ライフサイエンスコーパス: N-terminal fragment

1 nt) and a spatially adjacent C-degron (in an N-terminal fragment).

2 mammalian-derived expanded huntingtin exon-1 N-terminal fragment.

3 bound to GPIHBP1 avidly, independent of the N-terminal fragment.

4 ies of the amyloid-like aggregates of an htt N-terminal fragment.

5 for the coiled-coil Jun, is attached to the N-terminal fragment.

6 I, and restores motogenic activity to the FN N-terminal fragment.

7 ize a large conformational change within the N-terminal fragment.

8 mation to facilitate macrocyclization of the N-terminal fragment.

9 the htt(NT) domains of polyQ-containing htt N-terminal fragments.

10 he oligomer-mediated amyloid assembly of htt N-terminal fragments.

11 ach was used to stabilize the C-terminal and N-terminal fragments.

12 into two distinct forms: the C-terminal and N-terminal fragments.

13 diates the homo-trimeric DNA binding of Myrf N-terminal fragments.

14 defines the DNA binding specificity of Myrf N-terminal fragments.

15 ractions between amelogenin and ameloblastin N-terminal fragments.

16 rane binding by prothrombin, mediated by its N-terminal fragment 1 (F1) domain, plays an essential ro

17 hrombin and severs covalent linkage with the N-terminal fragment 1.2 (F12) region.

18 apatite (HA) formation and growth, while its N-terminal fragment (37K) promotes HA formation.

19 es an initial cleavage that releases a large N-terminal fragment (A1-F92) as well as multiple smaller

20 ved for a mixture of Abeta1-28WT and a short N-terminal fragment, Abeta1-6A2V, which supports a role

21 ormally, but no monomers or oligomers of the N-terminal fragments accumulated in the medium; medium f

22 The N-terminal fragment also rescued LTP inhibited by elevat

23 for the polypeptide backbone of a tetrameric N-terminal fragment (amino acids 1-181) of the Aplysia K

24 ucture of the complex between the mesothelin N-terminal fragment and Fab of MORAb-009 at 2.6 A resolu

25 collagen-like stalk, as the presence of C1q N-terminal fragment and low m.w. heparin but not the C-t

26 encoding compact beta variants of Htt exon 1 N-terminal fragment and tested their ability to aggregat

27 s with destabilized interactions between the N-terminal fragment and the channel domain.

28 s the orientation and/or distance of the PS1 N-terminal fragment and the PS1 C-terminal fragment, a r

29 e CUE domain, interact strongly with an RPM1 N-terminal fragment and weakly with a similar domain fro

30 tly visualized fluorescently labeled cMyBP-C N-terminal fragments and GFP-labeled myosin molecules bi

31 motility assays using expressed recombinant N-terminal fragments and in silico mechanistic modeling.

32 overning the biogenesis and function of Myrf N-terminal fragments and its physiological significance.

33 Two N-terminal fragments and one C-terminal fragment of E. c

34 t promotes the nuclear accumulation of small N-terminal fragments and reduces the interaction of N-te

35 peptides are simplified due to the enhanced N-terminal fragments and suppressed internal fragments.

36 sential for the biological functions of Myrf N-terminal fragment, and that the region adjacent to the

37 Smaller soluble N-terminal fragments appear to accumulate over time, pea

38 Although several p65 N-terminal fragments are generated by either protease cl

39 Consequently, Myrf N-terminal fragments are released from the ER only as ho

40 full-length mhtt and a small amount of mhtt N-terminal fragments are sufficient to elicit the diseas

41 nd limited proteolysis studies identified an N-terminal fragment as a candidate for one of the domain

42 Here, we report that Myrf N-terminal fragments assemble into stable homo-trimers b

43 e ABC-stroke score includes age, biomarkers (N-terminal fragment B-type natriuretic peptide and high-

44 Levels of N-terminal fragment B-type natriuretic peptide, high-sen

45 e, biomarkers [high-sensitivity troponin and N-terminal fragment B-type natriuretic peptide], and cli

46 xtensibility and shifting the phosphorylated N-terminal fragments back to the extended state, as if u

47 The N-terminal fragment bearing the bZIP DNA binding domain

48 We found that 1a and 1b N-terminal fragments bind in a direct and dose-dependent

49 /cytoplasmic C-terminal fragment but not the N-terminal fragment binding partner CD55.

50 udy the structural and functional effects of N-terminal fragments binding to thin filaments.

51 plexed with Dss1 binds DNA slowly, while the N-terminal fragment binds quickly.

52 11_0521, but not truncated forms lacking the N terminal fragment, block its interaction with ICAM-1.

53 the cleavage does not dissociate the C- and N-terminal fragments, but it generates a very stable "cl

54 ubiquitination of bacterially expressed IRS1 N-terminal fragment by CRL7 but at low levels.

55 lyzed post-MI in humans, which results in an N-terminal fragment, C0-C1f.

56 Therefore, the longer N-terminal fragment (C0C3) must possess the requisite do

57 The resulting N-terminal fragment, called fragment N, stimulates anti-

58 A specific N-terminal fragment, called the PF-AB domain, becomes pr

59 n cleavage and N-glycosylation, and that the N-terminal fragment can be released from the cell surfac

60 We show that an N-terminal fragment comprising the catalytic domain can

61 A chimeric N-terminal fragment containing residues from Venus and y

62 The N-terminal fragment containing the bZIP domain is then t

63 se-3 into two fragments during apoptosis, an N-terminal fragment containing the O-GlcNAcase active si

64 ate that TMEM106B is readily processed to an N-terminal fragment containing the transmembrane and int

65 Crystal structures of N-terminal fragments containing the VWA and TSR1 domains

66 on resonance measurements indicated that the N-terminal fragment contributes to the folding and incre

67 Although shorter N-terminal fragments (Cy3-C0C1 and Cy3-C0C1f) bound to t

68 tic cleavage of the channel because a mutant N-terminal fragment deficient in proteolytic activity is

69 mHTT N-terminal fragments detected in HD PBMCs may explain th

70 Unexpectedly, a shorter N-terminal fragment did not displace tropomyosin or acti

71 the Q193-G194 pair, resulting in a truncated N-terminal fragment disrupted for inducing cell pyroptos

72 inal (57K), and a chondroitin-sulfate-linked N-terminal fragment (DMP1-PG)], we predicted that each w

73 The Set1p N-terminal fragment does not exhibit significant homolog

74 s studies have shown that the aggregation of N-terminal fragments (encoded by HTT exon 1) underlies t

75 ng staurosporine-induced apoptosis, yielding N-terminal fragments encompassing the ligand-binding dom

76 Likewise, the N-terminal fragments extracted from axonemes contained L

77 racellular perfusion of the non-mRNA binding N-terminal fragment, FMRP(1-298), similarly restored den

78 II activate the receptor by dissociating the N-terminal fragment from its C-terminal fragment, enabli

79 downstream signaling without disengaging the N-terminal fragment from its C-terminal fragment.

80 it undergoes auto-processing to release its N-terminal fragment from the ER, which enters the nucleu

81 In particular, release of N-terminal fragments from the beta-chain of fibrin, whic

82 This sequence corresponds to a N-terminal fragment generated by the combined action of

83 erates two biologically active fragments, an N-terminal fragment (GrB-EH(ITSN)) with EC proliferative

84 The crystal structure of a mtMCM N-terminal fragment has been solved, but surprisingly on

85 However, the importance of smaller N-terminal fragments has been highlighted by their prese

86 linositol anchor-free) prion protein and its N-terminal fragment have a strong effect on the aggregat

87 sparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I2NTF) and the C-terminal fragment

88 this model in the context of the htt exon-1 N-terminal fragment in both mammalian cell culture and c

89 7 supported efficient ubiquitination of IRS1 N-terminal fragment in hyperphosphorylated form, which w

90 lization and functions of the DID-containing N-terminal fragment in podocytes and assessed whether th

91 r, addition of the C-terminal fragment to an N-terminal fragment in trans did not improve the aminoac

92 The role of these N-terminal fragments in disease pathogenesis has been qu

93 addition, there was distinct lack of NOTCH3 N-terminal fragments in the cerebral microvasculature of

94 expectedly consists of two polypeptides; the N-terminal fragment includes residues 1-116, and the C-t

95 Moreover, the N-terminal fragment inhibits the transcriptional activit

96 The light chain yields mainly N-terminal fragment ions due to the protection of the in

97 , we use this approach to distinguish b-type N-terminal fragment ions from both internal fragment ion

98 The N-terminal fragment is further processed into a small, r

99 sults indicate that overexpression of a Bub1 N-terminal fragment is insufficient to impair the spindl

100 type A (VWA) domain within the cleaved CLCA1 N-terminal fragment is necessary and sufficient for this

101 Proteolytic cleavage of Htt into toxic N-terminal fragments is believed to be a key aspect of p

102 th threshold of about 37, aggregation of htt N-terminal fragments is so rapid that it is difficult to

103 y 50% of its activity when normalized to PS1 N-terminal fragment levels.

104 e the proteasome-mediated destruction of the N-terminal fragment, liberating the C-terminal fragment

105 The N-terminal fragment, LL-37(1-12), was not active, while

106 echanism in which caspase-6, or other larger N-terminal fragments, mediate a neurotoxic process befor

107 he possibility of a functional role for such N-terminal fragment-membrane interactions.

108 d2L1-RACK1 interaction, we found that Pkd2L1 N-terminal fragment Met(1)-Pro(45), but not Ile(40)-Ile(

109 for the ATP7B variant that lacks the 29 kDa N-terminal fragment (mostly likely comprised of MBD1-3).

110 Both myristoylated N-terminal fragment mu1N and C-terminal fragment phi are

111 nd to L1 and that full-length Reelin and its N-terminal fragment N-R6 proteolytically cleave L1 to ge

112 e, we report that full-length Reelin and its N-terminal fragments N-R2 and N-R6 bind to L1 and that f

113 oresistant cells to CDDP, intact GSN and its N-terminal fragment (N-GSN) attenuated this response.

114 The resulting N-terminal fragments (N-ATF6 alpha and N-ATF6 beta) have

115 between residues 111/112 to yield a soluble N-terminal fragment (N1) and a membrane-anchored C-termi

116 Alpha- and beta-cleavage of PrP produces two N-terminal fragments, N1 and N2, respectively, which int

117 It was shown previously that an N-terminal fragment (nM60) that encompasses amino acid r

118 a1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfbeta), which can bind to a

119 eptide (BNP) concentration or its precursor (N-terminal fragment [NT-proBNP]) is recommended in patie

120 h undergoes autoproteolytic cleavage into an N-terminal fragment (NTF) and a seven-transmembrane-cont

121 lytically cleaved at their GPS sites into an N-terminal fragment (NTF) and C-terminal fragment.

122 ural crest cell EMT, which generates a Cad6B N-terminal fragment (NTF) and two C-terminal fragments (

123 y that clearance of the final membrane-bound N-terminal fragment (NTF) of CD74 is mediated by the int

124 ymphocytes of SPPL2a(-/-) mice accumulate an N-terminal fragment (NTF) of CD74, which severely impair

125 aved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associat

126 DAM10 and BACE1 released a signaling-capable N-terminal fragment (ntf), either Nrg1-ntfalpha or Nrg1-

127 In their absence, CD74 N-terminal fragments (NTFs) accumulate.

128 Exon 1 spanning N-terminal fragments (NTFs) of the Htt protein result fr

129 ysosomal degradation generate membrane-bound N-terminal fragments (NTFs), which we identified as nove

130 re included in this study and troponin I and N terminal fragment of B-type natriuretic peptide levels

131 r maximum AR transcriptional activation, the N terminal fragment of p44 alone maintains the basic eff

132 In solution, the N-terminal fragment of ALIX-PRD is dynamically disordere

133 experiments the levels of the cleaved 22-kDa N-terminal fragment of alpha was low and did not match t

134 Vv into host cells either as a fusion to the N-terminal fragment of anthrax toxin lethal factor or wh

135 In addition, an N-terminal fragment of apoE that also contains this bind

136 -secretase cleavage of APP and binding of an N-terminal fragment of APP to DR6 is required for their

137 l-d-aspartate (NMDA) receptor to generate an N-terminal fragment of approximately 65 kDa.

138 which posttranslational modifications of the N-terminal fragment of ataxin-7 modulate turnover and to

139 Under salt stress conditions, the N-terminal fragment of AtbZIP17 tagged with GFP was tran

140 An N-terminal fragment of ATG2A that supports lipid transfe

141 ouble Lansbury glycosylation en route to the N-terminal fragment of beta-hCG and the sequential insta

142 Additionally, the N-terminal fragment of Brd4 binds to both DNA and acetyl

143 roteins including antibody heavy chains, the N-terminal fragment of Cfa exhibits increased expression

144 Furthermore, an N-terminal fragment of Chmp6 inhibited both HIV-1 and AS

145 C activation requires cleavage to unmask the N-terminal fragment of CLCA1, which can independently ga

146 mapped the K7-binding region to a 30-residue N-terminal fragment of DDX3, ahead of the core RNA helic

147 is constitutively cleaved by ADAM12, and the N-terminal fragment of Dll1 is released to medium.

148 way determined previously for a similarsized N-terminal fragment of Drosophila conventional kinesin.

149 munostaining signals of dentin sialoprotein (N-terminal fragment of DSPP) were decreased in the denti

150 and apoE4 conferred protection but the major N-terminal fragment of each isoform did not.

151 e present a protocol for isolating the large N-terminal fragment of enhanced green fluorescent protei

152 FAK and p53 proteins, we determined that the N-terminal fragment of FAK directly interacts with the N

153 fferences were seen in binding of the 70-kDa N-terminal fragment of fibronectin that recognizes fibro

154 induced neuronal death, and expression of an N-terminal fragment of FISH reduces Abeta toxicity.

155 ther demonstrate that acutely introducing an N-terminal fragment of FMRP into BCs normalizes GABA rel

156 Expression of the 70 kD N-terminal fragment of FN blocks FN fibril assembly at g

157 We demonstrated that the N-terminal fragment of Fnm is required for full fibronec

158 we report a crystal structure of Get4 and an N-terminal fragment of Get5 from Saccharomyces cerevisae

159 ot only entirely precluded production of the N-terminal fragment of HDAC4 but also promoted Ca(2+)/ca

160 Reexpression of the N-terminal fragment of HDAC4 prevents HDAC4-dependent di

161 n is an essential step for production of the N-terminal fragment of HDAC4, which was attenuated by Ca

162 ted forms fused with the initially insoluble N-terminal fragment of hepatitis C virus' E2 protein wer

163 fragment of hGal-3 (hGal-3C), hGal-7, and an N-terminal fragment of hGal-9 (hGal-9N), were measured u

164 A 17-residue N-terminal fragment of htt(e1) (N17) has been suggested

165 R6/2 mice contain an N-terminal fragment of human huntingtin with an expanded

166 hermocellum ATCC 27405, with both SAM and an N-terminal fragment of its peptidyl-substrate at 2.04 A

167 TGATCATTGTG), the guests, complexed with the N-terminal fragment of MMLV reverse transcriptase, the h

168 drug-DNA interactions in which the host, the N-terminal fragment of Moloney murine leukemia virus rev

169 The crystal structure of the N-terminal fragment of mtMCM reveals a stable dHex archi

170 nsgenic mice that express a caspase-6 length N-terminal fragment of mutant htt (N586) with both norma

171 one important example, mice that express an N-terminal fragment of mutant htt terminating at the C-t

172 , we examine possible mechanisms by which an N-terminal fragment of mutant huntingtin (htt; N-htt) in

173 overexpressed reduce the toxic effects of an N-terminal fragment of mutant huntingtin with 103 Q.

174 ting proteins to IBs that are composed of an N-terminal fragment of mutant huntingtin, the causative

175 Ectopic expression of an N-terminal fragment of NleE (NleE(34-52)) in HeLa cells

176 her subunits of the CAF-1 complex because an N-terminal fragment of p150 (p150N) that cannot interact

177 Small linear peptides mimicking the N-terminal fragment of p53 have been shown to be potent

178 Here we report that an N-terminal fragment of p65 (amino acids 21-186) can sele

179 is in primary striatal neurons exposed to an N-terminal fragment of polyglutamine-expanded huntingtin

180 Control proteins, the N-terminal fragment of polymorphic membrane protein 8 an

181 report the structure of alpha4 bound to the N-terminal fragment of PP2Ac.

182 ty probe E2012-BPyne specifically labels the N-terminal fragment of presenilin-1 (PS1-NTF) in cell me

183 Levels of N-terminal fragment of prohormone B-type natriuretic pep

184 g, and diabetes) and newer CHD risk factors (N-terminal fragment of prohormone B-type natriuretic pep

185 on blood pressure (BP) and relationship with N-terminal fragment of prohormone B-type natriuretic pep

186 d by PS2 but not PS1 and is dependent on the N-terminal fragment of PS2 but not gamma-secretase activ

187 creen for this receptor that used a modified N-terminal fragment of PTH as a probe for small molecule

188 idues) are natural agonists of PTHR1, and an N-terminal fragment of PTH, PTH(1-34), is used clinicall

189 Ca(2+)-bound recoverin bound to a functional N-terminal fragment of rhodopsin kinase (residues 1-25,

190 The reconstituted highly conserved N-terminal fragment of RNase E (NRne, residues 1-499) bi

191 We found that an N-terminal fragment of RNF168 (1-220/N221*) efficiently

192 AA) amyloid deposits typically consist of an N-terminal fragment of SAA1 or SAA2, here, abundant C-te

193 Here, we present the crystal structure of an N-terminal fragment of Saccharomyces cerevisiae Hsp104 w

194 ive vaccine candidate, we have expressed the N-terminal fragment of SARS-CoV S protein (S1) in tomato

195 here the structure of a complex formed by an N-terminal fragment of Scm3 with the histone-fold domain

196 d to express Slit2 and Robo-1, the bioactive N-terminal fragment of Slit2 inhibited TGF-beta-induced

197 We find that a short palmitoylated N-terminal fragment of Sonic Hedgehog binds Patched1 and

198 m a duplication of the sequence encoding the N-terminal fragment of talin (the talin head domain) wit

199 Here we quantify plasma concentrations of an N-terminal fragment of tau (NT1) in a large, well-charac

200 We found the free N-terminal fragment of the adhesion G protein-coupled re

201 luster region and result in expression of an N-terminal fragment of the APC protein.

202 We also synthesized the short N-terminal fragment of the atypically split CL intein by

203 n self-catalytically form within an isolated N-terminal fragment of the enhanced green fluorescent pr

204 tigens and milk oligosaccharides, against an N-terminal fragment of the family 51 carbohydrate-bindin

205 of HAX-1 were mediated by its binding to the N-terminal fragment of the heat shock protein 90 (Hsp90)

206 The active cDNA encodes an N-terminal fragment of the heterogeneous nuclear ribonuc

207 rid assays showed that retinoschisin and the N-terminal fragment of the L-VGCCalpha1 subunit physical

208 article cryo-EM reconstruction of an ~160-kD N-terminal fragment of the lipid transport protein VPS13

209 Here, we show that an N-terminal fragment of the long CRMP-2 splice variant (C

210 p Fusion, using as a model system a 17.5 kDa N-terminal fragment of the mitotic regulator Bora.

211 Earlier, we reported an N-terminal fragment of the p160 coactivator TIF2, called

212 ch (brain natriuretic peptide [P < .001] and N-terminal fragment of the prohormone brain natriuretic

213 The complex includes the N-terminal fragment of the ribosomal protein S4, which i

214 The replacement of the N-terminal fragment of the VEEV capsid by its Sindbis vi

215 The N-terminal fragment of the Venus fluorescent protein fus

216 ial, viral, and human proteins, fused to the N-terminal fragment of the Yersinia enterocolitica T3S s

217 In this study, we investigated whether an N-terminal fragment of TLR9 could be responsible for reg

218 The structure of the 61 kDa N-terminal fragment of topoisomerase V reveals no struct

219 interaction between zebrafish Pcdh15a and an N-terminal fragment of transmembrane channel-like 2a (Tm

220 We genetically fused the N-terminal fragment of ultrafast split intein to the C t

221 In contrast, the N-terminal fragment of uPA, which binds to uPAR, but lac

222 The N-terminal fragment of wild-type huntingtin did not affe

223 As proof of concept, we used the N-terminal fragment of yellow fluorescent protein- or nV

224 ansverse sections, co-localization images of N-terminal fragments of amelogenin and ameloblastin arou

225 However, N-terminal fragments of CC2D1A that did not interact wit

226 tural observations of F-actin decorated with N-terminal fragments of cMyBP-C suggest that cMyBP-C bin

227 or the enzymatic reaction to take place, the N-terminal fragments of GNMT must have a significant deg

228 untingtin protein (HTT), studies reveal that N-terminal fragments of HTT containing the expanded Poly

229 omes are not directly impaired by aggregated N-terminal fragments of htt; instead, our data suggest t

230 The formation of short N-terminal fragments of huntingtin (cp-1/cp-2, cp-A/cp-B

231 The proteolytic enzymes generating short N-terminal fragments of huntingtin remain unknown.

232 N-terminal fragments of increasing length, in conjunctio

233 d this issue by NMR analysis of apomyoglobin N-terminal fragments of increasing length, taken as mode

234 eled inositol 1,4,5-trisphosphate (IP(3)) to N-terminal fragments of IP(3) receptors can be character

235 have expressed heterodimeric full-length and N-terminal fragments of Manduca sexta sGC in Escherichia

236 ts with menin in a bivalent mode involving 2 N-terminal fragments of MLL.

237 ronal degeneration and inclusions containing N-terminal fragments of mutant htt are present in the co

238 N-terminal fragments of mutant huntingtin (htt) that ter

239 Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the

240 Protein inclusions comprised of N-terminal fragments of mutant huntingtin are a characte

241 generation and protein inclusions containing N-terminal fragments of mutant huntingtin.

242 paran sulfate to induce amyloid formation in N-terminal fragments of proIAPP.

243 Vasoinhibins are N-terminal fragments of prolactin that prevent BRB break

244 Here, we show that overexpression of N-terminal fragments of Sir3 in strains lacking the full

245 We describe structures of N-terminal fragments of smooth muscle Tmalpha and Tmbeta

246 reviously shown that constructs representing N-terminal fragments of tau, which resemble the naturall

247 zed pathologically by aggregates composed of N-terminal fragments of the mutant form of the protein h

248 N-terminal fragments of the mutant Htt (mHtt) proteins c

249 beta and c-Myc are fused with C-terminal and N-terminal fragments of the split FL, respectively.

250 ipopeptides corresponding to the triacylated N-terminal fragments of three outer membrane proteins (O

251 Tagging N-terminal fragments of TMC1 with Aquaporin 3 (AQP3) and

252 echanotransduction in vivo, we overexpressed N-terminal fragments of Tmc2a in zebrafish hair cells.

253 mbin- and carboxypeptidase B2-double-cleaved N-terminal fragment (OPN-L), and C-terminal fragment (OP

254 Full-length OPN (OPN-FL), thrombin-cleaved N-terminal fragment (OPN-R), thrombin- and carboxypeptid

255 This cleavage generates an N-terminal fragment, p50 N-LOK, containing the kinase do

256 Simultaneously, CHK1 full length and its N-terminal fragments phosphorylate SPRTN at the C-termin

257 Pih1(1-230) as well as a shorter Pih1 N-terminal fragment Pih1(1-195) is able to bind Rvb1/Rvb

258 nking the polyQ sequence in huntingtin (htt) N-terminal fragments plays a crucial role in initiating

259 However, unlike the N-terminal fragment produced by caspase-1 cleavage, this

260 This cleavage generates a soluble N-terminal fragment (PrPN1) and a glycosylphosphatidylin

261 nstrated specific labeling of the presenilin N-terminal fragment (PS1-NTF) within the gamma-secretase

262 ese regions showed labeling for presenilin-1 N-terminal fragments (PS1-NTFs).

263 important co-factor of AVP, the role of the N-terminal fragment, pVIn, is currently elusive.

264 proteolytic processing, the liberated amino (N)-terminal fragment remains bound to the C terminus thr

265 The binding affinity of UDP-GalNAc to a K4CP N-terminal fragment (residues 58-357) was profoundly dec

266 Slit processing generates an N-terminal fragment (SlitN) that binds to Robo1 and Robo

267 roteinases, and the approximately 17-kDa PRL N-terminal fragment so produced is demonstrated to have

268 This cleavage produces a shorter N-terminal fragment spanning amino acids 1 to 193 (GSDMD

269 Recombinant N-terminal fragments such as C0-C1, C0-C4, and C0-C5 cos

270 x polyQ proteins, the behavior of huntingtin N-terminal fragments, such as exon-1, receives special a

271 it intein, which features the shortest known N-terminal fragment, supports rapid and efficient protei

272 ed by the human antibodies was mapped to the N-terminal fragment T22-S69.

273 Recently, a 236-residue N-terminal fragment, termed "L6," that spans the first L

274 B cleaves Hax-1 into two major fragments: an N-terminal fragment that localizes to mitochondria and a

275 tive caspases, which released a hyperactive, N-terminal fragment that translocated to the nucleus and

276 htt is important for the generation of small N-terminal fragments that are able to accumulate in the

277 eavage of mutant htt yields polyQ-containing N-terminal fragments that are prone to misfolding and ag

278 In the absence of the N-terminal fragment, the C-terminal fragment is redirect

279 tivity is not rescued by coexpression of the N-terminal fragment (TLR9(1-440)), inclusion of the hing

280 Of tropomodulin 1's 359 amino acids, an N-terminal fragment (Tmod1(1)(-)(92)) suffices for in vi

281 Cleavage allows the N-terminal fragment to function independently and helps

282 improve the aminoacylation efficiency of the N-terminal fragment to the level of the full-length enzy

283 s differences between the golden ions allows N-terminal fragments to be readily identified while othe

284 LC8 enhanced the binding of RSP3 N-terminal fragments to purified axonemes.

285 se of very short polyQ repeat lengths in htt N-terminal fragments to slow this disease-associated agg

286 t) protein with polyglutamine repeats, whose N-terminal fragment translocates to the nucleus to elici

287 icted to generate a glycosaminoglycan-bereft N-terminal fragment, versikine Myeloma-associated macrop

288 The inhibition of proliferation by the N-terminal fragment was independent of its mitochondrial

289 th bound with similar affinities to LPL, the N-terminal fragment was more potent in inactivating both

290 A 406-residue long N-terminal fragment was shown by sedimentation equilibri

291 tions, the expression of either one of these N-terminal fragments was sufficient to delocalize Plk4 f

292 Aromatic-aromatic interactions in the N-terminal fragment were proposed to be essential for LL

293 n, IgG and IgM titers against a unique Set1p N-terminal fragment were significantly higher among pati

294 While the N-terminal fragments were active in adenylate synthesis,

295 mbrane and that they are cleaved into active N-terminal fragments, which then translocate into the nu

296 cused on proteolytic steps producing shorter N-terminal fragments, which we term cp-1 and cp-2 (disti

297 and antimicrobial activity as a 16-residue, N-terminal fragment, while further shortening led to a m

298 The interaction of the N-terminal fragment with p65 enhanced entrance of p65 in

299 endoplasmic reticulum where co-expression of N-terminal fragments with hERG1 subunits disrupted oligo

300 The crystal structures show that the N-terminal fragment wraps around the TcrPDEC catalytic d