ライフサイエンスコーパス: N-acetylglucosaminyltransferase

1 n-synthesizing enzyme GCNT3 (core 2 beta-1,6 N-acetylglucosaminyltransferase).

2 cal fringe is also a fucose-specific beta1,3-N-acetylglucosaminyltransferase.

3 hamster ovary cells expressing core2 beta1,6-N-acetylglucosaminyltransferase.

4 which is synthesized by I-branching beta1, 6-N-acetylglucosaminyltransferase.

5 es, which are synthesized by core 2 beta-1,6-N-acetylglucosaminyltransferase.

6 drolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.

7 ein, a proposed substrate of Fringe beta-1,3-N-acetylglucosaminyltransferases.

8 eficient for the glycosyltransferase beta1,3-N-acetylglucosaminyltransferase 1 (beta3GnT1), a key enz

9 Core 2 N-acetylglucosaminyltransferase 1 (C2GnT1) is a key enzy

10 cosaminyltransferase (Mgat1), whose product, N-acetylglucosaminyltransferase 1 (GlcNAcT1) is necessar

11 rnatively, protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) catalyzes th

12 Mutations in protein O-mannose B1,2-N-acetylglucosaminyltransferase 1 (POMGNT1), which is cr

13 disease, mice deficient in O-mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1).

14 isease, mice deficient in O-mannose beta31,2-N-acetylglucosaminyltransferase 1 (POMGnT1).

15 ng fukutin, protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 and the fukutin-relate

16 -DG was increased by co-expression of core 2 N-acetylglucosaminyltransferase 1 with Large.

17 oss of an enzyme (protein O-mannose beta-1,2-N-acetylglucosaminyltransferase 1) that modifies O-manno

18 uding protein O-mannosyltransferase 1, beta3-N-acetylglucosaminyltransferase 1, and like-acetylglucos

19 eased by co-expression of protein:O-mannosyl N-acetylglucosaminyltransferase 1.

20 ed in the Golgi branching pathway, including N-acetylglucosaminyltransferases 1 and 2, which are requ

21 iated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 (beta3GnT1).

22 igands elaborated by LSST and core 2 beta1,6-N-acetylglucosaminyltransferase-1 (Core2GlcNAcT) have be

23 -185 targets UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT1) a

24 by the alternating iterative action of B1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) and B1,4-gala

25 the alternating iterative action of beta1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) and beta1,4-g

26 Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes th

27 Depressed beta1,6 N-acetylglucosaminyltransferase 2 in MM cells upregulate

28 Low beta1,6 N-acetylglucosaminyltransferase 2 levels correlated with

29 come-associated genes and found that beta1,6 N-acetylglucosaminyltransferase 2 was downregulated and

30 ough the loss of I-branching enzyme, beta1,6 N-acetylglucosaminyltransferase 2.

31 Core 2 N-acetylglucosaminyltransferase 2/M (C2GnT-M) synthesize

32 Core2 beta1,6-N-acetylglucosaminyltransferase-2 (C2GnT-2) was markedly

33 osyltransferase (C1GalT1) and core 2 beta1,6-N-acetylglucosaminyltransferase-2 or mucus type (C2GnT-M

34 es, beta1,4-galactosyltransferase-I, beta1,3-N-acetylglucosaminyltransferase-2, hCGn6ST, and keratan

35 In this study, we first show that beta1,3-N-acetylglucosaminyltransferase-3 (beta3GlcNAcT-3) is al

36 d in C2GnT-2 knock-out mice but not in core2 N-acetylglucosaminyltransferase-3 (C2GnT-3) nulls.

37 3 and LNCaP prostate cancer cells with beta3-N-acetylglucosaminyltransferase-6 (core3 synthase) requi

38 LEM domain nuclear lamina component by beta-N-acetylglucosaminyltransferase, a nutrient sensor that

39 an in vitro glycosylation assay to evaluate N-acetylglucosaminyltransferase activity after bacterial

40 d residues that are known to be critical for N-acetylglucosaminyltransferase activity of yeast chitin

41 e proteins possess a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that initiates

42 The mutant had normal levels of N-acetylglucosaminyltransferase activity, and the partia

43 The former mutant lacks the Golgi N-acetylglucosaminyltransferase activity, whereas the la

44 We conclude that beta-N-acetylglucosaminyltransferase, an essential enzyme, co

45 ar poly-N-acetyllactosamines, while beta1, 3-N-acetylglucosaminyltransferase and beta4Gal-TI efficien

46 rent cellular proteins catalyzed by O-linked N-acetylglucosaminyltransferase and O-linked N-acetylglu

47 presence of the enzymes for addition (O-beta-N-acetylglucosaminyltransferase) and removal (O-beta-N-a

48 The Fringe family of beta1,3-N-acetylglucosaminyltransferases are regulators of this

49 s-Golgi poly-LacNAc extension enzyme beta1,3-N-acetylglucosaminyltransferase (B3GNT).

50 beta1,3-N-acetylglucosaminyltransferases (B3GNTs) are Golgi-resi

51 B1,3-N-acetylglucosaminyltransferases (B3GNTs) are Golgi-resi

52 e gene encoding the K. lactis Golgi membrane N-acetylglucosaminyltransferase by complementation of th

53 o the alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C) gene on 12q21

54 esized with the Golgi enzyme core 2 beta-1,6-N-acetylglucosaminyltransferase (C2 GlcNAcT).

55 gulation of the expression of core-2 beta1,6-N-acetylglucosaminyltransferase (C2GnT) 1, a key enzyme

56 nsferase VII (Fuc-T VII) and core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) are critical for

57 ansgenic mice overexpressing core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) in T cells, and

58 de is synthesized only when core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GnT) is present, and

59 ) BW5147 T cells lacking the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) were resistant t

60 3-fucosyltransferase-VII, and core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT).

61 cause they do not express the core 2 beta1 6-N-acetylglucosaminyltransferase (C2GnT).

62 nds for galectin-1 created by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT-I).

63 Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GnT, is a key enzyme

64 s, we engineered mice lacking core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT), an enzyme predi

65 and Nod2 agonists upregulated core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT; an important enz

66 arcinoma AGS cells transfected with alpha1,4-N-acetylglucosaminyltransferase cDNA.

67 ctions mediated by UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase (chitobiosyl-P-P-lipid s

68 first demonstrate that I-branching beta1, 6-N-acetylglucosaminyltransferase cloned from human PA-1 e

69 one of the protein subunits of the alpha1-6-N acetylglucosaminyltransferase complex, which catalyses

70 The four known mucin beta1,6-N-acetylglucosaminyltransferases contain nine conserved

71 The core 2 beta-1, 6-N-acetylglucosaminyltransferase (core 2 GnT) creates a b

72 ar cloning of a HEV-expressed core1-beta 1,3-N-acetylglucosaminyltransferase (Core1-beta 3GlcNAcT) en

73 of glycoproteins by leukocyte core2 beta1,6-N-acetylglucosaminyltransferase (Core2GlcNAcT-I).

74 produced glycosyltransferases including key N-acetylglucosaminyltransferases (e.g., GnTI, GnTII, and

75 The Golgi N-acetylglucosaminyltransferases encoded by Mgat1, Mgat2

76 ne pemphigoid were characterized by marginal N-acetylglucosaminyltransferase expression and decreased

77 the surface of the eye through inhibition of N-acetylglucosaminyltransferase expression in the Golgi.

78 ubstrates equally, whereas the HS-initiating N-acetylglucosaminyltransferase EXTL3 is selective.

79 nly non-conserved residue within the beta1,6-N-acetylglucosaminyltransferase family, Cys235, is also

80 ongation of O-fucose on Notch by the beta1,3-N-acetylglucosaminyltransferase Fringe modulates the abi

81 Upon expression of the beta3-N-acetylglucosaminyltransferase Fringe with Notch, we ob

82 galactosyltransferase or beta1-2- or beta1-6-N-acetylglucosaminyltransferase genes have been found in

83 ynthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.

84 ries glycolipids is catalyzed by the beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1

85 s, GlcNAc transfer is mediated by a distinct N-acetylglucosaminyltransferase (GlcNAc-T) activity.

86 of the glycosylating enzyme core 2 beta 1,6-N-acetylglucosaminyltransferase (GlcNAc-T) through prote

87 ty of the regulatory enzyme lactosylceramide N-acetylglucosaminyltransferase (GlcNAc-Tr) with age in

88 lglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good subs

89 A paralog of GnT-Vb, N-acetylglucosaminyltransferase (GnT-V), is expressed in

90 Our previous studies on a beta1,6-N-acetylglucosaminyltransferase, GnT-IX (GnT-Vb), a homo

91 nits of the multisubunit enzyme complex, GPI-N-acetylglucosaminyltransferase (GPI-GnT), involved in t

92 is initiated by a multi-subunit enzyme, GPI-N-acetylglucosaminyltransferase (GPI-GnT).

93 (siaA), and the undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase homolog (wecA) produced

94 significantly lower levels of core 2 beta1,6 N-acetylglucosaminyltransferase I (C2GlcNAcT-I), but no

95 Core 2 beta1,6-N-acetylglucosaminyltransferase I (C2GnT-I) plays a pivo

96 those of transcripts encoding core 2 beta1,6-N-acetylglucosaminyltransferase I (Core2GlcNAcT-I).

97 The Mgat1 gene encodes N-acetylglucosaminyltransferase I (Glc-NAc-TI; EC 2.4.1.

98 etylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-TI, EC 2.4.1.1

99 sulted in a marked and specific reduction in N-acetylglucosaminyltransferase I (GlcNAcT-I) activity a

100 ression of erythropoietin (EPO) in a HEK293S N-acetylglucosaminyltransferase I (GnT I)(-/-) cell line

101 N-acetylglucosaminyltransferase I (GNT-I) contributes to

102 ed glycosylation caused by a mutation in the N-acetylglucosaminyltransferase I (GnT1) gene.

103 embryonic kidney 293 (HEK293S) cells lacking N-acetylglucosaminyltransferase I (GnTI(-)), and was rec

104 It was shown to lack N-acetylglucosaminyltransferase I (GnTI) activity, and c

105 ive alpha-1,2-mannosidase and human beta-1,2-N-acetylglucosaminyltransferase I (GnTI) in the secretor

106 often circumvent this problem by using B1,2-N-acetylglucosaminyltransferase I (MGAT1)-deficient mamm

107 ten circumvent this problem by using beta1,2-N-acetylglucosaminyltransferase I (MGAT1)-deficient mamm

108 ment to the NH2-terminal retention signal of N-acetylglucosaminyltransferase I (NAGT I).

109 , we identified a highly divergent T. brucei N-acetylglucosaminyltransferase I (TbGnTI) among a set o

110 sident UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I activity (TbGnTI).

111 the O-glycan branching enzyme core 2 beta1,6-N-acetylglucosaminyltransferase I and its independent re

112 in and siRNA-mediated knockdown of the Golgi N-acetylglucosaminyltransferase I gene (MGAT1) induce pa

113 inhibition of glycosylation in the Golgi by N-acetylglucosaminyltransferase I gene inactivation nor

114 his organism, no homologues of the canonical N-acetylglucosaminyltransferase I or II genes can be fou

115 pha-mannosidase I, Nicotiana tabacum beta1,2-N-acetylglucosaminyltransferase I, Arabidopsis Golgi alp

116 y the lowest levels, partial deficiencies in N-acetylglucosaminyltransferase I, II, and V (i.e. Mgat1

117 ialyltransferase, galactosyltransferase, and N-acetylglucosaminyltransferase I, was dramatically disr

118 , the protease was efficiently secreted from N-acetylglucosaminyltransferase I-deficient Lec1 Chinese

119 rate baculovirus, transduce HEK293S GnTI(-) (N-acetylglucosaminyltransferase I-negative) cells in sus

120 ly expressed alpha-2,6-sialyltransferase and N-acetylglucosaminyltransferase-I (NAGT-I), both C-termi

121 -selectin ligands derived from core2 beta1,6-N-acetylglucosaminyltransferase-I null mice.

122 ghly homologous to the I branching beta-1, 6-N-acetylglucosaminyltransferase (IGnT).

123 ce paucimannosidic N-glycans or elongated by N-acetylglucosaminyltransferase II (GNT-II) to produce c

124 sferase family, encodes an equally divergent N-acetylglucosaminyltransferase II (TbGnTII) activity.

125 insect cell lines lacked adequate endogenous N-acetylglucosaminyltransferase II activity for biantenn

126 ding UDP-GlcNAc:alpha-6-d-mannoside beta-1,2-N-acetylglucosaminyltransferase II enzyme exhibit defici

127 of mammalian glycosyltransferases, including N-acetylglucosaminyltransferase II.

128 Mice lacking N-acetylglucosaminyltransferase III (GlcNAc-TIII) exhibi

129 N-acetylglucosaminyltransferase III (GlcNAc-TIII) is enc

130 N-Acetylglucosaminyltransferase III (GlcNAc-TIII), the p

131 gene transfection of U373 MG cells with the N-acetylglucosaminyltransferase III (GnT-III).

132 ed gene expression of the responsible enzyme N-acetylglucosaminyltransferase III (GnT-III).

133 Downregulation of the bisecting N-acetylglucosaminyltransferase III (MGAT3) expression w

134 t polylactosamine elongation by knockdown of N-acetylglucosaminyltransferase III or V had no effect o

135 N-Acetylglucosaminyltransferase-III (GnT-III) is a glyco

136 Addition of O-GlcNAc by O-beta-N-acetylglucosaminyltransferase increased InsP(3)R-3 sin

137 nechocystis sp. strain PCC6803, which encode N-acetylglucosaminyltransferases involved in peptidoglyc

138 tion, suggesting developmental regulation of N-acetylglucosaminyltransferases IV and V and alpha6-fuc

139 thermore, the mRNA and protein expression of N-acetylglucosaminyltransferase IVa (GnT-IVa), which was

140 of this capsular polysaccharide involves in N-acetylglucosaminyltransferase (KfiA) and d-glucuronylt

141 The N-acetylglucosaminyltransferase known as GnT-Vb or -IX i

142 g), which encodes an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase known to modify epiderma

143 e 2 branching enzyme, termed core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (C2GnT-L)

144 Bovine core 2 beta1,6-N-acetylglucosaminyltransferase-M (bC2GnT-M) catalyzes t

145 ession of reporter N-linked glycoproteins in N-acetylglucosaminyltransferase MGAT1-null HEK293 cells

146 ath was enhanced by loss of Golgi-associated N-acetylglucosaminyltransferases MGAT1 or MGAT5.

147 is (hexosamine pathway) and in turn to Golgi N-acetylglucosaminyltransferases Mgat1, -2, -4, and -5.

148 that alpha-1,3-Mannosyl-Glycoprotein 2-beta-N-Acetylglucosaminyltransferase (MGAT1) served as the pi

149 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1), necessary for t

150 enes (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1), transducing-lik

151 mannosyl (alpha-1,3-)-glycoprotein beta-1,2- N-acetylglucosaminyltransferase (Mgat1), whose product,

152 ion of beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) (P < 0.001) and

153 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (Mgat4) with UDP-GlcNAc.

154 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Mgat5) in the Golgi mem

155 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Mgat5).

156 Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferases modulate Notch signalin

157 ogue of the cellular core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M), wh

158 fication of a thermostable archaeal beta-1,4-N-acetylglucosaminyltransferase, named archaeal glycosyl

159 ncreased mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (ncOGT).

160 c mutation in the gene encoding the alpha1-6-N-acetylglucosaminyltransferase necessary for the format

161 ligosaccharides on the physiology of plants, N-ACETYLGLUCOSAMINYLTRANSFERASE (NodC) of Azorhizobium c

162 ering the expression or activity of O-linked N-acetylglucosaminyltransferase, O-linked N-acetylglucos

163 r GnT1IP-L inhibits other N-glycan branching N-acetylglucosaminyltransferases of the medial Golgi.

164 O-Linked N-acetylglucosaminyltransferase (OGT) catalyzes the tran

165 her, the mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (OGT) increases 3.4-fold

166 tter did not have a soluble inhibitor of the N-acetylglucosaminyltransferase or a hexosaminidase that

167 n ligand-synthesizing enzymes core-2 beta1,6-N-acetylglucosaminyltransferase or fucosyltransferases I

168 ion is evident in protein O-mannose beta-1,2-N-acetylglucosaminyltransferase (POMGnT1) knockout mouse

169 -Man glycans, the protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, POMGnT1.

170 have identified an enzyme, polypeptide alpha-N-acetylglucosaminyltransferase (pp alpha-GlcNAc-T2), th

171 mZP3 and huZP3 affect the ability of core 2 N-acetylglucosaminyltransferase(s) to extend the core 1

172 the B3GNT7 transcript, which encodes a B1-3-N-acetylglucosaminyltransferase that can participate in

173 e B3GNT7 transcript, which encodes a beta1-3-N-acetylglucosaminyltransferase that can participate in

174 pressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synth

175 We demonstrate that MGAT4A, an N-acetylglucosaminyltransferase that installs the beta-1

176 -fucosyltransferase-1) and Fringe, a beta1,3-N-acetylglucosaminyltransferase that modifies O-fucose i

177 Fringe is a fucose-specific beta1,3-N-acetylglucosaminyltransferase that modifies O-fucose m

178 inge proteins are O-fucose-specific beta-1,3 N-acetylglucosaminyltransferases that glycosylate the ex

179 nd Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch recep

180 Fringe proteins are beta3-N-acetylglucosaminyltransferases that modulate Notch act

181 Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modulate signaling

182 ent in milk and the recently cloned beta-1,3-N-acetylglucosaminyltransferase, the formation of poly-N

183 xture of beta4Gal-TI and i-extension beta1,3-N-acetylglucosaminyltransferase, the major product was t

184 beta-1,6-N-Acetylglucosaminyltransferase V (EC 2.4.1.155) catalyz

185 activity and mRNA transcript levels encoding N-acetylglucosaminyltransferase V (GlcNAc-T V).

186 Changes in the levels of N-acetylglucosaminyltransferase V (GnT-V) can alter the

187 N-Acetylglucosaminyltransferase V (GnT-V) is an enzyme i

188 The expression of N-acetylglucosaminyltransferase V (GnT-V) mRNA, which is

189 small interfering RNA-directed knockdown of N-acetylglucosaminyltransferase V (GnT-V), a glycosyltra

190 human clinical samples, we demonstrated that N-acetylglucosaminyltransferase V (GnT-V)-mediated glyco

191 beta(1,6)-linked GlcNAc, synthesized by the N-acetylglucosaminyltransferase V (GnT-V).

192 glycans caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).

193 harides caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).

194 s, including branched N-glycans generated by N-acetylglucosaminyltransferase V (Mgat5) activity, form

195 chanistically, ALK4 loss upregulates beta1,6 N-acetylglucosaminyltransferase V (MGAT5) and galectin-3

196 N-Acetylglucosaminyltransferase V (MGAT5) mediates beta1

197 ed that beta1,6GlcNAc-branched complex-type (N-acetylglucosaminyltransferase V (Mgat5)) N-glycans on

198 cetylglucosamine:alpha-6-D-mannoside beta1,6-N-acetylglucosaminyltransferase V (MGAT5)-modified N-gly

199 Lec4 and Lec13 cells, which are defective in N-acetylglucosaminyltransferase V and GDP-fucose synthes

200 h aberrant N-glycosylation caused by altered N-acetylglucosaminyltransferase V(GnT-V, GnT-Va, and Mga

201 experiments indicated that HG-CD147 contains N-acetylglucosaminyltransferase V-catalyzed, beta1,6-bra

202 A glycosyltransferase that branches O-Man, N-acetylglucosaminyltransferase Vb (GnT-Vb), is highly e

203 hether Fringe, an O-fucose specific beta 1,3-N-acetylglucosaminyltransferase, was capable of modifyin

204 reover, beta4Gal-TIV, together with beta-1,3-N-acetylglucosaminyltransferase, was capable of synthesi

205 e identified one glycosyltransferase, core 2 N-acetylglucosaminyltransferase, which is down-regulated

206 TDC2) is a protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase whose product could be e

207 Here we report this enzyme is not a beta-1,3-N-acetylglucosaminyltransferase with catalytic activity