma showed a high ORR with durable res

178 posi sarcoma (SIR, 20.5; 95% CI, 17.7-23.7), Merkel cell carcinoma (SIR, 16.2; 95% CI, 14.5-18.1), an

179 -associated T cells correlates with improved Merkel cell carcinoma-specific survival, but the prognos

180 association with Kaposi sarcoma and include Merkel cell carcinoma, squamous cell carcinoma, and high

181 9, 95% confidence interval = 3.13-8.11), and Merkel cell carcinoma (standardized incidence ratio = 3.

182 noclonal antibody, in patients with stage IV Merkel cell carcinoma that had progressed after cytotoxi

183 MCV) causes an aggressive human skin cancer, Merkel cell carcinoma, through expression of small T (sT

184 that the 81% of patients with virus-positive Merkel cell carcinoma tumors had earlier stage disease a

185 has been shown to be the etiologic cause of Merkel cell carcinoma, understanding the mechanisms by w

186 Prior studies associating Merkel cell carcinoma viral status with prognosis have i

187 ons; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomaviru

188 t part of the initial increased incidence of Merkel cell carcinoma was associated with increased dete

189 yV-induced cellular proliferation.IMPORTANCE Merkel cell carcinoma was first described in 1972 as a n

190 idence for diffuse large B-cell lymphoma and Merkel cell carcinoma was observed only among people liv

191 with pembrolizumab in patients with advanced Merkel-cell carcinoma was associated with an objective r

192 ell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcrip

193 ed melanoma or basal, cutaneous squamous, or Merkel cell carcinomas were eligible.

194 lled study, we assigned adults with advanced Merkel-cell carcinoma who had received no previous syste