ライフサイエンスコーパス: Merkel

1 Merkel cell ablation also decreased downstream TrkB sign

2 Merkel cell carcinoma (MCC) is a cutaneous neuroendocrin

3 Merkel cell carcinoma (MCC) is a highly aggressive neuro

4 Merkel cell carcinoma (MCC) is a highly aggressive neuro

5 Merkel cell carcinoma (MCC) is a highly malignant neuroe

6 Merkel cell carcinoma (MCC) is a lethal skin cancer that

7 Merkel cell carcinoma (MCC) is a malignant neuroendocrin

8 Merkel cell carcinoma (MCC) is a neoplasm thought to ori

9 Merkel cell carcinoma (MCC) is a polyomavirus-associated

10 Merkel cell carcinoma (MCC) is a rare and aggressive cut

11 Merkel cell carcinoma (MCC) is a rare and aggressive for

12 Merkel cell carcinoma (MCC) is a rare and aggressive, ye

13 Merkel cell carcinoma (MCC) is a rare and deadly neuroen

14 Merkel cell carcinoma (MCC) is a rare and highly aggress

15 Merkel cell carcinoma (MCC) is a rare but aggressive ski

16 Merkel cell carcinoma (MCC) is a rare but highly aggress

17 Merkel cell carcinoma (MCC) is a rare, aggressive skin c

18 Merkel cell carcinoma (MCC) is a rare, aggressive, neuro

19 Merkel cell carcinoma (MCC) is a rare, highly aggressive

20 Merkel cell carcinoma (MCC) is a relatively rare, potent

21 Merkel cell carcinoma (MCC) is an aggressive cutaneous m

22 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

23 Merkel cell carcinoma (MCC) is an aggressive cutaneous n

24 Merkel cell carcinoma (MCC) is an aggressive skin cancer

25 Merkel cell carcinoma (MCC) is an aggressive skin cancer

26 Merkel cell carcinoma (MCC) is an aggressive, polyomavir

27 Merkel cell carcinoma (MCC) is an uncommon but highly in

28 Merkel cell carcinoma (MCC) is an uncommon, but highly m

29 Merkel cell carcinoma (MCC) is the most aggressive skin

30 Merkel cell carcinoma (MCC) tumor cells express several

31 Merkel cell carcinoma (MCC), a rare but aggressive cutan

32 Merkel cell carcinoma (MCC)-a neuroendocrine cancer of t

33 Merkel cell carcinoma is a highly aggressive form of ski

34 Merkel cell carcinoma is a rare cutaneous neoplasm.

35 Merkel cell carcinoma is a rare skin cancer associated w

36 Merkel cell carcinoma is a rare, aggressive skin cancer

37 Merkel cell carcinomas (MCCs) are rare but highly malign

38 Merkel cell clusters appear to have direct access to Fz6

39 Merkel cell polyoma virus (MCV) has been implicated in a

40 Merkel cell polyomavirus (MCPyV) causes the majority of

41 Merkel cell polyomavirus (MCPyV) causes the majority of

42 Merkel cell polyomavirus (MCPyV) expressing viral T anti

43 Merkel cell polyomavirus (MCPyV) is a human double-stran

44 Merkel cell polyomavirus (MCPyV) is a small, nonenvelope

45 Merkel cell polyomavirus (MCPyV) is frequently associate

46 Merkel cell polyomavirus (MCPyV) is the first human poly

47 Merkel cell polyomavirus (MCPyV) is the newest member of

48 Merkel cell polyomavirus (MCPyV) may contribute to tumor

49 Merkel cell polyomavirus (MCPyV) plays an important role

50 Merkel cell polyomavirus (MCPyV), identified in the majo

51 Merkel cell polyomavirus (MCV) causes an aggressive huma

52 Merkel cell polyomavirus (MCV) causes an aggressive skin

53 Merkel cell polyomavirus (MCV) contributes to approximat

54 Merkel cell polyomavirus (MCV) has been recently describ

55 Merkel cell polyomavirus (MCV) infection and DNA integra

56 Merkel cell polyomavirus (MCV) is a newly discovered hum

57 Merkel cell polyomavirus (MCV) is the first polyomavirus

58 Merkel cell polyomavirus (MCV) is the recently discovere

59 Merkel cell polyomavirus (MCV) small T (sT) oncoprotein

60 Merkel cell polyomavirus (MCV) small T antigen (sT) is t

61 Merkel cell polyomavirus could contribute to the origin

62 Merkel cell polyomavirus is a newly discovered human can

63 Merkel cell polyomavirus was detected in 32 of 38 specim

64 Merkel cell polyomavirus(+) and Merkel cell polyomavirus

65 Merkel cell polyomavirus, trichodysplasia spinulosa poly

66 Merkel cell-neurite complexes are located in touch-sensi

67 Merkel cells are essential for these tactile discriminat

68 Merkel cells are mechanosensitive skin cells whose produ

69 Merkel cells display fast, touch-evoked mechanotransduct

70 Merkel cells sense mechanical stimuli (through Piezo2),

71 Merkel discs are tactile end organs consisting of Merkel

72 Merkel discs transduce touch into slowly adapting impuls

73 Merkel-cell associated afferents are thought to play a m

74 Merkel-cell carcinoma is an aggressive skin cancer that

75 sed TUBB3(+) and protein gene product 9.5(+) Merkel cells during in vivo repair, after ES.

76 er Atoh1 was sufficient to create additional Merkel cells.

77 Advanced Merkel-cell carcinoma often responds to chemotherapy, bu

78 esents a new therapeutic option for advanced Merkel cell carcinoma.

79 with pembrolizumab in patients with advanced Merkel-cell carcinoma was associated with an objective r

80 lled study, we assigned adults with advanced Merkel-cell carcinoma who had received no previous syste

81 to the host genome correlate with 80% of all Merkel cell carcinoma cases.

82 MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuro

83 In this study, we analyzed Merkel cell differentiation during development and found

84 were found after Kaposi sarcoma (685.68) and Merkel cell carcinoma (117.23).

85 Mutations, copy number alterations, and Merkel cell polyomavirus (MCPyV) sequence were analyzed

86 skin tumors, basal cell carcinoma (BCC) and Merkel cell carcinoma (MCC), with overlapping histologic

87 es of melanoma, squamous cell carcinoma, and Merkel cell carcinoma in this high-risk population.

88 in stratified squamous epithelial cells and Merkel cells of the skin epidermis.

89 cerebellum, hair cells of the inner ear, and Merkel cells.

90 led 3 (Fz3) can rescue the hair follicle and Merkel cell polarity defects in frizzled 6-null (Fz6(-/-

91 e rise to the epidermis, hair follicles, and Merkel cells.

92 ients, with minor regressions in gastric and Merkel cell cancers.

93 ex Virus (HSV), Influenza A Virus (IAV), and Merkel Cell Polyomavirus (MCPyV) could be targeted.

94 innervation, and expansion of melanocyte and Merkel cell pool during repair.

95 ous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs recei

96 ing Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation.

97 vances, and areas of controversy in NMSC and Merkel cell carcinoma of the head and neck.

98 Merkel cell polyomavirus(+) and Merkel cell polyomavirus(-) cells express serine palmito

99 ding simian virus 40 (SV40), murine PyV, and Merkel cell PyV, are found integrated in the host genome

100 squamous cell carcinoma, Kaposi sarcoma, and Merkel cell carcinoma.

101 awi polyomavirus are shed from the skin, and Merkel cell polyomavirus, trichodysplasia spinulosa poly

102 Skin- and Merkel cell-specific deletion of Bdnf during embryogenes

103 Torque teno virus (TTV) and Merkel cell polyomavirus (MCV) were detected by qPCR in

104 rhans cells, while CK20 did not identify any Merkel cells.

105 n and in cutaneous mechanoreceptors known as Merkel-cell-neurite complexes.

106 l as diverse nonneuronal cell types, such as Merkel cells and intestinal secretory lineages.

107 Prior studies associating Merkel cell carcinoma viral status with prognosis have i

108 Synapse-like junctions are observed between Merkel cells and associated afferents, and yet it is unc

109 for a two-receptor-site model, in which both Merkel cells and innervating afferents act together as m

110 verses rodent cell transformation induced by Merkel cell polyomavirus small T antigen viral oncoprote

111 We conclude that BDNF produced by Merkel cells during a precise embryonic period guides SA

112 e development of an aggressive human cancer, Merkel cell carcinoma (MCC).

113 ated with an aggressive form of skin cancer, Merkel cell carcinoma (MCC).

114 MCV) causes an aggressive human skin cancer, Merkel cell carcinoma, through expression of small T (sT

115 avirus Merkel cell polyomavirus (MCV) causes Merkel cell carcinoma, an aggressive but rare human skin

116 le has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumo

117 lanceolate; clublike; and rete-ridge collar Merkel.

118 increase in the number of lineage-committed Merkel cells, a specialized subtype of skin cells involv

119 f labour in the Merkel cell-neurite complex: Merkel cells signal static stimuli, such as pressure, wh

120 therapy-refractory, histologically confirmed Merkel cell carcinoma (aged >/=18 years) were enrolled f

121 MCCs frequently contain Merkel cell polyomavirus (MCPyV) DNA and express viral t

122 In contrast, Merkel cell carcinoma is a rare and aggressive malignanc

123 hanoreceptors that form Meissner corpuscles, Merkel cell-neurite complexes, and circumferential hair

124 type I (SAI) neurons innervate skin-derived Merkel cells.

125 Notably, ectopic expression of different Merkel cell polyomavirus (MCPyV)-derived truncated large

126 onal epidermal barrier, formation of ectopic Merkel cells, and defective postnatal development of hai

127 onal epidermal barrier, formation of ectopic Merkel cells, and defective postnatal hair follicle deve

128 regions where Bdnf was deleted in embryonic Merkel cells.

129 Epidermal Merkel cells display features of sensory receptor cells

130 tal risk factor and prognostic biomarker for Merkel cell carcinoma.

131 llicle, such alignment was observed only for Merkel afferents; angular tuning of the other afferent t

132 tient for prostate cancer, and 1 patient for Merkel cell carcinoma.

133 ons; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomaviru

134 We conclude that MCV sT is required for Merkel cell carcinoma growth, but its in vitro transform

135 Accumulating evidence indicates a role for Merkel cell polyomavirus (MCPyV) in the development of M

136 ry afferents can functionally substitute for Merkel cell/neurite complexes in this sensory organ.

137 ients who underwent definitive treatment for Merkel cell carcinoma (MCC).

138 gina and vulva need to be distinguished from Merkel cell cancers.

139 ional network required to produce functional Merkel cells that are required for tactile discriminatio

140 , the median age was 70.5 years, and 64% had Merkel cell polyomavirus-positive tumors.

141 Human Merkel cell carcinomas (MCCs) that harbor a clonally int

142 he biophysical properties of piezo2 in human Merkel cell carcinoma (MCC)-13 cells; piezo2 is a low-th

143 cently described as the cause for most human Merkel cell carcinomas.

144 Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in

145 Ikeda et al. now implicate Merkel cells as the primary sites of tactile transductio

146 targeted therapeutic intervention.IMPORTANCE Merkel cell carcinoma (MCC) is the most aggressive cutan

147 yV-induced cellular proliferation.IMPORTANCE Merkel cell carcinoma was first described in 1972 as a n

148 -associated T cells correlates with improved Merkel cell carcinoma-specific survival, but the prognos

149 eleted Sox2 in DP cells via Blimp1Cre and in Merkel cells via K14Cre.

150 epresent a potential therapeutic approach in Merkel cell carcinoma.

151 uman polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens.

152 d that NDRG1 exerts its biological effect in Merkel cell lines by regulating the expression of the cy

153 ly activated cation channel, is expressed in Merkel cells.

154 ed to support the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extremely lethal form of

155 or clinical applications of such pathways in Merkel cell carcinoma (MCC), a rare but lethal cutaneous

156 that Piezo2 and Ca(2+)-action potentials in Merkel cells are required for behavioral tactile respons

157 ile stimuli into Ca(2+)-action potentials in Merkel cells, which drive Abeta-afferent nerve endings t

158 We studied this question in Merkel cell-neurite complexes, where slowly adapting typ

159 ator of Merkel cell development, its role in Merkel cell carcinoma (MCC) carcinogenesis remains contr

160 yomavirus (MCPyV) plays an important role in Merkel cell carcinoma (MCC).

161 adiation therapy (RT) to the primary site in Merkel cell carcinoma (MCC) is not uncommon.

162 een discovered in the last decade, including Merkel cell polyomavirus (MCPyV).

163 ription factor Atoh1 is required for initial Merkel cell specification.

164 vertebrate touch receptors, which innervate Merkel cells, encode shape and texture.

165 ratinocytes in juxtaposition with innervated Merkel cells.

166 mas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genome have low mutation

167 noclonal antibody, in patients with stage IV Merkel cell carcinoma that had progressed after cytotoxi

168 rnover of large T (LT) proteins from BK, JC, Merkel cell, HPyV7 and trichodysplasia spinulosa polyoma

169 ene expression and reduced expression of key Merkel cell lineage/MCC marker genes, including HES6, SO

170 We genetically engineered mice that lack Merkel cells to directly test the hypothesis that Merkel

171 Recordings from touch-dome afferents lacking Merkel cells demonstrate that Merkel cells confer high-f

172 Transgenic mice lacking Merkel cells had normal dorsal root ganglion (DRG) neuro

173 progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic rash or trichodysplasia

174 Seven cancers (non-Hodgkin lymphoma, Merkel cell carcinoma, gastric adenocarcinoma, hepatocel

175 s acquired several characteristics of mature Merkel cells in a time frame similar to that seen during

176 In at least 80% of all MCC, Merkel cell polyomavirus (MCPyV) DNA has undergone clona

177 auchene hair follicles and by mechanosensory Merkel cells in the touch domes of guard hairs.

178 se touch domes, which contain mechanosensory Merkel cell-neurite complexes and abut primary hair foll

179 patients with trunk/limb sarcomas, melanoma, Merkel-cell carcinoma, and colorectal/lung cancer.

180 d in the USA for the treatment of metastatic Merkel cell carcinoma, has shown antitumour activity and

181 ered in 2008, drives the development of most Merkel cell carcinomas (MCCs) through several canonical

182 CV) is the recently discovered cause of most Merkel cell carcinomas (MCCs), an aggressive form of non

183 viral T antigens is a common feature of most Merkel cell carcinomas, a primary neuroendocrine skin tu

184 mavirus (MCPyV), the causative agent of most Merkel cell carcinomas.

185 es: sebaceous glands, arrector pili muscles, Merkel cells, and sensory nerve endings.

186 reported in 2008 to be caused by a PyV named Merkel cell polyomavirus (MCPyV), the first PyV linked t

187 thought to originate from the neuroendocrine Merkel cells of the skin.

188 toh1 expression is sufficient to produce new Merkel cells in the epidermis, that epidermal cell compe

189 expansion of touch dome keratinocytes but no Merkel cell neoplasia.

190 s express several markers detected in normal Merkel cells, a nonproliferative population of neuroendo

191 seen during postnatal development of normal Merkel cells.

192 Keratin-17-expressing keratinocytes but not Merkel cells were necessary to establish innervation pat

193 genome has been observed in at least 80% of Merkel cell carcinoma (MCC).

194 characterized by a sequential activation of Merkel cell-specific genes.

195 However, activity of Merkel afferents during active touch has not been direct

196 to be clonally integrated in 80% of cases of Merkel cell carcinoma (MCC), a rare but aggressive form

197 irus (MCPyV) causes the majority of cases of Merkel cell carcinoma (MCC), an aggressive skin cancer w

198 main type of tactile end organ consisting of Merkel cells (MCs) and Abeta-afferent endings, are highl

199 l discs are tactile end organs consisting of Merkel cells and Abeta-afferent nerve endings and are lo

200 l polyomavirus (MCPyV) in the development of Merkel cell carcinoma (MCC), making MCPyV the first poly

201 the main oncoprotein for the development of Merkel cell carcinoma (MCC).

202 We found that mice devoid of Merkel cells could not detect textured surfaces with the

203 Induced expression of Merkel cell polyomavirus-large tumor antigen in human lu

204 to explain many of the enigmatic features of Merkel cell carcinoma (MCC).

205 anding controversy regarding the function of Merkel cells and their afferent nerve fiber partners.

206 echanisms underlying the tactile function of Merkel discs are obscured as to how MCs transmit tactile

207 Clonal integration of Merkel cell polyomavirus (MCV) DNA into the host genome

208 of the skin-is caused by the integration of Merkel cell polyomavirus and persistent expression of la

209 Electron microscopic investigations of Merkel endings and lanceolate endings at the level of th

210 lation of Sox2 results in a dramatic loss of Merkel cells, indicating that Sox2 is a critical regulat

211 The majority of Merkel cell carcinoma, a highly aggressive neuroendocrin

212 via K14Cre resulted in a decreased number of Merkel cells but had no effect on other epithelial compa

213 The reduced number of Merkel cells did not affect the number or patterning of

214 .5 (E16.5), touch domes emerge as patches of Merkel cells and keratinocytes clustered with a previous

215 s of Bcl-2 family profile or the presence of Merkel cell polyomavirus.

216 an option to interfere with proliferation of Merkel cell polyomavirus(+) Merkel cell carcinoma cell l

217 ting conclusions regarding the proportion of Merkel cell carcinomas (MCCs) that contain the Merkel ce

218 reading frame (ALTO) in the early region of Merkel cell polyomavirus (MCPyV), the causative agent of

219 iption factor ATOH1 is a master regulator of Merkel cell development, its role in Merkel cell carcino

220 y activates Atoh1, the obligate regulator of Merkel cell differentiation.

221 icating that Sox2 is a critical regulator of Merkel cell specification.

222 The subsequent maturation steps of Merkel cell differentiation are controlled by cooperativ

223 The literature on Merkel cell carcinoma (MCC) of the eyelid remains scarce

224 ing mitosis revealed by a viral oncoprotein, Merkel cell polyomavirus small T (MCV sT).

225 either melanoma, squamous cell carcinoma, or Merkel cell carcinoma.

226 lection was not based on PD-L1 expression or Merkel cell polyomavirus status.

227 made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-B

228 nts), squamous cell carcinoma (26 patients), Merkel cell carcinoma (6 patients), pigmented epithelioi

229 The double-stranded DNA polyomavirus Merkel cell polyomavirus (MCV) causes Merkel cell carcin

230 proliferation of Merkel cell polyomavirus(+) Merkel cell carcinoma cell lines.

231 d with clonal integration of a polyomavirus, Merkel cell polyomavirus (MCPyV), and MCC tumor cells ex

232 that the 81% of patients with virus-positive Merkel cell carcinoma tumors had earlier stage disease a

233 e- or pre-B cell rather than the postmitotic Merkel cells.

234 ceptor repertoire associated with 72 primary Merkel cell carcinomas and correlated metrics of the T-c

235 iltrate informs patient prognosis in primary Merkel cell carcinoma beyond the T-cell density.

236 Of these types, only ring-sinus Merkel endings exhibited slowly adapting properties.

237 eptors in the vibrissal follicle: ring-sinus Merkel; lanceolate; clublike; and rete-ridge collar Merk

238 Surprisingly, Merkel cells also mediate allodynia, providing a new cel

239 distant locations was a T2a (eyelid TNM)/T1 (Merkel TNM) tumor measuring 8 mm.

240 id disease of T category T2 (eyelid TNM)/T1 (Merkel TNM).

241 Two patients with T3a (eyelid TNM)/T2 (Merkel TNM) tumors died of metastatic MCC.

242 nn cells form nerve-like bundles that target Merkel cells in organoid hair follicles, mimicking the n

243 nd signaling pathways required for targeting Merkel-cell afferents to discrete mechanosensory compart

244 erents lacking Merkel cells demonstrate that Merkel cells confer high-frequency responses to dynamic

245 It has been demonstrated that Merkel cells have a role in vertebrate mechanosensation

246 l cells to directly test the hypothesis that Merkel cell/neurite complexes are necessary to perform t

247 Together, these findings indicate that Merkel cells actively tune mechanosensory responses to f

248 cent parallel studies clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel

249 Here, we show that Merkel and unidentified slowly adapting afferents in the

250 Here we show that Merkel cells actively participate in touch reception in

251 ogenetic approaches in intact skin show that Merkel cells are both necessary and sufficient for susta

252 We show that Merkel cells are required for the molecular and function

253 Here we show that Merkel cells produce touch-sensitive currents in vitro.

254 ing rat whisker hair follicles, we show that Merkel cells rather than Abeta-afferent nerve endings ar

255 n, but not in sensory neurons, and show that Merkel-cell mechanosensitivity completely depends on Pie

256 It has been shown that Merkel cells originate from epidermal stem cells, but th

257 These findings suggest that Merkel cell/neurite complexes are essential for texture

258 The Merkel cell polyomavirus (MCPyV) genome undergoes clonal

259 The Merkel cell polyomavirus (MCPyV), discovered in 2008, dr

260 The Merkel cell-neurite complex is a gentle touch receptor i

261 The Merkel disc has high tactile acuity for an object's phys

262 The Merkel disc, a main type of tactile end organ consisting

263 ked to exposure to ultraviolet light and the Merkel-cell polyomavirus (MCPyV).

264 n and identify the Piezo2 ion channel as the Merkel cell mechanical transducer.

265 ggressive skin cancer commonly driven by the Merkel cell polyomavirus (MCPyV).

266 n aggressive skin cancer often caused by the Merkel cell polyomavirus.

267 y adapting responses in vivo mediated by the Merkel cell-neurite complex show reduced static firing r

268 rkel cell carcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV) and the clinical signif

269 er myelinated mechanoreceptors that form the Merkel cell-neurite complex.

270 lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage.

271 How the Merkel cell-neurite complex transduces and encodes touch

272 se correlations were mostly preserved in the Merkel cell polyomavirus-negative subgroup.

273 results indicate a division of labour in the Merkel cell-neurite complex: Merkel cells signal static

274 Our results indicate that Piezo2 is the Merkel-cell mechanotransduction channel and provide the

275 implicate one of these mechanoreceptors, the Merkel cell/neurite complex, in two-point discrimination

276 r of differentiated cells in the case of the Merkel cell lineage and hair follicle type in the case o

277 1 expression drove ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epiderm

278 These findings elucidate that the Merkel disc is a unique serotonergic synapse located in

279 Thus, the Merkel cell-neurite complex is an unique sensory structu

280 ma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV).

281 y aggressive skin cancer associated with the Merkel cell polyomavirus (MCV).

282 ne skin tumor frequently associated with the Merkel cell polyomavirus.

283 Thus, Merkel afferents send to the brain multiplexed informati

284 eins such as MCV sT, which may contribute to Merkel cell carcinogenesis.

285 Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a lethal form of skin cance

286 Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ultraviolet-rad

287 ed stem cell niches and that might relate to Merkel cell and melanocyte ontogeny and tumorigenesis.

288 s malignancy linked to a contributory virus (Merkel cell polyomavirus).

289 However, whether Merkel cell/neurite complex function is required for the

290 However, whether Merkel cells or afferent fibres themselves sense mechani

291 ted afferents, and yet it is unclear whether Merkel cells are inherently mechanosensitive or whether

292 hat we believe to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomaviru

293 development and reveal a novel way in which Merkel cells participate in mechanosensation.

294 avirus (MCPyV) is frequently associated with Merkel cell carcinoma (MCC), a highly aggressive neuroen

295 n polyomavirus etiologically associated with Merkel cell carcinoma (MCC), a rare and aggressive form

296 cinoma is a rare skin cancer associated with Merkel cell polyomavirus in most cases.

297 crine cancer of the skin, is associated with Merkel cell polyomavirus infection.

298 rade neuroendocrine neoplasm consistent with Merkel cell carcinoma (MCC).

299 Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell

300 cts of touch sensation remain intact without Merkel cell activity.