ライフサイエンスコーパス: NGAL

1 NGAL and IL-18 quantiles also predicted graft recovery u

2 NGAL blockade may be a novel therapeutic approach for th

3 NGAL can inhibit erythroid cell production, leading to a

4 NGAL depicted CIN in patients who received iodinated con

5 NGAL expression and intensity was evaluated separately.

6 NGAL expression correlated with negative hormone recepto

7 NGAL expression did not correlate with pCR in the full p

8 NGAL expression was required for MMP-9 activity and tumo

9 NGAL improved the C-statistic (0.835 to 0.842) for predi

10 NGAL induced apoptosis via caspase 3 activation and up-r

11 NGAL is a glycoprotein released by damaged renal tubular

12 NGAL is a novel marker best known for its role in rapidl

13 NGAL is a potential biomarker for the early detection of

14 NGAL is significantly increased in patients with myocard

15 NGAL is transcriptionally regulated by NFkappaB, and S2R

16 NGAL together with creatinine clearance plus MCP-1 was a

17 NGAL was analytically superior to traditional AKI biomar

18 NGAL was detected in 42.2% of the breast carcinomas in t

19 NGAL-expressing neutrophils and CD3(+) T cells were in c

20 NGAL-knockout mice had attenuated proteinuria and improv

21 utcomes and urinary concentrations of KIM-1, NGAL, 8-OHdG, and F2-isoprostane controlling for sex, ag

22 re positively associated with urinary KIM-1, NGAL, 8-OHdG, and F2-isoprostane levels over time.

23 ve urine biomarkers of kidney injury (IL-18, NGAL, KIM-1, L-FABP, and albumin) and five plasma biomar

24 Accordingly, NGAL-mediated iron shuttling between the extracellular a

25 In multivariate analysis, NGAL expression remained an independent prognostic facto

26 At ROC analysis, NGAL showed high sensitivity and specificity (serum NGAL

27 sterin, IL-18, kidney injury molecule-1, and NGAL concentration were predictive of DGF.

28 dase], KIM-1 [kidney injury molecule-1], and NGAL [neutrophil gelatinase-associated lipocalin]) were

29 arkers, including circulating CRP, IL-6, and NGAL.

30 levels of IL-1beta, MMP-3, MMP-8, MMP-9, and NGAL compared with the other study groups, strengthening

31 Samples were blinded and NGAL concentrations determined by enzyme-linked immunoso

32 significant changes in serum creatinine and NGAL levels, and there were no cases of CIN.

33 y higher baseline concentrations of CysC and NGAL compared to patients without.

34 We determined the plasma levels of CysC and NGAL in 429 patients hospitalized for acute decompensati

35 CysC and NGAL were both predictive of 90-day mortality, with haza

36 although the relationship between ErbB2 and NGAL expression is not clear.

37 elated anemia, and the ErbB2, NF-kappaB, and NGAL pathways may serve as potential therapeutic targets

38 d alanine aminotransferase plasma levels and NGAL expression.

39 ated with persistently high NGAL levels, and NGAL was an independent predictive factor of AKI progres

40 human DKK3, BMP1, vasorin, neogenin, MIA and NGAL treatment increased cellular quiescence in both C4-

41 y of renal damage in NGAL wild-type mice and NGAL-knockout mice following induction of nephrotoxic ne

42 rating cells, and cytokines in wild-type and NGAL-deficient chimeric mice with anti-MPO antibody-indu

43 Lipocalin 2 (LCN2; also known as NGAL) is a secreted glycoprotein and its elevated expres

44 tic protein lipocalin 2 (LCN2; also known as NGAL).

45 e oxidation current upon the binding between NGAL and its antibody is obtained when compared to an un

46 cyclic voltammetry upon the binding between NGAL with its antibody.

47 n the fine-tuning of the interaction between NGAL and its cellular receptor or in a biochemical mecha

48 erminants underlying the interaction between NGAL and its cellular receptor remain largely unknown.

49 Tight correlations were observed between NGAL expression, renal histopathology, and urine NGAL ex

50 thesize siderophore-like molecules that bind NGAL.

51 9), decreased expression of injury biomarker NGAL (P = .012), improved microvascular perfusion on con

52 S2R(Pgrmc1) knock-down blocked NGAL/LCN2 expression at the protein and RNA levels and d

53 uated the liver stress response, measured by NGAL expression, in the hemolytic mice.

54 Human kidney CD4(+) T cell NGAL also increased significantly after ischemia.

55 onstrate an important role for CD4(+) T cell NGAL as a mechanism by which CD4(+) T cells mediate AKI

56 l CVD risk factors and creatinine clearance, NGAL was a significant predictor of CVD mortality (hazar

57 Consistently, NGAL deficiency in genetically modified mice leads to an

58 ated glomerular filtration rate, creatinine, NGAL, galectin-3, and urea.

59 de (NT-proBNP) and C-reactive protein (CRP), NGAL remained an independent predictor of each outcome.

60 ErbB2, NGAL, and anemia have all been associated with increased

61 The aim of this study was to evaluate NGAL as a predictor of response to NACT and to validate

62 iltration rate <60 ml/min/1.73 m(2), a first NGAL <150 ng/ml indicated a low likelihood of adverse ev

63 The first NGAL was a better predictor than peak NGAL, but similar

64 Peak NGAL was more predictive than the first NGAL, but neither added significant diagnostic utility o

65 os for CysC of 3.1 (95% CI, 2.1-4.7) and for NGAL of 1.9 (95% CI, 1.5-2.4).

66 ansfer of NGAL-deficient CD4(+) T cells from NGAL KO mice into CD4 KO or WT mice led to worse renal f

67 Furthermore, NGAL could be validated as an independent prognostic fac

68 Furthermore, NGAL overexpression potently decreased angiogenesis in v

69 At 6 h, NGAL, IL-18, and L-FABP each improved the AUC from 0.72

70 elimination by Cox regression analysis, high NGAL remained an independent predictor of all-cause mort

71 zation was associated with persistently high NGAL levels, and NGAL was an independent predictive fact

72 Patients with high NGAL (>75th percentile) had increased risk of all-cause

73 In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments

74 ceptor to discriminate between apo- and holo-NGAL.

75 te with pCR in the full population, however, NGAL expression and staining intensity were significantl

76 relatively high levels of lipocalin 2 (human NGAL) induced suppression of hematopoiesis in spleen and

77 recognized by antibodies specific for human NGAL or human MMP-9.

78 onformational stability of recombinant human NGAL and the solution phase binding properties of six mo

79 To determine if NGAL up-regulation is instrumental, we compared the seve

80 We found that ischemic AKI in NGAL knockout (KO) mice had worse renal outcomes compare

81 ceiving wild-type bone marrow, as well as in NGAL/IL-17A-deficient chimeras compared with NGAL-defici

82 we compared the severity of renal damage in NGAL wild-type mice and NGAL-knockout mice following ind

83 metabolites was associated with increases in NGAL (beta = 0.13 [95% CI: 0.05, 0.21], p = 0.001), KIM-

84 RNA more than the corresponding increases in NGAL.

85 Interest in NGAL has been sparked by the observation that NGAL is ma

86 In the iomeprol group, an early rise in NGAL was found, while serum creatinine level changes occ

87 trinsic neutrophil functions were similar in NGAL-deficient and wild-type neutrophils, whereas T cell

88 emia and ureteral obstruction also increased NGAL and MCP-1 gene expression.

89 with a model in which S2R(Pgrmc1) increases NGAL/LCN2 levels by activating NFkappaB via EGFR.

90 Similarly, following nephritis induction, NGAL injection significantly exacerbated nephritis and d

91 ate, or physiologic saline did not influence NGAL level.

92 We found that kidney NGAL expression, as well as urine NGAL levels, were sign

93 Human Lcn2 (NGAL) is increased in the blood and tissues in response

94 neutrophil protease genes (MMP8, OLFM4, LCN2/NGAL, LTF, PRTN3, MPO) and also of 5 genes involved in t

95 expressed by osteoblasts, while MIA, LECT1, NGAL and PEDF are expressed by other calvarial cells.

96 Likewise, NGAL was also an independent predictive factor of 28-day

97 neutrophil gelatinase-associated lipocalin (NGAL) and podocalyxin, concomitant with upregulated rena

98 neutrophil gelatinase-associated lipocalin (NGAL) can predict development of renal dysfunction (RD),

99 /neutrophil gelatinase-associated lipocalin (NGAL) complex is also significantly increased in AVM tis

100 neutrophil gelatinase-associated lipocalin (NGAL) detection has been developed.

101 neutrophil gelatinase-associated lipocalin (NGAL) had the highest fold increase (~60).

102 neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative o

103 neutrophil gelatinase-associated lipocalin (NGAL) in a large population of patients with ST-segment

104 Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa secreted acute phase protein, which is

105 Neutrophil gelatinase-associated lipocalin (NGAL) is a diagnostic marker of intrinsic kidney injury

106 Neutrophil gelatinase-associated lipocalin (NGAL) is a novel renal biomarker that may predict WRF in

107 Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted glycoprotein expressed in a variety

108 Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury (AKI).

109 neutrophil gelatinase-associated lipocalin (NGAL) is developed by the immobilization of rabbit polyg

110 Neutrophil gelatinase-associated lipocalin (NGAL) is expressed and secreted by immune cells, hepatoc

111 neutrophil gelatinase-associated lipocalin (NGAL) levels and cardiovascular and all-cause mortality

112 neutrophil gelatinase associated lipocalin (NGAL) was found to be involved in 1alpha,25(OH)2D3 and M

113 neutrophil gelatinase-associated lipocalin (NGAL) was lower (P = 0.031) in the treated group.

114 neutrophil gelatinase-associated lipocalin (NGAL) were found in diseased groups compared with the he

115 neutrophil gelatinase-associated lipocalin (NGAL) were the most robust markers but were not superior

116 neutrophil gelatinase-associated lipocalin (NGAL)), which is expressed in the distal nephron, has be

117 neutrophil gelatinase-associated lipocalin (NGAL), a comparator "AKI biomarker" gene.

118 neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether

119 neutrophil gelatinase-associated lipocalin (NGAL), a novel marker of renal tubular damage, in patien

120 neutrophil gelatinase-associated lipocalin (NGAL), an iron-binding protein up-regulated in response

121 neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein 1 (MCP-1).

122 neutrophil gelatinase associated lipocalin (NGAL), combined with contemporary biomarkers such as N-t

123 neutrophil gelatinase-associated lipocalin (NGAL), IL-18, and kidney injury molecule-1 (KIM-1) as bi

124 neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), kidney injury molecule-1

125 neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and endothelin-1

126 neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), IL-18, and live

127 neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), IL-18, and live

128 neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatt

129 neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, serum creatinine, and c

130 neutrophil gelatinase-associated lipocalin (NGAL), monomeric NGAL (mNGAL), interleukin-18, and stand

131 neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients woul

132 neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients woul

133 neutrophil gelatinase-associated lipocalin (NGAL), which is a new diagnostic marker of acute kidney

134 neutrophil gelatinase-associated lipocalin (NGAL).

135 neutrophil gelatinase-associated lipocalin (NGAL); each measurement was on the day of AKI diagnosis

136 neutrophil gelatinase-associated lipocalin (NGAL, also known as LCN2) and its cellular receptor (LCN

137 neutrophil gelatinase-associated lipocalin [NGAL]) and oxidative stress (8-hydroxy-2'-deoxyguanosine

138 neutrophil gelatinase-associated lipocalin [NGAL]) is an antimicrobial host defense factor produced

139 (neutrophil gelatinase-associated lipocalin [NGAL], interleukin [IL]-18, liver fatty acid-binding pro

140 neutrophil gelatinase-associated lipocalin, NGAL), kidney growth, and glomerulosclerosis, however, w

141 neutrophil gelatinase-associated lipocalin, NGAL.

142 , neutrophil gelatinase-associated lipocalin/NGAL, or 24p3).

143 on in vitro, whereas iron siderophore-loaded NGAL suppressed T(H)17 polarization.

144 isease (hazard ratio [per SD increase in log NGAL]=1.45 [1.22-1.72]; P<0.001 and hazard ratio=1.51 [1

145 ity and MACE compared with patients with low NGAL (log-rank test, p < 0.001).

146 elayed graft function (highest versus lowest NGAL tertile relative risk, 1.21; 95% confidence interva

147 regulation of urinary kidney injury markers (NGAL and KIM-1) and renal Interleukin-6 and Ngal mRNA ob

148 We measured NGAL in patients with ANCA-associated vasculitis and mic

149 Median NGAL and IL-18 levels, but not KIM-1 levels, were statis

150 Urinary levels of MMP9, NGAL, CXCL8 and IL-1beta together had a higher LR+ (6.1)

151 inase-associated lipocalin (NGAL), monomeric NGAL (mNGAL), interleukin-18, and standard biomarkers we

152 Moreover, NGAL overexpression reduced focal adhesion kinase (FAK)

153 ubular pathology, and decreased urinary NAG, NGAL, and TGF-beta1 in db/db mice.

154 bone marrow-derived, presumably neutrophil, NGAL protects from ANCA-induced NCGN by downregulating T

155 CysC, but not NGAL, was found to be predictive of RD (odds ratio, 9.4;

156 rve analysis suggested that the abilities of NGAL or IL-18 to predict dialysis within 1 wk were moder

157 The ability of NGAL to protect MMP-9 activity is relevant to cartilage

158 At 2 h, addition of NGAL increased the AUC from 0.74 to 0.85 (p < 0.0001).

159 cation improvement (>0) with the addition of NGAL was 18% (p = 0.02); the integrated discrimination i

160 or K562 clone (C6) expressing low amounts of NGAL.

161 With ML, the AKI predictive capability of NGAL was further enhanced when combined with NT-proBNP o

162 osensor was investigated by the detection of NGAL in both blood serum and urine samples.

163 n, the sensor is tested for the detection of NGAL in human urine, and the results correspond well wit

164 The detection of NGAL is based on the enhancement of oxidation current on

165 nt with upregulated renal gene expression of NGAL and kidney injury molecule 1 (KIM-1).

166 ic antibodies stimulates local expression of NGAL, which plays a crucial role in the pathogenesis of

167 Pgrmc1) markedly regulated the expression of NGAL/LCN2 (neutrophil gelatinase-associated lipocalin/li

168 or has been constructed by immobilization of NGAL capture antibodies to electropolymerized aniline de

169 lls mediate AKI and extend the importance of NGAL in AKI beyond diagnostics.

170 rtly abolished MART-10-induced inhibition of NGAL and cell growth in SNU308 cells.

171 wn cannot account for the internalization of NGAL by LCN2-R.

172 ed growth inhibition for CCA as knockdown of NGAL decreased Ki-67 expression in SNU308 cells and rend

173 nt of serum creatinine, and higher levels of NGAL and ET-1 were associated with a higher EVKP score (

174 xPC-3, and Capan-2) expressed high levels of NGAL but moderately to poorly differentiated PaCa cells

175 In multivariate analysis, elevated levels of NGAL or IL-18 predicted the need for dialysis after adju

176 Urinary levels of NGAL, KIM-1, and ET-1 were measured after EVKP.

177 To investigate the role of NGAL in antibody-mediated nephritis, we induced nephroto

178 in vitro and in vivo the functional role of NGAL in PaCa.

179 However, the role of NGAL produced by CD4(+) T cells is not known.

180 g creatinine, sensitivity and specificity of NGAL for detecting acute injury were 0.900 (95% CI, 0.73

181 Adoptive transfer of NGAL-deficient CD4(+) T cells from NGAL KO mice into CD4

182 These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGA

183 Taken together, upregulation of NGAL by ErbB2 through NF-kappaB activation is involved i

184 Conclusion: These results support the use of NGAL in clinical practice within the context of a diagno

185 However, the prognostic value of NGAL has never been studied in patients with myocardial

186 These pleiotropic functions mainly rely on NGAL's siderophore-mediated iron transport properties.

187 bone marrow from either IL-17A-deficient or NGAL/IL-17A double-deficient mice.

188 ce with bone marrow from either wild-type or NGAL-deficient mice; we also transplanted irradiated MPO

189 Finally, MIAPaCa-2 cells overexpressing NGAL reduced tumor volume (P = 0.012), local and distant

190 Compared with K562 cells, overexpressing NGAL in K562 led to a higher apoptosis rate and an atrop

191 In particular, NGAL is emerging as an excellent biomarker in the urine

192 surement of urinary biomarkers, particularly NGAL in combination with functional perfusion parameters

193 Peak NGAL was more predictive than the first NGAL, but neithe

194 first NGAL was a better predictor than peak NGAL, but similar to the first creatinine (areas under t

195 Plasma NGAL is a significant predictor of mortality and CVD in

196 Plasma NGAL levels were measured using a time-resolved immunofl

197 Plasma NGAL predicts mortality in patients with heart failure,

198 Plasma NGAL was not superior to creatinine for the prediction o

199 Plasma NGAL, estimated glomerular filtration rate (eGFR), and c

200 95% confidence interval=1.3-9.1), and plasma NGAL (odds ratio=7.7, 95% confidence interval=2.6-22.5).

201 clusion, urine IL-18, urine NGAL, and plasma NGAL associate with subsequent AKI and poor outcomes amo

202 highest quintiles of urine IL-18 and plasma NGAL associated with 6.8-fold and 5-fold higher odds of

203 Elevated urine IL-18 and urine and plasma NGAL levels associated with longer length of hospital st

204 Urine IL-18 and urine and plasma NGAL levels peaked within 6 hours after surgery.

205 Urine IL-18 and plasma NGAL significantly improved risk prediction over the cli

206 Urine IL-18 and plasma NGAL significantly improved the AUC to 0.76 and 0.75, re

207 High plasma NGAL independently predicts all-cause mortality and MACE

208 w cystatin C (median cut-off), higher plasma NGAL levels were independently associated with an increa

209 Higher plasma NGAL levels were independently associated with an increa

210 We measured plasma NGAL levels in 1,393 Rancho Bernardo Study participants

211 was 11.2 (7.7-16.2) mg/L, and median plasma NGAL was 85 (60-123) ng/mL.

212 , urine IL-18 and urine NGAL, but not plasma NGAL, associate with subsequent AKI and poor outcomes am

213 The use of plasma NGAL to diagnose acute kidney injury in AHF cannot be re

214 inase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would develop AKI and

215 inase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would develop AKI and

216 Others were plasma NGAL (neutrophil gelatinase-associated lipocalin) and NT

217 The primary outcome was whether plasma NGAL could predict the development of WRF, defined as a

218 d with the clinical model alone, with plasma NGAL performing the best (category-free net reclassifica

219 In univariate survival analysis, positive NGAL expression and strong staining intensity correlated

220 latinase in OA SF comigrated with a purified NGAL-MMP-9 complex.

221 Recently, NGAL has been proposed as an early biomarker in pancreat

222 ANCA-stimulated neutrophils released NGAL.

223 ase 1, and the inhibitors partially restored NGAL levels.

224 Serum NGAL is a highly sensitive but nonspecific predictor of

225 Serum NGAL was measured during the first 24 hrs of admission t

226 Serum NGAL was significantly increased in critically ill child

227 Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, and 48 hours aft

228 There was a significant difference in serum NGAL between healthy children (median 80 ng/mL, interqua

229 Further validation of serum NGAL as a biomarker of acute kidney injury in this popul

230 owed high sensitivity and specificity (serum NGAL: area under the curve, 0.995; 95% confidence interv

231 Lipocalin 2 (siderocalin, NGAL, 24p3), a siderophore-binding antimicrobial protein

232 untreated tissue microarray showed specific NGAL staining in resected PaCa specimens (P = 0.0167).

233 Stable NGAL overexpression (MIAPaCa-2 and PANC-1) significantly

234 Stable NGAL overexpression or underexpression had no effect on

235 In addition, strong NGAL expression correlated with higher pCR rates in node

236 The results show that in low-risk subgroups, NGAL was found to be a predictive marker for pCR after N

237 New data have demonstrated that NGAL is also stored in granules of mature neutrophils, a

238 GAL has been sparked by the observation that NGAL is massively upregulated after renal tubular injury

239 Regression analysis showed that NGAL independently predicted CIN.

240 In our previous work we showed that NGAL, a protein involved in the regulation of proliferat

241 o-simulated ischemia/reperfusion showed that NGAL-deficient CD4(+) T cells express higher levels of I

242 re neutrophils, and recent data suggest that NGAL may also be involved in the development of atherosc

243 Collectively, our results suggest that NGAL reduces adhesion/invasion partly by suppressing FAK

244 The NGAL increase in CD4(+) T cells during AKI was confirmed

245 in the absence of renal injury, induced the NGAL gene, but not MCP-1, suggesting the possibility of

246 ll as Akt and ERK inhibitors, suppressed the NGAL/LCN2 RNA and protein levels.

247 Thus, NGAL is a potential suppressor of invasion and angiogene

248 , we show that ErbB2 overexpression leads to NGAL upregulation, which is dependent on nuclear factor-

249 (50-500ngmL(-1)) and high specificity toward NGAL detection from small samples (10muL).

250 PANC-1 and MIAPaCa-2) expressed undetectable NGAL levels.

251 Urinary NGAL was assessed in spot urine of 182 outpatient renal

252 Urinary NGAL was measured by immunoblot, N-acetyl-beta-d-glucosa

253 Urinary NGAL, at respective cut-off, accurately discriminates ac

254 fidence interval [CI]: 0.868, 0.992; urinary NGAL: area under the curve, 0.992; 95% CI: 0.925, 1.000)

255 strated strongly increased serum and urinary NGAL levels.

256 Among all biomarkers, urinary NGAL measured at day 3 had the greatest accuracy for dif

257 In contrast, urinary NGAL did not correlate with proteinuria in human or in m

258 Here, we demonstrate urinary NGAL to allow for differential diagnosis of AKI, accurat

259 ipient characteristics, higher donor urinary NGAL concentrations associated with recipient delayed gr

260 al function demonstrated that higher urinary NGAL and L-FABP concentrations associated with slightly

261 ry had a significantly elevated mean urinary NGAL level compared with the other kidney function group

262 th stable allograft function, median urinary NGAL concentration was 7.8 ng/mL (interquartile range, 3

263 With a cut-off at 100 ng/mL, urinary NGAL accurately predicted acute rejection as underlying

264 A single measurement of urinary NGAL helps to distinguish acute injury from normal funct

265 We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVA

266 As a readily available parameter, urinary NGAL may guide differential diagnosis and initial therap

267 In multiple logistic regression, urinary NGAL level was highly predictive of clinical outcomes, i

268 In acute allograft rejection, urinary NGAL concentration was 339 ng/mL (165-499 ng/mL), and in

269 In summary, urinary NGAL and IL-18 are early, noninvasive, accurate predicto

270 Urine NGAL <20 ng/mL and sNGAL <179 ng/mL at 6 hours are relia

271 Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, a

272 Urine NGAL significantly increased in AKI patients at 2 h afte

273 Urine NGAL, IL-18, L-FABP, and KIM-1 are sequential predictive

274 In conclusion, urine IL-18, urine NGAL, and plasma NGAL associate with subsequent AKI and

275 e highest quintiles of urine IL-18 and urine NGAL associated with 6.9- and 4.1-fold higher odds of AK

276 expression, renal histopathology, and urine NGAL excretion.

277 The accuracy of urine IL-18 and urine NGAL for diagnosis of severe AKI was moderate, with area

278 Elevated urine IL-18 and urine NGAL levels associated with longer hospital stay, longer

279 he first postoperative urine IL-18 and urine NGAL levels strongly associated with severe AKI.

280 In conclusion, urine IL-18 and urine NGAL, but not plasma NGAL, associate with subsequent AKI

281 hat kidney NGAL expression, as well as urine NGAL levels, were significantly increased in mice with n

282 duced AKI occurred at 6 hours for both urine NGAL (>/=20 ng/mL; 97% negative predictive value and 27%

283 nclusion, among prevalent KTRs, higher urine NGAL, KIM-1, and IL-18 levels independently and differen

284 Each log increase in urine NGAL/creatinine independently associated with a 24% grea

285 The treatment groups had lower urine NGAL, an early marker of kidney injury (P = 0.01), lower

286 ents (validation set), no patient with urine NGAL <20 ng/mL or sNGAL <179 ng/mL at 6 hours developed

287 redictor of response to NACT and to validate NGAL as a prognostic factor for clinical outcome in pati

288 Moreover, when NGAL was entered in the multivariable risk prediction mo

289 stly improved the prediction of DGF, whereas NGAL, serum creatinine, and the creatinine reduction rat

290 Whether NGAL plays a mechanistic role in ANCA-associated vasculi

291 We undertook this study to determine whether NGAL is instrumental in the pathogenesis of nephritis, i

292 This study sought to determine whether NGAL is superior to creatinine for prediction and/or pro

293 ay represent an important mechanism by which NGAL may contribute to the loss of cartilage matrix prot

294 at day 3 did not provide any benefit; while NGAL is also associated with short-term mortality, it fa

295 NGAL/IL-17A-deficient chimeras compared with NGAL-deficient chimeras.

296 The use of AI/ML could be employed with NGAL to accelerate detection of AKI in at-risk burn and

297 intrinsically disordered and interacts with NGAL preferentially in its apo state to form a fuzzy com

298 Mice with NGAL-deficient bone marrow developed worsened MPO-ANCA-i

299 immunity was increased in chimeric mice with NGAL-deficient neutrophils with more renal infiltrating

300 Participants with NGAL and NT-proBNP above the median had increased risk o