ライフサイエンスコーパス: Michael

1 Michael addition has been achieved with a variety of ami

2 Michael addition of phosphorus nucleophiles to the unsym

3 Michael addition of thiourea to enones with subsequent i

4 Michael Gross reports.

5 Michael Gross rounds up some unusual suspects.

6 Michael J Fox Foundation for Parkinson's Research.

7 Michael Parker and Dominic Kwiatkowski discuss important

8 Michael Tomasello explains the human sense of obligation

9 Michael's Hospital for bleb leaks repaired with MICS fro

10 ly observed electrophilic reactivities of 44 Michael acceptors and their calculated methyl anion affi

11 onding tert-butyl ester 3 was initiated by a Michael reaction to introduce the cyclohexyl ring.

12 f a caffeic acid ortho-quinone followed by a Michael-type reaction, and radical coupling of a semiqui

13 ) also determines the outcome of combining a Michael reaction with a porphyrin-based supramolecular s

14 Only Bar-Me forms a Michael addition adduct with glutathione (GSH) and inhib

15 via isobenzofuranone ring opening of 2 in a Michael-type reaction.

16 proceeds via a cascade reaction involving a Michael addition-6pi-electrocyclic ring opening-proton t

17 ing group was added at the alpha-carbon of a Michael acceptor.

18 etitive inhibition of CLK1 is dependent on a Michael acceptor forming an irreversible bond with Cys 2

19 s by intramolecular nucleophilic attack on a Michael acceptor with an allylic leaving group.

20 applied to detect cyanide (CN(-)) based on a Michael-type nucleophilic addition reaction and intramol

21 The reaction proceeds through a Michael addition followed by ring expansion of methylene

22 enerated thiol-terminated polymers undergo a Michael-type addition to Diels-Alder (DA) adducts of fur

23 enone-aldehydes and 1,3-carbonyls undergo a Michael/aldol/hemiketalization/retro-aldol cascade for t

24 yzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-vinylglyoxylate, which then forms a

25 dehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidati

26 modified quantum dots (QDs) nanohybrid via a Michael's type adduction, quenching the fluorescence of

27 ated peptide crosslinker (CGPQG IWGQC) via a Michael-type addition reaction.

28 er merely the same reaction conditions via a Michael/aldol/lactonization/decarboxylation cascade.

29 ulation of N-sulfonyl-1,2,3-triazoles with a Michael acceptor-tethered indole derivative have been ac

30 hioaryl radical to alkyne over the activated Michael acceptor.

31 Almost 50 years ago, Michael Rosenzweig pointed out that nutrient addition ca

32 ctivity, including both C- and O-alkylation, Michael addition via C-5 to an acetylenic ester, tetrach

33 tics, are viable reaction partners, allowing Michael-type reactivity to be expanded beyond alpha,beta

34 Although Michael acceptors display a potent and broad spectrum of

35 starting from alpha-bromoamido alcohols and Michael acceptors under mild conditions is presented.

36 n a Perspective article, Sigrid Carlsson and Michael Kattan discuss Gnanapragasam and colleagues' acc

37 Disney and Michael J.

38 Semenkovich, MD, the Irene E. and Michael M.

39 hiobarbiturate with diarylcarbenium ions and Michael acceptors have been determined in dimethyl sulfo

40 reaction tolerates a variety of nitriles and Michael acceptors with different steric features and acc

41 r Tuberculosis Collection, Piero Olliaro and Michael Vaillant discuss the considerations when choosin

42 Jakub Prokop and Michael Engel introduce palaeodictyopterids, a very dive

43 onors Ralf Bartenschlager, Charles Rice, and Michael Sofia, pioneers in the development of curative a

44 warded to Jeffrey Hall, Michael Rosbash, and Michael Young for elucidating molecular mechanisms of th

45 ces the reactivity between a given thiol and Michael acceptor.

46 zed by Carol Mason (Columbia University) and Michael Crair (Yale University).

47 Allene carboxylates, scarcely used as Michael acceptors, serve as acceptors in the annulation

48 cisely on a gram scale through an asymmetric Michael addition, nitro-Mannich/lactamisation, Tsuji-Tro

49 ine-squaramide organocatalyst for asymmetric Michael reactions has been elaborated.

50 ed, synthesized, and utilized for asymmetric Michael reactions.

51 imbane skeleton via a sequence of asymmetric Michael-Michael-Mannich-reduction-amidation-Bischler-Nap

52 his catalyst effectively promotes asymmetric Michael additions of aldehydes to challenging but biolog

53 t cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.

54 tomeric products generated by the asymmetric Michael reactions of cyclic carbon acids with beta,gamma

55 ine was accomplished in three steps: (1) aza-Michael addition of allylamine to tricarbonyl(tropone)ir

56 nt, one-pot domino process through a 1,6-aza-Michael addition-triggered sequence and an original Mits

57 y diastereoselective reductive amination/aza-Michael reaction sequence to achieve rapid construction

58 example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to alpha,bet

59 heterocyclic systems is initiated by an aza-Michael reaction followed by intramolecular cyclization.

60 of condensation, Mannich, oxidation, and aza-Michael addition reactions, employing a variety of funct

61 this annulation are alkyne insertion and aza-Michael addition under oxidant-free mild reaction condit

62 leading to quinazolinone derivatives and aza-Michael adducts under mild reaction conditions.

63 regioselective N-arylation, followed by aza-Michael addition, is disclosed using 2-aminobenzothiazol

64 An unprecedented catalytic aza-Michael addition to substituted 3-vinyl-1,2,4-triazines,

65 ghlights a rare example of the catalytic aza-Michael reaction to alkenylazaarenes but also proves to

66 reoselective (dr >/=96:4) acid-catalyzed aza-Michael reaction to give trans-2,5-disubstituted pyrroli

67 nd formation through palladium-catalyzed aza-Michael reaction.

68 Study of the intramolecular aza-Michael addition reaction from an aminofluorovinylsulfon

69 of the thiazole ring and intramolecular aza-Michael addition to furnish the title products.

70 eagent and its subsequent intramolecular aza-Michael cyclization.

71 aziridines followed by an intramolecular aza-Michael reaction in a domino fashion.

72 followed by base-mediated intramolecular aza-Michael reaction.

73 on, which relies on an omega-TA-mediated aza-Michael reaction.

74 he reaction involves a tandem pathway of aza-Michael addition, SN2, and a unique redox-neutral proces

75 Lewis acids affect these one-pot aza-Michael-addition/cyclization/dehydration reaction sequen

76 annich reaction/proline hydrolysis/retro aza-Michael cascade to form an intermediate alpha,beta-unsat

77 l reaction followed by a tandem Robinson-aza-Michael double cyclization catalyzed by PS-BEMP, and (ii

78 A subsequent stereoselective aza-Michael addition and an intramolecular Heck-type reactio

79 Products are formed by the aza-Michael addition followed by intramolecular acyl substit

80 ride/p-toluenesulfonic acid-water in the aza-Michael addition of arylamines to maleimide to obtain am

81 tional study and kinetic analysis of the aza-Michael addition of primary and secondary amines to acry

82 The aza-Michael addition of the in situ formed enamine, generate

83 at for primary and secondary amines, the aza-Michael addition to ethyl acrylate occurs preferentially

84 ty and exquisite site-selectivity of the aza-Michael ligation described herein allows the constructio

85 The aza-Michael reaction was first observed when the starting en

86 (ii) installation of the amino group via aza-Michael addition/elimination, and crucially (iii) facile

87 ion of acrylamides with 2-alkynoates via aza-Michael/C-H activation sequence for the synthesis of var

88 (3)-catalyzed [4 + 1]-cycloaddition with aza-Michael addition reactions.

89 s starting from the versatile chromone-based Michael acceptors platform are reported herein.

90 Using an improved maleimide-thiol based Michael Addition during (water-in-oil) Emulsion (MADE) m

91 rphenyls were synthesized in good yields, by Michael addition of a conjugate base of core-substituted

92 a-amino ester)s (HPAEs) via a new "A2+B3+C2" Michael addition approach demonstrating 2 to 126-fold hi

93 nd alpha-hydrazinonitroalkenes via a cascade Michael addition-cyclization protocol to afford nitrodih

94 This strategy, which involves a cascade Michael addition-Dieckmann cyclization-elimination seque

95 scribe herein a catalyst/ligand free cascade Michael-type addition/intramolecular cyclization/carbohy

96 The first example of a catalytic Michael addition reaction of non-activated aliphatic nit

97 cular vessel has been utilized for catalytic Michael addition reactions of a series of nitrostyrene d

98 Pivoting on a two-stage catalytic Michael addition/condensation strategy, the use of an al

99 amine the two key processes of the catalytic Michael reaction between propanal and beta-nitrostyrene

100 ehyde, diastereoselective Cu(OTf)2-catalyzed Michael reaction/tandem aldol cyclizations, and one-pot

101 urea was used to trigger the base-catalyzed Michael addition of a water-soluble trithiol to a polyet

102 mine promotes an accompanying base-catalyzed Michael addition of alpha1(I) H932 imidazole to the alph

103 r the enantioselective isothiourea-catalyzed Michael addition of nitroalkanes to alpha,beta-unsaturat

104 simple, bioinspired synthetic cage catalyzes Michael addition reactions using only Coulombic and othe

105 In this issue of Developmental Cell, Michael and colleagues (2016) show that the actin bindin

106 In this issue of Developmental Cell, Michael et al. (2019) use the RIP-Tag mouse model to sho

107 ic base-free addition of several challenging Michael partners.

108 versary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his death.

109 ganobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is presented for t

110 eamlined access to an important class of cis-Michael acceptors from readily available feedstocks.

111 ify the electrophilic reactivities of common Michael acceptors, we measured the kinetics of the react

112 l Diels-Alder cycloaddition or a competitive Michael addition/reduction to access aspidosperma-type a

113 involved sequential Knoevenagel condensation-Michael addition-intramolecular oxa-Michael addition-int

114 efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to 99%) in high chem

115 of action by cytotoxic compounds containing Michael acceptor groups and help to explain previous rep

116 of cytotoxic synthetic compounds containing Michael acceptor groups inhibit proteasome substrate pro

117 on (SI-GTP), and extension to N-coordinating Michael-type monomers (2-vinylpridine (2VP), 2-isopropen

118 However, covalent Michael adduct formation with Cys-18, a residue present

119 A cascade Friedel-Crafts/Michael annulation reaction between acryloyl chloride an

120 compounds possess a piperidinyl crotonamide Michael acceptor and a 3-chloro-4-fluoroaniline, indicat

121 from 4-methyleneisoxazol-5-ones via "cyanide Michael addition/methylation/reductive isoxazole-pyrrole

122 ive recoverable organocatalysts in different Michael additions, in neat conditions at room temperatur

123 al theory (DFT), investigating the different Michael-addition approaches of the sulfur ylide, the tra

124 talyzed and highly diastereoselective direct Michael addition-isomerization sequence is presented for

125 reoselective phase-transfer-catalyzed domino Michael-cyclization reaction with acetylacetone.

126 nt and application of the arene-fused domino Michael/Mannich route to the tetrahydrocarbazole (ABE) c

127 The route to (-)-1 is based on a double Michael addition for the formation of the bridged diazad

128 s the cascade transformation based on double Michael addition and aromatization (retro-Claisen cleava

129 ides are cyclized through a proximity-driven Michael addition reaction between a cysteine and an ambe

130 mine) and the electrophilic component (i.e., Michael acceptor).

131 releasing methods, such as beta-elimination/Michael addition, are not specific to O-glycan release a

132 acycline (1) has been developed by employing Michael-Dieckmann cyclization between enone 3 and a full

133 synthesis of dihydroisoquinolines employing Michael acceptor-tethered aniline derivatives.

134 es, proteins, and oligonucleotides employing Michael addition and Diels-Alder cycloaddition reactions

135 nes via two alternative enantiocomplementary Michael-type reactions: enamine-mediated addition of ace

136 As an extension, one enantiopure Michael adduct has been utilized to synthesize optically

137 Enantioselective Michael addition of tertiary alpha-nitroesters to beta-u

138 Enantioselective Michael addition-cyclization reactions using different a

139 An isothiourea-catalyzed enantioselective Michael addition of aryl ester pronucleophiles to vinyl

140 on with the organocatalytic enantioselective Michael-acetalization-Henry reaction of 2-hydroxynitrost

141 Amide coupling and thiol-ene Michael addition were found to be ineffective for the sy

142 organic synthesis such as acetals, enolates, Michael acceptors, acylating reagents, and activated aro

143 ectrophiles such as alkyl halides, epoxides, Michael acceptors, and lambda(3)-iodanes in moderate to

144 t time, to catalytically polymerize extended Michael systems, like 4-vinylpyridine.

145 to be a similar if not superior catalyst for Michael additions compared with typical Lewis acids.

146 n effective hydrogen-bond-donor catalyst for Michael reactions of a series of water-insoluble nitro-o

147 empirical electrophilicity parameters E for Michael acceptors 1 and 2.

148 d reaction progressed via enamine formation, Michael addition, intramolecular cyclization, and intram

149 work on two models of joint action, one from Michael Bratman, the other from Margaret Gilbert.

150 uble cyclopropanation of this functionalized Michael-acceptor will be useful guidelines for the synth

151 so typical that many have proper names (e.g. Michael addition, Amadori rearrangement, and Pictet-Spen

152 ago in a seminal review by Joseph Goldstein, Michael Brown, and Richard Anderson.

153 Andras Varro, Heike Wulff, Eleonora Grandi, Michael Sanguinetti, Donald Bers, Jeanne Nerbonne and Ni

154 r's Lasker Clinical Research Award honors H. Michael Shepard, Dennis J. Slamon, and Axel Ullrich for

155 Physiology has been awarded to Jeffrey Hall, Michael Rosbash, and Michael Young for elucidating molec

156 lear that a good understanding of the hetero-Michael addition reaction and the relative reactivities

157 Hurricane Michael (2018) was the first Category 5 storm on record

158 LPE that was directly affected by Hurricane Michael in 2018, an unprecedented Category 5 storm.

159 long-term context for events like Hurricane Michael and suggests that the observational period 1851

160 ures occurred prior to landfall of Hurricane Michael during October of 2018 and, as critical contribu

161 However, the hypothetical Michael adducts in this mechanism have only been detecte

162 mation of the substrate into the impermanent Michael adduct.

163 a systematic assessment of its reactivity in Michael, radical, and cycloaddition reactions.

164 isms of known aminotransferase inactivators: Michael addition, enamine addition, and fluoride ion eli

165 polar products are also isolated, including Michael adducts, hemiacetal adducts, and pyridinium salt

166 rans through a cascade S(N)2'-intramolecular Michael reaction, followed by aromatization.

167 reaction channel involves an intramolecular Michael addition leading to the experimentally observed

168 into tricyclic compounds via intramolecular Michael addition.

169 The multicascade process involves Michael addition, Dieckmann cyclization, and a series of

170 s of all reactants; (ii) a turnover-limiting Michael addition step, (iii) product inhibition, (iv) th

171 The divergent growth via thiol-maleimide Michael coupling allows precise arrangements of the 0- a

172 ynine, employing a proline-catalyzed Mannich-Michael reaction sequence as the key transformation.

173 s is described, which includes base-mediated Michael addition/intramolecular cyclization/[1,5]-H shif

174 National Library of Medicine Michael E.

175 The fluoride-promoted vinylogous Mukaiyama-Michael reaction of 2-[(trimethylsilyl)oxy]furan with di

176 2-hydroxyacetophenones is disclosed, namely Michael-hemiacetalization reaction of 2-hydroxyacetophen

177 n initial allylic substitution to form a new Michael acceptor, followed by the addition of a second e

178 l assembly were achieved by a combination of Michael-type thiol-ene addition and copper(I)-mediated a

179 cientific and philosophical contributions of Michael Polanyi, is based on the presentation given by D

180 eaction mixtures confirmed the formations of Michael adduct and Schiff base of HMF with amino acids.

181 84 named Faradaurate-279 (F-279) in honor of Michael Faraday's (1857) pioneering work on nanoparticle

182 This article is dedicated to the memory of Michael G.

183 reaction in the Lewis pair polymerization of Michael acceptors, for which the conjugated addition of

184 d to calculate the rates of the reactions of Michael acceptors 1 and 2 with any nucleophile of known

185 ce the electrophilicity and reversibility of Michael acceptors.

186 Because of the large structural variety of Michael acceptors considered for these correlations, whi

187 s can be effectively trapped by a variety of Michael acceptors, leading to the corresponding hydroalk

188 report a new dynamic polymerization based on Michael addition-elimination reaction of structurally di

189 Humanities was the title of the symposium on Michael Polanyi that took place at the Technische Univer

190 ex mixtures via a Strecker-like synthesis or Michael addition.

191 As an example the organocatalysed Michael addition reaction between nitrostyrene and 3-met

192 tereochemical outcome of the organocatalytic Michael reactions between benzylic aldehydes and nitrost

193 lementary strategies: (i) an organocatalyzed Michael reaction followed by a tandem Robinson-aza-Micha

194 verse-electron-demand hetero-Diels-Alder/oxa-Michael reaction catalyzed by modularly designed organoc

195 The asymmetric oxa-Michael addition of salicylaldehyde to conjugated nitroa

196 y a final intramolecular amine-catalyzed oxa-Michael addition.

197 tive phenolic oxidation and deallylation/oxa-Michael cascade was implemented to access caesalpinnone

198 tion of a phenol and a hemiacetalization/oxa-Michael cascade to form the tricyclic ring system.

199 lective allylations, a hemiacetalization/oxa-Michael sequence, and a 1,3-syn reduction.

200 ensation-Michael addition-intramolecular oxa-Michael addition-intramolecular aldol reactions.

201 catalyzed stereoselective intramolecular oxa-Michael reaction, E-selective ring-closing metathesis, D

202 ue, biomimetic asymmetric intramolecular oxa-Michael reaction/hydrogenation sequence that allows dias

203 y a dynamic kinetic (DyKat) ketalization/oxa-Michael addition cascade using cinchona alkaloid-based c

204 n, butenolide formation, and spontaneous oxa-Michael addition of MeOH.

205 nyl l-prolinamide, for asymmetric tandem oxa-Michael-Henry reaction of salicylaldehyde with conjugate

206 icylaldehyde reduces further to make the oxa-Michael reaction reversible.

207 to a cascade of reactions, namely oxidation, Michael addition, reduction, acetylation, and cycloconde

208 an acid-catalyzed tandem intermolecular oxy-Michael/intramolecular trans-ketalization reaction and s

209 An intramolecular oxy-Michael reaction under basic conditions was used to cons

210 nds covalently to Keap1 by forming permanent Michael adducts with eight different cysteines, and acyl

211 We report the use of a phospha-Michael reaction to label proteins and peptides modified

212 clic phosphine (NHP) and allenes via phospha-Michael/intramolecular nucleophilic substitution reactio

213 In the photograph: Michael Polanyi at the Fritz Haber Institute in 1968.

214 11-keto group in CF3DODA-Me, which prevents Michael addition by the conjugated en-one in the A-ring.

215 ications: First, a fast exothermic reaction (Michael addition) was monitored with backscattering fibe

216 ycloaddition, 1,3-sigmatropic rearrangement, Michael addition, and Pictet-Spengler reaction among oth

217 sease Modeling Systems, by Kristina Rehbach, Michael B.

218 nomers were prepared via the highly reliable Michael addition of ethenesulfonyl fluoride and amines/a

219 heir catalytic performance in representative Michael addition reactions was used in an effort to comp

220 The Canadian Institutes of Health Research, Michael Smith Foundation for Health Research, and BC Cen

221 Molecular modeling of the resulting Michael adduct suggested stabilization of the co-substra

222 c product is formed subsequently via a retro Michael elimination of a hindered ether followed by addi

223 he nucleophile to this and, finally, a retro Michael reaction.

224 s favored by glutathione, indicating a retro-Michael reaction, which unveils new implications of cyPG

225 fenate anions generated in situ, via a retro-Michael reaction.

226 Reversible Michael acceptors have been reported in which an additio

227 A reversible Michael addition reaction between thiol nucleophiles and

228 and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key sig

229 mines, aldehydes, ketones, pyridinium salts, Michael acceptors, epoxides, and Pd-catalyzed Sonogashir

230 ptors and a single thiol or between a single Michael acceptor and two thiols using three different ca

231 e recorded among infertile women seen at St. Michael's Hospital in Bristol, United Kingdom, during th

232 n subject of this paper, features a one-step Michael addition of t-butyl 2-((diphenylmethylene)amino)

233 ing of the 3-aroylbenzofurans and subsequent Michael addition of the resulting 1,3-dicarbonyl interme

234 SN(Ar) displacement reaction and subsequent Michael addition onto acrylate leads to the formation of

235 A highly enantioselective cascade sulfa-Michael/Julia-Kocienski olefination reaction between 2-m

236 ne or cinchona alkaloid-urea catalyzed sulfa-Michael addition reactions, also applies to the catalyti

237 (aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reacti

238 late-stage, highly diastereoselective, sulfa-Michael addition.

239 his manuscript, a simple and efficient sulfa-Michael addition reaction of aryl thiols to trisubstitut

240 The mechanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona alkalo

241 el formulation that uses thiol-vinyl sulfone Michael addition for crosslinking.

242 n-intramolecular S(N)Ar reaction or a tandem Michael addition-intramolecular Ad(N)E process to furnis

243 nsformations proceed through either a tandem Michael addition-intramolecular S(N)Ar reaction or a tan

244 ones through a transition-metal-free, tandem Michael addition-S(N)Ar process is delineated.

245 rocyclization of peptides bearing N-terminal Michael acceptors has been developed.

246 The Michael acceptors inhibited both rhodesain and falcipain

247 The Michael addition of free amino acids to acrylamide was f

248 The Michael addition of phosphorus nucleophiles is postulate

249 Bis-cinchona catalyst 3b activates the Michael addition reaction between malononitrile derivati

250 zes the intermediate carbanion, allowing the Michael adduct to be captured by an added electrophile.

251 with an alpha,beta-unsaturated ketone as the Michael acceptor and does not occur when an alpha,beta-u

252 step, the nucleophilic attack of 3-5 at the Michael acceptors with formation of acyclic intermediate

253 ared and screened as organocatalysts for the Michael addition reaction of aldehydes with beta-nitroal

254 n stereoselectivity and reaction rate in the Michael addition was observed.

255 when an alpha,beta-unsaturated ester is the Michael acceptor.

256 ng electron-withdrawing group as part of the Michael acceptor, a high energy concerted SN2' reaction

257 n ONIOM(QM/MM) study on the mechanism of the Michael addition to triple bonds catalyzed by chiral dii

258 nic transition state and intermediate of the Michael addition, but less intuitively, it destabilizes

259 ing was involved in the stabilization of the Michael adduct intermediate.

260 n RAD51, and this alkylation depended on the Michael acceptor properties of OA-NO(2) because nonnitra

261 of a COOEt-stabilized sulfur ylide onto the Michael acceptor.

262 e tertiary amine that is able to promote the Michael reaction between enolizable carbonyl compounds a

263 For thiol addition to be reversible, the Michael acceptor must also contain a suitable substituen

264 y profiles from DFT calculations suggest the Michael addition of the 1,3-dipole to be the rate- and e

265 We found that the Michael acceptor bis(2-hydoxybenzylidene)acetone (HBB2),

266 the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation

267 in contrast to expectation from HSAB theory, Michael-acceptor ketones, aldehydes and esters may form

268 These Michael adducts allow rapid access to several natural pr

269 ns to determine why thiol additions to these Michael acceptors are reversible.

270 ped a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be

271 stries are thiol-disulfide exchange and thio-Michael addition, sharing the thiol as the common buildi

272 reversibly switched from predominantly thio-Michael chemistry to predominantly disulfide chemistry,

273 otopically labeled acetyl-alanine; (3) thiol Michael addition of an isotopically labeled acetyl-cyste

274 These reagents undergo rapid thiol Michael-addition under biocompatible conditions in stoic

275 Thiol-Michael "click" reactions are essential synthetic tools

276 This protocol is based on a thiol-Michael-type addition of native or engineered cysteine r

277 Despite increasing efforts to apply thiol-Michael chemistry in a controlled fashion, the selectivi

278 undamental study of the selectivity of thiol-Michael reactions through a series of 270 ternary reacti

279 ivity of base- or nucleophile-promoted thiol-Michael reactions in complex mixtures of multiple thiols

280 insights into the design of selective thiol-Michael reactions that can be used for the synthesis and

281 -pot quaternary, and sequential senary thiol-Michael reactions were designed and their selectivities

282 The thiol-Michael addition (TMA) is a powerful methodology to clic

283 nctionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-p

284 tion proves that the reaction occurs through Michael addition.

285 at target nine nucleophilic residues through Michael addition, including Gln, Arg, and Asn, which are

286 thermodynamically stable product compared to Michael adducts and hemiacetal adducts and also indicati

287 Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of se

288 us was obtained by a cascade of transannular Michael reaction, carbonate elimination, butenolide form

289 explored using ternary reactions between two Michael acceptors and a single thiol or between a single

290 The reaction happens through an uncommon Michael reaction between aromatic derivatives as aromati

291 The strategy exploits hitherto unknown Michael addition of PH-containing compounds (diphenylpho

292 tions using different alpha,beta-unsaturated Michael acceptors have been performed to form dihydropyr

293 Various Michael-type compounds were designed and synthesized, an

294 which then react with cysteine residues via Michael addition.

295 ed covalent immobilisation of tryptamine via Michael type-reaction.

296 this 3 + 2 annulation involved a vinylogous Michael addition followed by an intramolecular enamine a

297 ylation/[1,2]-Brook rearrangement/vinylogous Michael cascade of silyl glyoximide, vinylmagnesium brom

298 anched C-H alkylation of benzimidazoles with Michael acceptors.

299 lways forms the initial reaction of GSH with Michael-acceptor carbonyls.

300 ative reactivities of biological thiols with Michael acceptors under physiological conditions is need