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1                                              NCS-1 and PI4Kbeta coimmunoprecipitate, opening up the p
2                                              NCS-1 and TRPC5 are in the same protein complex in rat b
3                                              NCS-1 binds directly to PICK1 via its BAR domain in a Ca
4                                              NCS-1 is a multispecific protein interacting with a numb
5                                              NCS-1 was shown to modulate the effects of expression of
6                                              NCS-1-D2 receptor interaction may serve to couple dopami
7  that the neuronal calcium sensor protein-1 (NCS-1), another member of the recoverin-neuronal calcium
8 n, which degrades neuronal calcium sensor 1 (NCS-1) and subsequent loss of intracellular calcium sign
9 the Ca(2+) sensor neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a cor
10                   Neuronal calcium sensor 1 (NCS-1) interacts with D(2)R in a Ca(2+)-dependent manner
11            Neuron specific calcium sensor 1 (NCS-1) is widely expressed in the developing and adult n
12 ific reduction in neuronal calcium sensor 1 (NCS-1) protein levels, a known modulator of InsP(3) rece
13 l binding protein, neuronal Ca(2+) sensor 1 (NCS-1), a Ca(2+) binding protein that interacts with the
14               The neuronal calcium sensor 1 (NCS-1), an EF-hand Ca(2+) binding protein, and Ric-8A co
15 tween paclitaxel, neuronal calcium sensor 1 (NCS-1), and the inositol 1,4,5-trisphosphate receptor (I
16 ess I(Ca), unless neuronal calcium sensor-1 (NCS-1) activity was blocked by a dominant-negative NCS-1
17 heral neuropathy, neuronal calcium sensor-1 (NCS-1) and calpain.
18 teraction between neuronal calcium sensor-1 (NCS-1) and the GTPase ARF1.
19 ts mammalian homolog neuronal Ca2+ sensor-1 (NCS-1) belong to a family of Ca2+ sensors with EF hands
20  we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine recept
21 m binding protein neuronal calcium sensor-1 (NCS-1) can switch paired-pulse depression to facilitatio
22 eins (KChIPs) and neuronal calcium sensor-1 (NCS-1) have been shown to interact with Kv4 channel alph
23                   Neuronal calcium sensor-1 (NCS-1) is a small calcium binding protein that plays a k
24                   Neuronal calcium sensor-1 (NCS-1) is the primordial member of a family of proteins
25                   Neuronal calcium sensor-1 (NCS-1) is the primordial member of the neuronal calcium
26                   Neuronal calcium sensor-1 (NCS-1) mediates changes in cellular function by regulati
27 ism involving the neuronal calcium sensor-1 (NCS-1) protein.
28                   Neuronal calcium sensor-1 (NCS-1), a Ca(2+)-binding protein, plays an important rol
29 tudy, addition of neuronal calcium sensor-1 (NCS-1), a high-affinity, low-capacity, calcium-binding p
30  with that of the neuronal calcium sensor-1 (NCS-1), a neuron-specific calcium-binding and D2-interac
31 -binding protein, neuronal calcium sensor-1 (NCS-1), can physically associate with the type III PI4Kb
32 in, also known as neuronal calcium sensor-1 (NCS-1), is an N-myristoylated Ca2+-binding protein that
33 mination of the crystal structures of Ca(2+)/NCS-1 alone and in complex with peptides derived from D2
34 ind within the hydrophobic crevice on Ca(2+)/NCS-1, but only one copy of the GRK1 peptide binds.
35                                In the Ca(2+)/NCS-1.D2R peptide complex, the C-terminal region adopts
36 hat this adaptive signalling network (Cav1.3/NCS-1/D2/GIRK2) is also active in human SN DA neurons, a
37                             Thus, Cav2.3 and NCS-1 may constitute potential therapeutic targets for c
38 in the same protein complex in rat brain and NCS-1 directly binds to the TRPC5 C-terminus.
39 ly block the interaction between the D2R and NCS-1.
40 errogate the interaction between the D2R and NCS-1.
41              Furthermore, in vitro, Frq1 and NCS-1 (either N-myristoylated or unmyristoylated) compet
42 is with chimeric proteins between KChIP2 and NCS-1 reveals that the three regions of KChIP2 (the link
43 ce in these three regions between KChIPs and NCS-1 determines the specificity and affinity for intera
44  When expressed in COS-7 cells, PI4Kbeta and NCS-1 formed a complex that could be immunoprecipitated
45                 Transfection of PI4Kbeta and NCS-1 had no effect on basal PIP synthesis in permeabili
46 osphoinositide-mediated Ca(2+) signaling and NCS-1 protein levels.
47              Inhibitory mutants of TRPC5 and NCS-1 enhance neurite outgrowth similarly.
48 and PI 4-kinase activity was present in anti-NCS-1 immunoprecipitates.
49  suggest protein-protein interaction between NCS-1 and TRPC5, and involvement of this protein complex
50            In the developing olfactory bulb, NCS-1 was expressed in the processes of mitral/tufted an
51  and D2-autoreceptor activity, controlled by NCS-1, and indicate that this adaptive signalling networ
52  the different molecular states populated by NCS-1 was monitored in real time through constant-force
53                             Like calmodulin, NCS-1 is a member of a family of calcium binding protein
54                                  Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and
55                                    Expressed NCS-1-YFP showed co-localization with endogenous PI4Kbet
56                                       First, NCS-1 levels and intracellular calcium signaling were fo
57 as a physiological cofactor with calcium for NCS-1-D2R binding.
58       The latter finding suggests a role for NCS-1 in desensitization of D2 in the prefrontal cortex.
59 av2.3 deficiency upregulated transcripts for NCS-1, a Ca(2+)-binding protein implicated in neuroprote
60                                    Frequenin/NCS-1 has been shown to enhance exocytotic activity in a
61                                 Furthermore, NCS-1 did not alter the insulin-stimulated protein kinas
62  to NCS-1 shifted titration curves to higher NCS-1 concentrations, suggesting that the binding of NCS
63   When cells were stimulated with histamine, NCS-1 overexpression led to higher exocytosis, as well a
64                     To better understand how NCS-1 regulates stimulus-secretion coupling, bovine chro
65 ing proteins on Kv4 channel gating, however, NCS-1 co-expression does not measurably affect the volta
66 omyces cerevisiae frequenin (Frq1) and human NCS-1 is also reflected at the functional level.
67                          Expression of human NCS-1 in yeast, but not a close relative (human KChIP2),
68                                 Importantly, NCS-1 induces a structural rearrangement in Ric-8A that
69 and Ca(2+)-induced conformational changes in NCS-1 as compared with the role in the nonmyristoylated
70 yristoyl-dependent conformational changes in NCS-1.
71 lished after a single amino acid mutation in NCS-1 that has been shown to impair the calcium-binding
72  activation of calpain and the reductions in NCS-1 levels and calcium signaling associated with these
73  interface and uncovers a suitable region in NCS-1 for development of additional drugs of potential u
74  to study the folding behavior of individual NCS-1 molecules in the presence of Mg(2+) and in the abs
75 on InsP3R1 function, suggesting that InsP3R1/NCS-1 interaction is an essential component of the patho
76                 To determine whether InsP3R1/NCS-1 interaction could be functionally relevant in bipo
77             In the absence of divalent ions, NCS-1 unfolds and refolds reversibly in a two-state reac
78 ow D2R peptide concentrations calcium-loaded NCS-1 binds to the D2R peptide in a monomeric form.
79 her observed that short hairpin RNA-mediated NCS-1 knockdown had a similar effect on phosphoinositide
80                                    Moreover, NCS-1 levels were reduced in a human iPSC-model of famil
81                                    Moreover, NCS-1 showed partial colocalization with GLUT4-EGFP in t
82                                       Mutant NCS-1 does not inhibit surface-expression of TRPC5 but g
83               (3) N-Terminally myristoylated NCS-1 dimerizes in a calcium-dependent manner.
84 ee of cooperativity; thus, the myristoylated NCS-1 binds Ca(2+) more strongly (with three Ca(2+) bind
85  activity was blocked by a dominant-negative NCS-1 construct.
86 nt protein imaging show that KChIPs (but not NCS-1) effectively bind to Kv4.3 protein and localize at
87                               The ability of NCS-1 to modulate D2 receptor signaling was abolished af
88                            In the absence of NCS-1, worms show delayed onset and a shorter duration o
89                     The inhibitory action of NCS-1 was independent of calcium sequestration since nei
90  is known that the physiological activity of NCS-1 is governed by its myristoylation.
91            Our data show that the binding of NCS-1 and Galpha to Ric-8A are mutually exclusive.
92 ncentrations, suggesting that the binding of NCS-1 to the D2R is highly specific and that binding occ
93                   Taxol increased binding of NCS-1 to the inositol 1,4,5-trisphosphate receptor.
94        The data also show the coexistence of NCS-1 and D2 at the ultrastructural level.
95                            Colocalization of NCS-1 and D2 receptors was examined in both primate and
96 rminal helix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction.
97 cells from paclitaxel-induced degradation of NCS-1 by inhibiting calpain activity.
98 nduces activation of calpain, degradation of NCS-1, and loss of intracellular calcium signaling.
99 u-calpain, which leads to the degradation of NCS-1, which, in turn, attenuates InsP(3)mediated Ca(2+)
100 tochemistry showed a similar distribution of NCS-1 and phosphatidylinositol 4-kinase beta (PI4Kbeta).
101  for the target specificity and diversity of NCS-1.
102    Lithium inhibited the enhancing effect of NCS-1 on InsP3R1 function, suggesting that InsP3R1/NCS-1
103                               This effect of NCS-1 was accompanied by an increase in D2 receptor-medi
104                                The effect of NCS-1 was specific for GLUT4 and the insulin-responsive
105         We demonstrate antagonist effects of NCS-1 and ARF on constitutive and regulated exocytosis.
106                                Expression of NCS-1 (neuronal calcium sensor-1, also termed frequenin)
107                             Co-expression of NCS-1 also decreases the rate of inactivation of Kv4 alp
108                We examined the expression of NCS-1 in the developing and mature olfactory system to d
109            During development, expression of NCS-1 in the olfactory epithelium was localized in the d
110      In intact cells, enhanced expression of NCS-1 resulted in increased intracellular calcium releas
111  We propose, therefore, that the function of NCS-1 in mammals may closely resemble that of Frq1 in S.
112      Short hairpin RNA-mediated knockdown of NCS-1 in the same cell line abrogated the response to ta
113 antia nigra dopamine messenger RNA levels of NCS-1 (but not Cav1.2 or Cav1.3) after cocaine in mice,
114  site of NCS-1 to decrease the likelihood of NCS-1 degradation.
115  consistent with the genetic manipulation of NCS-1.
116 lus NCS-1, except that the overexpression of NCS-1 resulted in a faster rundown in exocytosis.
117  fluorescence anisotropy (FA) and a panel of NCS-1 EF-hand variants to interrogate the interaction be
118 sults allowed us to trace the progression of NCS-1 folding along its energy landscapes and provided a
119  to impair the calcium-binding properties of NCS-1.
120 2R peptide binds to the first 60 residues of NCS-1.
121 ta suggest multiple and overlapping roles of NCS-1 in the developing and mature olfactory system.
122  P2 position of the calpain cleavage site of NCS-1 to decrease the likelihood of NCS-1 degradation.
123  made possible by the C-lobe-binding site of NCS-1, which adopts alternative conformations in each co
124     Under tension, the Mg(2+)-bound state of NCS-1 unfolds and refolds in a three-state process by po
125                     The crystal structure of NCS-1 bound to FD44 and the structure-function studies p
126      Expression of either mutated version of NCS-1 in neuroblastoma cells protected intracellular cal
127      Next, we tested two mutated versions of NCS-1 developed with point mutations at the P2 position
128  green fluorescent protein (GFP) or GFP plus NCS-1, except that the overexpression of NCS-1 resulted
129       Mutants with defects in four potential NCS-1 targets (arf-1.1, pifk-1, trp-1 and trp-2) showed
130 ng that the NCS-1 C-terminal region prevents NCS-1 oligomerization.
131 ves the neuronal Ca(2+) sensor (NCS) protein NCS-1.
132 orest virus (SFV) vectors containing the rat NCS-1 gene.
133 ase activity when incubated with recombinant NCS-1, but only if the latter was myristoylated.
134                        We have reconstituted NCS-1/Ric-8A complexes to conduct a multimodal approach
135 e interaction of the neuronal calcium sensor NCS-1 with D2-autoreceptors.
136                                 In striatum, NCS-1 and D2 receptors were found to colocalize within s
137 studies revealed that these compounds target NCS-1, overlap the D(2)R binding site, and perturb the d
138 expressed in adult mouse ventricles and that NCS-1 co-immunoprecipitates with Kv4.3 from (adult mouse
139 pitation experiments in HEK-293 confirm that NCS-1 can oligomerize in cell lysates and that oligomeri
140                           We also found that NCS-1 is readily degraded by mu-calpain in vitro and tha
141  in vitro and cellular assays, we found that NCS-1 promotes D(2)R trafficking to the plasma membrane
142         These results together indicate that NCS-1 is able to interact with PI4Kbeta also in mammalia
143 an embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalizatio
144 uency trains of stimulation, indicating that NCS-1 can recruit 'dormant' vesicles.
145 ression studies in HEK-293 cells reveal that NCS-1 increases membrane expression of Kv4 alpha-subunit
146 xperiments from striatal neurons reveal that NCS-1 is found in association with both the D2 receptor
147 g(2+) FA titration experiments revealed that NCS-1 EF-hands 2-4 (EF2-4) contributed to binding with t
148                                 We show that NCS-1 can exert bidirectional effects to activate PI(4)K
149                     Our results suggest that NCS-1 acts as a calcium sensor for short-term plasticity
150   Taken together, these results suggest that NCS-1 is an accessory subunit of Kv4-encoded I(to,f) cha
151                   These results suggest that NCS-1 may regulate cellular activity through the modulat
152                                          The NCS-1-ARF1 interaction and its specificity have been dem
153                                          The NCS-1-ARF1 interaction provides evidence for functional
154 ystallographic data reported here define the NCS-1/Ric-8A interface and will allow the development of
155                             Furthermore, the NCS-1-PICK1 association is stimulated by activation of m
156                    Given the interest in the NCS-1/Ric-8A complex as a therapeutic target in nervous
157               In contrast, expression of the NCS-1 effector phosphatidylinositol 4-kinase (PI 4-kinas
158          We determined NMR structures of the NCS-1 homolog from fission yeast (Ncs1), which activates
159 ient to promote high-affinity binding of the NCS-1 monomer to the D2R peptide.
160 all molecules as potential inhibitors of the NCS-1/Ric8a interaction.
161       Our study shows the drugability of the NCS-1/Ric8a interface and uncovers a suitable region in
162 d the large hydrophobic crevice based on the NCS-1 crystal structure, this crevice may be the associa
163 an inactive PI 4-kinase mutant prevented the NCS-1-induced inhibition.
164 n interaction (PPI) modulators targeting the NCS-1/D(2)R interface.
165 ant that formed a dimer, indicating that the NCS-1 C-terminal region prevents NCS-1 oligomerization.
166                                        Thus, NCS-1 plays a distinct role in mGluR-LTD.
167  compete with labeled peptide for binding to NCS-1 shifted titration curves to higher NCS-1 concentra
168               Similarly, in vitro translated NCS-1, but not its myristoylation-defective mutant, was
169 y a model in which the D2R peptide binds two NCS-1 monomers sequentially in a cooperative fashion.
170                                         When NCS-1 protein levels recovered, so did InsP(3)-mediated
171    However, the molecular mechanism by which NCS-1 regulates Ric-8A activity and its interaction with
172 nt in bipolar disorders, conditions in which NCS-1 is highly expressed, we tested the effect of lithi
173 aved more favorably by calpain compared with NCS-1 WT, whereas the other mutant was less favorably cl
174 ) activity toward Galpha when complexed with NCS-1, and restoration of nucleotide exchange activity u
175 d an intermediate phenotype, consistent with NCS-1 and ARF-1.1 acting in the same pathway.
176 4 translocation through its interaction with NCS-1.
177 findings suggest that ARF-1.1 interacts with NCS-1 in AIY neurons and potentially pifk-1 in the Ca(2+
178  The aminophenothiazine FD44 interferes with NCS-1/Ric8a binding, and it restores normal synapse numb

 
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