ライフサイエンスコーパス: NK cell

1 ) or negative (NC) sera to measure IFNgamma+ NK cell%.

2 ve individuals is an expansion of NKG2C(pos) NK cells.

3 s at a 5.6-fold lower rate compared to fresh NK cells.

4 o determine expression on tumor-infiltrating NK cells.

5 s and previous reports of CD16a from primary NK cells.

6 ng the transcriptional signature of immature NK cells.

7 (high) T cells in the presence of NKG2C(pos) NK cells.

8 the early maternal-fetal interface have been NK cells.

9 stage 4B-like phenotype by the NKDI-derived NK cells.

10 peripheral blood mononuclear and engineered NK cells.

11 detected by KIR and CD94:NKG2A receptors of NK cells.

12 a reduced frequency and a reduced number of NK cells.

13 nterest in understanding the role of PD-1 on NK cells.

14 igand of LILRB1 and suppress the function of NK cells.

15 ng term pregnancy dNK are a distinct type of NK cells.

16 which interact with inhibitory receptors of NK cells.

17 ptor NKG2A/CD94 on terminally differentiated NK cells.

18 hey could be efficiently differentiated into NK cells.

19 ells, thus activating the immune response of NK cells.

20 nal link between CD56 and signaling in human NK cells.

21 acilitated by the Fc receptor CD16a on human NK cells.

22 l NK cells (dNK)1-3, ILC3s and proliferating NK cells.

23 and resulting in an increased PD-1 amount in NK cells.

24 and confrontation assays with primary human NK cells.

25 nd factors mediating LILRB1 transcription in NK cells.

26 CD38KO) in ex vivo expanded peripheral blood NK cells.

27 ocytosis and promoting cytotoxicity in human NK cells.

28 inflammatory cytokine profile and activated NK cells.

29 ls were higher in IL-15- than in IL-2-primed NK cells.

30 emonstrating positive regulatory function of NK cells.

31 of an immune cell known as a natural killer (NK) cell.

32 aracterized by activation of natural killer (NK) cells.

33 urvival and proliferation of natural killer (NK) cells.

34 acute HIV-1 infection reproduced the ILC and NK cell abnormalities ex vivo.

35 or specific ablation of GM-CSF production in NK cells, abrogated disease.

36 NK cells activated with TEPP-46 had reduced effector fun

37 ulticolor flow cytometry during a variety of NK cell activation conditions was completed on primary h

38 that addition of missing self to DSA-induced NK cell activation increased endothelial damage.

39 a monocytogenes (L.m) infection, and whether NK cell activation was affected.

40 ating antibody effector functions, including NK cell activation, monocyte phagocytosis, and complemen

41 d immunodeficiency with defects in T, B, and NK cell activation.

42 g cleft, HLA-B*57:01 more potently inhibited NK cell activation.

43 To analyze human natural killer (NK) cell activation by both species, we performed ex viv

44 expressing TAMs blocked cytotoxic T-cell and NK-cell activation, inhibiting their proliferation, cyto

45 eases pDC-induced MM-specific CD8(+) CTL and NK cell activity against autologous tumor cells.

46 a 6-fold decrease in the fraction of motile NK cells after cryopreservation.

47 Finally, heterogeneity in NK cell age diversifies NK cell function, with "older" N

48 relative to alphabeta T cells, B cells, and NK cells, allowing immunosurveillance for signatures of

49 as survival of Th17 cells and homeostasis of NK cells among others.

50 nsely methylated in less mature CD56(bright) NK cells and are progressively demethylated in CD56(dim)

51 tive lymphocytes, with a particular focus on NK cells and CD8(+) T cells.

52 ber of SMAPs were secreted per cell for both NK cells and CTLs, but NK cell SMAPs were larger.

53 with increased expression of CD103 in colon NK cells and curtailment of CXCR3, and a significant dec

54 Cocultures of human NK cells and endothelial cells confirmed that addition o

55 d decreased numbers of circulating T, B, and NK cells and exhibited a skewing of CD8+ T cells toward

56 titution experiments in pups, we showed that NK cells and granzyme B were required for IL-25 inductio

57 on of stimulatory receptor Ly49D on educated NK cells and increased expression of inhibitory receptor

58 he acquisition of innate memory in activated NK cells and macrophages.

59 the CNS, including most prominently Ly49D(+) NK cells and neutrophils, but not microglia.

60 data show novel associations between MZB and NK cells and p24 production in RM and underscore the imp

61 significantly with the absence of activated NK cells and predicts unfavorable clinical outcomes.

62 tolytic activity and antitumoral capacity of NK cells and T cells and downmodulated Treg cell activit

63 on conditions was completed on primary human NK cells and the NK92MI cell line.

64 ther insights into the antiviral function of NK cells and the pathways involved, their constituent pr

65 ed to a depletion of ILC3 and an increase of NK cells and to a functional shift from a homeostatic to

66 rter mouse model to permanently "time stamp" NK cells and type 1 innate lymphoid cells (ILC1s) to cha

67 lised predominantly on human natural killer (NK) cells and monocytes.

68 hat this resistance requires natural killer (NK) cells and other immune cells.

69 In natural killer (NK) cells and other innate lymphoid cells, competent enh

70 icant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells pref

71 ed numbers of NK cells, EBV predominantly in NK cells, and immature NK cells in the blood.

72 toxic T cells, loss of CD56bright regulatory NK cells, and increased ST2 and soluble CD13.

73 a cellular cascade of synovial macrophages, NK cells, and neutrophils mediates persistent joint infl

74 8-positive (CD8(+)) T cells, natural killer (NK) cells, and NK-T cells and increased accumulation of

75 Ly6C, CD73, and T-bet expression in T-cell, NK-cell, and monocytic populations as distinguishing fea

76 vironment (TME) contains ROS, which suppress NK cell antitumor activity.

77 Despite being prolific innate killers, NK cells are also key helper cells in antiviral defense,

78 Although activated NK cells are armed to combat tumors, the tumor microenvi

79 Circulating NK cells are known to convert to a type 1 innate lymphoi

80 NK cells are likely key sources of IFN-gamma in this mod

81 While exhausted CD4, CD8 T and NK cells are major proliferative cell components in the

82 Natural killer (NK) cells are a critical component of the innate immune

83 Natural killer (NK) cells are a promising cellular immunotherapy for can

84 Human natural killer (NK) cells are defined as CD56(+)CD3(-).

85 Natural killer (NK) cells are important effector cells in the immune res

86 Natural killer (NK) cells are important effectors of innate and adaptive

87 Natural killer (NK) cells are innate lymphoid cells being explored as th

88 death-ligand 1 (PD-L1), and natural killer (NK) cells are involved in trophoblast immunosurveillance

89 Natural killer (NK) cells are key effector cells of innate resistance ca

90 are progressively demethylated in CD56(dim) NK cells as they mature and acquire KIR.

91 nificant increase in mature CD27(-) CD11b(+) NK cells as well as a significant reduction in disease b

92 en gel, however, are killed by cryopreserved NK cells at a 5.6-fold lower rate compared to fresh NK c

93 The former does not detect NK cells at the tumor site, and the latter is inaccurate

94 dies thus provide a rationale for developing NK cell-based therapies to effectively treat MYC-driven

95 exed assemblies that combine natural killer (NK) cell-based cancer immunotherapy with radiotherapy an

96 Natural killer (NK) cells belong to the innate immune system and contrib

97 s revealed that half of the mTORC2-deficient NK cells belongs to the least mature NK cluster.

98 d increased phosphorylation of Akt and S6 in NK cells, but no increase in total STAT1.

99 Depletion of NK cells by anti-NK1.1 Abs drastically improved cognitiv

100 chanism for the activation and regulation of NK cells by Ebola glycoprotein.TRIAL REGISTRATIONClinica

101 anges induced in CD8(+) T or natural killer (NK) cells by MTEX or non-MTEX were compared.

102 diated by CD8(+) T cells and natural killer (NK) cells, by obstructing contact between immune cells a

103 We evaluated 2 patients with natural killer (NK) cell CAEBV and studied their NK cell phenotype and s

104 that extracellular vesicles (EV) released by NK cells carry proteins and miRNAs able to exert an anti

105 In CSF of VSP patients, NK cells (CD3-CD161 +) were increased during the acute p

106 inflammatory cytokines are required to drive NK cell clonal expansion, additional stimulatory signals

107 humans possess a vast diversity of distinct NK cell clones, each with the capacity to vary along thi

108 evelopmental relation between human ILC1 and NK cells, comprising group 1 ILCs, is still elusive.

109 s are monitored through measuring peripheral NK cell concentrations or changes in tumor volume over t

110 ilizumab restored the cytotoxic potential of NK cells.CONCLUSIONThe association between IL-6 serum le

111 Activated NK cells contribute to microvascular inflammation leadin

112 Natural killer (NK) cells control viral infection through the interactio

113 19-CAR-ML NK cells controlled lymphoma burden in vivo and improved

114 ithin proximal KIR promoters in CD56(bright) NK cells cultured with ascorbic acid.

115 upregulation and persistent natural killer (NK) cell cytolytic killing.

116 an NK cells the role of CD56 (NCAM) in human NK cell cytotoxic function has not been defined.

117 this review, we discuss how NKDs that affect NK cell cytotoxicity can be approached in the clinic and

118 onstrate that alpha-syn aggregates attenuate NK cell cytotoxicity in a dose-dependent manner and decr

119 sion was normal; and degranulation tests and NK cell cytotoxicity were not different from those in DC

120 septin cytoskeleton significantly inhibited NK cell cytotoxicity.

121 d a systematic evaluation of natural killer (NK) cell cytotoxicity in adult patients with secondary H

122 Our data provide further insight into NK cell defects caused by STAT5b deficiency.

123 NK cells deficient in alpha2beta1 had no impairment at e

124 We analyzed NK cell degranulation and IFNgamma-response along with S

125 Collectively, we describe an NK cell-dependent endotype of AAD that emerged in early

126 NK cell depletion did not affect amyloid beta concentrat

127 HER2 transgenic mice received Ad/E2TM after NK cell depletion, and they produced less HER2 IgG, demo

128 we administered HLA-mismatched anti-CD19 CAR-NK cells derived from cord blood to 11 patients with rel

129 Human NK cells develop in tonsils through discrete NK cell dev

130 ther, our results reveal anatomic control of NK cell development and maintenance as tissue-resident p

131 genitors, there is an implied stage of human NK cell development in which DNA demethylation takes pla

132 mechanisms, and patients who have defective NK cell development or function can present with atypica

133 orn errors of immunity that lead to impaired NK cell development, function, or both.

134 NK cells develop in tonsils through discrete NK cell developmental intermediates (NKDIs), yet the mec

135 ependent roles for Notch in regulating human NK cell developmental plasticity and maturation.

136 on of key transcription factors that control NK cell differentiation (ie, E4BP4, TXNIP, TBET, GATA3,

137 phoid cell differentiation at the expense of NK cell differentiation.

138 factor ETS1 is critically required for human NK cell differentiation.

139 Mechanistically, CISH(-/-) iPSC-NK cells display improved metabolic fitness characterize

140 Decidual NK cells (dNK) are the main lymphocyte population in ear

141 haracterise five main dILC subsets: decidual NK cells (dNK)1-3, ILC3s and proliferating NK cells.

142 Lesional AD skin shows a NK-cell dysregulation, which despite clinical improvemen

143 Both patients had increased numbers of NK cells, EBV predominantly in NK cells, and immature NK

144 es can bind to HLA-E and block inhibition of NK cell effector function.

145 SIONThis study demonstrates the induction of NK cell effector functions early after Ad26.ZEBOV, MVA-B

146 pe 2 immune response and that IL-25 mediated NK cell effects on type 2 response and AAD.

147 Still, alpha2beta1-deficient NK cells efficiently protected from lethal mousepox and

148 Thus, CAR engineering of ML NK cells enhanced responses against resistant cancers an

149 O QTL analysis, we show that MHC-IB reactive NK cells exert positive influence on the immunity, count

150 ILC3 and NK cells exhibited alterations in their trafficking repe

151 T cells and NK cells exhibited impaired cytolytic activity, and mice

152 e diversifies NK cell function, with "older" NK cells exhibiting more potent IFN-gamma production to

153 The infused CAR-NK cells expanded and persisted at low levels for at lea

154 CD8(-) cDCs and Nphs, and BAFF(+) CD11b(hi) NK cells expanded in draining lymph nodes.

155 NK cell frequencies significantly increased in responder

156 NK cell frequency inversely correlated with that of Lox-

157 NK cells freshly isolated from peripheral blood of healt

158 We evaluated NK cells from primary human tumor samples, after ex vivo

159 inoic acid (ATRA) on wild-type NK and CD38KO NK cell function and highlighted potential benefits and

160 Here, we tested whether maintaining NK cell function during DARA therapy could maximize DARA

161 tivirals (DAAs) and addition of RBV improves NK cell function in liver transplant (LTx) recipients.

162 d adaptive immune responses to pathogens and NK cell function is altered in smokers and COPD.

163 function, but a role for PD-1 in regulating NK cell function is only beginning to emerge.

164 er, the underlying reasons for this impaired NK cell function remain to be uncovered.

165 ess the role of NK cells in PD pathogenesis, NK cell function was investigated in a preformed fibril

166 e evolved a multitude of mechanisms to evade NK cell function, such as the targeting of pathways for

167 ly, heterogeneity in NK cell age diversifies NK cell function, with "older" NK cells exhibiting more

168 naling that directly contributes to enhanced NK cell function.

169 rucial role of a 3-D environment for testing NK cell function.

170 c modulation of the TME to enhance antitumor NK cell function.

171 Interestingly, whereas NK cell functional maturation from stage 3 and 4A NKDIs

172 blockade of inhibitory receptors that limit NK cell functions, and therapeutic modulation of the TME

173 ely controls intestinal inflammation through NK cell functions.

174 Furthermore, 19-CAR-ML NK cells generated from lymphoma patients exhibited impr

175 Collectively, the absence or presence of NK cells, governs the net tumor-modulatory effects of ne

176 Furthermore, human STAT5b-deficient NK cells had low cytolytic capacity, and fixed-cell micr

177 cted selectively on EP2 and EP4 receptors on NK cells, hampered the TME switch, and enabled immune ev

178 Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric

179 NK cells that, similar to murine EMP-derived NK cells, harbor a potent cytotoxic degranulation bias.

180 While the expression of PD-1 on NK cells has been controversial, with papers publishing

181 al innate cytokine response, but the role of NK cells has not been thoroughly examined.METHODSThe nov

182 Natural Killer (NK) cells have an important role in immune responses to

183 NK cell homeostatic turnover is further accelerated with

184 ition to the impaired terminal maturation of NK cells, human STAT5b mutation leads to impairments in

185 However, the control of NK cell IFN-gamma production was not cell intrinsic, rev

186 ith DAA-therapy for HCV increased CD56Bright NK cell IFNgamma-responses in LTx-recipients (70.9% vs 8

187 tudies demonstrate that in vivo depletion of NK cells in a preclinical mouse PD model resulted in exa

188 ken to exploit the therapeutic properties of NK cells in cancer.

189 In turn, the activation of NK cells in coculture with CMV-specific CD8 T cells prom

190 The altered phenotype of NK cells in HCV-infected LTx-recipients was accompanied

191 Whether chronic infections similarly affect NK cells in humans should be explored.IMPORTANCE Infecti

192 taken together, suggest an important role by NK cells in inducing inflammation in CL, thereby contrib

193 ider the requirements for such a response in NK cells in light of those for T cells.

194 To address the role of NK cells in PD pathogenesis, NK cell function was invest

195 We report the presence of NK cells in post-mortem ALS motor cortex and spinal cord

196 Activation of human NK cells in response to Candida in human blood mainly oc

197 EBV predominantly in NK cells, and immature NK cells in the blood.

198 issue of Cell, Crespo et al. show that human NK cells in the decidual region of the uterus can clear

199 n the colon and an increase in the levels of NK cells in tonsils and oral lymph nodes.

200 agent of mousepox) and that natural killer (NK) cells in CL13-infected mice are reduced in numbers a

201 ies of B cells, T cells, and natural killer (NK) cells in Rabl3 (xm/xm) mice.

202 fector T cells and decreased natural killer (NK) cells in these tumors.

203 re indispensable for PD-1 induction on human NK cells, in cooperation with a combination of cytokines

204 cytokine/chemokine landscape, transactivated NK cells, increased MHC class II expression on macrophag

205 rthermore, the percentage of PD-1 expressing NK cells increases with age and cumulative malaria expos

206 Following NACT, increased natural killer (NK) cell infiltration and oligoclonal expansion of T cel

207 Our data show that NKG2C(pos) NK cells interact with HLA-E(high) CD8 T cells, which ma

208 herapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME), blockade

209 ing an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform.

210 ria monocytogenes infection and suggest that NK cell is one of the main targets of VPA, but further w

211 tro studies revealed that PD-1 expression on NK cells is associated with diminished natural cytotoxic

212 Expression of PD-1 on NK cells is controversial despite rapid incorporation in

213 Genetic or antibody-mediated depletion of NK cells leads to sustained improvements in neurogenesis

214 proresolving mediator lipoxin A(4) promoted NK cell LIMK expression, lytic granule polarization to t

215 CD34(-)CD117(+/-)CD94(+)NKp80(+)) NKDIs were NK cell lineage committed despite Notch activation.

216 degree of functional differentiation of the NK cell lineage influences the magnitude and specificity

217 pproach by comparing CD16a isolated from two NK cell lines, NK92 and YTS, with CD16a expressed by HEK

218 ast cell lines, and MCM10 knockdown in human NK cell lines, we have shown that loss of MCM10 function

219 to impairments in early activation events in NK cell lytic synapse formation.

220 ance complex member 10 (MCM10) that impaired NK cell maturation in a child with fatal susceptibility

221 ggesting that STAT5b is involved in terminal NK cell maturation in Stat5b(-/-) mice.

222 We observed low NK cell numbers and impaired NK cell maturation, suggesting that STAT5b is involved i

223 In this review, we examine these types of NK cell memory, highlighting their unique features and u

224 riptional signatures of CD4 T, CD8 T, B, and NK cells, monocytes, myeloid dendritic cells (mDCs), and

225 e immune properties, such as natural killer (NK) cells, NKT cells, gammadelta T cells, and macrophage

226 We observed low NK cell numbers and impaired NK cell maturation, suggest

227 Consistent with this, NK cells of malaria-naive adults upregulated PD-1 follow

228 ritis, via GM-CSF production, as deletion of NK cells, or specific ablation of GM-CSF production in N

229 hree doses (1x10(5), 1x10(6), or 1x10(7) CAR-NK cells per kilogram of body weight) after lymphodeplet

230 severe and transient lymphopenia, activated NK cell phenotype (eg, increased CD69, ICAM-1, HLADR, an

231 ptive and FcepsilonRIgamma(pos) conventional NK cell phenotype and function before and after DAA trea

232 ral killer (NK) cell CAEBV and studied their NK cell phenotype and signaling pathways in cells.

233 pluripotent stem cell-derived NK cell (iPSC-NK cell) platform.

234 NK cells play an important role in antiviral resistance.

235 Conversely, vaccination with MF59 recruited NK cells poorly and drove moderate monocyte phagocytic a

236 This NK cell population was also detected in the circulation

237 the fate of the recently described adaptive NK cell population, endowed with increased ability to me

238 Here, we report that NK cell potential first arises from Hoxa(neg/low) Kit(+)

239 By modeling MCM10 deficiency in primary NK cell precursors, including patient-derived induced pl

240 f NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activ

241 Synovial NK cell production of GM-CSF is IL-18-dependent.

242 ghlight the variety of ways in which diverse NK cell products and their auxiliary therapeutics are be

243 commonly not generated from previously known NK cell progenitor sources.

244 Because KIR genes are densely methylated in NK cell progenitors, there is an implied stage of human

245 Synovial NK cells promote a neutrophilic inflammatory cell infilt

246 NK cells provide a defense against virally infected cell

247 dies suggest that harnessing natural killer (NK) cell reactivity mediated through killer cell immunog

248 ction, such as the targeting of pathways for NK cell receptors and their ligands, apoptosis, and cyto

249 carcinoma (RCC) tumors were stained for the NK cell receptors CD56, NKp30, and NKp46 to determine ex

250 quired for N-glycosylation of key T cell and NK cell receptors that can account for some of the clini

251 r, many cancers are not fully recognized via NK cell receptors.

252 estigation, with the potential to broaden ML NK cell recognition against a variety of NK cell-resista

253 haps because of the combined effect of T and NK cell reconstitution.

254 Interestingly, NK cell recruitment and activation were impaired, and me

255 NK cells regulate immune functions and are modulated by

256 tus, characterized by overexpression of ILC1/NK cell-related genes and downregulation of type 3 signa

257 ML NK cell recognition against a variety of NK cell-resistant tumors.

258 ss to innate environmental cues, FcRgamma(-) NK cells responded robustly to adaptive Ab-mediated sign

259 s primarily been observed in natural killer (NK) cells responding to cytomegalovirus infection, and c

260 ll-extrinsic downregulation of the antiviral NK cell response by adrenergic neuroendocrine signals.

261 ould result in complementary improvements in NK cell responses against NK-resistant cancers.

262 The control of NK cell responses is complex and only partially understo

263 Optimal NK cell responses were dependent on IL-18 and IL-12, whe

264 c signaling is required for optimal adaptive NK cell responses.

265 llular metabolism is essential for effective NK cells responses.

266 transcriptional control, facilitate optimal NK cells responses.

267 suggests that dysfunctional natural killer (NK) cell responses during hepatitis C virus (HCV) infect

268 nduced depletion of CD38high natural killer (NK) cells resulting in crippled antibody-dependent cellu

269 Individual NK cells secreted SMAPs, CD63+ vesicles, or both.

270 ted per cell for both NK cells and CTLs, but NK cell SMAPs were larger.

271 Moreover, highly enriched NK cell subpopulations implicated in the regression mode

272 ation generated a nonfunctional CD56(bright) NK cell subset characterized by low cytokine production.

273 In contrast, a CD27(+) Natural killer (NK) cell subset accumulated in the lungs of LTBI macaque

274 ompletely understood how cancer cells escape NK cell surveillance.

275 NK cell synaptic secretion, triggered by ligation of NKp

276 ther demonstrated that MCM10 is required for NK cell terminal maturation and acquisition of immunolog

277 was a stronger activator for isolated human NK cells than C. glabrata.

278 human cord blood CD34(+) cells, give rise to NK cells that exhibit an attenuated degranulation respon

279 ppears to be the only activating receptor on NK cells that is cleaved by the metalloprotease a disint

280 15Ralpha-IL-15 provides a mode of regulating NK cells that is not afforded to IL-2 and is distinct fr

281 XA(neg/low) CD34(+) progenitors give rise to NK cells that, similar to murine EMP-derived NK cells, h

282 Despite its ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell cytoto

283 In this study, in human NK cells, the glucocorticoid dexamethasone downregulated

284 NK cell therapies are monitored through measuring periph

285 ndings may explain the persistent failure of NK cell therapy in patients with solid tumors and highli

286 yTOF to define the conversion of circulating NK cells to an ILC1-like phenotype and have clarified th

287 Exposure of NK cells to innate DC-derived costimulatory factors trig

288 covered that exposure to cancer cells causes NK cells to lose their cytotoxic ability and promote met

289 lammatory signals, and a refined capacity of NK cells to target malaria parasites more precisely, par

290 heir function, is a functional adaptation of NK cells to the fatty-acid rich lymphoma environment.

291 ring mouse cytomegalovirus (MCMV) infection, NK cells up-regulated Adrb2 (which encodes the beta2-adr

292 , we develop human CISH-knockout (CISH(-/-)) NK cells using an induced pluripotent stem cell-derived

293 king, and function of group 3 ILC (ILC3) and NK cells using polychromatic flow cytometry and cell sti

294 sight into how the functional response of an NK cell varies over its lifespan.

295 These CD38KO NK cells were completely resistant to DARA-induced fratr

296 NK cells were the main source of IFN-gamma production, w

297 NK cells were transduced with a retroviral vector expres

298 IFNgamma+ NK cell% were significantly elevated in HS versus NC ser

299 eral immune cells, including Natural Killer (NK) cells, which play an important role in the containme

300 reduction of STAT1 phosphorylation in their NK cells with JAK inhibitors suggests a novel approach t