ライフサイエンスコーパス: NICU

1 NICU treatments used to improve neurodevelopmental outco

2 In 2012, there were 43.0 NICU admissions per 1000 normal-birth-weight infants (25

3 Combined BPD or death rates across 116 NICUs varied from 17.7% to 73.4% (interquartile range, 3

4 tational age (OR = 1.10; 95% CI, 1.05-1.16), NICU admission (OR = 1.12; 95% CI, 1.07-1.17), hyperbili

5 167 NICUs participated in the survey, representing 28 Europe

6 1.8% vs 17.2%; RR, 1.48; 95% CI, 1.00-2.19), NICU admission (12.1% vs 17.7%; RR, 1.54; 95% CI, 1.05-2

7 30, 2013, 6680 neonates were enrolled in 243 NICUs in 18 European countries.

8 gar score less than 7 (RR 2.11 [1.03-4.29]), NICU admission (RR 3.34 [1.61-6.9]) and Neonatal Near Mi

9 Setting: Two German level-3 NICUs.

10 1, 2007, through December 31, 2012, from 348 NICUs managed by the Pediatrix Medical Group.

11 ole-genome sequencing (STATseq) in a level 4 NICU and PICU to assess the rate and types of molecular

12 It took 3 years before 445 NICUs (75.0%) achieved the 2005 shrunken adjusted rate f

13 Interviews included 50 NICU mothers and 59 stakeholders who provide services to

14 pidemiologique de la flore), in 20 of the 64 NICUs, analyzed the intestinal microbiota by culture and

15 Most (78%) NICUs were interested in participating in a trial evalua

16 t-level demographic and outcomes data from 8 NICUs who were long term CQI collaborators within the Ve

17 Hospital length of stay increased in the 8 NICUs 64 to 71 days (P <.001), and a similar increase wa

18 based analyses were performed in 29/32 (91%) NICU newborns and 6/127 (5%) healthy newborns who later

19 9% vs 2.5%; adjusted odds ratio [OR], 1.92), NICU or neonatology service admission (8.8% vs 5.3%; adj

20 l containment of an adenovirus outbreak in a NICU associated with contaminated handheld ophthalmologi

21 ing the study period, newborns admitted to a NICU were larger and less premature, although no consist

22 are increasingly likely to be admitted to a NICU, which raises the possibility of overuse of neonata

23 It is challenging to know whether a NICU is becoming more proficient, and it is not usually

24 Analysis within a NICU showed that exposure of an infant to a specific ant

25 investigate the impact of cleaning within a NICU, a high-throughput short-amplicon-sequencing approa

26 fants included, 6.6% received care in type A NICUs with restrictions, 29.3% in type A NICUs without r

27 e A NICUs with restrictions, 29.3% in type A NICUs without restrictions, 39.7% in type B NICUs, and 2

28 Additional NICU samples were included from 14/29 infants.

29 Risk-adjusted NICU ranks were computed for each of 8 measures of quali

30 onatal intensive care unit (NICU) admission, NICU length of stay, hyperbilirubinemia, respiratory dis

31 CCC occurred in 0.1% of all NICU admissions (21 of 19 303) and 0.6% of infants <1000

32 centers reporting that more than 20% of all NICU days were attributed to the care of these infants i

33 parents of sick children and who were also "NICU parents." We have developed an etiquette-based syst

34 h very low birth weight (below 1500 g) among NICUs with various levels of care and different volumes

35 cal and molecular epidemiology of MRSA in an NICU between 2003 and 2013, in the decade following the

36 1000 admissions among infants admitted to an NICU.

37 olates were obtained from patients within an NICU.

38 ficantly different from hospitals without an NICU, and was significantly higher than hospitals with l

39 Compared with hospitals without an NICU, infants born in a hospital with a level III NICU w

40 rth (1.57, 95% CI 1.38-1.79, p < 0.001), and NICU admission (1.41, 95% CI 1.25-1.59, p < 0.001).

41 gnancy (RR, 1.32 [1.08-1.60], p < 0.01), and NICU admission among women exposed to gabapentin both ea

42 Hospital administrators and NICU managers should assess their staffing decisions to

43 life environment factors (breast-feeding and NICU admission) might contribute to EoE susceptibility.

44 atory complications, hyperbilirubinemia, and NICU admission, were increased in association with mater

45 = .02) and rs17815905 (LOC283710/KLF13) and NICU admission (P = .02) but not with any of the factors

46 <34 weeks), the number of neonatologist and NICU beds, 25.2% and 58.7% of the HSA-level variance in

47 itivity or detectable C-reactive protein and NICU admission and length of stay.

48 This report focuses on safety and NICU deaths by marginal comparisons of 72 hours' vs 120

49 ), but resulted in less probability that any NICU infant received a lumbar puncture (p = .0001) or pe

50 We categorized diet at NICU discharge/transfer as: 1) human milk only (no formu

51 spital with a level III NICU with an average NICU census of at least 15 patients per day had signific

52 NICUs without restrictions, 39.7% in type B NICUs, and 24.4% in type C NICUs.

53 Compared with mothers of well babies, NICU mothers had more chronic diseases, experienced more

54 ifferent Shannon diversity was shown between NICU and PD samples.

55 dation and analgesia practices occur between NICUs and countries.

56 f etiquette are not always applied in a busy NICU or in the hospital at large.

57 nfants born at hospitals with a level IIIB/C NICU and lowest among infants born at hospitals with a l

58 s delivered at hospitals with a level IIIB/C NICU.

59 , 39.7% in type B NICUs, and 24.4% in type C NICUs.

60 d respected as they go through a challenging NICU stay.

61 Significant decreases in common NICU organisms including K. oxytoca and E. faecalis and

62 ematurely and/or with medical complications (NICU children) and 25 control children born at term were

63 e" combined outcome (early preterm delivery, NICU, SGA).

64 general" combined outcome (preterm delivery, NICU, SGA); and "severe" combined outcome (early preterm

65 imate standardized morbidity ratios for each NICU.

66 nd resource utilization scores that estimate NICU CQI proficiency.

67 longer cooling, deeper cooling, or both for NICU death was less than 2%.

68 the odds ratio (95% confidence interval) for NICU admission was 2.14 (1.01 to 4.54); for a length of

69 ure to oral pathogens increases the risk for NICU admission and the length of stay.

70 ission (p = .003) and a 12% greater risk for NICU discharge (p = .02) were found in the after period

71 rm births (38.4%) and increased the risk for NICU or neonatology service admission (12.2%) and morbid

72 The adjusted risk ratio (RR) for NICU deaths for the 120 hours group vs 72 hours group wa

73 nient access to maternal health services for NICU mothers should be explored to reduce adverse matern

74 first, to our knowledge, web-based tool for NICUs to calculate their own composite morbidity and res

75 erculosis, longer hospital stays, and/or ICU/NICU admission.

76 care unit/neonatal intensive care unit (ICU/NICU) admissions (OR = 1.5; CI, 1.4-1.6; P < .0001) were

77 atients who eventually die in neonatal ICUs (NICUs) and adult medical ICUs (MICUs).

78 e of sedation or analgesia in neonatal ICUs (NICUs) in European countries.

79 in this study who had been in the NICU (ie, NICU graduates).

80 fants born at hospitals with a level I or II NICU compared with infants delivered at hospitals with a

81 k for developing BPD was higher for level II NICUs (odds ratio, 1.23; 95% CI, 1.02-1.49) and similar

82 vel III NICUs, and in level II+ and level II NICUs, regardless of size, was not significantly differe

83 er of hospitals that could provide level III NICU care has the potential to decrease neonatal mortali

84 infants born in a hospital with a level III NICU with an average NICU census of at least 15 patients

85 95% CI, 1.02-1.49) and similar for level III NICUs (odds ratio, 1.04; 95% CI, 0.95-1.14).

86 fants born at hospitals with large level III NICUs were not more than those for infants born at other

87 tality for infants born in smaller level III NICUs, and in level II+ and level II NICUs, regardless o

88 rage census, >15 patients per day) level III NICUs.

89 infants born at hospitals with a level IIIA NICU.

90 pitals (low-volume level IIIB and level IIIA NICUs) had odds of death ranging from 1.42 (95% CI, 1.08

91 impetus for the regionalization of important NICU resources.

92 ncomycin, indicating convergent evolution in NICU-associated pathogens.

93 mework for precision medicine for infants in NICU and PICU who are diagnosed with genetic diseases to

94 nosocomial bacteraemia was less frequent in NICUs with low neonatal consultant provision (odds ratio

95 edominant mode of acquisition by neonates in NICUs at this hospital; mothers may be colonized with mu

96 rces dedicated to critically ill neonates in NICUs nationwide.

97 l not survive than does care for newborns in NICUs.

98 ent of sedation and analgesia in patients in NICUs.

99 approaches used for heelsticks performed in NICUs.

100 Heelstick was very frequently performed in NICUs.

101 8 drugs studied in neonates were not used in NICUs; 8 (29%) were used in fewer than 60 neonates.

102 r the support and survival of these infants, NICU sensory environments are dramatically different fro

103 Significant inter-NICU variation in both composite scores was noted in the

104 ediate NICU: level II; expanded intermediate NICU: level II+: tertiary NICU: level III) and by the av

105 re available (no NICU: level I; intermediate NICU: level II; expanded intermediate NICU: level II+: t

106 Compared with level IV NICUs, the risk for developing BPD was higher for level

107 a hospital with a high-volume B- or C-level NICU.

108 e of VLBW infant deliveries and a high-level NICU.

109 ese infants, 53229 were classified as likely NICU admissions.

110 term led to an improved version of the Mayo NICU model.

111 , relative mortality reduction 21%) and mean NICU LOS from 3.5 to 2.9 days (95% confidence interval,

112 red for at 756 Vermont Oxford Network member NICUs in the United States were evaluated.

113 Among LPT and NPT newborns, NICU capacity was associated with higher inpatient morta

114 fied by the level of NICU care available (no NICU: level I; intermediate NICU: level II; expanded int

115 cci are the most common causes of nosocomial NICU infections.

116 the risk of death during the first 3 days of NICU admission (p = .003) and a 12% greater risk for NIC

117 When the effects of NICU level and annual volume of VLBW infant deliveries w

118 ionship was observed in the smaller group of NICU women (r = .40, p = .099).

119 rs, other children in the home, or length of NICU stay.

120 Patient volume and level of NICU care at the hospital of birth both had significant

121 Hospitals were classified by the level of NICU care available (no NICU: level I; intermediate NICU

122 takeholders acknowledged the unique needs of NICU mothers and cited system challenges, lack of clarit

123 al workload was operationalized as number of NICU infants cared for by the individual houseofficer on

124 that increased clinical workload (number of NICU infants) resulted in a significantly greater probab

125 ie (birth weight < 751 g), the percentage of NICU bed-days allocated to nonsurviving infants was less

126 significantly larger than the percentage of NICU bed-days devoted to nonsurviving babies (7.8%).

127 The total percentage of NICU days nationwide that were attributed to the neonata

128 From 2004 through 2013, the rate of NICU admissions for the neonatal abstinence syndrome inc

129 es (6.8%) had a significantly higher rate of NICU or neonatology service admission compared with term

130 gs suggest that increased regionalization of NICU care may reduce BPD among VLBW infants.

131 Only 38% of NICUs had a protocol for BPD prevention and 47% routinel

132 Within 8 years, 75% of NICUs achieved rates of performance from the best quarti

133 5 and the number of years it took for 75% of NICUs to achieve the 2005 rates from the best quartile w

134 retrospective cohort study was conducted of NICUs in California.

135 means of managing the microbial ecosystem of NICUs and of future opportunities to minimize exposures

136 1980s, coinciding with the establishment of NICUs and the increasing use of vancomycin in these unit

137 In this review we focus on the impact of NICUs in tissue physiology and how this fast-evolving fi

138 sed with increasing workload in all types of NICUs.

139 ry studies on neonates admitted to operating NICUs demonstrate performance comparable to the most adv

140 ber 31, 2011, at each of the 8 participating NICUs.

141 In the participating NICUs, the median use of sedation or analgesia was 89.3%

142 ssociated with higher risks for prematurity, NICU admission, and SGA status compared with longer inte

143 t 33.5 degrees C for 72 hours did not reduce NICU death.

144 5% confidence interval, 0.2 to 0.9, relative NICU LOS reduction 17%).

145 d women who delivered, 257 neonates required NICU admission, and 24 (9.3%) developed BSI.

146 tive including more than 90% of California's NICUs.

147 nsecutively admitted to 54 randomly selected NICUs.

148 sis in term newborns could result in shorter NICU stays and less antibiotic usage.

149 1-3 years post discharge (PD) from a single NICU.

150 Why some NICUs improve their scores more successfully than others

151 virus identified from any clinical specimen (NICU patient or employee) or compatible illness in a fam

152 or DCDD among neonates who died in the study NICU.

153 Substantial NICU nurse understaffing relative to national guidelines

154 As such, NICUs are emerging as important orchestrators of multipl

155 nts without diagnosed BPD, and six full-term NICU patients (gestational ages, 23-39 wk) at near term-

156 anded intermediate NICU: level II+: tertiary NICU: level III) and by the average patient census in th

157 nded randomized clinical trial in 2 tertiary NICUs in Baltimore, Maryland.

158 The NICU admission rate was not significantly higher for tho

159 The NICU death rates were 7 of 95 neonates (7%) for the 33.5

160 Comparisons between the NICU and control groups on the CANTAB subscales indicate

161 data from pilot clinical studies in both the NICU and PICU.

162 ly be due to the better documentation by the NICU team in the after period.

163 ixed models to account for clustering by the NICU.

164 e neonate, and the distinct environment, the NICU, is imperative.

165 rd genetic testing in a case series from the NICU and PICU of a large children's hospital between Nov

166 l 24 strains could be distinguished from the NICU isolates by at least one genomic marker.

167 Overall mortality in the NICU (66/827; 7.9%) was significantly lower than in the

168 of babies in this study who had been in the NICU (ie, NICU graduates).

169 after period, fewer of them occurred in the NICU (odds ratio, 0.2; 95% confidence interval, 0.08 to

170 5 p = .017, respectively) and for men in the NICU (r = .55, p = .003) and the SICU (r = .29, p = .036

171 relationships between procedural pain in the NICU and early brain development in very preterm infants

172 s cross transmission between patients in the NICU and other wards.

173 ency in the infants during their stay in the NICU and persisted in a proportion of infants.

174 The clinical workload of housestaff in the NICU can affect decisions to perform procedures on infan

175 The unadjusted mortality in the NICU decreased from 8% to 6.3% (95% confidence interval,

176 cent (37/66) of all neonates who died in the NICU did so within the first 48 hr of life.

177 al opportunistic yeasts were detected in the NICU environment, demonstrating that these NICU surfaces

178 All ELBW infants in the NICU had an increased incidence of sepsis evaluations an

179 who acquired C. albicans colonization in the NICU had C. albicans-positive mothers; specimens from al

180 The 136 deaths that occurred in the NICU of the Primary Children's Hospital, Salt Lake City,

181 ses altered the management of infants in the NICU or PICU.

182 e 42 studies that discussed GS and ES in the NICU setting, six themes were identified: disease detect

183 of an infant to a specific antibiotic in the NICU was not a risk factor for the carriage of a strain

184 All newborns in the NICU with a maximum corrected age of 44 weeks +6 days of

185 Of 136 deaths in the NICU, 60 (44.1%) met criteria for DCDD; however, fewer t

186 Pneumothorax, mortality in the NICU, and antenatal corticosteroid use loaded on factor

187 life, chronic lung disease, mortality in the NICU, and discharge on any human breast milk.

188 proach to communication with families in the NICU.

189 with medical imaging techniques used in the NICU.

190 fant was not affected by the workload in the NICU.

191 e effects of workload on patient care in the NICU.

192 ions to perform procedures on infants in the NICU.

193 II) and by the average patient census in the NICU.

194 ncidence of pCMV infection through BM in the NICU.

195 e average severity-of-illness of each of the NICU infants, the experience and residency program of th

196 ted an antibiogram identical to those of the NICU isolates, all 24 strains could be distinguished fro

197 l by neonatologists and other members of the NICU team would likely result in a significant increase

198 receiving increased antibiotics while on the NICU did not significantly impact the microbiome PD.

199 All 31 housestaff rotating on the NICU service during the academic year 1993 to 1994 were

200 wards during a 4-month period preceding the NICU outbreak.

201 s on the CANTAB subscales indicated that the NICU children had a shorter spatial memory span length a

202 These results suggest that the NICU isolates had a common origin and that genomic finge

203 mples collected from infants admitted to the NICU for suspected sepsis were analyzed for bacterial gr

204 Admission to the NICU in those without the susceptibility gene variant at

205 Admission to the NICU or neonatology service.

206 disposition of all patients admitted to the NICU were compared between two 19-month periods, before

207 All neonates admitted to the NICU were enrolled.

208 95% CI, 0.90 to 1.63), and admission to the NICU with moderate-to-severe hypoxic-ischemic encephalop

209 650 infants, 45 (6.9%) were admitted to the NICU.

210 ckground), 1243 (88.5%) were admitted to the NICU; 490 of 546 infants (89.7%) born to mothers with a

211 nfants; neurobehavior was assessed using the NICU Network Neurobehavioral Scales (NNNS) in an indepen

212 The NICUs varied substantially in their clinical performance

213 and serious morbidities decreased among the NICUs in this study.

214 st 1 corticosteroid of interest during their NICU stay, including 279 exposed to dexamethasone, 137 e

215 ix infants acquired C. albicans during their NICU stay.

216 Hospitals understaffed 31% of their NICU infants and 68% of high-acuity infants relative to

217 rom their admission to the 14th day of their NICU stay or discharge, whichever occurred first.

218 loci differed between infants based on their NICU Network Neurobehavioral Scale (NNNS) profile classi

219 e NICU environment, demonstrating that these NICU surfaces represent a potential vector for spreading

220 otable exception of death after admission to NICU (0.95 [0.89, 1.01]).

221 Admission to NICU also did not differ between groups (19 [29%] expose

222 ith no migration background were admitted to NICU (fully adjusted RR, 1.03; 95% CI, 0.99-1.08).

223 perinatal databases, and data pertaining to NICU or neonatology service admissions were extracted fr

224 red during the first 28 days of admission to NICUs.

225 Admissions to NICUs and mortality within the first week, month, and ye

226 All neonates admitted to NICUs during 1 month were included in this study.

227 Among 674,845 infants admitted to NICUs, we identified 10,327 with the neonatal abstinence

228 endently, showing parallel evolution towards NICU specialization and non-susceptibility to vancomycin

229 186 UK NICUs were stratified according to volume of patients, n

230 e prematurity, neonatal intensive care unit (NICU) admission, congenital malformation, small for gest

231 resuscitation, neonatal intensive care unit (NICU) admission, NICU length of stay, hyperbilirubinemia

232 the following: neonatal intensive care unit (NICU) admission, surfactant, assisted ventilation, antib

233 pathogens and neonatal intensive care unit (NICU) admission.

234 (SGA/LGA), and neonatal intensive care unit (NICU) admission.

235 ital ized in a neonatal intensive care unit (NICU) after birth.

236 cedures in the neonatal intensive care unit (NICU) during a period of rapid brain development.

237 babies in the neonatal intensive care unit (NICU) face a host of challenges following childbirth.

238 the Tuebingen neonatal intensive care unit (NICU) from 1995-1998 served as historical controls.

239 erm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and metabolome long-te

240 infants in the neonatal intensive care unit (NICU) is associated with adverse events, including fever

241 the impact of neonatal intensive care unit (NICU) level on moderate and late preterm (MLP) care qual

242 risk than does neonatal intensive care unit (NICU) level.

243 collected from neonatal intensive care unit (NICU) patients within 7 days of discontinuation of thera

244 systems in the neonatal intensive care unit (NICU) require multiple wires connected to rigid sensors

245 s and from the neonatal intensive care unit (NICU) room environment.

246 lation between neonatal intensive care unit (NICU) strategies concerning the rate of progression of e

247 mission to the neonatal intensive care unit (NICU) with moderate-to-severe hypoxic-ischemic encephalo

248 dmitted to the neonatal intensive care unit (NICU), and one of them had bilateral hearing impairment.

249 ner within our neonatal intensive care unit (NICU), diagnostic-quality MRIs using commercially availa

250 ction with the neonatal intensive care unit (NICU), it is often not because they think their baby has

251 fection in the neonatal intensive care unit (NICU), often associated with significant morbidity.

252 institutional neonatal intensive care unit (NICU), whose gestational age at birth was 30 or more wee

253 infants in the neonatal intensive care unit (NICU).

254 8 infants in a neonatal intensive care unit (NICU).

255 outbreak in a neonatal intensive care unit (NICU).

256 ization in the neonatal intensive care unit (NICU).

257 heater (OT) or neonatal intensive care unit (NICU).

258 admitted to a neonatal intensive care unit (NICU).

259 ections in the neonatal intensive care unit (NICU).

260 SGA); need for neonatal intensive care unit (NICU); new onset of hypertension; new onset/doubling of

261 reast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets in the home).

262 d death in the neonatal intensive care unit [NICU]) after the first 50 neonates were enrolled, then a

263 admission to a neonatal intensive care unit [NICU]) of patients who received antenatal chemotherapy w

264 eonatal and paediatric intensive care units (NICU and PICU) is not sufficiently timely to guide acute

265 e admitted to neonatal intensive care units (NICU) annually.

266 infants at 16 neonatal intensive care units (NICU) within the NICHD Neonatal Research Network.

267 neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monit

268 mitted to 290 neonatal intensive care units (NICUs) (the Pediatrix Data Warehouse) in the United Stat

269 irst weeks in neonatal intensive care units (NICUs) [1].

270 h 2013 in 299 neonatal intensive care units (NICUs) across the United States.

271 re infants in neonatal intensive care units (NICUs) are highly susceptible to infection due to the im

272 adenovirus in neonatal intensive care units (NICUs) can lead to widespread transmission and serious a

273 om 2 academic neonatal intensive care units (NICUs) from 2004 to 2015.

274 st that large neonatal intensive-care units (NICUs) have better outcomes than small units, although t

275 proportion of neonatal intensive care units (NICUs) in 2014 that achieved rates for death and major m

276 the number of neonatal intensive care units (NICUs) in community hospitals and the complexity of the

277 nursed in two neonatal intensive care units (NICUs) in East London, United Kingdom.

278 and midlevel neonatal intensive care units (NICUs) in recent decades.

279 361) from 32 neonatal intensive care units (NICUs) in the United States were randomly assigned to re

280 aureus in the neonatal intensive care units (NICUs) of two hospitals.

281 taffing in US neonatal intensive care units (NICUs) relative to national guidelines.

282 difficult for neonatal intensive care units (NICUs) to determine the overall efficacy of multiple con

283 rm infants in neonatal intensive care units (NICUs) worldwide.

284 surveys from neonatal intensive care units (NICUs), offices and molecular biology laboratories, and

285 e in European neonatal intensive care units (NICUs).

286 n neonates in neonatal intensive care units (NICUs).

287 cedure in the neonatal intensive care units (NICUs).

288 ss the importance of neuroimmune cell units (NICUs) in intestinal development, homeostasis and diseas

289 sensed by discrete neuro-immune cell units (NICUs), which represent defined anatomical locations in

290 Data were collected from all infants until NICU discharge or death (last day of data collected, Dec

291 dy included 972 VLBW infants treated in 6 US NICUs, with admission dates from January 1, 2006, to Dec

292 We studied infants from 777 US NICUs in the Vermont Oxford Network database.

293 ied are either not used or rarely used in US NICUs.

294 High-volume NICUs treated the sickest infants and had highest crude

295 When NICU graduates were included in the comparison, a signif

296 ciated with high neonatal morbidity and with NICU or neonatology service admission.

297 igate the costs and benefits associated with NICU care expansion.

298 eight deliveries occurred in facilities with NICUs that offered a high level of care and had a high v

299 r deliveries that occurred in hospitals with NICUs that had both a high level of care and a high volu

300 ose for infants born at other hospitals with NICUs.