ライフサイエンスコーパス: N-acetylated

1 s of M. leprae peptidoglycan are exclusively N acetylated.

2 ns), and its N-terminal residue, alanine, is N-acetylated.

3 copic analysis indicates that Trm1-II-GFP is N-acetylated.

4 terial peptidoglycan are N-glycolylated, not N-acetylated.

5 zyme that specifically acts on N-sulfated or N-acetylated 6-O-sulfated glucosamines present at the no

6 retical J-couplings were calculated in model N-acetylated aldopyranosides using density functional th

7 ive inhibitor of the NAAG hydrolyzing enzyme N-acetylated alpha-linked acidic dipeptidase (NAAG pepti

8 hese compounds to inhibit the neuropeptidase N-acetylated alpha-linked acidic dipeptidase (NAALADase)

9 ubstrate and pharmacologic properties of the N-acetylated alpha-linked acidic dipeptidase (NAALADase)

10 tylaspartylglutamate, has also been known as N-acetylated alpha-linked acidic dipeptidase (NAALADase)

11 The brain enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase)

12 N-acetylated alpha-linked acidic dipeptidase (NAALADase)

13 nked acidic dipeptidase-like protein (NLDL), N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2)

14 s, pig folylpoly-gamma-carboxypeptidase, rat N-acetylated alpha-linked acidic dipeptidase, and human

15 ties of folylpoly-gamma-carboxypeptidase and N-acetylated alpha-linked acidic dipeptidase, while immu

16 N-acetylated alpha-linked acidic dipeptidase-like protei

17 lutamate carboxypeptidase II (GCP2 or PSMA), N-acetylated alpha-linked acidic dipeptidase-like protei

18 es for intestinal folate hydrolase and brain N-acetylated alpha-linked acidic dipeptidase.

19 tate-specific membrane antigen and rat brain N-acetylated alpha-linked acidic dipeptidase.

20 stroke, through the inhibition of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase), an enzyme

21 reason for the higher biological activity of N-acetylated alphaMSH (Act-alphaMSH) compared with that

22 inosine, indole-3-acetate, galactose, and an N-acetylated amino acid (NAA), showed a high sensitivity

23 acids (tryptophan, tyrosine, phenylalanine), N-acetylated amino acids (N-acetyl-tryptophan, N-acetyl-

24 er activity than the wild-type on a range of N-acetylated amino acids.

25 enzymatic synthetic strategies for preparing N-acetylated analogues of O-acetylated NmW CPS oligosacc

26 Conversely, blocking protonation by N-acetylated analogues, greatly enhanced their diffusion

27 Employing a set of N-acetylated and C-amidated synthetic peptides, biophysi

28 drazine (<10 min), the oligosaccharides were N-acetylated and derivatized with AA in the same reactio

29 ans heparin and heparan sulfate occurring in N-acetylated and N-sulfated forms, and as the unmodified

30 The latter are embedded within N-acetylated and N-sulfated sequences, forming extended

31 Uniquely, sections comprising alternating N-acetylated and N-sulfated units are resistant to the e

32 r of various cysteine sulfinyl ions (intact, N-acetylated, and O-methylated), new members of the gas-

33 xopeptidase that catalyzes the hydrolysis of N-acetylated aspartate-glutamate (NAAG) to N-acetyl aspa

34 [3H]N-acetylbenzidine had a similar ratio of N-acetylated benzidines (N-acetylbenzidine + N',N'-diace

35 irmed to be the Vi monomer both de-O- and de-N-acetylated by mono- and bidimensional Nuclear Magnetic

36 The N-acetylated, C-amidated peptide corresponds to the sequ

37 larger (i.e. degrees of polymerization = 8) N-acetylated chitin molecules with a 50% inhibition of i

38 ures were mono- or dihexoses rather than the N-acetylated chitobiosyl core that is characteristic of

39 We show that efficient passage of the N-acetylated chitohexaose through the chitoporin is faci

40 her anti-HIV activity than the corresponding N-acetylated conjugates against cell-free virus.

41 el, however, was not observed for protonated N-acetylated cysteine sulfinyl radicals (Ac-(SO*)Cys); i

42 N-Acetylated cysteine was also inhibitory, but this inhi

43 go-alpha-(1 -> 4)-d-galactosamines and their N-acetylated derivatives allowed the first precise analy

44 pared for the first time together with their N-acetylated derivatives.

45 ithin non-sulfated sequences of four or more N-acetylated disaccharides.

46 exosite 2 defective mutant, and a synthetic N-acetylated dodecapeptide, Ac-Asn-Gly-Asp-Phe-Glu-Glu-I

47 fated, iduronate-rich domains alternate with N-acetylated domains.

48 nd 10% of the muramic acid residues) was not N-acetylated, explaining the resistance of the peptidogl

49 (S) and 'B-type' (B) conformers, whereas the N-acetylated FAAF also samples a 'wedge' (W) conformer.

50 s acid hydrolysis under conditions where the N-acetylated form is completely labile.

51 Peptide 3 is a cyclic analogue of the N-acetylated form of the heptapeptide C-terminus of the

52 ine (4-amino-4,6-dideoxy- d-mannose), or its N-acetylated form, is one of several dideoxy sugars foun

53 2-(4-Aminophenyl)benzothiazoles 1 and their N-acetylated forms have been converted to C- and N-hydro

54 and free amino groups available on partially N-acetylated fucosamine residues.

55 nd that alpha2-3-linked Neu on chemically de-N-acetylated G(M3) ganglioside resists acid hydrolysis u

56 p to the hexauronic acid that is adjacent to N-acetylated galactosamine.

57 taphylococcal surface of polysaccharide poly-N-acetylated glucosamine (PNAG) by use of human monoclon

58 icylic acid and sodium acetate as well as by N-acetylated glucosamine and galactosamine (GlcNAc and G

59 rtion duplication mutagenesis produced fully N-acetylated glycan and became hypersensitive to exogeno

60 nd a poorly resolved envelope of albumin and N-acetylated glycoprotein resonances.

61 onin T that varied in affinity in the order: N-acetylated > Gly > AlaSer > unacetylated.

62 ation in the order of heparin > N-desulfated N-acetylated heparin > completely desulfated N-sulfated

63 rin > 2-O,3-O-desulfated > or = N-desulfated/N-acetylated heparin > or = carboxyl-reduced heparin > o

64 N-acetylated heparin (NAc-Hep) lacked detectable anticoa

65 ately sulfated adhesin analog, N-desulfated, N-acetylated heparin, was able to compete with chlamydia

66 d N-sulfated heparin > completely desulfated N-acetylated heparin.

67 The N-acetylated hexapeptide WLLLLL (AcWL5) partitions into

68 rms, the secondary amides of peptides and of N-acetylated hexose sugars.

69 y generating modelled structures of proteins N-acetylated in mouse liver, we show that proximity to a

70 GlcN-UA-GlcNAc from HS and from partially de-N-acetylated K5 polysaccharide.

71 Structural studies on N-acetylated KRAS-GDP lacking the iMet revealed the pres

72 Chitosans, beta-1,4-linked partially N-acetylated linear polyglucosamines, are very versatile

73 Moreover, administration of 6-de-O-sulfated, N-acetylated low-molecular-weight heparin, a competitive

74 Using N-acetylated lysine and arginine as models for peptide-b

75 atalyzing the removal of acetyl groups from -N-acetylated lysine residues of various protein substrat

76 d bactericidal activity were inhibited by de-N-acetylated MBPS and re-N-acetylated MBPS, which indica

77 ere inhibited by de-N-acetylated MBPS and re-N-acetylated MBPS, which indicate that N-propionyl group

78 c acid, and 3-methoxytyramine in addition to N-acetylated metabolites including N-acetyldopamine, N-a

79 a of the imidazole and methionine adducts of N-acetylated microperoxidase 8.

80 occurrence of N-glycolylated, in addition to N-acetylated, muramic acid residues and direct cross-lin

81 id hydroxylase activity and synthesizes only N-acetylated muropeptide precursors.

82 this work also provide first evidence of de-N-acetylated muropeptides from P. aeruginosa The method

83 fated S domains interspersed by transitional N-acetylated/N-sulfated domains.

84 A series of N-acetylated, non-alpha, aromatic amino acids was prepar

85 dies were conducted on a subtilisin-digested N-acetylated peptide of the major positional isomer [PEG

86 N-Acetylated peptides AcVYK-amide (AcVYK), AcIVYK-amide

87 investigate this regioselectivity with four N-acetylated peptides as substrates: neurotransmitter me

88 he isolated PDZ10 domain for variable-length N-acetylated peptides from the 5HT2c serotonin receptor

89 is/trans isomerization of the amide bonds of N-acetylated peptoid monomers, dipeptoids, and tripeptoi

90 Binding of N-acetylated Phe-tRNA(Phe), an analog of the initiator f

91 inding mode suitable for interaction with de-N-acetylated PNAG (dPNAG).

92 DspB has increased catalytic activity on de-N-acetylated PNAG oligosaccharides, but the molecular ba

93 osans, a family of B-(1,4)-linked, partially N-acetylated polyglucosamines, are considered to be amon

94 gh purity and as substrates the partially de-N-acetylated polysaccharide of Escherichia coli K5 strai

95 rotein binding and which are interspersed by N-acetylated, poorly sulfated regions.

96 quires that they possess a free amino group; N-acetylated prenylcysteines and prenyl peptides are not

97 oadipate and tryptophan, to their respective N-acetylated products in several plant species.

98 receptors 1 and 2 on neutrophils, similar to N-acetylated proline-glycine-proline (N-alpha-PGP).

99 d to tetanus toxoid, including completely de-N-acetylated PSA.

100 44 on MIP1alpha and that the interconnecting N-acetylated region is of sufficient length to allow the

101 -rich S-domains separated by a short central N-acetylated region.

102 MAb is a MBPS disaccharide containing one de-N-acetylated residue.

103 consisted of a mixture of N-glycolylated and N-acetylated residues.

104 lting new N termini were N-myristoylated and N-acetylated, respectively.

105 it erythrocytes, which could be inhibited by N-acetylated saccharides.

106 mably single, N-sulfated domain linked to an N-acetylated sequence contiguous with the linkage to cor

107 efined model of the structure of HS in which N-acetylated sequences of four to five disaccharide unit

108 Recombinant (unacetylated) TM2 and N-acetylated striated muscle TM (stTM), long alpha-tropo

109 -fold but totally abolished the activity for N-acetylated substrates, indicating that residue S306 pl

110 e enzyme's specificity for N-formylated over N-acetylated substrates.

111 sule (and, potentially, glucuronic acid, any-N-acetylated sugar, or ribitol).

112 ntaining monosaccharides, phosphorylated and N-acetylated sugars, polyols, carboxylic acids, nucleoti

113 amines and amides, primary amides, and novel N-acetylated sugars, which together account for nearly 5

114 ns and that the predominant adduct formed is N-acetylated, supporting the concept that monofunctional

115 Non N-acetylated TPMs did not rescue GG-actin polymerization

116 D-glucosamine-alpha-1-phosphate is N-acetylated with [14C]acetate using N-ethoxycarbonyl-2-

117 n of amyloid fibrils formed from full-length N-acetylated WT SOD1 with trypsin, chymotrypsin, or Pron